Most cited biochemistry, genetics and molecular biology papers
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Optimal trade-off control in machine learning–based library design, with application to adeno-associated virus (AAV) for gene therapy
Zhu, D., Brookes, D. H., Busia, A., Carneiro, A., Fannjiang, C., Popova, G., Shin, D., Donohue, K. C., Lin, L. F., Miller, Z. M., et al. (2024) · Science Advances
Virus-based gene therapy researchRNA Interference and Gene Delivery
Cited by 63
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OPG/membranous–RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation
Tat, S. K., Padrines, M., Theoleyre, S., Couillaud-Battaglia, S., Heymann, D., Redini, F., & Fortun, Y. (2006) · Bone
Bone Metabolism and DiseasesCellular transport and secretion
Cited by 63
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The Snail repressor positions Notch signaling in the Drosophila embryo
Cowden, J., & Levine, M. (2002) · Development
Developmental Biology and Gene RegulationGenomics and Chromatin Dynamics
Cited by 63
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S100A6: molecular function and biomarker role
Wang, Y., Kang, X., Kang, X., & Yang, F. (2023) · Biomarker Research
S100 Proteins and AnnexinsCalpain Protease Function and Regulation
Cited by 63
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Oncostatin M induces basic fibroblast growth factor expression in endothelial cells and promotes endothelial cell proliferation, migration and spindle morphology
Wijelath, E. S., Carlsen, B., Cole, T., Chen, J., Kothari, S., & Hammond, W. P. (1997) · Journal of Cell Science
Fibroblast Growth Factor ResearchAngiogenesis and VEGF in Cancer
Cited by 63
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Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor.
Chen, Q., Kaji, H., Sugimoto, T., & Chihara, K. (2001) · FEBS Letters
Bone Metabolism and DiseasesEstrogen and related hormone effects
Cited by 63
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An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability
Schütte, J., Wang, H., Antoniou, S., Jarratt, A., Wilson, N. K., Riepsaame, J., Calero-Nieto, F. J., Moignard, V., Basilico, S., Kinston, S. J., et al. (2016) · eLife
Gene Regulatory Network AnalysisGenomics and Chromatin Dynamics
Cited by 63
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Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M., & Christopoulos, A. (2021) · Frontiers in Pharmacology
Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research
Cited by 63
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Frequent sgRNA-barcode recombination in single-cell perturbation assays
Xie, S., Cooley, A., Armendariz, D., Zhou, P., & Hon, G. C. (2018) · PLOS ONE
CRISPR and Genetic EngineeringSingle-cell and spatial transcriptomics
Cited by 63
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Pol I transcription and pre-rRNA processing are coordinated in a transcription-dependent manner in mammalian cells
Kopp, K., Gasiorowski, J. Z., Chen, D., Gilmore, R., Norton, J. T., Wang, C., Leary, D. J., Chan, E. K. L., Dean, D. A., & Huang, S. (2007) · Molecular Biology of the Cell
Nuclear Structure and FunctionGenomics and Chromatin Dynamics
Cited by 63
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Characterization of Phospholipase Cγ Enzymes with Gain-of-Function Mutations
Everett, K. L., Bunney, T. D., Yoon, Y., Rodrigues-Lima, F., Harris, R., Driscoll, P. C., Abe, K., Fuchs, H., Hrabé de Angelis, M., Yu, P., et al. (2009) · Journal of Biological Chemistry
Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases
Cited by 63
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Role of Cytoplasmic Dynein in Perinuclear Aggregation of Phagocytosed Melanosomes and Supranuclear Melanin Cap Formation in Human Keratinocytes
Randolph Byers, H., Maheshwary, S., Amodeo, D. M., & Dykstra, S. G. (2003) · Journal of Investigative Dermatology
melanin and skin pigmentationMicrotubule and mitosis dynamics
Cited by 63
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Generation of CRISPR–Cas9-mediated genetic knockout human intestinal tissue–derived enteroid lines by lentivirus transduction and single-cell cloning
Lin, S.-C., Haga, K., Zeng, X.-L., & Estes, M. K. (2022) · Nature Protocols
CRISPR and Genetic EngineeringVirus-based gene therapy research
Cited by 63
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Automated analysis of images for molecular quantification in immunohistochemistry
Guirado, R., Carceller, H., Castillo-Gómez, E., Castrén, E., & Nacher, J. (2018) · Heliyon
Cell Image Analysis TechniquesAdvanced Fluorescence Microscopy Techniques
Cited by 63
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The regulation mechanisms of AhR by molecular chaperone complex
Kudo, I., Hosaka, M., Haga, A., Tsuji, N., Nagata, Y., Okada, H., Fukuda, K., Kakizaki, Y., Okamoto, T., Grave, E., et al. (2018) · The Journal of Biochemistry
Heat shock proteins researchToxic Organic Pollutants Impact
Cited by 63
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Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration
Buchheit, C. L., Angarola, B. L., Steiner, A., Weigel, K. J., & Schafer, Z. T. (2015) · Cell Death & Differentiation
Cell death mechanisms and regulationBreast Cancer Treatment Studies
Cited by 63
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The isolation and characterisation of a new type of dimeric adenine photoproduct in UV-irradiated deoxyadenylates
Kumar, S., Sharma, N. D., Davies, R. J. H., Phillipson, D. W., & McCloskey, J. A. (1987) · Nucleic Acids Research
DNA and Nucleic Acid ChemistryDNA Repair Mechanisms
Cited by 63
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From engineering to editing the rat genome
Meek, S., Mashimo, T., & Burdon, T. (2017) · Mammalian Genome
Animal Genetics and ReproductionCRISPR and Genetic Engineering
Cited by 63
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Optimal Prediction by Cellular Signaling Networks
Becker, N. B., Mugler, A., & ten Wolde, P. R. (2015) · Physical Review Letters
Gene Regulatory Network Analysisstochastic dynamics and bifurcation
Cited by 63
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Comparison of Analysis Tools for miRNA High Throughput Sequencing Using Nerve Crush as a Model
Metpally, R. P. R., Nasser, S., Malenica, I., Courtright, A., Carlson, E., Ghaffari, L., Villa, S., Tembe, W., & Van Keuren-Jensen, K. (2013) · Frontiers in Genetics
MicroRNA in disease regulationGenomics and Phylogenetic Studies
Cited by 63
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Characterization and Repurposing of Type I and Type II CRISPR–Cas Systems in Bacteria
Hidalgo-Cantabrana, C., Goh, Y. J., & Barrangou, R. (2019) · Journal of Molecular Biology
CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology
Cited by 63
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Molecular Analysis of the Interaction between the Hematopoietic Master Transcription Factors GATA-1 and PU.1
Liew, C. W., Rand, K. D., Simpson, R. J. Y., Yung, W. W., Mansfield, R. E., Crossley, M., Proetorius-Ibba, M., Nerlov, C., Poulsen, F. M., & Mackay, J. P. (2006) · Journal of Biological Chemistry
Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders
Cited by 63
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Continuous RANKL Inhibition in Osteoprotegerin Transgenic Mice and Rats Suppresses Bone Resorption without Impairing Lymphorganogenesis or Functional Immune Responses
Stolina, M., Dwyer, D., Ominsky, M. S., Corbin, T., Van, G., Bolon, B., Sarosi, I., McCabe, J., Zack, D. J., & Kostenuik, P. (2007) · The Journal of Immunology
Bone Metabolism and DiseasesRheumatoid Arthritis Research and Therapies
Cited by 63
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Maintenance of Primary Hepatocyte Functions In Vitro by Inhibiting Mechanical Tension-Induced YAP Activation
Sun, P., Zhang, G., Su, X., Jin, C., Yu, B., Yu, X., Lv, Z., Ma, H., Zhang, M., Wei, W., et al. (2019) · Cell Reports
Hippo pathway signaling and YAP/TAZLiver physiology and pathology
Cited by 63
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