Krystal, John H.

Lower synaptic density is associated with depression severity and network alterations

Holmes, S. E., Scheinost, D., Finnema, S. J., Naganawa, M., Davis, M. T., DellaGioia, N., Nabulsi, N., Matuskey, D., Angarita, G. A., Pietrzak, R. H., et al. (2019) · Nature Communications

Treatment of Major DepressionFunctional Brain Connectivity Studies

Cited by 484

Ketamine: A Paradigm Shift for Depression Research and Treatment

Krystal, J. H., Abdallah, C. G., Sanacora, G., Charney, D. S., & Duman, R. S. (2019) · Neuron

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 455

Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum

Martinez, D., Gil, R., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Kegeles, L., Talbot, P., Evans, S., Krystal, J., et al. (2005) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 445

Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects of N-methyl-D-aspartate Receptor Antagonists

Anand, A., Charney, D. S., Oren, D. A., Berman, R. M., Hu, X. S., Cappiello, A., & Krystal, J. H. (2000) · Archives of General Psychiatry

Treatment of Major DepressionSchizophrenia research and treatment

Cited by 426

Ketamine and Rapid-Acting Antidepressants: A Window into a New Neurobiology for Mood Disorder Therapeutics

Abdallah, C. G., Sanacora, G., Duman, R. S., & Krystal, J. H. (2015) · Annual Review of Medicine

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 422

A prospective cohort study investigating factors associated with depression during medical internship

Sen, S., Kranzler, H. R., Krystal, J. H., Speller, H., Chan, G., Gelernter, J., & Guille, C. (2010) · Archives of General Psychiatry

Healthcare professionals’ stress and burnoutInnovations in Medical Education

Cited by 411

Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond

Krystal, J. H., Sanacora, G., & Duman, R. S. (2013) · Biological Psychiatry

Treatment of Major DepressionElectroconvulsive Therapy Studies

Cited by 406

Toward a neurobiology of delusions

Corlett, P. R., Taylor, J. R., Wang, X.-J., Fletcher, P. C., & Krystal, J. H. (2010) · Progress in Neurobiology

Mental Health and PsychiatrySchizophrenia research and treatment

Cited by 394

Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers.

Jacobsen, L. K., Krystal, J. H., Mencl, W. E., Westerveld, M., Frost, S. J., & Pugh, K. R. (2005) · Biological Psychiatry

Smoking Behavior and CessationNicotinic Acetylcholine Receptors Study

Cited by 393

Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

Preller, K. H., Burt, J. B., Ji, J. L., Schleifer, C. H., Adkinson, B. D., Stämpfli, P., Seifritz, E., Repovs, G., Krystal, J. H., Murray, J. D., et al. (2018) · eLife

Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 390

Comparative and Interactive Human Psychopharmacologic Effects of Ketamine and Amphetamine: Implications for Glutamatergic and Dopaminergic Model Psychoses and Cognitive Function

Krystal, J. H., Perry, E. B., Gueorguieva, R., Belger, A., Madonick, S. H., Abi-Dargham, A., Cooper, T. B., MacDougall, L., Abi-Saab, W., & D’Souza, D. C. (2005) · Archives of General Psychiatry

Schizophrenia research and treatmentNeurotransmitter Receptor Influence on Behavior

Cited by 317

Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: An open-label trial

Coric, V., Taskiran, S., Pittenger, C., Wasylink, S., Mathalon, D. H., Valentine, G., Saksa, J., Wu, Y.-T., Gueorguieva, R., Sanacora, G., et al. (2005) · Biological Psychiatry

Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Cited by 314

Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology

Stone, J. M., Dietrich, C., Edden, R., Mehta, M. A., De Simoni, S., Reed, L. J., Krystal, J. H., Nutt, D., & Barker, G. J. (2012) · Molecular Psychiatry

Treatment of Major DepressionSchizophrenia research and treatment

Cited by 295

Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach

Chekroud, A. M., Gueorguieva, R., Krumholz, H. M., Trivedi, M. H., Krystal, J. H., & McCarthy, G. (2017) · JAMA Psychiatry

Treatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Cited by 276

Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample

Hoffman, R. E., Gueorguieva, R., Hawkins, K. A., Varanko, M., Boutros, N. N., Wu, Y.-T., Carroll, K., & Krystal, J. H. (2005) · Biological Psychiatry

Transcranial Magnetic Stimulation StudiesSchizophrenia research and treatment

Cited by 272

Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects

Krystal, J. H., Abi-Saab, W., Perry, E., D’Souza, D. C., Liu, N., Gueorguieva, R., McDougall, L., Hunsberger, T., Belger, A., Levine, L., et al. (2005) · Psychopharmacology

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 272

Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder

Anticevic, A., Hu, S., Zhang, S., Savic, A., Billingslea, E., Wasylink, S., Repovs, G., Cole, M. W., Bednarski, S., Krystal, J. H., et al. (2014) · Biological Psychiatry

Obsessive-Compulsive Spectrum DisordersFunctional Brain Connectivity Studies

Cited by 268

It is time to address the crisis in the pharmacotherapy of posttraumatic stress disorder: A consensus statement of the PTSD psychopharmacology working group

Krystal, J. H., Davis, L. L., Neylan, T. C., A. Raskind, M., Schnurr, P. P., Stein, M. B., Vessicchio, J., Shiner, B., Gleason, T. D., & Huang, G. D. (2017) · Biological Psychiatry

Posttraumatic Stress Disorder ResearchSleep and related disorders

Cited by 265

Global Prefrontal and Fronto-Amygdala Dysconnectivity in Bipolar I Disorder with Psychosis History

Anticevic, A., Brumbaugh, M. S., Winkler, A. M., Lombardo, L. E., Barrett, J., Corlett, P. R., Kober, H., Gruber, J., Repovs, G., Cole, M. W., et al. (2013) · Biological Psychiatry

Bipolar Disorder and TreatmentFunctional Brain Connectivity Studies

Cited by 263

Ketamine and rapid antidepressant action: New treatments and novel synaptic signaling mechanisms

Krystal, J. H., Kavalali, E. T., & Monteggia, L. M. (2024) · Neuropsychopharmacology

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 262

Reductions in Occipital Cortex GABA Levels in Panic Disorder Detected With 1H-Magnetic Resonance Spectroscopy

Goddard, A. W., Mason, G. F., Almai, A., Rothman, D. L., Behar, K. L., Petroff, O. A. C., Charney, D. S., & Krystal, J. H. (2001) · Archives of General Psychiatry

Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesAdvanced MRI Techniques and Applications

Cited by 255

Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model

Murray, J. D., Anticevic, A., Gancsos, M., Ichinose, M., Corlett, P. R., Krystal, J. H., & Wang, X.-J. (2014) · Cerebral Cortex

Neural dynamics and brain functionSchizophrenia research and treatment

Cited by 255

Illusory generalizability of clinical prediction models

Chekroud, A. M., Hawrilenko, M., Loho, H., Bondar, J., Gueorguieva, R., Hasan, A., Kambeitz, J., Corlett, P. R., Koutsouleris, N., Krumholz, H. M., et al. (2024) · Science

Machine Learning in HealthcareSchizophrenia research and treatment

Cited by 251

Efficacy of D-Cycloserine for Enhancing Response to Cognitive-Behavior Therapy for Panic Disorder

Otto, M. W., Tolin, D. F., Simon, N. M., Pearlson, G. D., Basden, S., Meunier, S. A., Hofmann, S. G., Eisenmenger, K., Krystal, J. H., & Pollack, M. H. (2010) · Biological Psychiatry

Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychotherapy Techniques and Applications

Cited by 251