Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes

Gillen, J. B.; Little, J. P.; Punthakee, Z.; Tarnopolsky, M. A.; Riddell, M. C.; Gibala, M. J.

doi:10.1111/j.1463-1326.2012.01564.x

Cited by 272Diabetes Management and ResearchPhysical Activity and HealthCardiovascular and exercise physiology

Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes

Gillen, J. B., Little, J. P., Punthakee, Z., Tarnopolsky, M. A., Riddell, M. C., Gibala, M. J.·2012·Diabetes, Obesity and Metabolism

DOI 10.1111/j.1463-1326.2012.01564.x

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Abstract

High‐volume endurance exercise (END) improves glycaemic control in type 2 diabetes (T2D) but many individuals cite ‘lack of time’ as a barrier to regular participation. High‐intensity interval training (HIT) is a time‐efficient method to induce physiological adaptations similar to END, but little is known regarding the effect of HIT in T2D. Using continuous glucose monitoring (CGM), we examined the 24‐h blood glucose response to one session of HIT consisting of 10 × 60 s cycling efforts at ∼90% maximal heart rate, interspersed with 60 s rest. Seven adults with T2D underwent CGM for 24‐h on two occasions under standard dietary conditions: following acute HIT and on a non‐exercise control day (CTL). HIT reduced hyperglycaemia measured as proportion of time spent above 10 mmol/l (HIT: 4.5 ± 4.4 vs. CTL: 15.2 ± 12.3%, p = 0.04). Postprandial hyperglycaemia, measured as the sum of post‐meal areas under the glucose curve, was also lower after HIT vs. CTL (728 ± 331 vs. 1142 ± 556 mmol/l·9 h, p = 0.01). These findings highlight the potential for HIT to improve glycaemic control in T2D.

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It is possible, after a familiarization period, for previously untrained persons to successfully perform this kind of training.
“we and others [8,60], have demonstrated that it is possible, after a familiarization period, for previously untrained persons to successfully perform this kind of training”
From High-Intensity Interval Resistance Training (HIRT) influences resting energy expenditure and respiratory ratio in non-dieting individuals (2012) · cites this paper as [60]
Time-efficient HIIT rapidly improves glucose control in individuals with T2D.
“For example, time-efficient HIIT has been shown to rapidly improve glucose control in individuals with prediabetes [13, 14] and T2D [12, 15].”
From High-Intensity Interval Training as an Efficacious Alternative to Moderate-Intensity Continuous Training for Adults with Prediabetes (2015) · cites this paper as [15]

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Short-Term High-Intensity Interval Training Reduces Hyperglycemia in Type 2 Diabetics
Gillen, J. B., Little, J. P., Punthakee, Z., Tarnopolsky, M. A., & Gibala, M. J. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000389559.04357.1d
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The effect on glycaemic control of low‐volume high‐intensity interval training versus endurance training in individuals with type 2 diabetes
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Extremely short duration interval exercise improves 24-h glycaemia in men with type 2 diabetes
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EFFICACY OF ACUTE HIGH-INTENSITY INTERVAL TRAINING IN LOWERING GLYCEMIA IN PATIENTS WITH TYPE 2 DIABETES: DIABETES EM MOVIMENTO® PILOT STUDY
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High-intensity Interval Training Increases Muscle GLUT4 and Mitochondrial Capacity in Prediabetes and Type 2 Diabetes
Little, J. P., Gillen, J. B., Percival, M., Safdar, A., Punthakee, Z., Tarnopolsky, M. A., & Gibala, M. J. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000402886.71869.aa
Self-citation

Authors: Gillen, J. B., Little, J. P., Punthakee, Z., Tarnopolsky, M. A., Riddell, M. C., & Gibala, M. J.
Affiliations: McMaster University (CA)
York University (CA)
Corresponding author: Gibala, M. J.
ORCID: Gillen, J. B.
Little, J. P.
Punthakee, Z.
Tarnopolsky, M. A.
Riddell, M. C.
Gibala, M. J.
Venue: Diabetes, Obesity and Metabolism
Publisher: Wiley
Published: 2012-02-20
Volume: 14
Issue: 6
Pages: 575-577
ISSN: 1462-8902 (ISSN-L)
1463-1326
DOI: 10.1111/j.1463-1326.2012.01564.x
OpenAlex: W1987329229
Cited by: 272
References: 13
Citations by year: 2026: 10 · 2025: 7 · 2024: 13 · 2023: 13 · 2022: 21 · 2021: 19 · 2020: 20 · 2019: 19 · 2018: 23 · 2017: 21 · 2016: 22 · 2015: 20 · 2014: 18 · 2013: 39 · 2012: 6
FWCI: 21.27
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes Obesity and Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Diabetes Association
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Physiology › Physical Activity and Health
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: high-intensity interval training, type 2 diabetes, postprandial blood glucose, hyperglycemia, glycemic control, acute exercise, continuous glucose monitoring, time-efficient exercise, endurance exercise
MeSH terms: Blood Glucose, Diabetes Mellitus, Type 2, Exercise Therapy, Female, Humans, Hyperglycemia, Male, Middle Aged, Time Factors, Blood Glucose Self-Monitoring, Exercise, Prevalence, Postprandial Period

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Acute high‐intensity interval exercise reduces the postprandial glucose response and prevalence of hyperglycaemia in patients with type 2 diabetes

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