Nedergaard, Maiken

The Brain’s Glymphatic System: Current Controversies

Mestre, H., Mori, Y., & Nedergaard, M. (2020) · Trends in Neurosciences

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 609

Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

Snyder, H. M., Corriveau, R. A., Craft, S., Faber, J. E., Greenberg, S. M., Knopman, D., Lamb, B. T., Montine, T. J., Nedergaard, M., Schaffer, C. B., et al. (2015) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and Treatments

Cited by 603

Signaling at the Gliovascular Interface

Simard, M., Arcuino, G., Takano, T., Liu, Q. S., & Nedergaard, M. (2003) · The Journal of Neuroscience

Barrier Structure and Function StudiesConnexins and lens biology

Cited by 586

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Peng, W., Achariyar, T. M., Li, B., Liao, Y., Mestre, H., Hitomi, E., Regan, S., Kasper, T., Peng, S., Ding, F., et al. (2016) · Neurobiology of Disease

Cerebrospinal fluid and hydrocephalusAlzheimer's disease research and treatments

Cited by 580

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

Plog, B. A., Dashnaw, M. L., Hitomi, E., Peng, W., Liao, Y., Lou, N., Deane, R., & Nedergaard, M. (2015) · The Journal of Neuroscience

Traumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalus

Cited by 525

Strategies to advance translational research into brain barriers

Neuwelt, E., Abbott, N. J., Abrey, L., Banks, W. A., Blakley, B., Davis, T., Engelhardt, B., Grammas, P., Nedergaard, M., Nutt, J., et al. (2008) · The Lancet Neurology

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 474

Cortical spreading depression causes and coincides with tissue hypoxia

Takano, T., Tian, G.-F., Peng, W., Lou, N., Lovatt, D., Hansen, A. J., Kasischke, K. A., & Nedergaard, M. (2007) · Nature Neuroscience

Migraine and Headache StudiesTraumatic Brain Injury and Neurovascular Disturbances

Cited by 472

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

Cai, R., Pan, C., Ghasemigharagoz, A., Todorov, M. I., Förstera, B., Zhao, S., Bhatia, H. S., Parra-Damas, A., Mrowka, L., Theodorou, D., et al. (2019) · Nature Neuroscience

Advanced Fluorescence Microscopy TechniquesCell Image Analysis Techniques

Cited by 470

Ultra-fast magnetic resonance encephalography of physiological brain activity – Glymphatic pulsation mechanisms?

Kiviniemi, V., Wang, X., Korhonen, V., Keinänen, T., Tuovinen, T., Autio, J., LeVan, P., Keilholz, S., Zang, Y.-F., Hennig, J., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism

Advanced MRI Techniques and ApplicationsCerebrospinal fluid and hydrocephalus

Cited by 453

Beyond the role of glutamate as a neurotransmitter

Nedergaard, M., Takano, T., & Hansen, A. J. (2002) · Nature Reviews Neuroscience

Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and Metabolism

Cited by 450

Perivascular spaces, glymphatic dysfunction, and small vessel disease

Mestre, H., Kostrikov, S., Mehta, R. I., & Nedergaard, M. (2017) · Clinical Science

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 403

Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance

O’Donnell, J., Zeppenfeld, D., McConnell, E., Pena, S., & Nedergaard, M. (2012) · Neurochemical Research

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 399

Mechanisms of cognitive dysfunction in CKD

Viggiano, D., Wagner, C. A., Martino, G., Nedergaard, M., Zoccali, C., Unwin, R., & Capasso, G. (2020) · Nature Reviews Nephrology

Dementia and Cognitive Impairment ResearchDialysis and Renal Disease Management

Cited by 392

ATP-Mediated Glia Signaling

Cotrina, M. L., Lin, J. H.-C., López-Garcı́a, J. C., Naus, C. C. G., & Nedergaard, M. (2000) · The Journal of Neuroscience

Adenosine and Purinergic SignalingConnexins and lens biology

Cited by 388

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, M., et al. (2015) · Nature Communications

Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and Applications

Cited by 381

Purinergic receptor P2RY12-dependent microglial closure of the injured blood–brain barrier

Lou, N., Takano, T., Pei, Y., Xavier, A. L., Goldman, S. A., & Nedergaard, M. (2016) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 364

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions

Sun, W., Cornwell, A., Li, J., Peng, S., Osorio, M. J., Aalling, N., Wang, S., Benraiss, A., Lou, N., Goldman, S. A., et al. (2017) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 357

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Hauglund, N. L., Andersen, M., Tokarska, K., Radovanovic, T., Kjaerby, C., Sørensen, F. L., Bojarowska, Z., Untiet, V., Ballestero, S. B., Kolmos, M. G., et al. (2025) · Cell

Cerebrospinal fluid and hydrocephalusSleep and Wakefulness Research

Cited by 349

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

Yang, L., Kress, B. T., Weber, H. J., Thiyagarajan, M., Wang, B., Deane, R., Benveniste, H., Iliff, J. J., & Nedergaard, M. (2013) · Journal of Translational Medicine

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 317

Impairment of the glymphatic system after diabetes

Jiang, Q., Zhang, L., Ding, G., Davoodi-Bojd, E., Li, Q., Li, L., Sadry, N., Nedergaard, M., Chopp, M., & Zhang, Z. (2017) · Journal of Cerebral Blood Flow & Metabolism

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 308

Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

Kjaerby, C., Andersen, M., Hauglund, N., Untiet, V., Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, P., et al. (2022) · Nature Neuroscience

Sleep and Wakefulness ResearchMemory and Neural Mechanisms

Cited by 306

Loss of astrocytic domain organization in the epileptic brain

Oberheim, N. A., Tian, G.-F., Han, X., Peng, W., Takano, T., Ransom, B., & Nedergaard, M. (2008) · The Journal of Neuroscience

Epilepsy research and treatmentNeuroscience and Neuropharmacology Research

Cited by 303

Contributions of the Na + /K + ‐ATPase, NKCC1, and Kir4.1 to hippocampal K + clearance and volume responses

Larsen, B. R., Assentoft, M., Cotrina, M. L., Hua, S. Z., Nedergaard, M., Kaila, K., Voipio, J., & MacAulay, N. (2014) · Glia

Ion Transport and Channel RegulationIon channel regulation and function

Cited by 269

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

Mortensen, K. N., Sanggaard, S., Mestre, H., Lee, H., Kostrikov, S., Xavier, A. L. R., Gjedde, A., Benveniste, H., & Nedergaard, M. (2019) · The Journal of Neuroscience

Cerebrospinal fluid and hydrocephalusAdvanced MRI Techniques and Applications

Cited by 266