Mattson, Mark P.

Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity

Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., & Mattson, M. P. (2000) · The Journal of Neuroscience

Folate and B Vitamins ResearchCell death mechanisms and regulation

Cited by 784

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

Tang, S.-C., Arumugam, T. V., Xu, X., Cheng, A., Mughal, M. R., Jo, D. G., Lathia, J. D., Siler, D. A., Chigurupati, S., Ouyang, X., et al. (2007) · Proceedings of the National Academy of Sciences

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 779

Brain metabolism in health, aging, and neurodegeneration

Camandola, S., & Mattson, M. P. (2017) · The EMBO Journal

Neuroscience and Neuropharmacology ResearchMitochondrial Function and Pathology

Cited by 752

Calcium and neurodegeneration

Mattson, M. P. (2007) · Aging Cell

Mitochondrial Function and PathologyIon channel regulation and function

Cited by 751

Superoxide flashes in single mitochondria

Wang, W., Fang, H., Groom, L., Cheng, A., Zhang, W., Liu, J., Wang, X., Li, K., Han, P., Zheng, M., et al. (2008) · Cell

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 715

An overview of APP processing enzymes and products.

Chow, V. W., Mattson, M. P., Wong, P. C., & Gleichmann, M. (2010) · NeuroMolecular Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 684

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

Mattson, M. P. (2008) · Annals of the New York Academy of Sciences

Neuroscience and Neuropharmacology ResearchNerve injury and regeneration

Cited by 640

Intermittent metabolic switching, neuroplasticity and brain health

Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience

Dietary Effects on HealthDiet and metabolism studies

Cited by 624

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma

Johnson, J. B., Summer, W., Cutler, R. G., Martin, B., Hyun, D.-H., Dixit, V. D., Pearson, M., Nassar, M., Tellejohan, R., Maudsley, S., et al. (2007) · Free Radical Biology and Medicine

Dietary Effects on HealthAsthma and respiratory diseases

Cited by 604

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

Kapogiannis, D., & Mattson, M. P. (2011) · The Lancet Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 594

How does hormesis impact biology, toxicology, and medicine?

Calabrese, E. J., & Mattson, M. P. (2017) · npj Aging and Mechanisms of Disease

Effects of Radiation ExposureGenetics, Aging, and Longevity in Model Organisms

Cited by 593

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

Li, Y., Perry, T., Kindy, M. S., Harvey, B. K., Tweedie, D., Holloway, H. W., Powers, K., Shen, H., Egan, J. M., Sambamurti, K., et al. (2009) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsNeuroprotection in Cerebral Ischemia

Cited by 589

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

Halagappa, V. K. M., Guo, Z., Pearson, M., Matsuoka, Y., Cutler, R. G., LaFerla, F. M., & Mattson, M. P. (2007) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDietary Effects on Health

Cited by 580

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism

Sirtuins and Resveratrol in MedicineDNA Repair Mechanisms

Cited by 575

BDNF mediates adaptive brain and body responses to energetic challenges

Marosi, K., & Mattson, M. P. (2014) · Trends in Endocrinology & Metabolism

Regulation of Appetite and ObesityNerve injury and regeneration

Cited by 568

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

Mark, R. J., Pang, Z., Geddes, J. W., Uchida, K., & Mattson, M. P. (1997) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 551

NAD(+) in aging: molecular mechanisms and translational implications

Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017) · Trends in Molecular Medicine

Sirtuins and Resveratrol in MedicineBiochemical and Molecular Research

Cited by 501

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Guo, Q., Fu, W., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Nature Medicine

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 489

NAD + supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

Hou, Y., Lautrup, S., Cordonnier, S., Wang, Y., Croteau, D. L., Zavala, E., Zhang, Y., Moritoh, K., O’Connell, J. F., Baptiste, B. A., et al. (2018) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsSirtuins and Resveratrol in Medicine

Cited by 472

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

Haughey, N. J., Nath, A., Chan, S. L., Borchard, A. C., Rao, M. S., & Mattson, M. P. (2002) · Journal of Neurochemistry

Neurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Cited by 466

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

Lee, J., Seroogy, K. B., & Mattson, M. P. (2002) · Journal of Neurochemistry

Neurogenesis and neuroplasticity mechanismsNerve injury and regeneration

Cited by 455

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

Keller, J. N., Pang, Z., Geddes, J. W., Begley, J. G., Germeyer, A., Waeg, G., & Mattson, M. P. (1997) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 439

The Endoplasmic Reticulum Stress-Responsive Protein GRP78 Protects Neurons Against Excitotoxicity and Apoptosis: Suppression of Oxidative Stress and Stabilization of Calcium Homeostasis

Yu, Z., Luo, H., Fu, W., & Mattson, M. P. (1999) · Experimental Neurology

Endoplasmic Reticulum Stress and DiseaseHeat shock proteins research

Cited by 438

Energy intake and exercise as determinants of brain health and vulnerability to injury and disease

Mattson, M. P. (2012) · Cell Metabolism

Dietary Effects on HealthGenetics, Aging, and Longevity in Model Organisms

Cited by 434