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Cited by 289

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Recovery in Major Depressive Disorder: Analysis With the Life Table and Regression Models

Keller, Martin B.·1982·Archives of General Psychiatry
DOI 10.1001/archpsyc.1982.04290080025004
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Abstract

Regression models and life tables were used to describe the phenomenon of recovery from major depressive disorder for 101 patients in a naturalistic study in which treatment was not controlled by the investigators. Time to recovery from the onset of the episode was protracted, as only about 50% of patients recovered by one year. Annual rates of recovery then declined steadily to 28% in the second year, 22% in the third year, and 18% in the fourth year. In contrast, speed of recovery from entry into the study was more rapid, and 63% of patients recovered by four months. The recovery rates were about 20% each month for the first four months and then declined sharply for the remaining months of the one-year follow-up. Several clinical variables were statistically significant predictors of recovery when measured from entry into the study: superimposition of the acute episode on a chronic underlying depression, acuteness of onset of he depression, and severity of depression for the subgroup of patients without superimposed illness.

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Metadata

Authors
Keller, M. B.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1982-08-01
Volume
39
Issue
8
Pages
905
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1982.04290080025004
OpenAlex
W2037574354
Cited by
289
References
0
FWCI
5.11
Type
journal article
Language
en
Open access
closed

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