Rewiring of Genetic Networks in Response to DNA Damage
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DNA Damage Pathways Revealed: Despite the dynamic nature of cellular responses, the genetic networks that govern these responses have been mapped primarily as static snapshots. Bandyopadhyay et al. (p. 1385 ; see the Perspective by Friedman and Schuldiner ) report a comparison of large genetic interactomes measured among all yeast kinases, phosphatases, and transcription factors, as the cell responded to DNA damage. The interactomes revealed were highly dynamic structures that changed dramatically with changing conditions. These dynamic interactions reveal genetic relationships that can be more effective than classical “static” interactions (for example, synthetic lethals and epistasis maps) in identifying pathways of interest.
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- Authors
- Bandyopadhyay, S., Mehta, M., Kuo, D., Sung, M.-K., Chuang, R., Jaehnig, E. J., Bodenmiller, B., Licon, K., Copeland, W., Shales, M., Fiedler, D., Dutkowski, J., Guénolé, A., van Attikum, H., Shokat, K. M., Kolodner, R. D., Huh, W.-K., Aebersold, R., Keogh, M.-C., Krogan, N. J., & Ideker, T.
- Affiliations
- University of California San Diego (US)
- Albert Einstein College of Medicine (US)
- Seoul National University (KR)
- University of Zurich (CH)
- University of California, San Francisco (US)
- Howard Hughes Medical Institute (US)
- Leiden University Medical Center (NL)
- Department of Toxicogenetics, Leiden University Medical Center, Leiden, Netherlands.
- Corresponding author
- Keogh, Michael-Christopher
- Krogan, Nevan J.
- Ideker, Trey
- ORCID
- Venue
- Science
- Published
- 2010-12-03
- Volume
- 330
- Issue
- 6009
- Pages
- 1385-1389
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3006187
- OpenAlex
- W1988263223
- Cited by
- 447
- References
- 23
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 12 · 2023: 10 · 2022: 17 · 2021: 18 · 2020: 31 · 2019: 40 · 2018: 22 · 2017: 42 · 2016: 28 · 2015: 37 · 2014: 55 · 2013: 51 · 2012: 41
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Cancer Institute (P30CA013330)
- National Institute of General Medical Sciences (R01GM084448, P50GM081879, R01GM084279, R37GM026017, R01GM026017)
- National Institute of Environmental Health Sciences (R01ES014811)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- DNA damage response, genetic interaction networks, phosphatase, transcription factors, DNA repair pathways, protein complex stability, network rewiring
- MeSH terms
- Chromatin, DNA Damage, DNA Repair, DNA, Fungal, Epistasis, Genetic, Genes, Fungal, Histones, Methyl Methanesulfonate, Mutagens, Mutation, Phosphoprotein Phosphatases, Saccharomyces cerevisiae, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Mitogen-Activated Protein Kinases, Protein Interaction Mapping, Saccharomyces cerevisiae Proteins, Gene Regulatory Networks
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