Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania
Abstract
Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.
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CBD increased the levels of brain-derived neurotrophic factor (BDNF).
“However, we found that CBD seems to have antioxidant and neuroprotective properties, as it increased the levels of brain-derived neurotrophic factor (89, 90).”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [89]
CBD exerts antioxidant activities against toxicity induced by different agents, such as amphetamine.
“Furthermore, CBD exerts antioxidant activities against toxicity induced different agents, such as amphetamine (89, 116, 121)”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [89]
In an animal model of mania induced by chronic D-AMPH (2 mg/kg), CBD was not able to prevent or reverse hyperlocomotion.
“In this model, however, CBD was not able to prevent or reverse the hyperlocomotion induced by D-AMPH.”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [89]
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The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects
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Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation
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- Authors
- Valvassori, S. S., Elias, G., de Souza, B., Petronilho, F., Dal-Pizzol, F., Kapczinski, F., Trzesniak, C., Tumas, V., Dursun, S., Nisihara Chagas, M. H., Hallak, J. E., Zuardi, A. W., Quevedo, J., & Crippa, J. A.
- Affiliations
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil.
- Department of Behavioral Neurosciences; Division of Psychiatry, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto SP, Brazil.
- ORCID
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2009-11-25
- Volume
- 25
- Issue
- 2
- Pages
- 274-280
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2029086034
- Cited by
- 80
- References
- 42
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 6
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Universidade do Extremo Sul Catarinense
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- cannabidiol, oxidative stress, brain-derived neurotrophic factor, protein carbonylation, neuroprotection, hippocampus, prefrontal cortex, striatum, hyperactivity, mood stabilizers, animal model of mania
- MeSH terms
- Amphetamine, Animals, Bipolar Disorder, Cannabidiol, Corpus Striatum, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Hippocampus, Hyperkinesis, Male, Motor Activity, Dopamine Agents, Rats, Wistar, Prefrontal Cortex, Oxidative Stress, Antimanic Agents, Brain-Derived Neurotrophic Factor, Protein Carbonylation, Rats
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