Cited by 528Child Abuse and TraumaChild and Adolescent Psychosocial and Emotional DevelopmentPosttraumatic Stress Disorder Research

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Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication II: Associations With Persistence of DSM-IV Disorders

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McLaughlin, Katie A., Green, Jennifer Greif, Gruber, Michael J., Sampson, Nancy A., Zaslavsky, Alan M., Kessler, Ronald C.·2010·Archives of General Psychiatry

DOI 10.1001/archgenpsychiatry.2009.187PMC PMC2847359

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Abstract

CONTEXT: Although significant associations of childhood adversities (CAs) with adult mental disorders have been widely documented, associations of CAs with onset and persistence of disorders have not been distinguished. This distinction is important for conceptual and practical purposes. OBJECTIVE: To examine the multivariate associations of 12 retrospectively reported CAs with persistence of adult DSM-IV disorders in the National Comorbidity Survey Replication. DESIGN: Cross-sectional community survey. SETTING: Household population in the United States. PARTICIPANTS: Nationally representative sample of 5692 adults. MAIN OUTCOME MEASURES: Recency of episodes was assessed separately for each of 20 lifetime DSM-IV mood, anxiety, disruptive behavior, and substance use disorders in respondents with a lifetime history of these disorders using the Composite International Diagnostic Interview. Predictors of persistence were examined using backward recurrence survival models to predict time since most recent episode controlling for age at onset and time since onset. RESULTS: The CAs involving maladaptive family functioning (parental mental illness, substance use disorder, criminality, family violence, physical and sexual abuse, and neglect) but not other CAs were significantly but modestly related to persistence of mood, substance abuse, and anxiety disorders. Number of maladaptive family functioning CAs had statistically significant, but again substantively modest, subadditive associations with the same outcomes. Exposure to multiple other CAs was significantly associated with persistence of mood and anxiety disorders. Associations remained statistically significant throughout the life course, although the substantive size of associations indicated by simulations showing time to most recent episode would increase by only 1.6% (from a mean of 8.3 years to a mean of 8.4 years) in the absence of CAs. CONCLUSIONS: The overall statistically significant associations of CAs with adult DSM-IV/Composite International Diagnostic Interview disorders are due largely to component associations with onsets rather than with persistence, indirectly suggesting that the greatest focus of public health attention on CAs should be aimed at primary rather than secondary prevention.

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Authors: McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C.
Affiliations: Harvard University (US)
Corresponding author: Kessler, Ronald C.
ORCID: McLaughlin, Katie A.
Green, Jennifer Greif
Gruber, Michael J.
Sampson, Nancy A.
Zaslavsky, Alan M.
Kessler, Ronald C.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2010-02-01
Volume: 67
Issue: 2
Pages: 124
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archgenpsychiatry.2009.187
PMC: PMC2847359
OpenAlex: W198999120
Cited by: 528
References: 45
Citations by year: 2026: 10 · 2025: 20 · 2024: 20 · 2023: 26 · 2022: 33 · 2021: 41 · 2020: 39 · 2019: 41 · 2018: 25 · 2017: 38 · 2016: 39 · 2015: 41 · 2014: 33 · 2013: 34 · 2012: 37
FWCI: 42.35
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Robert Wood Johnson Foundation (044780)
John W. Alden Trust
Bristol-Myers Squibb
Eli Lilly and Company
Pfizer
GlaxoSmithKline
Sanofi
Harvard University
Michigan State University
Johns Hopkins University
University of Pittsburgh
National Institutes of Health (5r13mh066849-04, 5r01mh069864-04, 5r01mh070884-05)
Substance Abuse and Mental Health Services Administration
College of Engineering, Michigan State University
National Institute of Mental Health (R13-MH-066849, R01‐MH070884, MH60220, U13MH066849, K01MH092526, U01MH060220, R01‐MH069864)
National Institute on Drug Abuse (K05DA015799, R01DA016558)
Fogarty International Center (R03TW006481)
Topics: Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
Keywords: childhood adversity, mental illness, mood disorders, anxiety disorders, substance use disorders, disruptive behavior disorders, parental mental illness, domestic violence, child abuse, family functioning, primary prevention, secondary prevention, National Comorbidity Survey Replication
MeSH terms: Adult, Anxiety Disorders, Mental Disorders, Child, Child Abuse, Child, Preschool, Crime, Cross-Sectional Studies, Family, Female, Humans, Life Change Events, Male, Parent-Child Relations, Parents, Surveys and Questionnaires, Retrospective Studies, Severity of Illness Index, United States, Comorbidity, Prevalence, Age of Onset, Mood Disorders, Substance-Related Disorders, Diagnostic and Statistical Manual of Mental Disorders, Young Adult

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Childhood Adversities and Adult Psychiatric Disorders in the National Comorbidity Survey Replication II: Associations With Persistence of DSM-IV Disorders

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