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Neuropsychological Assessment of Monozygotic Twins Discordant for Schizophrenia
Abstract
A comparison of monozygotic twins discordant for schizophrenia controls for genetic variance and reduces variance due to environmental circumstances, thus serving to highlight differences due to phenotypic-related variables. In this study, we assessed 16 such twin pairs on a wide range of neuropsychological tests. The affected twins tended to perform worse than their unaffected counterparts on most of the tests. Deficits were especially severe on tests of vigilance, memory, and concept formation, suggesting that dysfunction is greatest in the frontotemporal cortex. While manifest symptoms were not highly associated with neuropsychological scores, global level of functioning was. To address the issue of genetic liability, we also compared the sample of discordant unaffected twins with a sample of seven pairs of normal monozygotic twins. No significant differences between the groups were found for any neuropsychological test. In fact, the results suggest that neuropsychological dysfunction is a consistent feature of schizophrenia and that it is related primarily to the clinical disease process and not to genetic or nonspecific environmental factors.
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Cites
Bogerts, B. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790310046006 · Cited by 880
Cited by
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Green, M. F., Nuechterlein, K. H., Gold, J. M., Barch, D. M., Cohen, J., Essock, S., Fenton, W. S., Frese, F., Goldberg, T. E., Heaton, R. K., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.023 · Cited by 919
Self-citationSchizophrenia Is a Cognitive Illness: Time for a Change in Focus
Kahn, R. S., & Keefe, R. S. E. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.155 · Cited by 825
Sustained attention deficit in bipolar disorder
Clark, L., Iversen, S. D., & Goodwin, G. M. (2002) · British Journal of Psychiatry · doi:10.1192/bjp.180.4.313 · Cited by 539
Buchanan, R. W. (2005) · Schizophrenia Bulletin · doi:10.1093/schbul/sbi020 · Cited by 438
Neurophysiological and neuropsychological evidence for attentional dysfunction in schizophrenia
Cullum, C. M., Harris, J. G., Waldo, M. C., Smernoff, E., Madison, A., Nagamoto, H. T., Griffith, J., Adler, L. E., & Freedman, R. (1993) · Schizophrenia Research · doi:10.1016/0920-9964(93)90048-n · Cited by 212
Cognitive functioning, cortisol release, and symptom severity in patients with schizophrenia
Walder, D. J., Walker, E. F., & Lewine, R. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01052-0 · Cited by 192
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Gourovitch, M. L., Torrey, E. F., Gold, J. M., Randolph, C., Weinberger, D. R., & Goldberg, T. E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00148-6 · Cited by 179
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The brief assessment of cognition in schizophrenia. Normative data for the Italian population
Anselmetti, S., Poletti, S., Ermoli, E., Bechi, M., Cappa, S., Venneri, A., Smeraldi, E., & Cavallaro, R. (2008) · Neurological Sciences · doi:10.1007/s10072-008-0866-9 · Cited by 129
Heritability of Changes in Brain Volume Over Time in Twin Pairs Discordant for Schizophrenia
Brans, R. G. H., van Haren, N. E. M., van Baal, G. C. M., Schnack, H. G., Kahn, R. S., & Pol, H. E. H. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1259 · Cited by 129
Set-Shifting Ability and Schizophrenia: A Marker of Clinical Illness or an Intermediate Phenotype?
Ceaser, A. E., Goldberg, T. E., Egan, M. F., McMahon, R. P., Weinberger, D. R., & Gold, J. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.009 · Cited by 100
Self-citationVelligan, D., Mintz, J., Maples, N., Xueying, L., Gajewski, S., Carr, H., & Sierra, C. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs116 · Cited by 87
Woodward, N. D., & Heckers, S. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv048 · Cited by 85
Cognitive impairment as a risk factor for psychosis
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Metadata
- Authors
- Goldberg, T. E.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1990-11-01
- Volume
- 47
- Issue
- 11
- Pages
- 1066
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2106013922
- Cited by
- 384
- References
- 1
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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