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Norepinephrine: A Neuromodulator That Boosts the Function of Multiple Cell Types to Optimize CNS Performance
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Norepinephrine triggers rapid changes in neural activity, which in turn can modulate the volume of the interstitial space.
“NE triggers rapid changes in neural activity (27, 28), which in turn can modulate the volume of the interstitial space volume (29).”
From Sleep Drives Metabolite Clearance from the Adult Brain (2013) · cites this paper as [28]
In peripheral tissues, such as kidney and heart, noradrenaline regulates the activity of membrane transporters and channels that control cell volume.
“In peripheral tissues, such as kidney and heart, noradrenaline regulates the activity of membrane transporters and channels that control cell volume (28).”
From Sleep Drives Metabolite Clearance from the Adult Brain (2013) · cites this paper as [28]
The astrocyte β-adrenergic-receptors section discusses regulation of Na+/K+-ATPase and potassium clearance in the brain, not cell-volume control in peripheral tissues. Searches for kidney, heart, cell volume, and peripheral transporters found no passage in our copy addressing the attributed claim; page numbers were not available. (LLM, conf=0.72)
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Metadata
- Authors
- O’Donnell, J., Zeppenfeld, D., McConnell, E., Pena, S., & Nedergaard, M.
- Affiliations
- University of Rochester Medicine (US)
- Corresponding author
- Nedergaard, Maiken
- Venue
- Neurochemical Research
- Published
- 2012-06-21
- Volume
- 37
- Issue
- 11
- Pages
- 2496-2512
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- PMC
- PMC3548657
- OpenAlex
- W2072773125
- Cited by
- 399
- References
- 23
- Citations by year
- 2026: 31 · 2025: 41 · 2024: 45 · 2023: 42 · 2022: 26 · 2021: 36 · 2020: 28 · 2019: 22 · 2018: 21 · 2017: 22 · 2016: 30 · 2015: 21 · 2014: 14 · 2013: 19 · 2012: 1
- FWCI
- 1.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS078304, R01NS078167, R01NS075177)
- National Center for Research Resources (TL1RR024135)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- norepinephrine, neuromodulation, locus coeruleus, noradrenergic signaling, astrocytes, microglia, neurons, neuroplasticity, neuroinflammation, brain energy metabolism, cortical circuits, central nervous system function
- MeSH terms
- Adaptation, Physiological, Animals, Astrocytes, Central Nervous System, Humans, Norepinephrine, Microglia
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