Cited by 365Psychopathy, Forensic Psychiatry, Sexual OffendingNeural and Behavioral Psychology StudiesChild and Adolescent Psychosocial and Emotional Development

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Abnormal Ventromedial Prefrontal Cortex Function in Children With Psychopathic Traits During Reversal Learning

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Finger, Elizabeth C., Marsh, Abigail A., Mitchell, Derek G., Reid, Marguerite E., Sims, Courtney, Budhani, Salima, Kosson, David S., Chen, Gang, Towbin, Kenneth E., Leibenluft, Ellen, Pine, Daniel S., Blair, James R.·2008·Archives of General Psychiatry

DOI 10.1001/archpsyc.65.5.586PMC PMC3104600

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Abstract

CONTEXT: Children and adults with psychopathic traits and conduct or oppositional defiant disorder demonstrate poor decision making and are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated. Furthermore, despite high comorbidity of psychopathic traits and attention-deficit/hyperactivity disorder, to our knowledge, no research has attempted to distinguish neural correlates of childhood psychopathic traits and attention-deficit/hyperactivity disorder. OBJECTIVE: To determine the neural regions that underlie the reversal learning impairments in children with psychopathic traits plus conduct or oppositional defiant disorder. DESIGN: Case-control study. SETTING: Government clinical research institute. PARTICIPANTS: Forty-two adolescents aged 10 to 17 years: 14 with psychopathic traits and oppositional defiant disorder or conduct disorder, 14 with attention-deficit/hyperactivity disorder only, and 14 healthy controls. MAIN OUTCOME MEASURE: Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging during a probabilistic reversal task. RESULTS: Children with psychopathic traits showed abnormal responses within the ventromedial prefrontal cortex (Brodmann area 10) during punished reversal errors compared with children with attention-deficit/hyperactivity disorder and healthy children (P < .05 corrected for multiple comparisons). CONCLUSIONS: To our knowledge, this study provides the first evidence of abnormal ventromedial prefrontal cortex responsiveness in children with psychopathic traits and demonstrates this dysfunction was not attributable to comorbid attention-deficit/hyperactivity disorder. These findings suggest that reversal learning impairments in patients with developmental psychopathic traits relate to abnormal processing of reinforcement information.

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Authors: Finger, E. C., Marsh, A. A., Mitchell, D. G., Reid, M. E., Sims, C., Budhani, S., Kosson, D. S., Chen, G., Towbin, K. E., Leibenluft, E., Pine, D. S., & Blair, J. R.
Affiliations: National Institutes of Health (US)
Western University (CA)
ORCID: Finger, Elizabeth C.
Marsh, Abigail A.
Mitchell, Derek G.
Kosson, David S.
Chen, Gang
Towbin, Kenneth E.
Leibenluft, Ellen
Pine, Daniel S.
Blair, James R.
Venue: Archives of General Psychiatry
Publisher: American Medical Association (AMA)
Published: 2008-05-01
Volume: 65
Issue: 5
Pages: 586
ISSN: 0003-990X (ISSN-L)
DOI: 10.1001/archpsyc.65.5.586
PMC: PMC3104600
OpenAlex: W2172003132
Cited by: 365
References: 83
Citations by year: 2026: 3 · 2025: 2 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 12 · 2020: 54 · 2019: 16 · 2018: 13 · 2017: 24 · 2016: 26 · 2015: 28 · 2014: 25 · 2013: 38 · 2012: 30
FWCI: 23.74
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Archives of General Psychiatry (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
PhilPapers (PhilPapers Foundation) (submittedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH057714, ZIAMH002860)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: psychopathic traits, ventromedial prefrontal cortex, reversal learning, conduct disorder, oppositional defiant disorder, attention deficit hyperactivity disorder, adolescents, decision-making, neural correlates
MeSH terms: Adolescent, Antisocial Personality Disorder, Attention Deficit Disorder with Hyperactivity, Female, Humans, Male, Reversal Learning, Severity of Illness Index, Ventromedial Hypothalamic Nucleus, Prefrontal Cortex, Diagnostic and Statistical Manual of Mental Disorders

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Abnormal Ventromedial Prefrontal Cortex Function in Children With Psychopathic Traits During Reversal Learning

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