Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 1,555

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

Chaudhary, N., Weissman, D., & Whitehead, K. A. (2021) · Nature Reviews Drug Discovery

RNA Interference and Gene DeliverySARS-CoV-2 and COVID-19 Research

Cited by 1,555

Autophagy in mammalian development and differentiation

Mizushima, N., & Levine, B. (2010) · Nature Cell Biology

Autophagy in Disease and TherapyDevelopmental Biology and Gene Regulation

Cited by 1,555

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J., & Cantley, L. C. (2002) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerTuberous Sclerosis Complex Research

Cited by 1,555

Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro

Imlay, J. A., Chin, S. M., & Linn, S. (1988) · Science

Redox biology and oxidative stressMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,555

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

Sato, K., Suematsu, A., Okamoto, K., Yamaguchi, A., Morishita, Y., Kadono, Y., Tanaka, S., Kodama, T., Akira, S., Iwakura, Y., et al. (2006) · The Journal of Experimental Medicine

Bone Metabolism and DiseasesPsoriasis: Treatment and Pathogenesis

Cited by 1,554

Network organization of the human autophagy system

Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 1,554

Mitochondrial DNA sequences of primates: tempo and mode of evolution

Brown, W. M., Prager, E. M., Wang, A., & Wilson, A. C. (1982) · Journal of Molecular Evolution

Genomics and Phylogenetic StudiesGenetic diversity and population structure

Cited by 1,554

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction

Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell

Estrogen and related hormone effectsGenomics and Chromatin Dynamics

Cited by 1,553

Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations

MacParland, S. A., Liu, J. C., Ma, X.-Z., Innes, B. T., Bartczak, A. M., Gage, B. K., Manuel, J., Khuu, N., Echeverri, J., Linares, I., et al. (2018) · Nature Communications

Single-cell and spatial transcriptomicsLiver physiology and pathology

Cited by 1,552

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Hu, J. H., Miller, S. M., Geurts, M. H., Tang, W., Chen, L., Sun, N., Zeina, C. M., Gao, X., Rees, H. A., Lin, Z., et al. (2018) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,552

Noncoding RNA therapeutics—Challenges and potential solutions

Winkle, M., El-Daly, S. M., Fabbri, M., & Calin, G. A. (2021) · Nature Reviews Drug Discovery

RNA Interference and Gene DeliveryCancer-related molecular mechanisms research

Cited by 1,551

MicroRNA Expression in Zebrafish Embryonic Development

Wienholds, E., Kloosterman, W. P., Miska, E., Alvarez-Saavedra, E., Berezikov, E., de Bruijn, E., Horvitz, H. R., Kauppinen, S., & Plasterk, R. H. A. (2005) · Science

Developmental Biology and Gene RegulationMicroRNA in disease regulation

Cited by 1,551

PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data

Franzén, O., Gan, L.-M., & Björkegren, J. L. M. (2019) · Database

Single-cell and spatial transcriptomicsBioinformatics and Genomic Networks

Cited by 1,551

Population genomics of Bronze Age Eurasia

Allentoft, M. E., Sikora, M., Sjögren, K.-G., Rasmussen, S., Rasmussen, M., Stenderup, J., Damgaard, P. B., Schroeder, H., Ahlström, T., Vinner, L., et al. (2015) · Nature

Forensic and Genetic ResearchPleistocene-Era Hominins and Archaeology

Cited by 1,550

Autosomal dominant polycystic kidney disease

Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet

Genetic and Kidney Cyst DiseasesTuberous Sclerosis Complex Research

Cited by 1,550

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,550

An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,550

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

Amir, E.-A. D., Davis, K. L., Tadmor, M. D., Simonds, E. F., Levine, J. H., Bendall, S. C., Shenfeld, D. K., Krishnaswamy, S., Nolan, G. P., & Pe'er, D. (2013) · Nature Biotechnology

Single-cell and spatial transcriptomicsData Visualization and Analytics

Cited by 1,550

The cell biology of mitochondrial membrane dynamics

Giacomello, M., Pyakurel, A., Glytsou, C., & Scorrano, L. (2020) · Nature Reviews Molecular Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,550

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

Garraway, L. A., Widlund, H. R., Rubin, M. A., Getz, G., Berger, A. J., Ramaswamy, S., Beroukhim, R., Milner, D. A., Granter, S. R., Du, J., et al. (2005) · Nature

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 1,548

Engineering exosomes for targeted drug delivery

Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics

Extracellular vesicles in diseaseNanoparticle-Based Drug Delivery

Cited by 1,547

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

Hark, A. T., Schoenherr, C. J., Katz, D. J., Ingram, R. S., Levorse, J. M., & Tilghman, S. M. (2000) · Nature

Genetic Syndromes and ImprintingGenomics and Chromatin Dynamics

Cited by 1,547

Characterization of single-nucleotide polymorphisms in coding regions of human genes

Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., Nemesh, J., et al. (1999) · Nature Genetics

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 1,547