The role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: moderation by FK506 binding protein 5 haplotype
Open accessAbstract
Childhood maltreatment is associated with lasting changes in neuroendocrine regulation, alterations in brain structure and function, and symptoms of “limbic irritability.” Limbic irritability symptoms include somatic, sensory, and behavioral phenomena and may stem from increased excitatory neurotransmission following maltreatment. We tested the hypotheses that child maltreatment is indirectly associated with depressive and dissociative symptomatology via indicators of limbic irritability and that variation within the FK506 binding protein 5 gene (FKBP5), a gene involved in glucorticoid receptor functioning, moderates these effects. The sample consisted of high-risk, low-income women (N= 236) living in an inner-city environment. Child maltreatment, limbic irritability, and symptoms of depression and dissociation were measured cross-sectionally using self-report assessments. Haplotype analyses were conducted across four FKBP5 single nucleotide polymorphisms:rs3800373,rs9296158,rs1360870, and rs9470080. Path analysis using bootstrapping procedures was performed to test hypotheses regarding indirect and conditional indirect effects. We found significant indirect effects of maltreatment on depression (β = 0.088,p< .01) and dissociation (β = 0.105,p< .01) via limbic irritability. In addition, variation within FKBP5 moderated these significant indirect effects. For individuals with one to two copies of the CATT haplotype, the indirect effects of maltreatment on depression (β = 0.137,p <.01) and dissociation (β = 0.132,p< .01) via limbic irritability were significant, whereas the indirect paths were not significant for individuals with no copies of this haplotype (depression: β = 0.037,p >.05; dissociation: β = 0.002,p> .05). These results add to the growing evidence that child maltreatment may lead to symptoms of internalizing psychopathology through its impact on the limbic system. In addition, this study revealed a potential role of FKBP5 gene variants in contributing to risk for limbic system dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Limbic irritability symptoms were markedly higher in adults with maltreatment histories.
“In previous work, these ‘limbic irritability’ symptoms were dramatically elevated among adults with maltreatment histories (33, 63, 65, 118).”
From Disorganized attachment in infancy predicts greater amygdala volume in adulthood (2016) · cites this paper as [63]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Haploview: analysis and visualization of LD and haplotype maps
Barrett, J., Fry, B., Maller, J., & Daly, M. (2005) · Bioinform. · doi:10.1093/bioinformatics/bth457 · Cited by 15,086 · see citing works
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
Mediation in experimental and nonexperimental studies: New procedures and recommendations.
Shrout, P. E., & Bolger, N. (2002) · Psychological Methods · doi:10.1037/1082-989x.7.4.422 · Cited by 11,335 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
A New Statistical Method for Haplotype Reconstruction from Population Data
Stephens, M., Smith, N. J. C., & Donnelly, P. (2001) · The American Journal of Human Genetics · doi:10.1086/319501 · Cited by 7,460 · see citing works
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
Bernstein, D. P., Stein, J. A., Newcomb, M. D., Walker, E., Pogge, D., Ahluvalia, T., Stokes, J., Handelsman, L., Medrano, M., Desmond, D., et al. (2003) · Child Abuse & Neglect · doi:10.1016/s0145-2134(02)00541-0 · Cited by 6,419 · see citing works
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256 · see citing works
Introduction to Statistical Mediation Analysis
MacKinnon, D. P. (2012) · doi:10.4324/9780203809556 · Cited by 5,618 · see citing works
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433 · see citing works
Stress, adaptation, and disease. Allostasis and allostatic load
McEWEN, B. S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09546.x · Cited by 5,092 · see citing works
Role of genotype in the cycle of violence in maltreated children
Caspi, A., McClay, J., Moffitt, T. E., Mill, J., Martin, J., Craig, I. W., Taylor, A., & Poulton, R. (2002) · Science · doi:10.1126/science.1072290 · Cited by 4,842 · see citing works
McEwen, B. S. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.18.2093 · Cited by 4,365 · see citing works
da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,012 · see citing works
Development, reliability, and validity of a dissociation scale
BERNSTEIN, E. M., & PUTNAM, F. W. (1986) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198612000-00004 · Cited by 3,793 · cited 1× · see citing works
“The DES has high internal consistency (a ¼ 0.93) and convergent validity with other measures of dissociation (r ¼ .67; Bernstein & Putnam, 1986; van IJzendoorn & Schuengel, 1996).”
BackgroundInfluentialEtkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · see citing works
The concept of allostasis in biology and biomedicine
McEwen, B. S., & Wingfield, J. C. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00024-7 · Cited by 3,302 · cited 1× · see citing works
“Under these circumstances, prolonged and repeated stress exposure may result in physiological dysregulation, leading to inefficient homeostatic functioning (McEwen, 1998; McEwen & Stellar, 1993; McEwen & Wingfield, 2003).”
BackgroundLiu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170 · see citing works
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works
Green, J. G., McLaughlin, K. A., Berglund, P. A., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.186 · Cited by 2,323 · see citing works
The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009 · see citing works
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968 · see citing works
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848 · see citing works
Edwards, V. J., Holden, G. W., Felitti, V. J., & Anda, R. F. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.8.1453 · Cited by 1,832 · see citing works
Traumatic stress: the effects of overwhelming experience on mind, body, and society
(1996) · Choice Reviews Online · doi:10.5860/choice.34-2469 · Cited by 1,818 · see citing works
Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
Gilbertson, M. W., Shenton, M. E., Ciszewski, A., Kasai, K., Lasko, N. B., Orr, S. P., & Pitman, R. K. (2002) · Nature Neuroscience · doi:10.1038/nn958 · Cited by 1,635 · see citing works
Shields, A., & Cicchetti, D. (1997) · Developmental Psychology · doi:10.1037/0012-1649.33.6.906 · Cited by 1,499 · see citing works
Self-citationThe neurobiological consequences of early stress and childhood maltreatment
Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., Navalta, C. P., & Kim, D. M. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00007-1 · Cited by 1,465 · see citing works
Caldji, C., Tannenbaum, B., Sharma, S., Francis, D., Plotsky, P. M., & Meaney, M. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5335 · Cited by 1,437 · see citing works
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362 · see citing works
Accounting for Decay of Linkage Disequilibrium in Haplotype Inference and Missing-Data Imputation
Stephens, M., & Scheet, P. A. (2005) · The American Journal of Human Genetics · doi:10.1086/428594 · Cited by 1,337 · see citing works
Direct and Indirect Effects: Classical and Bootstrap Estimates of Variability
Bollen, K. A., & Stine, R. (1990) · Sociological Methodology · doi:10.2307/271084 · Cited by 1,305 · see citing works
(1993) · Cited by 1,279 · see citing works
Kim, J., & Cicchetti, D. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2009.02202.x · Cited by 1,229 · see citing works
Self-citationThe APSAC Handbook on Child Maltreatment
Myers, J. E. B. (2001) · Medical Entomology and Zoology · Cited by 1,219 · see citing works
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works
Adolescent cortical development: A critical period of vulnerability for addiction
Crews, F., He, J., & Hodge, C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.001 · Cited by 1,091 · see citing works
Roberts, A. L., Gilman, S. E., Breslau, J., Breslau, N., & Koenen, K. C. (2010) · Psychological Medicine · doi:10.1017/s0033291710000401 · Cited by 1,083 · see citing works
Spatz Widom, C., DuMont, K., & Czaja, S. J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.49 · Cited by 1,059 · see citing works
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058 · see citing works
The development of depression in children and adolescents.
Cicchetti, D., & Toth, S. L. (1998) · American Psychologist · doi:10.1037//0003-066x.53.2.221 · Cited by 989 · see citing works
Self-citationBinder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977 · see citing works
Developmental traumatology part II: brain development∗∗See accompanying Editorial, in this issue.
De Bellis, M. D., Keshavan, M. S., Clark, D. B., Casey, B. J., Giedd, J. N., Boring, A. M., Frustaci, K., & Ryan, N. D. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00045-1 · Cited by 974 · see citing works
Binder, E. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.021 · Cited by 968 · see citing works
Fourth National Incidence Study of Child Abuse and Neglect (NIS-4): Report to Congress
Sedlak, A. J. (2010) · PsycEXTRA Dataset · Cited by 963 · see citing works
Dannlowski, U., Stuhrmann, A., Beutelmann, V., Zwanzger, P., Lenzen, T., Grotegerd, D., Domschke, K., Hohoff, C., Ohrmann, P., Bauer, J., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.021 · Cited by 954 · see citing works
Posttraumatic stress disorder in abused and neglected children grown up
Widom, C. S. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1223 · Cited by 945 · see citing works
Prenatal stress, glucocorticoids and the programming of the brain
Welberg, L. A. M., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2001.00601.x · Cited by 928 · see citing works
Hippocampal volume in women victimized by childhood sexual abuse
STEIN, M. B., KOVEROLA, C., HANNA, C., TORCHIA, M. G., & McCLARTY, B. (1997) · Psychological Medicine · doi:10.1017/s0033291797005242 · Cited by 924 · see citing works
Prenatal Stress, Glucocorticoids and the Programming of the Brain
Welberg, L., & Seckl, J. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00601.x · Cited by 922 · see citing works
A meta‐analytic study of changes in brain activation in depression
Fitzgerald, P. B., Laird, A. R., Maller, J., & Daskalakis, Z. J. (2008) · Human Brain Mapping · doi:10.1002/hbm.20426 · Cited by 903 · see citing works
Cicchetti, D., & Toth, S. L. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.144029 · Cited by 861 · see citing works
Self-citationChild abuse trauma: theory and treatment of the lasting effects
(1993) · Choice Reviews Online · doi:10.5860/choice.30-5867 · Cited by 832 · see citing works
Childhood trauma associated with smaller hippocampal volume in women with major depression
Vythilingam, M., Heim, C., Newport, J., Miller, A. H., Anderson, E., Bronen, R., Brummer, M., Staib, L., Vermetten, E., Charney, D. S., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.12.2072 · Cited by 812 · see citing works
Andersen, S. L., Tomada, A., Vincow, E. S., Valente, E., Polcari, A., & Teicher, M. H. (2008) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.2008.20.3.292 · Cited by 788 · see citing works
Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746 · see citing works
Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder
(1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.5.624 · Cited by 721 · see citing works
Collishaw, S., Pickles, A., Messer, J., Rutter, M., Shearer, C., & Maughan, B. (2007) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2007.02.004 · Cited by 720 · see citing works
Resilience under conditions of extreme stress: a multilevel perspective
Cicchetti, D. (2010) · World Psychiatry · doi:10.1002/j.2051-5545.2010.tb00297.x · Cited by 705 · see citing works
Self-citationThe development of depression in children and adolescents.
Cicchetti, D., & Toth, S. L. (1998) · American Psychologist · doi:10.1037/0003-066x.53.2.221 · Cited by 705 · see citing works
Self-citationStorch, E. A., Roberti, J. W., & Roth, D. A. (2004) · Depression and Anxiety · doi:10.1002/da.20002 · Cited by 694 · see citing works
Henslin, J. M., Hartup, W. W., & Rubin, Z. (1987) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2069837 · Cited by 682 · see citing works
Shields, A., & Cicchetti, D. (2001) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3003_7 · Cited by 671 · see citing works
Self-citationMacQueen, G., & Frodl, T. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.80 · Cited by 665 · see citing works
van Ijzendoorn, M. H., & Schuengel, C. (1996) · Clinical Psychology Review · doi:10.1016/0272-7358(96)00006-2 · Cited by 643 · cited 1× · see citing works
“The DES has high internal consistency (a ¼ 0.93) and convergent validity with other measures of dissociation (r ¼ .67; Bernstein & Putnam, 1986; van IJzendoorn & Schuengel, 1996).”
BackgroundInfluentialWochnik, G. M., Rüegg, J., Abel, G. A., Schmidt, U., Holsboer, F., & Rein, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407498200 · Cited by 638 · see citing works
Sticks, stones, and hurtful words: relative effects of various forms of childhood maltreatment
Teicher, M. H., Samson, J. A., Polcari, A., & McGreenery, C. E. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.993 · Cited by 634 · see citing works
A multimethodological analysis of cumulative risk and allostatic load among rural children
Evans, G. W. (2003) · Developmental Psychology · doi:10.1037/0012-1649.39.5.924 · Cited by 624 · see citing works
Cicchetti, D., & Toth, S. L. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01979.x · Cited by 617 · see citing works
Self-citationDevelopmental neurobiology of childhood stress and trauma
Teicher, M. H., Andersen, S. L., Polcari, A., Anderson, C. M., & Navalta, C. P. (2002) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(01)00003-x · Cited by 607 · see citing works
Caldji, C. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00110-4 · Cited by 606 · see citing works
Dissociation in children and adolescents: a developmental perspective
(1998) · Choice Reviews Online · doi:10.5860/choice.35-4803 · Cited by 590 · see citing works
McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.187 · Cited by 528 · see citing works
Sedlak, A. J., Mettenburg, J., Basena, M., Petta, I., McPherson, K. S., Greene, A., & Li, S. (2010) · PsycEXTRA Dataset · doi:10.1037/e565022012-001 · Cited by 510 · see citing works
Shields, A., & Cicchetti, D. (1998) · Journal of Clinical Child Psychology · doi:10.1207/s15374424jccp2704_2 · Cited by 496 · see citing works
Self-citationChildhood neglect is associated with reduced corpus callosum area
Teicher, M. H., Dumont, N. L., Ito, Y., Vaituzis, C., Giedd, J. N., & Andersen, S. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.016 · Cited by 484 · see citing works
Childhood sexual abuse, stressful life events and risk for major depression in women
KENDLER, K. S., KUHN, J. W., & PRESCOTT, C. A. (2004) · Psychological Medicine · doi:10.1017/s003329170400265x · Cited by 475 · see citing works
The Developmental Impact of Different Forms of Child Abuse and Neglect
Trickett, P. K., & McBride-Chang, C. (1995) · Developmental Review · doi:10.1006/drev.1995.1012 · Cited by 472 · see citing works
(2005) · PubMed · Cited by 470 · see citing works
(2013) · Psychology Press eBooks · doi:10.4324/9780203781760 · Cited by 467 · see citing works
Development and self-regulatory structures of the mind
Cicchetti, D., & Tucker, D. (1994) · Development and Psychopathology · doi:10.1017/s0954579400004673 · Cited by 429 · see citing works
Self-citationA New First Step in Activation of Steroid Receptors
Davies, T. H., Ning, Y.-M., & Sánchez, E. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100531200 · Cited by 427 · see citing works
Dynamic mapping of normal human hippocampal development
Gogtay, N., Nugent, T. F., Herman, D. H., Ordonez, A., Greenstein, D., Hayashi, K. M., Clasen, L., Toga, A. W., Giedd, J. N., Rapoport, J. L., et al. (2006) · Hippocampus · doi:10.1002/hipo.20193 · Cited by 426 · see citing works
Childhood maltreatment and the structure of common psychiatric disorders
Keyes, K., Eaton, N., Krueger, R., McLaughlin, K., Wall, M., Grant, B., & Hasin, D. (2012) · British Journal of Psychiatry · doi:10.1192/bjp.bp.111.093062 · Cited by 425 · see citing works
Traumatic Stress: The Effects of Overwhelming Experience on Mind, Body, and Society
Geller, J. L., & Breslin, D. L. (1997) · Psychiatric Services · doi:10.1176/ps.48.2.250-a · Cited by 420 · see citing works
Sánchez, M. M., Young, L. J., Plotsky, P. M., & Insel, T. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-12-04657.2000 · Cited by 420 · see citing works
Status of Glucocorticoid Alterations in Post‐traumatic Stress Disorder
Yehuda, R. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04979.x · Cited by 409 · see citing works
Child Abuse Trauma: Theory and Treatment of the Lasting Effects
Ford, D. Y., & Briere, J. (1993) · Family Relations · doi:10.2307/585465 · Cited by 403 · see citing works
Choi, J., Jeong, B., Rohan, M. L., Polcari, A. M., & Teicher, M. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.022 · Cited by 376 · see citing works
Risk and resilience: genetic and environmental influences on development of the stress response
Gillespie, C. F., Phifer, J., Bradley, B., & Ressler, K. J. (2009) · Depression and Anxiety · doi:10.1002/da.20605 · Cited by 351 · see citing works
Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
Xie, P., Kranzler, H. R., Poling, J., Stein, M. B., Anton, R. F., Farrer, L. A., & Gelernter, J. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.37 · Cited by 327 · see citing works
Heightened neural reactivity to threat in child victims of family violence
McCrory, E. J., De Brito, S. A., Sebastian, C. L., Mechelli, A., Bird, G., Kelly, P. A., & Viding, E. (2011) · Current Biology · doi:10.1016/j.cub.2011.10.015 · Cited by 327 · see citing works
Kim‐Spoon, J., Cicchetti, D., & Rogosch, F. A. (2012) · Child Development · doi:10.1111/j.1467-8624.2012.01857.x · Cited by 319 · see citing works
Self-citationBrain development and behavior
Sterman, M. B., McGinty, D., & Adinolfi, A. M. (1971) · Medical Entomology and Zoology · Cited by 317 · see citing works
Delayed Effects of Early Stress on Hippocampal Development
Andersen, S. L., & Teicher, M. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300528 · Cited by 313 · see citing works
Dixon, L., Browne, K. D., & Hamilton-Giachritsis, C. E. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00339.x · Cited by 312 · see citing works
Ising, M., Depping, A., Siebertz, A., Lucae, S., Unschuld, P. G., Kloiber, S. M., Horstmann, S., Uhr, M., Müller‐Myhsok, B., & Holsboer, F. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06332.x · Cited by 312 · see citing works
Child abuse and neglect and the development of mental disorders in the general population
COHEN, P., BROWN, J., & SMAILES, E. (2001) · Development and Psychopathology · doi:10.1017/s0954579401004126 · Cited by 309 · see citing works
Vermeer, H., Hendriks-Stegeman, B. I., van der Burg, B., van Buul-Offers, S. C., & Jansen, M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020354 · Cited by 285 · see citing works
Lekman, M., Laje, G., Charney, D., Rush, A. J., Wilson, A. F., Sorant, A. J. M., Lipsky, R., Wisniewski, S. R., Manji, H., McMahon, F. J., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.026 · Cited by 284 · see citing works
Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., & Enoch, M.-A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.236 · Cited by 282 · see citing works
Segman, R. H., Shefi, N., Goltser-Dubner, T., Friedman, N., Kaminski, N., & Shalev, A. Y. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001636 · Cited by 281 · see citing works
Touma, C., Gassen, N. C., Herrmann, L., Cheung‐Flynn, J., Büll, D., Ionescu, I. A., Heinzmann, J.-M., Knapman, A., Siebertz, A., Depping, A., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.023 · Cited by 270 · see citing works
Zimmermann, P., Brückl, T., Nocon, A., Pfister, H., Binder, E. B., Uhr, M., Lieb, R., Moffitt, T. E., Caspi, A., Holsboer, F., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111577 · Cited by 262 · see citing works
Cicchetti, D. (1989) · Child Maltreatment · doi:10.1017/cbo9780511665707.014 · Cited by 260 · see citing works
Self-citationShields, A. M., Ryan, R. M., & Cicchetti, D. (2001) · Developmental Psychology · doi:10.1037/0012-1649.37.3.321 · Cited by 258 · see citing works
Self-citationStructural MRI correlates for vulnerability and resilience to major depressive disorder
Amico, F. (2011) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.090186 · Cited by 256 · see citing works
Teicher, M. H., Ito, Y., Glod, C. A., Andersen, S. L., Dumont, N., & Ackerman, E. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb48277.x · Cited by 239 · see citing works
Scammell, J. G., Denny, W. B., Valentine, D. L., & Smith, D. F. (2001) · General and Comparative Endocrinology · doi:10.1006/gcen.2001.7696 · Cited by 238 · see citing works
Child maltreatment and vulnerability to depression
Toth, S. L., Manly, J. T., & Cicchetti, D. (1992) · Development and Psychopathology · doi:10.1017/s0954579400005587 · Cited by 236 · see citing works
Self-citationAppel, K., Schwahn, C., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Stender, J., Barnow, S., John, U., Teumer, A., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.81 · Cited by 234 · see citing works
P3b reflects maltreated children's reactions to facial displays of emotion
Pollak, S. D., Klorman, R., Thatcher, J. E., & Cicchetti, D. (2001) · Psychophysiology · doi:10.1111/1469-8986.3820267 · Cited by 234 · see citing works
Self-citationThe development of dissociation in maltreated preschool-aged children
Macfie, J., Cicchetti, D., & Toth, S. L. (2001) · Development and Psychopathology · doi:10.1017/s0954579401002036 · Cited by 223 · see citing works
Self-citationDecreased hippocampal volume in healthy girls at risk of depression
Chen, M. C., Hamilton, J. P., & Gotlib, I. H. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.202 · Cited by 220 · see citing works
Lowy, M. T., Wittenberg, L., & Yamamoto, B. K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65010268.x · Cited by 217 · see citing works
Choi, J., Jeong, B., Polcari, A., Rohan, M. L., & Teicher, M. H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.033 · Cited by 215 · see citing works
Physiologic Programming of the Fetus
Seckl, J. R. (1998) · Clinics in Perinatology · doi:10.1016/s0095-5108(18)30091-5 · Cited by 214 · see citing works
Early childhood abuse and limbic system ratings in adult psychiatric outpatients
(1993) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.5.3.301 · Cited by 214 · see citing works
Bradley, B., Westen, D., Mercer, K. B., Binder, E. B., Jovanovic, T., Crain, D., Wingo, A., & Heim, C. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000162 · Cited by 213 · see citing works
Gene × environment vulnerability factors for PTSD: The HPA-axis
Mehta, D., & Binder, E. B. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.009 · Cited by 211 · see citing works
Teicher, M. H., Samson, J. A., Sheu, Y.-S., Polcari, A., & McGreenery, C. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10010030 · Cited by 211 · see citing works
Childhood stress, serotonin transporter gene and brain structures in major depression
Frodl, T., Reinhold, E., Koutsouleris, N., Donohoe, G., Bondy, B., Reiser, M., Möller, H.-J., & Meisenzahl, E. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.8 · Cited by 200 · see citing works
Childhood Sexual Abuse Is Associated with Reduced Gray Matter Volume in Visual Cortex of Young Women
Tomoda, A., Navalta, C. P., Polcari, A., Sadato, N., & Teicher, M. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.021 · Cited by 200 · see citing works
Yehuda, R., Golier, J. A., Yang, R.-K., & Tischler, L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.010 · Cited by 196 · see citing works
PTSD and gene variants: new pathways and new thinking
Skelton, K., Ressler, K. J., Norrholm, S. D., Jovanovic, T., & Bradley-Davino, B. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.013 · Cited by 191 · see citing works
Horstmann, S., Lucae, S., Menke, A., Hennings, J. M., Ising, M., Roeske, D., Müller-Myhsok, B., Holsboer, F., & Binder, E. B. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.180 · Cited by 185 · see citing works
Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children
Koenen, K. C., Saxe, G., Purcell, S., Smoller, J. W., Bartholomew, D. A., Miller, A. B., Hall, E., Kaplow, J. B., Enlow, M. B., Moulton, S. L., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001727 · Cited by 183 · see citing works
Rao, H., Betancourt, L., Giannetta, J. M., Brodsky, N. L., Korczykowski, M., Avants, B. B., Gee, J. C., Wang, J., Hurt, H., Detre, J. A., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.07.003 · Cited by 178 · see citing works
Orr, S. P., Lasko, N. B., Metzger, L. J., Berry, N. J., Ahern, C. E., & Pitman, R. K. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.66.6.906 · Cited by 173 · see citing works
McLaughlin, K. A., Green, J. G., Gruber, M. J., Sampson, N. A., Zaslavsky, A. M., & Kessler, R. C. (2009) · Psychological Medicine · doi:10.1017/s0033291709991115 · Cited by 172 · see citing works
Simeon, D., Knutelska, M., Yehuda, R., Putnam, F., Schmeidler, J., & Smith, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.030 · Cited by 167 · see citing works
(1993) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.5.4.401 · Cited by 158 · see citing works
The Psychobiological Functions of Dissociation
Ludwig, A. M. (1983) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.1983.10404149 · Cited by 151 · see citing works
Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks
Sarapas (2011) · PubMed · doi:10.3233/dma-2011-0764 · Cited by 143 · see citing works
Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks
Sarapas, C., Cai, G., Bierer, L. M., Golier, J. A., Galea, S., Ising, M., Rein, T., Schmeidler, J., Müller-Myhsok, B., Uhr, M., et al. (2011) · Disease Markers · doi:10.1155/2011/328054 · Cited by 143 · see citing works
Cicchetti, D., Rogosch, F. A., & Thibodeau, E. L. (2012) · Development and Psychopathology · doi:10.1017/s0954579412000442 · Cited by 141 · see citing works
Self-citationLyons‐Ruth, K., & Spielman, E. (2004) · Infant Mental Health Journal · doi:10.1002/imhj.20008 · Cited by 140 · see citing works
Dannlowski, U., Ohrmann, P., Bauer, J., Kugel, H., Arolt, V., Heindel, W., Kersting, A., Baune, B. T., & Suslow, T. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0742 · Cited by 139 · see citing works
Preliminary Evidence for Aberrant Cortical Development in Abused Children: A Quantitative EEG Study
Ito, Y., Teicher, M. H., Glod, C. A., & Ackerman, E. (1998) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.10.3.298 · Cited by 139 · see citing works
Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood:
Anderson, C. M., Teicher, M. H., Polcari, A., & Renshaw, P. F. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00047-6 · Cited by 139 · cited 2× · see citing works
“There is also evidence of functional impairments within limbic regions for individuals with histories of childhood maltreatment (Anderson et al., 2002; Ito, Teicher, Glod, & Ackerman, 1998; Ito et al., 1993; Teicher et al., 1997).”
BackgroundIs Psychopharmacologic "Inoculation" Effective in Preventing Posttraumatic Stress Disorder?
Stahl, S. M. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0101 · Cited by 139 · see citing works
Orr, S. P., Lasko, N. B., Metzger, L. J., et al. (1998) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.66.6.906 · Cited by 139 · see citing works
Bevilacqua, L. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.152 · Cited by 137 · cited 2× · see citing works
“In a recent investigation, the presence of two CATT haplotype copies predicted aggressive and violent behavior in prison inmates exposed to childhood trauma (Bevilacqua et al., 2012).”
BackgroundGene‐environment interaction in posttraumatic stress disorder: An update
Koenen, K. C., Amstadter, A. B., & Nugent, N. R. (2009) · Journal of Traumatic Stress · doi:10.1002/jts.20435 · Cited by 129 · see citing works
Cicchetti, D., & Curtis, W. J. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050315 · Cited by 125 · see citing works
Self-citationKrämer, U. M., Toni Cunillera, B., Càmara, E., Marco‐Pallarés, J., Cucurell, D., Nager, W., Bauer, P. O., Schüle, R., Schöls, L. J., Rodríguez‐Fornells, A., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4229-07.2007 · Cited by 124 · see citing works
Dissociation in maltreated versus nonmaltreated preschool-aged children
Macfie, J., Cicchetti, D., & Toth, S. L. (2001) · Child Abuse & Neglect · doi:10.1016/s0145-2134(01)00266-6 · Cited by 123 · see citing works
Self-citationHawkins, K. A., Mohamed, S., & Woods, S. W. (1999) · Psychological Medicine · doi:10.1017/s0033291798006990 · Cited by 120 · see citing works
Childhood abuse is associated with increased startle reactivity in adulthood
Jovanović, T., Blanding, N. Q., Norrholm, S. D., Duncan, E., Bradley, B., & Ressler, K. J. (2009) · Depression and Anxiety · doi:10.1002/da.20599 · Cited by 119 · see citing works
Cicchetti, D., Rogosch, F., & Oshri, A. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000599 · Cited by 111 · see citing works
Self-citationDNA sequence variants of the FKBP5 gene are associated with unipolar depression
Zobel, A. W., Schuhmacher, A., Jessen, F., Höfels, S., von Widdern, O., Metten, M., Pfeiffer, U., Hanses, C., Becker, T., Rietschel, M., et al. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709991155 · Cited by 108 · see citing works
Velders, F. P., Kuningas, M., Kumari, M., Dekker, M. J., Uitterlinden, A. G., Kirschbaum, C., Hek, K., Hofman, A., Verhulst, F. C., Kivimaki, M., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.01.003 · Cited by 106 · see citing works
Karg, K., Burmeister, M., Shedden, K., & Sen, S. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.189 · Cited by 87 · see citing works
Åslund, C., Leppert, J., Comasco, E., Nordquist, N., Oreland, L., & Nilsson, K. W. (2009) · Behavior Genetics · doi:10.1007/s10519-009-9285-9 · Cited by 75 · see citing works
Cicchetti, D., Rogosch, F. A., Sturge‐Apple, M. L., & Toth, S. L. (2009) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp078 · Cited by 74 · see citing works
Self-citationGibb, B. E., Uhrlass, D. J., Grassia, M., Benas, J. S., & McGeary, J. E. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0016765 · Cited by 68 · see citing works
Association of FKBP5 gene haplotypes with completed suicide in the Japanese population
Supriyanto, I., Sasada, T., Fukutake, M., Asano, M., Ueno, Y., Nagasaki, Y., Shirakawa, O., & Hishimoto, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.019 · Cited by 67 · see citing works
Denny, W. B., Valentine, D. L., Reynolds, P. D., Smith, D. F., & Scammell, J. G. (2000) · Endocrinology · doi:10.1210/en.141.11.4107 · Cited by 66 · see citing works
Veltman, D. J., de Ruiter, M. B., Rombouts, S. A. R. B., Lazeron, R. H. C., Barkhof, F., van Dyck, R., Dolan, R. J., & Phaf, R. H. (2005) · Psychological Medicine · doi:10.1017/s0033291704002971 · Cited by 65 · see citing works
Neurological impairment in maltreated children
Green, A. H., Voeller, K. K. S., Gaines, R., & Kubie, J. L. (1981) · Child Abuse & Neglect · doi:10.1016/0145-2134(81)90031-4 · Cited by 56 · see citing works
Kang, J. I., Chung, H. C., Jeung, H., Kim, S. J., An, S. K., & Namkoong, K. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.02.017 · Cited by 49 · see citing works
Hyman, S. M., García, M., Kemp, K. A., Mazure, C. M., & Sinha, R. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.08.009 · Cited by 46 · see citing works
Meaney, M. J., Stewart, J., & Beatty, W. W. (1982) · Hormones and Behavior · doi:10.1016/0018-506x(82)90054-x · Cited by 41 · see citing works
Multilevel dynamics in developmental psychopathology: The Minnesota Symposia on Child Psychology
Masten, A. S. (2007) · Cited by 25 · see citing works
Johnson, A. L., Gibb, B. E., & McGeary, J. E. (2009) · Cognitive Therapy and Research · doi:10.1007/s10608-009-9269-3 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- Cicchetti D Lynch M Cicchetti D Cohen DJ Failures in the expectable environment and their impact on individual development: The case of child maltreatment Developmental psychopathology: Vol. 2.Risk, disorder and adaptation 1995 2 32 71 New York Wiley
- Cicchetti D Rogosch FA Toth SL Luthar SS Burack JA Cicchetti D Weisz JR Ontonogenesis, depressotypic organization, and the depressive spectrum Developmental Psychopathology: Perspective on adjustment, risk, and disorder 1997 273 349 Cambridge, U.K Cambridge University Press
- Cicchetti D Toth SL Cicchetti D Cohen DJ Developmental psychopathology and disorders of affect Developmental psychopathology: Risk, disorder, and adaptation 1995 2 369 420 New York Wiley
- Cicchetti D Valentino K Cicchetti D Cohen D An ecological-transactional perspective on child maltreatment: failure of the average expectable environment and its influences on child development Development and Psychopathology: Vol. 3. Risk, disorder, and adaptation 2006 2nd ed. 129 201 New York Wiley
- Lupien SJ Ouellet-Morin I Hupbach A Tu MT Buss C Walker D Cicchetti D Cohen D Beyond the stress concept: Allostatic load—A developmental biological and cognitive perspective Developmental psychopathology: Vol. 2. Developmental neuroscience 2006 2nd ed. 578 628 New York Wiley
- van der Kolk B Greenberg MS van der Kolk B The psychobiology of the trauma response: hyperarousal, constriction, and addiction to traumatic reexposure Psychological Trauma 1987 63 87 Washington, D.C American Psychiatric Press
Cited by
Sorted by citations
Gene–Stress–Epigenetic regulation of FKBP5: clinical and translational implications
Zannas, A. S., Wiechmann, T., Gassen, N. C., & Binder, E. B. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.235 · Cited by 622 · see citing works
Wang, Q., Shelton, R. C., & Dwivedi, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.066 · Cited by 201 · see citing works
Disorganized attachment in infancy predicts greater amygdala volume in adulthood
Lyons-Ruth, K., Pechtel, P., Yoon, S. A., Anderson, C. M., & Teicher, M. H. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.050 · Cited by 142 · see citing works
Zaba, M., Kirmeier, T., Ionescu, I. A., Wollweber, B., Buell, D. R., Gall-Kleebach, D. J., Schubert, C. F., Novak, B., Huber, C., Köhler, K., et al. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.02.005 · Cited by 101 · see citing works
Wolf, E. J., Rasmusson, A. M., Mitchell, K. S., Logue, M. W., Baldwin, C. T., & Miller, M. W. (2014) · Depression and Anxiety · doi:10.1002/da.22260 · Cited by 75 · see citing works
Stevens, J. S., Ely, T. D., Sawamura, T., Guzman, D., Bradley, B., Ressler, K. J., & Jovanovic, T. (2016) · Depression and Anxiety · doi:10.1002/da.22506 · Cited by 40 · see citing works
- Authors
- Dackis, M. N., Rogosch, F. A., Oshri, A., & Cicchetti, D.
- Affiliations
- University of Rochester (US)
- University of Minnesota (US)
- Corresponding author
- Dackis, Melissa N.
- Rogosch, Fred A.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-10-15
- Volume
- 24
- Issue
- 4
- Pages
- 1237-1252
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC3697116
- OpenAlex
- W2111150529
- Cited by
- 71
- References
- 165
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 14 · 2015: 12 · 2014: 5 · 2013: 2 · 2012: 1
- FWCI
- 7.27
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01mh083979-04)
- National Institute of Mental Health (R01‐MH083979, MH083979)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- child abuse, FKBP5, depression, dissociation, glucocorticoid receptor, low-income women, inner-city women, internalizing psychopathology, gene-environment moderation, excitatory neurotransmission
- MeSH terms
- Tacrolimus Binding Protein 5, Adult, Depression, Depressive Disorder, Dissociative Disorders, Female, Genotype, Haplotypes, Humans, Limbic System, Poverty, Risk Factors, Women, Polymorphism, Single Nucleotide, Tacrolimus Binding Proteins, Adult Survivors of Child Abuse
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
