Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus
Abstract
Previous results from our laboratory indicate that two nights of voluntary wheel running upregulates brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampus. In order to investigate the time-course of the BDNF response and to examine how physical activity preferentially activates particular transcriptional pathways, the effects of 6 and 12 h of voluntary wheel running on BDNF and exons I-IV mRNA expression were investigated in rats. Hippocampal full-length BDNF mRNA expression was rapidly influenced by physical activity, showing significant increases in expression levels as soon as 6 h of voluntary wheel running. Moreover, there was a strong positive correlation between distance run and BDNF mRNA expression. Exon I mRNA expression was significantly upregulated after 6 h of running and was maintained or enhanced by 12 h of voluntary running. Exon II had a slower time-course and was significantly upregulated after 12 h, selectively in the CA1 hippocampal region. Exon III and Exon IV showed no significant increase in expression level after 6 or 12 h of running in the paradigm studied. It is significant that the rapid neurotrophin response is demonstrated for a physiologically relevant stimulus, as opposed to the extreme conditions of seizure paradigms. Furthermore, exercise-induced upregulation of BDNF may help increase the brain's resistance to damage and neurodegeneration that occurs with aging.
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Rodent studies demonstrate increased BDNF mRNA and BDNF protein within the hippocampus in response to wheel running for 1-8 weeks.
“Rodent studies demonstrate increased BDNF mRNA and BDNF protein within the hippocampus in response to wheel running for 1-8 weeks (87-92).”
From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [89]
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- Authors
- Oliff, H. S., Berchtold, N. C., Isackson, P., & Cotman, C. W.
- Affiliations
- University of California, Irvine (US)
- Mayo Clinic (US)
- Corresponding author
- Oliff, Heather S.
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 61
- Issue
- 1-2
- Pages
- 147-153
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W1969060329
- Cited by
- 361
- References
- 23
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 14 · 2021: 17 · 2020: 9 · 2019: 13 · 2018: 14 · 2017: 14 · 2016: 16 · 2015: 19 · 2014: 18 · 2013: 22 · 2012: 14
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerul Cercetării, Inovării şi Digitalizării
- National Institute on Aging (AG13411, R01AG013411)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- brain-derived neurotrophic factor, BDNF mRNA expression, voluntary wheel running, hippocampus, CA1 region, temporal gene expression, physical activity
- MeSH terms
- Animals, Physical Exertion, Gene Expression Regulation, Hippocampus, Male, Physical Conditioning, Animal, Rats, Inbred F344, Time Factors, Transcription, Genetic, Up-Regulation, Brain-Derived Neurotrophic Factor, Rats
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