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Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms

Soderstrom, K., Soliman, E., & Dross, R. V. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00720 · Cited by 51 · see citing works

Evidences for the Anti-panic Actions of Cannabidiol

Soares-Rachetti, V. D. P., & Campos, A. C. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160509123955 · Cited by 47 · see citing works

Glial Cells and Their Contribution to the Mechanisms of Action of Cannabidiol in Neuropsychiatric Disorders

Scarante, F. F., Ribeiro, M. A., Almeida-Santos, A. F., Guimarães, F. S., & Campos, A. C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.618065 · Cited by 40 · see citing works

The Management of Cancer Symptoms and Treatment-Induced Side Effects With Cannabis or Cannabinoids

Sexton, M., Garcia, J. M., Jatoi, A., Clark, C. S., & Wallace, M. S. (2021) · JNCI Monographs · doi:10.1093/jncimonographs/lgab011 · Cited by 36 · see citing works

Novel investigational therapeutics for panic disorder

Perna, G., Schruers, K. R. J., Alciati, A., & Caldirola, D. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.996286 · Cited by 32 · see citing works

Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray

Vázquez-León, P., Miranda-Páez, A., Valencia-Flores, K., & Sánchez-Castillo, H. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01262-z · Cited by 29 · see citing works

CBD and the 5-HT1A receptor: A medicinal and pharmacological review

Alexander, C., Jeon, J., Nickerson, K., Hassler, S. N., & Vasefi, M. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116742 · Cited by 28 · see citing works

Medicinal Cannabis and Central Nervous System Disorders

Ortiz, Y. T., McMahon, L. R., & Wilkerson, J. L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.881810 · Cited by 27 · see citing works

The Anxiolytic Effects of Cannabidiol (CBD)

Zuardi, A. W., Crippa, J. A. S., Hallak, J. E. C., Campos, A. C., & Guimarães, F. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00097-1 · Cited by 27 · see citing works

Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews

Rock, E. M., Sullivan, M. T., Collins, S. A., Goodman, H., Limebeer, C. L., Mechoulam, R., & Parker, L. A. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05559-z · Cited by 24 · see citing works

Autism and associated disorders: cannabis as a potential therapy

Babayeva, M., Assefa, H., Basu, P., & Loewy, Z. G. (2022) · Frontiers in Bioscience-Elite · doi:10.31083/j.fbe1401001 · Cited by 21 · see citing works

THC and CBD produce divergent effects on perception and panic behaviours via distinct cortical molecular pathways

Szkudlarek, H. J., Rodríguez-Ruiz, M., Hudson, R., Felice, M. D., Jung, T., Rushlow, W. J., & Laviolette, S. R. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110029 · Cited by 19 · see citing works

Systematic literature review of human studies assessing the efficacy of cannabidiol for social anxiety

Fliegel, D. K., & Lichenstein, S. D. (2022) · Psychiatry Research Communications · doi:10.1016/j.psycom.2022.100074 · Cited by 17 · see citing works

Periaqueductal gray and emotions: the complexity of the problem and the light at the end of the tunnel, the magnetic resonance imaging

Zelena, D., Menant, O., Andersson, F., & Chaillou, É. (2018) · Endocrine Regulations · doi:10.2478/enr-2018-0027 · Cited by 16 · see citing works

Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats

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Overlapping Mechanisms of Stress-Induced Relapse to Opioid Use Disorder and Chronic Pain: Clinical Implications

Ghitza, U. E. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00080 · Cited by 15 · see citing works

Sex and estrous cycle-linked differences in the effect of cannabidiol on panic-like responding in rats and mice

Hernandes, P. M., Batistela, M. F., Nascimento‐Silva, J. M., Frias, A. T., Matthiesen, M., Campos, A. C., Lovick, T. A., & Zangrossi, H. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114663 · Cited by 12 · see citing works

The endocannabinoid system in social anxiety disorder: from pathophysiology to novel therapeutics

Ahmed, M., Boileau, I., Le Foll, B., Carvalho, A. F., & Kloiber, S. (2022) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2021-1926 · Cited by 11 · see citing works

Cannabidiol and 5-HT1A Receptors

Fogaça, M. V., Campos, A. C., & Guimarães, F. S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00070-5 · Cited by 11 · see citing works

Role of 5-HT1A and 5-HT2C receptors of the dorsal periaqueductal gray in the anxiety- and panic-modulating effects of antidepressants in rats

Vilela‐Costa, H. H., Maraschin, J. C., Casarotto, P. C., Sant’Ana, A. B., de Bortoli, V. C., Vicente, M. A., Campos, A. C., Guimarães, F. S., & Zangrossi, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113159 · Cited by 10 · see citing works

A double-blind, randomized, placebo-controlled test of the effects of cannabidiol on fear elicited by a 10% carbon dioxide-enriched air breathing challenge

Leen‐Feldner, E. W., Bynion, T., Eglit, G. M. L., Bonn‐Miller, M. O., Gournay, L. R., & Feldner, M. T. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06258-7 · Cited by 10 · see citing works

Effects of alprazolam and cannabinoid-related compounds in an animal model of panic attack

Batista, L. A., Haibara, A. S., Schenberg, L. C., & Moreira, F. A. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.017 · Cited by 9 · see citing works

Therapeutic Molecular Insights into the Active Engagement of Cannabinoids in the Therapy of Parkinson’s Disease: A Novel and Futuristic Approach

Jain, V., Behl, T., Sehgal, A., Singh, S., Sharma, N., Makeen, H. A., Albratty, M., Meraya, A. M., & Najmi, A. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00619-y · Cited by 8 · see citing works

Cannabidiol in anxiety disorders: Current and future perspectives

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Interactions Between Cannabinoid Signaling and Anxiety: A Comparative Analysis of Intervention Tools and Behavioral Effects

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A Review of Recent Advances in the Therapeutic Uses of Secondary Cannabinoids

Morabito, D. M., Soyster, P. D., Ramey-Wright, S., Belendiuk, K. A., & Bonn‐Miller, M. O. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0096-9 · Cited by 4 · see citing works

Medicinal Plants for Major Depressive Disorder

Bertollo, A. G., Spohr, L., BEARZI, A. E., Kreuz, K. M., & Ignácio, Z. M. (2026) · Brain Sciences · doi:10.3390/brainsci16020223 · Cited by 3 · see citing works

Anxiolytic and antidepressant effects of cannabidiol: a systematic review

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Cannabinoids For Fibromyalgia: An Updated Systematic ReviewPreprint

Scicluna, J. C., & Giovanni, G. D. (2022) · medRxiv · doi:10.1101/2022.05.17.22275200 · Cited by 2 · see citing works

Anxiety

O’Brien, K., & Blair, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-78559-8_5 · Cited by 1 · see citing works

Efeitos do canabidiol no comportamento agressivo induzido por isolamento social em camundongos

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Anxiety: Involvement of cannabinergic signaling and cross-talk with serotonergic and opioidergic pathways.

Freels, T. G., & Cook, M. N. (2016) · Psychology & Neuroscience · doi:10.1037/pne0000071

A cannabidiol (CBD) oral lipid-based nanoemulsion induces anxiolytic- and panicolytic-like effects and increases delta-FosB immunoreactivity in serotonergic cells of the dorsal raphe lateral wingsPreprint

Rosário, B. D. A., de Lima, M. P., Vieira, M. G., de Aquino, P. É. A., Viana, G. S. D. B., Silveira, E. R., de Brito, D. H. A., Zampieri, D., Lemes, J. A., de Nazaré, M. D. F. S., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3705796/v1

Catalepsia induzida por haloperidol: eficácia do canabigerol isolado e associado ao canabidiol

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Canabidiol, ansiedade e memórias aversivas: uma revisão das evidências pré-clínicas

Portes, M. A. M., Werle, I., Soares, L. A., Guterres, F. D. S., & Bertoglio, L. J. (2025) · Revista Fitos · doi:10.32712/2446-4775.2025.1817

A cannabidiol (CBD) lipid-based nanoemulsion induces anxiolytic- and panicolytic-like effects and increases FosB/deltaFosB immunoreactivity in serotonergic cells of the dorsal raphe

Rosário, B. D. A., de Lima, M. P., Vieira, M. G., Leite, L. G., de Aquino, P. É. A., Viana, G. S. D. B., Silveira, E. R., de Brito, D. H. A., Zampieri, D., Ricardo, N. M. P. S., et al. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149791

The perception of pet owners on their dog’s anxiety while supplemented with cannabidiol in a double-blinded randomized placebo-controlled cross-over clinical trial

Alvarenga, I. C., Hess, H., Fagen, A., Feldman, A., Wilson, K., Wernimont, S. M., & McGrath, S. (2026) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2025.12.012

Angststörungen

O’Brien, K., & Blair, P. (2026) · Springer eBooks · doi:10.1007/978-3-032-14521-5_5

Psychopharmacological Effects of Cannabidiol in Rodent Models of Autism Spectrum Disorder: A Systematic Review of Behavioral Outcomes, Neurobiological Mechanisms, and Methodological QualityPreprint

Domingues, B. R. R., Félix, G. S., Bezerra, M. F. L., de Medeiros, P. S., & de Freitas, R. L. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.09.757959

Intra-dorsal periaqueductal gray administration of cannabidiol blocks panic-like response by activating 5-HT1A receptors

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Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats

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New Findings on the Neurotransmitter Modulation of Defense in the Dorsal Periaqueductal Gray

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The role of 5-HT 1A receptors in the anti-aversive effects of cannabidiol on panic attack-like behaviors evoked in the presence of the wild snake Epicrates cenchria crassus (Reptilia, Boidae)

Twardowschy, A., Castiblanco-Urbina, M. A., Uribe-Mariño, A., Biagioni, A. F., Salgado-Rohner, C. J., Crippa, J. A. S., & Coimbra, N. C. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113493363 · Cited by 56 · see citing works

Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT _1A and µ-receptors

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