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Cited by 1,141

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men<subtitle>A Prospective Study</subtitle>

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Giovannucci, Edward·2008·Archives of Internal Medicine
DOI 10.1001/archinte.168.11.1174
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Abstract

BACKGROUND: Vitamin D deficiency may be involved in the development of atherosclerosis and coronary heart disease in humans. METHODS: We assessed prospectively whether plasma 25-hydroxyvitamin D (25[OH]D) concentrations are associated with risk of coronary heart disease. A nested case-control study was conducted in 18,225 men in the Health Professionals Follow-up Study; the men were aged 40 to 75 years and were free of diagnosed cardiovascular disease at blood collection. The blood samples were returned between April 1, 1993, and November 30, 1999; 99% were received between April 1, 1993, and November 30, 1995. During 10 years of follow-up, 454 men developed nonfatal myocardial infarction or fatal coronary heart disease. Using risk set sampling, controls (n = 900) were selected in a 2:1 ratio and matched for age, date of blood collection, and smoking status. RESULTS: After adjustment for matched variables, men deficient in 25(OH)D ( or=30 ng/mL) (relative risk [RR], 2.42; 95% confidence interval [CI], 1.53-3.84; P < .001 for trend). After additional adjustment for family history of myocardial infarction, body mass index, alcohol consumption, physical activity, history of diabetes mellitus and hypertension, ethnicity, region, marine omega-3 intake, low- and high-density lipoprotein cholesterol levels, and triglyceride levels, this relationship remained significant (RR, 2.09; 95% CI, 1.24-3.54; P = .02 for trend). Even men with intermediate 25(OH)D levels were at elevated risk relative to those with sufficient 25(OH)D levels (22.6-29.9 ng/mL: RR, 1.60 [95% CI, 1.10-2.32]; and 15.0-22.5 ng/mL: RR, 1.43 [95% CI, 0.96-2.13], respectively). CONCLUSION: Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.

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Metadata

Authors
Giovannucci, E.
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2008-06-09
Volume
168
Issue
11
Pages
1174
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.168.11.1174
OpenAlex
W2035139971
Cited by
1,141
References
13
FWCI
80.47
Type
journal article
Language
en
Open access
green

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