Cited by 80Cannabis and Cannabinoid ResearchBipolar Disorder and TreatmentSchizophrenia research and treatment

Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania

Valvassori, Samira S, Elias, Guilherme, de Souza, Bruna, Petronilho, Fabrícia, Dal-Pizzol, Felipe, Kapczinski, Flávio, Trzesniak, Clarissa, Tumas, Vitor +6 more·2011·Journal of Psychopharmacology

Abstract

Cannabidiol (CBD), a Cannabis sativa constituent, may present a pharmacological profile similar to mood stabilizing drugs, in addition to anti-oxidative and neuroprotective properties. The present study aims to directly investigate the effects of CBD in an animal model of mania induced by D-amphetamine (D-AMPH). In the first model (reversal treatment), rats received saline or D-AMPH (2 mg/kg) once daily intraperitoneal (i.p.) for 14 days, and from the 8th to the 14th day, they were treated with saline or CBD (15, 30 or 60 mg/kg) i.p. twice a day. In the second model (prevention treatment), rats were pretreated with saline or CBD (15, 30, or 60 mg/kg) regime i.p. twice a day, and from the 8th to the 14th day, they also received saline or D-AMPH i.p. once daily. In the hippocampus CBD (15 mg/kg) reversed the d-AMPH-induced damage and increased (30 mg/kg) brain-derived neurotrophic factor (BDNF) expression. In the second experiment, CBD (30 or 60 mg/kg) prevented the D-AMPH-induced formation of carbonyl group in the prefrontal cortex. In the hippocampus and striatum the D-AMPH-induced damage was prevented by CBD (15, 30 or 60 mg/kg). At both treatments CBD did not present any effect against d-AMPH-induced hyperactivity. In conclusion, we could not observe effects on locomotion, but CBD protect against d-AMPH-induced oxidative protein damage and increased BDNF levels in the reversal model and these effects vary depending on the brain regions evaluated and doses of CBD administered.

Integrity signals

Registry

Crossref · 10.1177/0269881109106925

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Valvassori, S. S., Elias, G., de Souza, B., Petronilho, F., Dal-Pizzol, F., Kapczinski, F., Trzesniak, C., Tumas, V., Dursun, S., Nisihara Chagas, M. H., Hallak, J. E., Zuardi, A. W., Quevedo, J., & Crippa, J. A.
Affiliations
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
  • Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brasil.
  • Department of Behavioral Neurosciences; Division of Psychiatry, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto SP, Brazil.
Venue
Journal of Psychopharmacology
Published
2009-11-25
Volume
25
Issue
2
Pages
274-280
ISSN
  • 0269-8811 (ISSN-L)
  • 1461-7285
OpenAlex
W2029086034
Cited by
80
References
42
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 3 · 2012: 6
FWCI
3.12
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
Funders
  • Fundação de Amparo à Pesquisa do Estado de São Paulo
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Universidade do Extremo Sul Catarinense
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
cannabidiol, oxidative stress, brain-derived neurotrophic factor, protein carbonylation, neuroprotection, hippocampus, prefrontal cortex, striatum, hyperactivity, mood stabilizers, animal model of mania
MeSH terms
Amphetamine, Animals, Bipolar Disorder, Cannabidiol, Corpus Striatum, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Administration Schedule, Hippocampus, Hyperkinesis, Male, Motor Activity, Dopamine Agents, Rats, Wistar, Prefrontal Cortex, Oxidative Stress, Antimanic Agents, Brain-Derived Neurotrophic Factor, Protein Carbonylation, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review