Children under stress–COMT genotype and stressful life events predict cortisol increase in an acute social stress paradigm
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Dopamine and norepinephrine are key regulators of cognitive and affective processes. The enzyme catechol-O-methyltransferase (COMT) catabolizes catecholamines and the COMT Val158Met polymorphism has been linked to several neuropsychiatric variables. Additionally, stressful life events (SLEs) contribute substantially to affective processes. We used the stress-induced activation of the hypothalamic-pituitary-adrenal axis to investigate the effects of COMT and SLEs on the cortisol response in 119 healthy children (8-12 yr). Saliva cortisol was measured during and after the Trier Social Stress Test for Children. SLEs were assessed with a standardized interview with one of the children's parents. Linear regression analysis revealed a significant effect for COMT, with Met allele carriers showing a higher cortisol response (β=0.300, p=0.001). In turn, more SLEs lead to a less pronounced cortisol increase (β=-0.192, p=0.029) probably indicating increased resilience. Our results further underscore the essential and differential role of genetic variation and environmental factors on stress responsivity.
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The COMT genotype is associated with an altered cortisol response.
“The COMT genotype, which influences the enzyme’s stability and hence dopaminergic activity [17], is also associated with an altered cortisol response [26,27].”
From Dynamic DNA methylation changes in the COMT gene promoter region in response to mental stress and its modulation by transcranial direct current stimulation (2021) · cites this paper as [26]
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Self-citationWiegand, A., Blickle, A., Brückmann, C., Weller, S., Nieratschker, V., & Plewnia, C. (2021) · Biomolecules · doi:10.3390/biom11111726 · Cited by 19 · see citing works
- Authors
- Armbruster, D., Mueller, A., Strobel, A., Lesch, K.-P., Brocke, B., & Kirschbaum, C.
- Affiliations
- Technische Universität Dresden (DE)
- University of Würzburg (DE)
- Venue
- The International Journal of Neuropsychopharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12-12
- Volume
- 15
- Issue
- 09
- Pages
- 1229-1239
- ISSN
- 1461-1457 (ISSN-L)
- 1469-5111
- OpenAlex
- W2140289027
- Cited by
- 87
- References
- 88
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 6 · 2017: 10 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 3
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The International Journal of Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (KI 537/20-1, SFB 581, KI 537/20-1, 20-3, KFO125, SFB TTR 58)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- catechol-O-methyltransferase, COMT Val158Met polymorphism, life events, cortisol, acute social stress, children, hypothalamic-pituitary-adrenal axis, stress responsivity, resilience, genetic variation, environmental factors
- MeSH terms
- Alleles, Catechol O-Methyltransferase, Child, DNA, Female, Gene Frequency, Genotype, Humans, Hydrocortisone, Life Change Events, Male, Neuropsychological Tests, Regression Analysis, Saliva, Social Environment, Stress, Psychological, Genetic Variation, Reproducibility of Results, Brain-Derived Neurotrophic Factor
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