BDNF mediates adaptive brain and body responses to energetic challenges
Open accessAbstract
Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread roles in regulating energy homeostasis by controlling patterns of feeding and physical activity, and by modulating glucose metabolism in peripheral tissues. BDNF mediates the beneficial effects of energetic challenges such as vigorous exercise and fasting on cognition, mood, cardiovascular function, and on peripheral metabolism. By stimulating glucose transport and mitochondrial biogenesis BDNF bolsters cellular bioenergetics and protects neurons against injury and disease. By acting in the brain and periphery, BDNF increases insulin sensitivity and parasympathetic tone. Genetic factors, a 'couch potato' lifestyle, and chronic stress impair BDNF signaling, and this may contribute to the pathogenesis of metabolic syndrome. Novel BDNF-focused interventions are being developed for obesity, diabetes, and neurological disorders.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
BDNF may be involved in cancer, angiogenesis, reduction of glucose production from the liver, and uptake of glucose in peripheral tissues.
“Therefore, it may also be involved in cancer, angiogenesis, reduction of glucose production from the liver [23], and in the uptake of glucose in peripheral tissues (see [24] for review).”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [24]
BDNF is important in development, maintenance, and plasticity of the central and peripheral nervous system and protects the aging brain against injury and disease by stimulating glucose transport and mitochondrial biogenesis.
“The neurotrophin brain-derived neurotrophic factor (BDNF) is important in the development, maintenance, and plasticity of the central and peripheral nervous system; it also protects the aging brain against injury and disease through stimulation of glucose transport and mitochondrial biogenesis (Marosi and Mattson, 2014).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Marosi and Mattson, 2014
Growth factors, particularly BDNF, have systemic effects in regulating cellular bioenergetic function, which is disrupted in multiple mental health conditions, making it more difficult to facilitate affective control, cultivate flexible response patterns, or facilitate synaptic plasticity adaptations within supportive neurocircuitry.
“Growth factors, particularly BDNF, also have systemic effects in regulating cellular bioenergetic function (32), which is disrupted in multiple mental health conditions (33), making it more difficult to facilitate affective control, cultivate flexible response patterns, or facilitate synaptic plasticity adaptations within supportive neurocircuitry (34).”
From The Role of Exercise in Management of Mental Health Disorders: An Integrative Review (2021) · cites this paper as [32]
Exercise stimulates brain-derived neurotrophic factor (BDNF) activation and secretion from skeletal muscle.
“Exercise also stimulates brain-derived neurotrophic factor (BDNF) activation and secretion from skeletal muscle (36).”
From Exercise Counters the Age-Related Accumulation of Senescent Cells (2022) · cites this paper as [36]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Synaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747 · see citing works
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
Kops, G. J. P. L., Dansen, T. B., Polderman, P. E., Saarloos, I., Wirtz, K. W. A., Coffer, P. J., Huang, T.-T., Bos, J. L., Medema, R. H., & Burgering, B. M. T. (2002) · Nature · doi:10.1038/nature01036 · Cited by 1,580 · see citing works
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway
Wrann, C. D., White, J. P., Salogiannnis, J., Laznik-Bogoslavski, D., Wu, J., Ma, D., Lin, J. D., Greenberg, M. E., & Spiegelman, B. M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.008 · Cited by 1,440 · see citing works
Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375 · see citing works
Lee, J., Duan, W., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01085.x · Cited by 975 · see citing works
Self-citationBrain-derived neurotrophic factor in neurodegenerative diseases
Zuccato, C., & Cattaneo, E. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.54 · Cited by 947 · see citing works
Timing to perfection: the biology of central and peripheral circadian clocks
Albrecht, U. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.006 · Cited by 915 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
BDNF regulates eating behavior and locomotor activity in mice
Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806 · see citing works
Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.171 · Cited by 804 · see citing works
Self-citationHigh impact running improves learning
Winter, B., Breitenstein, C., Mooren, F. C., Voelker, K., Fobker, M., Lechtermann, A., Krueger, K., Fromme, A., Korsukewitz, C., Flöel, A., et al. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.11.003 · Cited by 796 · see citing works
Rios, M., Fan, G., Fekete, C., Kelly, J., Bates, B., Kuehn, R., Lechan, R. M., & Jaenisch, R. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.10.0706 · Cited by 781 · see citing works
Tang, S. J., Reis, G., Kang, H., Gingras, A.-C., Sonenberg, N., & Schuman, E. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012605299 · Cited by 734 · see citing works
Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia · doi:10.1007/s00125-009-1364-1 · Cited by 722 · cited 1× · see citing works
“Ex vivo and in vivo studies showed that BDNF treatment increases phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase (ACCβ) resulting in enhanced fat oxidation in the skeletal muscle [49].”
BackgroundBrain-derived neurotrophic factor (BDNF) and type 2 diabetes
Krabbe, K. S., Nielsen, A. R., Krogh‐Madsen, R., Plomgaard, P., Rasmussen, P., Erikstrup, C., Fischer, C. P., Lindegaard, B., Petersen, A. M. W., Taudorf, S., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0537-4 · Cited by 703 · see citing works
Neurotrophin signalling in health and disease
Chao, M. V., Rajagopal, R., & Lee, F. S. (2006) · Clinical Science · doi:10.1042/cs20050163 · Cited by 619 · see citing works
Johnson, J. B., Summer, W., Cutler, R. G., Martin, B., Hyun, D.-H., Dixit, V. D., Pearson, M., Nassar, M., Tellejohan, R., Maudsley, S., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.005 · Cited by 604 · see citing works
Self-citationLi, Y., Perry, T., Kindy, M. S., Harvey, B. K., Tweedie, D., Holloway, H. W., Powers, K., Shen, H., Egan, J. M., Sambamurti, K., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806720106 · Cited by 589 · see citing works
Self-citationAerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
Griffin, É. W., Mullally, S. L., Foley, C., Warmington, S. A., O’Mara, S. M., & Kelly, A. M. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.06.005 · Cited by 543 · see citing works
Management of type 2 diabetes: new and future developments in treatment
Tahrani, A. A., Bailey, C. J., Prato, S. D., & Barnett, A. H. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60207-9 · Cited by 532 · see citing works
Exenatide and the treatment of patients with Parkinson's disease
Aviles-Olmos, I., Dickson, J., Kefalopoulou, Z., Djamshidian, A., Ell, P., Soderlund, T., Whitton, P., Wyse, R., Isaacs, T., Lees, A., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68295 · Cited by 529 · see citing works
Gray, J. A., Yeo, G. S. H., Cox, J. J., Morton, J., Adlam, A., Keogh, J. M., Yanovski, J. A., Gharbawy, A. E., Han, J. C., Tung, Y. C. L., et al. (2006) · Diabetes · doi:10.2337/db06-0550 · Cited by 515 · see citing works
Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice
Duman, C. H., Schlesinger, L., Russell, D. S., & Duman, R. S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.12.047 · Cited by 465 · see citing works
Takei, N., Inamura, N., Kawamura, M., Namba, H., Hara, K., Yonezawa, K., & Nawa, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1427-04.2004 · Cited by 442 · see citing works
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434 · see citing works
Self-citationSmall molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., Nehama, D., Rajadas, J., & Longo, F. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41356 · Cited by 406 · see citing works
Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines
Cheng, A., Wan, R., Yang, J.-L., Kamimura, N., Son, T. G., Ouyang, X., Luo, Y., Okun, E., & Mattson, M. P. (2012) · Nature Communications · doi:10.1038/ncomms2238 · Cited by 401 · see citing works
Self-citationWhen neurogenesis encounters aging and disease
Lazarov, O., Mattson, M. P., Peterson, D. A., Pimplikar, S. W., & van Praag, H. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.09.003 · Cited by 389 · see citing works
Self-citationRunning is the neurogenic and neurotrophic stimulus in environmental enrichment
Kobilo, T., Liu, Q.-R., Gandhi, K., Mughal, M., Shaham, Y., & van Praag, H. (2011) · Learning & Memory · doi:10.1101/lm.2283011 · Cited by 385 · see citing works
Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 380 · see citing works
Unger, T. J., Calderon, G. A., Bradley, L., Sena‐Esteves, M., & Rios, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3308-07.2007 · Cited by 370 · see citing works
Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363 · see citing works
Self-citationHormetic Dietary Phytochemicals
Son, T. G., Camandola, S., & Mattson, M. P. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8037-y · Cited by 362 · see citing works
Self-citationMolteni, R., Wu, A., Vaynman, S., Ying, Z., Barnard, R. J., & Gómez‐Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.020 · Cited by 350 · see citing works
Running induces widespread structural alterations in the hippocampus and entorhinal cortex
Stranahan, A. M., Khalil, D., & Gould, E. (2007) · Hippocampus · doi:10.1002/hipo.20348 · Cited by 327 · see citing works
Characteristics of BDNF-induced weight loss
Pelleymounter, M. A., Cullen, M. J., & Wellman, C. L. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90045-4 · Cited by 321 · see citing works
Li, Y., Duffy, K. B., Ottinger, M. A., Ray, B., Bailey, J. A., Holloway, H. W., Tweedie, D., Perry, T., Mattson, M. P., Kapogiannis, D., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1314 · Cited by 319 · see citing works
Self-citationLevivier, M., Przedborski, S., Bencsics, C., & Kang, U. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07810.1995 · Cited by 274 · see citing works
Aguiar, A. S., de Castro, A. A., Moreira, E. L. G., Glaser, V., Santos, A. R. S., Tasca, C. I., Latini, A., & Prediger, R. D. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.09.005 · Cited by 266 · see citing works
BDNF activates mTOR to regulate GluR1 expression required for memory formation
Slipczuk, L., Bekinschtein, P., Katche, C., Cammarota, M., Izquierdo, I., & Medina, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006007 · Cited by 246 · see citing works
Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview
Lebrun, B., Bariohay, B., Moyse, E., & Jean, A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.027 · Cited by 219 · see citing works
Schéle, E., Grahnemo, L., Anesten, F., Hallén, A., Bäckhed, F., & Jansson, J.-O. (2013) · Endocrinology · doi:10.1210/en.2012-2151 · Cited by 209 · see citing works
Duan, W., Guo, Z., Jiang, H., Ware, M., & Mattson, M. P. (2003) · Endocrinology · doi:10.1210/en.2002-0113 · Cited by 194 · see citing works
Self-citationMarais, L., Stein, D. J., & Daniels, W. M. U. (2009) · Metabolic Brain Disease · doi:10.1007/s11011-009-9157-2 · Cited by 190 · see citing works
Martin, B., Golden, E. J., Carlson, O. D., Pistell, P. J., Zhou, J., Kim, W., Frank, B. P., Thomas, S., Chadwick, W., Greig, N. H., et al. (2008) · Diabetes · doi:10.2337/db08-0799 · Cited by 181 · see citing works
Self-citationIntermittent Food Deprivation Improves Cardiovascular and Neuroendocrine Responses to Stress in Rats
Wan, R., Camandola, S., & Mattson, M. P. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1921 · Cited by 175 · see citing works
Self-citationRecruiting adaptive cellular stress responses for successful brain ageing
Stranahan, A. M., & Mattson, M. P. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3151 · Cited by 169 · see citing works
Self-citationRendeiro, C., Vauzour, D., Rattray, M., Waffo‐Téguo, P., Mérillon, J., Butler, L. T., Williams, C. M., & Spencer, J. P. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063535 · Cited by 169 · see citing works
Hopkins, M. E., Nitecki, R., & Bucci, D. J. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.071 · Cited by 160 · see citing works
Yang, J.-L., Lin, Y.-T., Chuang, P.-C., Bohr, V. A., & Mattson, M. P. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-013-8270-x · Cited by 159 · see citing works
Self-citationNeurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence
Neto, F. L. M., Borges, G., Torres-Sánchez, S., Micó, J. A., & Berrocoso, E. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376262 · Cited by 150 · see citing works
Deep brain stimulation in the treatment of obesity
Halpern, C. H., Wolf, J. A., Bale, T. L., Stunkard, A. J., Danish, S. F., Grossman, M., Jaggi, J. L., Grady, M. S., & Baltuch, G. H. (2008) · Journal of neurosurgery · doi:10.3171/jns/2008/109/10/0625 · Cited by 150 · see citing works
Whiting, D. M., Tomycz, N. D., Bailes, J. E., de Jonge, L., Lecoultre, V., Wilent, W. B., Alcindor, D. S., Prostko, E. R., Cheng, B. C., Angle, C., et al. (2013) · Journal of neurosurgery · doi:10.3171/2013.2.jns12903 · Cited by 144 · see citing works
Wang, R., Li, Y.-B., Li, Y.-H., Xu, Y., Wu, H., & Li, X.-J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.104 · Cited by 141 · see citing works
A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor
Yang, B. K., Slonimsky, J. D., & Birren, S. J. (2002) · Nature Neuroscience · doi:10.1038/nn0602-853 · Cited by 137 · see citing works
Pollock, G. S., Vernon, E. M., Forbes, M. E., Yan, Q., Ma, Y.-T., Hsieh, T., Robichon, R., Frost, D. O., & Johnson, J. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-11-03923.2001 · Cited by 134 · see citing works
Brain-Derived Neurotrophic Factor Stimulates Energy Metabolism in Developing Cortical Neurons
Burkhalter, J., Fiumelli, H., Allaman, I., Chatton, J., & Martin, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-23-08212.2003 · Cited by 133 · see citing works
Exercise activates the phosphatidylinositol 3-kinase pathway
Chen, M. J., & Russo‐Neustadt, A. A. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.001 · Cited by 132 · see citing works
Nonomura, T., Tsuchida, A., Ono‐Kishino, M., Nakagawa, T., Taiji, M., & Noguchia, H. (2001) · Journal of Diabetes Research · doi:10.1155/edr.2001.201 · Cited by 131 · see citing works
Liang, F.-Q., Allen, G. C., & Earnest, D. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-08-02978.2000 · Cited by 130 · see citing works
Rantamäki, T., Vesa, L., Antila, H., Di Lieto, A., Tammela, P., Schmitt, A., Lesch, K.-P., Rios, M., & Castrén, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020567 · Cited by 124 · see citing works
Evolutionary aspects of human exercise—Born to run purposefully
Mattson, M. P. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.007 · Cited by 123 · see citing works
Self-citationFortin, D. A., Srivastava, T., Dwarakanath, D., Pierre, P., Nygaard, S., Derkach, V. A., & Soderling, T. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6034-11.2012 · Cited by 120 · see citing works
Sartori, C. R., Vieira, A. S., Ferrari, E. M., Langone, F., Tongiorgi, E., & Parada, C. A. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.02.055 · Cited by 118 · see citing works
Spieles-Engemann, A. L., Steece‐Collier, K., Behbehani, M. M., Collier, T. J., Wohlgenant, S. L., Kemp, C. J., Cole-Strauss, A., Levine, N. D., Gombash, S. E., Thompson, V. B., et al. (2011) · Journal of Parkinson s Disease · doi:10.3233/jpd-2011-11008 · Cited by 103 · see citing works
Vaynman, S., Ying, Z., & Gómez‐Pinilla, F. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.005 · Cited by 100 · see citing works
Markham, A., Cameron, I., Bains, R. S., Franklin, P., Kiss, J., Schwendimann, L., Gressèns, P., & Spedding, M. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07965.x · Cited by 98 · see citing works
Tsuchida, A., Nakagawa, T., Itakura, Y., Ichihara, J., Ogawa, W., Kasuga, M., Taiji, M., & Noguchi, H. (2001) · Diabetologia · doi:10.1007/s001250051661 · Cited by 91 · see citing works
Naert, G., IXART, G., Tapia‐Arancibia, L., & Givalois, L. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.028 · Cited by 90 · see citing works
Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice
Tsuchida, A., Nonomura, T., Ono‐Kishino, M., Nakagawa, T., Taiji, M., & Noguchi, H. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801678 · Cited by 86 · see citing works
Briz, V., Hsu, Y., Li, Y., Lee, E., Bi, X., & Baudry, M. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4907-12.2013 · Cited by 85 · see citing works
TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice
Tsao, D., Thomsen, H. K., Chou, J., Stratton, J., Hagen, M., Loo, C., García, C., Sloane, D. L., Rosenthal, A., & Lin, J. C. (2007) · Endocrinology · doi:10.1210/en.2007-1166 · Cited by 83 · see citing works
Goshen, I., Avital, A., Kreisel, T., Licht, T., Segal, M., & Yirmiya, R. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5352-08.2009 · Cited by 82 · see citing works
Hell, R. C. R., Costa, M. M. S., Goes, A. M., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.017 · Cited by 82 · see citing works
Marini, A. M., Jiang, X., Wu, X., Pan, H., Guo, Z., Mattson, M. P., Blondeau, N., Novelli, A., & Lipsky, R. H. (2006) · Amino Acids · doi:10.1007/s00726-006-0414-y · Cited by 81 · see citing works
Self-citationYamanaka, M., Tsuchida, A., Nakagawa, T., Nonomura, T., Ono‐Kishino, M., Sugaru, E., Noguchi, H., & Taiji, M. (2006) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00572.x · Cited by 80 · see citing works
Protective effect of brain-derived neurotrophic factor on pancreatic islets in obese diabetic mice
Yamanaka, M., Itakura, Y., Inoue, T., Tsuchida, A., Nakagawa, T., Noguchi, H., & Taiji, M. (2006) · Metabolism · doi:10.1016/j.metabol.2006.04.017 · Cited by 79 · see citing works
Effects of adult-onset calorie restriction on anxiety-like behavior in rats
Levay, E. A., Govic, A., Penman, J., Paolini, A. G., & Kent, S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.06.018 · Cited by 75 · see citing works
Kim, J. H., Roberts, D. S., Hu, Y., Lau, G. C., Brooks‐Kayal, A. R., Farb, D. H., & Russek, S. J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07555.x · Cited by 69 · see citing works
Fargali, S., Sadahiro, M., Jiang, C. S., Frick, A. L., Indall, T., Cogliani, V., Welagen, J., Lin, W., & Salton, S. R. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9790-9 · Cited by 69 · see citing works
Robinet, C., & Pellerin, L. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.208 · Cited by 61 · see citing works
Bretzner, F., Liu, J., Currie, E., Roskams, A. J., & Tetzlaff, W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06462.x · Cited by 60 · see citing works
Circadian variations in expression of the trkB receptor in adult rat hippocampus
Dolci, C., Montaruli, A., Roveda, E., Barajon, I., Vizzotto, L., Zucconi, G. G., & Carandente, F. (2003) · Brain Research · doi:10.1016/j.brainres.2003.09.018 · Cited by 58 · see citing works
BDNF Val66Met polymorphism alters sympathovagal balance in healthy subjects
Yang, A. C., Chen, T., Tsai, S., Hong, C., Kuo, C., Yang, C., & Kao, K. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31069 · Cited by 57 · see citing works
Gene therapy for Huntington's disease
Ramaswamy, S., & Kordower, J. H. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.030 · Cited by 57 · see citing works
Dean, C., Liu, H., Staudt, T., Stahlberg, M. A., Vingill, S., Bückers, J., Kamin, D., Engelhardt, J., Jackson, M. B., Hell, S. W., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4515-11.2012 · Cited by 56 · see citing works
Vagus Nerve Stimulation Reduces Body Weight and Fat Mass in Rats
Banni, S., Carta, G., Murru, E., Cordeddu, L., Giordano, E., Marrosu, F., Puligheddu, M., Floris, G., Asuni, G. P., Cappai, A. L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044813 · Cited by 53 · see citing works
Diabetes type II: A risk factor for depression-Parkinson–Alzheimer?
Riederer, P., Bartl, J., Laux, G., & Grünblatt, E. (2011) · Neurotoxicity Research · doi:10.1007/s12640-010-9203-1 · Cited by 51 · see citing works
Caloric Restriction Enhances Fear Extinction Learning in Mice
Riddle, M. C., McKenna, M. C., Yoon, Y., Pattwell, S. S., Santos, P. M. G., Casey, B. J., & Glatt, C. E. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.268 · Cited by 51 · see citing works
Tissue-specific and neural activity-regulated expression of human BDNF gene in BAC transgenic mice
Koppel, I., Aid‐Pavlidis, T., Jaanson, K., Sepp, M., Pruunsild, P., Palm, K., & Timmusk, T. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-68 · Cited by 45 · see citing works
Teillon, S., Calderon, G. A., & Rios, M. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0405 · Cited by 43 · see citing works
Griffioen, K. J. S., Wan, R., Brown, T. R., Okun, E., Camandola, S., Mughal, M. R., Phillips, T. M., & Mattson, M. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.030 · Cited by 34 · see citing works
Self-citationGirardet, C., Lebrun, B., Cabirol, M.-J., et al. (2013) · Glia · doi:10.1002/glia.22509 · Cited by 31 · see citing works
Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice
Mughal, M. R., Baharani, A., Chigurupati, S., Son, T. G., Chen, E., Yang, P. H., Okun, E., Arumugam, T. V., Chan, S. L., & Mattson, M. P. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq512 · Cited by 28 · see citing works
Self-citationGotoh, K., Masaki, T., Chiba, S., Ando, H., Fujiwara, K., Shimasaki, T., Mitsutomi, K., Katsuragi, I., Kakuma, T., Sakata, T., et al. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12003 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [43]Rios M Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity Mol Endocrinol 2001 15 1748 1757 11579207
- [55]Gray J Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene Diabetes 2006 55 3366 3371 17130481 PMC2413291
- [94]Massa SM Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents J Clin Invest 2010 120 1774 1785 20407211 PMC2860903
Cited by
Sorted by citations
Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman, R. S., Aghajanian, G. K., Sanacora, G., & Krystal, J. H. (2016) · Nature Medicine · doi:10.1038/nm.4050 · Cited by 1,750 · see citing works
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works
Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works
Self-citationKalinkovich, A., & Livshits, G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.008 · Cited by 882 · see citing works
NAD+ in Brain Aging and Neurodegenerative Disorders
Lautrup, S., Sinclair, D. A., Mattson, M. P., & Fang, E. F. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.09.001 · Cited by 790 · see citing works
Self-citationIntermittent metabolic switching, neuroplasticity and brain health
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624 · see citing works
Self-citationThe Role of Exercise in Management of Mental Health Disorders: An Integrative Review
Smith, P. J., & Merwin, R. M. (2021) · Annual Review of Medicine · doi:10.1146/annurev-med-060619-022943 · Cited by 360 · see citing works
Exercise and mitochondrial health
Memme, J. M., Erlich, A. T., Phukan, G., & Hood, D. A. (2021) · The Journal of Physiology · doi:10.1113/jp278853 · Cited by 343 · see citing works
Neuroprotective effects of physical activity on the brain: a closer look at trophic factor signaling
Phillips, C., Baktir, M. A., Srivatsan, M., & Salehi, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00170 · Cited by 330 · see citing works
Duman, R. S., Deyama, S., & Fogaça, M. V. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14630 · Cited by 321 · see citing works
Walsh, J. J., & Tschakovsky, M. E. (2018) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0192 · Cited by 256 · see citing works
Neuroprotective strategies for retinal disease
Pardue, M. T., & Allen, R. S. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.02.002 · Cited by 237 · see citing works
Marosi, K., Kim, S. W., Moehl, K., Scheibye‐Knudsen, M., Cheng, A., Cutler, R., Camandola, S., & Mattson, M. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13868 · Cited by 242 · see citing works
Self-citationBDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle
Delezie, J., Weihrauch, M., Maier, G., Tejero, R., Ham, D. J., Gill, J. F., Karrer-Cardel, B., Rüegg, M. A., Tabares, L., & Handschin, C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1900544116 · Cited by 141 · see citing works
Cavaleri, D., Moretti, F., Bartoccetti, A., Mauro, S., Crocamo, C., Carrà, G., & Bartoli, F. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105159 · Cited by 146 · see citing works
Protective actions of exercise-related FNDC5/irisin in memory and Alzheimer's disease
de Freitas, G. B., Lourenco, M. V., & De Felice, F. G. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15039 · Cited by 120 · see citing works
Developmental origins of cardiovascular disease: Impact of early life stress in humans and rodents
Murphy, M. O., Cohn, D. M., & Loria, A. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.018 · Cited by 117 · see citing works
Brain-derived neurotrophic factor and schizophrenia
Di Carlo, P., Punzi, G., & Ursini, G. (2019) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000237 · Cited by 110 · see citing works
Bernardo, T. C., Marques‐Aleixo, I., Beleza, J., Oliveira, P. J., Ascensão, A., & Magalhães, J. (2016) · Brain Pathology · doi:10.1111/bpa.12403 · Cited by 108 · see citing works
Gutierrez, L., Folch, A., Rojas, M., Cantero, J. L., Atienza, M., Folch, J., Camins, A., Ruiz, A., Papandreou, C., & Bulló, M. (2021) · Nutrients · doi:10.3390/nu13113728 · Cited by 105 · see citing works
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
Guo, A., Li, K., & Xiao, Q. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111022 · Cited by 83 · see citing works
Liu, D., Zhang, Y., Gharavi, R., Park, H. R., Lee, J., Siddiqui, S., Telljohann, R., Nassar, M. R., Cutler, R. G., Becker, K. G., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13176 · Cited by 68 · see citing works
Exercise Counters the Age-Related Accumulation of Senescent Cells
Zhang, X., Englund, D. A., Aversa, Z., Jachim, S. K., White, T. A., & LeBrasseur, N. K. (2022) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000302 · Cited by 63 · see citing works
Wu, Z., Chen, C., Kang, S. S., Liu, X., Gu, X., Yu, S. P., Keene, C. D., Cheng, L., & Ye, K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100986118 · Cited by 34 · see citing works
Harder-Lauridsen, N. M., Nielsen, S. T., Mann, S. P., Lyngbæk, M. P., Benatti, F. B., Langkilde, A. R., Law, I., Wedell-Neergaard, A.-S., Thomsen, C., Møller, K., et al. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00846.2016 · Cited by 27 · see citing works
Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms
Zhang, Y., Wang, R., Liu, T., & Wang, R. (2024) · Metabolites · doi:10.3390/metabo14110589 · Cited by 27 · see citing works
Beyond Calories: An Integrated Approach to Promote Health, Longevity, and Well-Being
Bertozzi, B., Tosti, V., & Fontana, L. (2017) · Gerontology · doi:10.1159/000446346 · Cited by 25 · see citing works
Song, H.-D., Kim, S. N., Saha, A., Ahn, S.-Y., Akindehin, S., Son, Y., Cho, Y. K., Kim, M., Park, J.-H., Jung, Y.-S., et al. (2020) · Aging and disease · doi:10.14336/ad.2019.0810 · Cited by 14 · see citing works
- Authors
- Marosi, K., & Mattson, M. P.
- Affiliations
- National Institute on Aging (US)
- Johns Hopkins University (US)
- Corresponding author
- Mattson, Mark P.
- ORCID
- Mattson, Mark P.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 25
- Issue
- 2
- Pages
- 89-98
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3915771
- OpenAlex
- W2079338662
- Cited by
- 568
- References
- 96
- Citations by year
- 2026: 26 · 2025: 46 · 2024: 61 · 2023: 47 · 2022: 57 · 2021: 54 · 2020: 50 · 2019: 60 · 2018: 54 · 2017: 39 · 2016: 33 · 2015: 22 · 2014: 19
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (ZIAAG000314, ZIAAG000315, ZIAAG000317)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK079637)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- brain-derived neurotrophic factor, energy homeostasis, feeding behavior, physical activity, fasting, glucose metabolism, mitochondrial biogenesis, glucose transport, insulin sensitivity, parasympathetic activity, chronic stress, metabolic syndrome, obesity, diabetes mellitus, neuroprotection, BDNF signaling
- MeSH terms
- Adaptation, Biological, Animals, Blood Glucose, Brain, Circadian Rhythm, Cognition, Energy Metabolism, Heart Rate, Homeostasis, Humans, Insulin Resistance, Motor Activity, Neuronal Plasticity, Signal Transduction, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
