Levine, Arnold J.

Tumour-associated mutant p53 drives the Warburg effect

Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A. J., et al. (2013) · Nature Communications

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 434

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

Zhang, C., Lin, M., Wu, R., Wang, X., Yang, B., Levine, A. J., Hu, W., & Feng, Z. (2011) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 431

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

Tao, W., & Levine, A. J. (1999) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 355

Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S. (2006) · Genes & Development

PI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

Cited by 321

MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner

Bond, G. L., Hirshfield, K. M., Kirchhoff, T., Alexe, G., Bond, E. E., Robins, H., Bartel, F., Taubert, H., Wuerl, P., Hait, W., et al. (2006) · Cancer Research

Cancer-related Molecular PathwaysEstrogen and related hormone effects

Cited by 287

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

Tucci, P., Agostini, M., Grespi, F., Markert, E. K., Terrinoni, A., Vousden, K. H., Muller, P. A. J., Dötsch, V., Kehrloesser, S., Sayan, B. S., et al. (2012) · Proceedings of the National Academy of Sciences

MicroRNA in disease regulationProstate Cancer Treatment and Research

Cited by 286

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysGenetics, Aging, and Longevity in Model Organisms

Cited by 264

Combinatorial patterns of somatic gene mutations in cancer

Yeang, C.-H., McCormick, F., & Levine, A. (2008) · The FASEB Journal

Cancer Genomics and DiagnosticsChromatin Remodeling and Cancer

Cited by 251

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

Feng, Z., Liu, L., Zhang, C., Zheng, T., Wang, J., Lin, M., Zhao, Y., Wang, X., Levine, A. J., & Hu, W. (2012) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCancer, Stress, Anesthesia, and Immune Response

Cited by 209

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

Kang, H.-J., Feng, Z., Sun, Y., Atwal, G., Murphy, M. E., Rebbeck, T. R., Rosenwaks, Z., Levine, A. J., & Hu, W. (2009) · Proceedings of the National Academy of Sciences

Reproductive Biology and FertilityReproductive System and Pregnancy

Cited by 193

The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability

Overholtzer, M., Rao, P. H., Favis, R., Lu, X.-Y., Elowitz, M. B., Barany, F., Ladanyi, M., Gorlick, R., & Levine, A. J. (2003) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysSarcoma Diagnosis and Treatment

Cited by 193

The many faces of p53: something for everyone

Levine, A. J. (2019) · Journal of Molecular Cell Biology

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 163

WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase

Su, F., Overholtzer, M., Besser, D., & Levine, A. J. (2002) · Genes & Development

Connective Tissue Growth Factor ResearchCell death mechanisms and regulation

Cited by 153

A High-Frequency Regulatory Polymorphism in the p53 Pathway Accelerates Tumor Development

Post, S. M., Quintás-Cardama, A., Pant, V., Iwakuma, T., Hamir, A., Jackson, J. G., Maccio, D. R., Bond, G. L., Johnson, D. G., Levine, A. J., et al. (2010) · Cancer Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 127

The Roles of Initiating Truncal Mutations in Human Cancers: The Order of Mutations and Tumor Cell Type Matters

Levine, A. J., Jenkins, N. A., & Copeland, N. G. (2019) · Cancer Cell

Cancer Genomics and DiagnosticsCancer Immunotherapy and Biomarkers

Cited by 121

Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis

Chen, L., Marechal, V., Moreau, J., Levine, A. J., & Chen, J. (1997) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 121

P53 and The Immune Response: 40 Years of Exploration—A Plan for the Future

Levine, A. J. (2020) · International Journal of Molecular Sciences

Cancer-related Molecular PathwaysImmunotherapy and Immune Responses

Cited by 97

Targeting Therapies for the p53 Protein in Cancer Treatments

Levine, A. J. (2019) · Annual Review of Cancer Biology

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 84

Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system

Greenbaum, B. D., Rabadan, R., & Levine, A. J. (2009) · PLoS ONE

Evolution and Genetic DynamicsImmune Response and Inflammation

Cited by 76

Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells

Tanne, A., Muniz, L. R., Puzio-Kuter, A., Leonova, K. I., Gudkov, A. V., Ting, D. T., Monasson, R., Cocco, S., Levine, A. J., Bhardwaj, N., et al. (2015) · Proceedings of the National Academy of Sciences

Immune Response and InflammationCancer-related molecular mechanisms research

Cited by 74

Accurate modeling of peptide-MHC structures with AlphaFold

Mikhaylov, V., Brambley, C. A., Keller, G. L. J., Arbuiso, A. G., Weiss, L. I., Baker, B. M., & Levine, A. J. (2024) · Structure

vaccines and immunoinformatics approachesProtein Structure and Dynamics

Cited by 72

Accurate modeling of peptide-MHC structures with AlphaFold

Mikhaylov, V., & Levine, A. J. (2023) · Structure

vaccines and immunoinformatics approachesProtein Structure and Dynamics

Cited by 72

Mutant p53 protein, master regulator of human malignancies: A report on the Fifth Mutant p53 Workshop

Blandino, G., Deppert, W., Hainaut, P., Levine, A., Lozano, G., Olivier, M., Rotter, V, Wiman, K., & Oren, M. (2012) · Cell Death & Differentiation

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 34

Clustering of TP53 variants into functional classes correlates with cancer risk and identifies different phenotypes of Li-Fraumeni syndrome

Montellier, E., Lemonnier, N., Penkert, J., Freycon, C., Blanchet, S., Amadou, A., Chuffart, F., Fischer, N. W., Achatz, M.-I., Levine, A. J., et al. (2024) · iScience

Cancer-related Molecular PathwaysGenomics and Rare Diseases

Cited by 29