Conduct disorder and callous-unemotional traits in youth

Blair, R. James R.; Leibenluft, Ellen; Pine, Daniel S.

doi:10.1056/nejmra1315612

Cited by 371Psychopathy, Forensic Psychiatry, Sexual OffendingChild and Adolescent Psychosocial and Emotional DevelopmentPersonality Disorders and Psychopathology

Conduct disorder and callous-unemotional traits in youth

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Blair, R. James R., Leibenluft, Ellen, Pine, Daniel S.·2014·New England Journal of Medicine

DOI 10.1056/nejmra1315612PMC PMC6312699

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Abstract

Children with repetitive rule-breaking, aggression, and disregard for others are at increased risk for substance abuse, educational disruption, and criminal behavior. Progress is being made toward understanding the clinical and neurocognitive features of callous youth.

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Emotional instability disorders are characterized by emotional hyper-responsiveness in amygdala and insula, regions involved in shaping emotional responses and experience.
“These “emotional instability disorders” are characterized by emotional hyper-responsiveness in amygdala and insula, regions involved in shaping emotional responses and experience (Blair, 2010; Rubia, 2011; Blair et al., 2014; Glenn and Raine, 2014; Krause-Utz et al., 2014).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Blair et al., 2014
The “Heightened Threat Sensitivity” section (page not supplied) reports elevated amygdala responses to threat in youth with conduct problems without callous–unemotional traits. It does not establish hyper-responsiveness in the insula or characterize emotional instability disorders generally this way; it also describes reduced amygdala responses in youth with callous–unemotional traits. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Structurally, the gray matter volumes of amygdala and insula are often reduced in emotional instability disorders.
“Structurally, the gray matter volumes of amygdala and insula are often reduced in such disorders (Blair, 2010; Rubia, 2011; Blair et al., 2014; Glenn and Raine, 2014; Krause-Utz et al., 2014).”
From Top-Down Dysregulation—From ADHD to Emotional Instability (2016) · cites this paper as Blair et al., 2014
The References section (page unavailable) cites a study associating lower amygdala volume in men with childhood aggression, psychopathic traits, and future violence. That lends limited support to the amygdala-volume portion, but the paper does not report reduced insula volume or establish that both volumes are often reduced across emotional-instability disorders. Its Neurocognitive Dysfunctions sections discuss amygdala responses and function rather than structural volume. (LLM, conf=0.70)
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Behavioral Interventions for Anger, Irritability, and Aggression in Children and Adolescents
Sukhodolsky, D. G., Smith, S. D., McCauley, S. A., Ibrahim, K., & Piasecka, J. B. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0120 · Cited by 256 · see citing works
Top-Down Dysregulation—From ADHD to Emotional Instability
Petrovic, P., & Castellanos, F. X. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00070 · Cited by 179 · see citing works
“…these disorders also include sub-populations with callousunemotional traits that are associated with decreased behavioral and neural responding to emotional stimuli, potentially confounding the contribution from emotional instability traits (Blair, 2010, 2013; Rubia, 2011; Blair et al., 2014).”
BackgroundInfluential
Meta-Analysis of fMRI Studies of Disruptive Behavior Disorders
Alegria, A. A., Radua, J., & Rubia, K. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15081089 · Cited by 174 · see citing works
Heritable and Nonheritable Pathways to Early Callous-Unemotional Behaviors
Hyde, L. W., Waller, R. E., Trentacosta, C. J., Shaw, D. S., Neiderhiser, J. M., Ganiban, J. M., Reiss, D., & Leve, L. D. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15111381 · Cited by 158 · see citing works
Neuro-cognitive system dysfunction and symptom sets: A review of fMRI studies in youth with conduct problems
Blair, J., Veroude, K., & Buitelaar, J. K. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.022 · Cited by 140 · see citing works
Towards understanding atypical social affiliation in psychopathy
Viding, E. M., & McCrory, E. J. P. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30049-5 · Cited by 141 · see citing works
The Sensitivity to Threat and Affiliative Reward (STAR) model and the development of callous-unemotional traits
Waller, R. E., & Wagner, N. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.005 · Cited by 138 · see citing works
The neuroscience of empathy
Marsh, A. A. (2018) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.12.016 · Cited by 122 · see citing works
Tics and Tourette Syndrome
Singer, H. S. (2019) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000752 · Cited by 122 · see citing works
Conduct Disorders and Empathy Development
Frick, P. J., & Kemp, E. C. (2020) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-105809 · Cited by 114 · see citing works
Understanding the development of psychopathy: progress and challenges
Viding, E. M., & McCrory, E. J. P. (2017) · Psychological Medicine · doi:10.1017/s0033291717002847 · Cited by 109 · see citing works
White-matter tract abnormalities and antisocial behavior: A systematic review of diffusion tensor imaging studies across development
Waller, R. E., Dotterer, H. L., Murray, L., Maxwell, A. M., & Hyde, L. W. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.014 · Cited by 107 · see citing works
Assessing Callous-Unemotional Traits Using the Total Score from the Inventory of Callous-Unemotional Traits: A Meta-Analysis
Ray, J. V., & Frick, P. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2018.1504297 · Cited by 89 · see citing works
Maternal substance use during pregnancy and offspring conduct problems: A meta-analysis
Ruisch, I. H., Dietrich, A., Glennon, J. C., Buitelaar, J. K., & Hoekstra, P. J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.014 · Cited by 90 · see citing works
Neural Correlates of the Propensity for Retaliatory Behavior in Youths With Disruptive Behavior Disorders
White, S. F., VanTieghem, M., Brislin, S. J., Sypher, I., Sinclair, S., Pine, D. S., Hwang, S., & Blair, J. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020250 · Cited by 84 · see citing works
Self-citation
Proactive and Reactive Aggression Subgroups in Typically Developing Children: The Role of Executive Functioning, Psychophysiology, and Psychopathy
Thomson, N. D., & Centifanti, L. C. M. (2017) · Child Psychiatry and Human Development · doi:10.1007/s10578-017-0741-0 · Cited by 78 · see citing works
Dual neurocircuitry dysfunctions in disruptive behavior disorders: emotional responding and response inhibition
Hwang, S., Nolan, Z. T., White, S. F., Williams, W. C., Sinclair, S., & Blair, J. (2016) · Psychological Medicine · doi:10.1017/s0033291716000118 · Cited by 81 · see citing works
Genetic influences on conduct disorder
Salvatore, J. E., & Dick, D. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.034 · Cited by 76 · see citing works
Are impairments in emotion recognition a core feature of callous–unemotional traits? Testing the primary versus secondary variants model in children
Dadds, M. R., Kimonis, E. R., Schollar‐Root, O., Moul, C., & Hawes, D. J. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000475 · Cited by 76 · see citing works
Structural and Functional Alterations in Right Dorsomedial Prefrontal and Left Insular Cortex Co-Localize in Adolescents with Aggressive Behaviour: An ALE Meta-Analysis
Raschle, N., Menks, W., Fehlbaum, L., Tshomba, E., & Stadler, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136553 · Cited by 73 · see citing works
Neurofunctional abnormalities in antisocial spectrum: A meta-analysis of fMRI studies on Five distinct neurocognitive research domains
Dugre, J. R., Raduà, J., Carignan-Allard, M., Dumais, A., Rubia, K., & Potvin, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.013 · Cited by 71 · see citing works
Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder
Holz, N. E., Boecker-Schlier, R., Buchmann, A. F., Blomeyer, D., Jennen-Steinmetz, C., Baumeister, S., Plichta, M. M., Cattrell, A., Schumann, G., Esser, G., et al. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw120 · Cited by 70 · see citing works
New Clinically Relevant Findings about Violence by People with Schizophrenia
Hodgins, S., & Klein, S. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716648300 · Cited by 68 · see citing works
Distinct brain structure and behavior related to ADHD and conduct disorder traits
Bayard, F., Nymberg Thunell, C., Abé, C., Almeida, R., Banaschewski, T., Barker, G., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-018-0202-6 · Cited by 67 · see citing works
Longitudinal Links between Executive Function, Anger, and Aggression in Middle Childhood
Rohlf, H. L., Holl, A. K., Kirsch, F., Krahé, B., & Elsner, B. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00027 · Cited by 67 · see citing works
The long reach of early adversity: Parenting, stress, and neural pathways to antisocial behavior in adulthood
Gard, A. M., Waller, R., Shaw, D., Forbes, E. E., Hariri, A., & Hyde, L. (2017) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.06.005 · Cited by 70 · see citing works
Investigating Sex Differences in Emotion Recognition, Learning, and Regulation Among Youths With Conduct Disorder
Kohls, G., Baumann, S., Gundlach, M., Scharke, W., Bernhard, A., Martinelli, A., Ackermann, K., Kersten, L., Prätzlich, M., Oldenhof, H., et al. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.04.003 · Cited by 64 · see citing works
Characterising youth with callous–unemotional traits and concurrent anxiety: evidence for a high-risk clinical group
Cecil, C. A. M., McCrory, E. J. P., Barker, E. D., Guiney, J., & Viding, E. M. (2017) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-017-1086-8 · Cited by 61 · see citing works
Reward Processing in Children With Disruptive Behavior Disorders and Callous-Unemotional Traits in the ABCD Study
Hawes, S. W., Waller, R. E., Byrd, A. L., Bjork, J. M., Dick, A. S., Sutherland, M. T., Riedel, M. C., Tobia, M. J., Thomson, N. D., Laird, A. R., et al. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.19101092 · Cited by 60 · see citing works
Early warm‐rewarding parenting moderates the genetic contributions to callous–unemotional traits in childhood
Henry, J., Dionne, G., Viding, E. M., Vitaro, F., Brendgen, M. R., Tremblay, R. E., & Boivin, M. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12918 · Cited by 59 · see citing works
Dissecting the Role of Amygdala Reactivity in Antisocial Behavior in a Sample of Young, Low-Income, Urban Men
Hyde, L. W., Shaw, D. S., Murray, L., Gard, A. M., Hariri, A. R., & Forbes, E. E. (2015) · Clinical Psychological Science · doi:10.1177/2167702615614511 · Cited by 54 · see citing works
Can the fear recognition deficits associated with callous-unemotional traits be identified in early childhood?
White, S. F., Briggs‐Gowan, M. J., Voss, J. L., Petitclerc, A., McCarthy, K., Blair, J., & Wakschlag, L. S. (2016) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2016.1149154 · Cited by 56 · see citing works
Sex Differences in the Relationship Between Conduct Disorder and Cortical Structure in Adolescents
Smaragdi, A., Cornwell, H., Toschi, N., Riccelli, R., González-Madruga, K., Wells, A. E., Clanton, R. L., Baker, R., Rogers, J. C., Martin-Key, N. A., et al. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.05.015 · Cited by 53 · see citing works
Disrupted default mode network connectivity in male adolescents with conduct disorder
Zhou, J., Yao, N., Fairchild, G. F., Cao, X., Zhang, Y., Xiang, Y., Zhang, L., & Wang, X. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9465-6 · Cited by 52 · see citing works
Intranasal oxytocin administration promotes emotional contagion and reduces aggression in a mouse model of callousness
Zoratto, F., Sbriccoli, M., Martinelli, A., Glennon, J. C., Macrı̀, S., & Giovanni Laviola, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.010 · Cited by 51 · see citing works
Grey Matter Volumes in Children with Conduct Problems and Varying Levels of Callous-Unemotional Traits
Sebastian, C. L., Brito, S. A. D., McCrory, E. J. P., Hyde, Z. H., Lockwood, P. L., Cecil, C. A. M., & Viding, E. M. (2015) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-015-0073-0 · Cited by 53 · see citing works
Amygdala reactivity predicts adolescent antisocial behavior but not callous-unemotional traits
Dotterer, H. L., Hyde, L. W., Swartz, J. R., Hariri, A. R., & Williamson, D. E. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.02.008 · Cited by 53 · see citing works
Developing Cutoff Scores for the Inventory of Callous-Unemotional Traits (ICU) in Justice-Involved and Community Samples
Kemp, E. C., Frick, P. J., Matlasz, T. M., Clark, J. E., Robertson, E., Ray, J. V., Thornton, L. C., Myers, T. D. W., Steinberg, L. D., & Cauffman, E. E. (2021) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2021.1955371 · Cited by 50 · see citing works
Some critical considerations in applying the construct of psychopathy to research and classification of childhood disruptive behavior disorders
Frick, P. J. (2022) · Clinical Psychology Review · doi:10.1016/j.cpr.2022.102188 · Cited by 48 · see citing works
Pharmacotherapy of Aggression in Child and Adolescent Psychiatric Disorders
Gurnani, T., Ivanov, I., & Newcorn, J. H. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2015.0167 · Cited by 48 · see citing works
Low empathy-like behaviour in male mice associates with impaired sociability, emotional memory, physiological stress reactivity and variations in neurobiological regulations
Laviola, G., Zoratto, F., Ingiosi, D., Carito, V., Huzard, D., Fiore, M., & Macrı̀, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188907 · Cited by 47 · see citing works
Systematic review and meta-analysis of socio-cognitive and socio-affective processes association with adolescent substance use
Winters, D. E., Brandon-Friedman, R. A., Yepes, G. J. D. F., & Hinckley, J. D. (2020) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2020.108479 · Cited by 46 · see citing works
Posttraumatic Stress and Youth Violence Perpetration: a Population-Based Cross-Sectional Study
Aebi, M., Mohler-Kuo, M., Barra, S., Schnyder, U., Maier, T., & Landolt, M. A. (2017) · European Psychiatry · doi:10.1016/j.eurpsy.2016.08.007 · Cited by 45 · see citing works
Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim, K., Noble, S., He, G. S., Lacadie, C., Crowley, M. J., McCarthy, G., Scheinost, D., & Sukhodolsky, D. G. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01317-5 · Cited by 44 · see citing works
The pharmacological treatment of aggression in children and adolescents with conduct disorder. Do callous—unemotional traits modulate the efficacy of medication?
Balia, C., Carucci, S., Coghill, D., & Zuddas, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.024 · Cited by 44 · see citing works
Interaction between Prenatal Maternal Stress and Autonomic Arousal in Predicting Conduct Problems and Psychopathic Traits in Children
Gao, Y., Huang, Y., & Li, X. (2016) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-016-9556-8 · Cited by 41 · see citing works
Genetic and environmental influences on the developmental trajectory of callous‐unemotional traits from childhood to adolescence
Takahashi, Y., Pease, C., Pingault, J.-B., & Viding, E. (2020) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/jcpp.13259 · Cited by 34 · see citing works
Risky Sex, Drugs, Sensation Seeking, and Callous Unemotional Traits in Justice-Involved Male Adolescents
Thornton, L. C., Frick, P. J., Ray, J. V., Myers, T. D. W., Steinberg, L. D., & Cauffman, E. E. (2017) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2017.1399398 · Cited by 42 · see citing works
Multisystemic therapy versus management as usual in the treatment of adolescent antisocial behaviour (START): 5-year follow-up of a pragmatic, randomised, controlled, superiority trial
Fonagy, P., Butler, S., Cottrell, D. J., Scott, S., Pilling, S., Eisler, I., Fuggle, P., Kraam, A., Byford, S., Wason, J. M. S., et al. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30131-0 · Cited by 42 · see citing works
Facial emotion recognition in children with externalising behaviours: A systematic review
Cooper, S., Hobson, C. W., & van Goozen, S. H. M. (2020) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104520945390 · Cited by 45 · see citing works
Severe Mental Illness
Hodgins, S., & Klein, S. (2019) · Wiley eBooks · doi:10.1002/9781119139980.ch16 · Cited by 42 · see citing works
High-quality foster care mitigates callous-unemotional traits following early deprivation in boys: a Randomized Controlled Trial
Humphreys, K. L., McGoron, L., Sheridan, M. A., McLaughlin, K. A., Fox, N. A., Nelson, C. A., & Zeanah, C. H. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.09.010 · Cited by 41 · see citing works
“5,6 7-9 The challenges that CU traits and psychopathy pose for intervention 3 and the enormous societal costs associated with antisocial behavior make it imperative to develop strategies for preventing the onset of CU traits in those at increased risk.”
Background
Neural bases of frustration-aggression theory: A multi-domain meta-analysis of functional neuroimaging studies
Dugre, J. R., & Potvin, S. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.005 · Cited by 42 · see citing works
Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia
Oakley, Ç., Harris, S. T., Fahy, T. A., Murphy, D., & Picchioni, M. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.047 · Cited by 40 · see citing works
Do neurocognitive deficits in decision making differentiate conduct disorder subtypes?
Fanti, K. A., Kimonis, E. R., Hadjicharalambous, M., & Steinberg, L. D. (2016) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-016-0822-9 · Cited by 40 · see citing works
The link between callous-unemotional traits and neural mechanisms of reward processing: An fMRI study
Veroude, K., von Rhein, D. T., Chauvin, R. J., van Dongen, E. V., Mennes, M., Franke, B., Heslenfeld, D. J., Oosterlaan, J., Hartman, C. A., Hoekstra, P. J., et al. (2016) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2016.08.005 · Cited by 39 · see citing works
Effects of Behavioral Treatment Modified to Fit Children with Conduct Problems and Callous-Unemotional (CU) Traits
Waschbusch, D. A., Willoughby, M. T., Haas, S. M., Ridenour, T. A., Helseth, S. A., Crum, K. I., Altszuler, A. R., Ross, J. M., Coles, E. K., & Pelham, W. E. (2019) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2019.1614000 · Cited by 39 · see citing works
Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group.
Gao, Y.-D., Staginnus, M., Townend, S., Arango, C., Bajaj, S., Banaschewski, T., Barker, E., Benegal, V., Berluti, K., Bernhard, A., et al. (2024) · Lancet psychiatry · doi:10.1016/s2215-0366(24)00187-1 · Cited by 29 · see citing works
Self-citation
Specific cortical and subcortical alterations for reactive and proactive aggression in children and adolescents with disruptive behavior
Naaijen, J., Mulder, L. M., Ilbegi, S., de Bruijn, S., Deters, R. K., Dietrich, A., Hoekstra, P. J., Marsman, J.-B. C., Aggensteiner, P.-M., Holz, N. E., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102344 · Cited by 37 · see citing works
Facial reactions to violent and comedy films: Association with callous–unemotional traits and impulsive aggression
Fanti, K. A., Kyranides, M. N., & Panayiotou, G. (2015) · Cognition & Emotion · doi:10.1080/02699931.2015.1090958 · Cited by 36 · see citing works
Emotional processing deficits in Italian children with Disruptive Behavior Disorder: The role of callous unemotional traits
Billeci, L., Muratori, P., Calderoni, S., Chericoni, N., Levantini, V., Milone, A., Nocentini, A., Papini, M., Ruglioni, L., & Dadds, M. R. (2018) · Behaviour Research and Therapy · doi:10.1016/j.brat.2018.12.011 · Cited by 36 · see citing works
Disruptive Behavior Disorders: The Challenge of Delineating Mechanisms in the Face of Heterogeneity
Viding, E. M., & McCrory, E. J. P. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20070998 · Cited by 34 · see citing works
Startle modulation during violent films: Association with callous–unemotional traits and aggressive behavior
Fanti, K. A., Panayiotou, G., Kyranides, M. N., & Avraamides, M. N. (2015) · Motivation and Emotion · doi:10.1007/s11031-015-9517-7 · Cited by 34 · see citing works
Gene x environment interactions in conduct disorder: Implications for future treatments
Holz, N. E., Zohsel, K., Laucht, M., Banaschewski, T., Hohmann, S., & Brandeis, D. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.017 · Cited by 34 · see citing works
A Unique Path to Callous-Unemotional Traits for Children who are Temperamentally Fearless and Unconcerned about Transgressions: a Longitudinal Study of Typically Developing Children from age 2 to 12
Goffin, K. C., Boldt, L. J., Kim, S., & Kochanska, G. (2017) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-017-0317-2 · Cited by 34 · see citing works
Genetics of child aggression, a systematic review
Koyama, E., Kant, T., Takata, A., Kennedy, J. L., & Zai, C. C. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02870-7 · Cited by 33 · see citing works
Atypical Dorsolateral Prefrontal Activity in Female Adolescents With Conduct Disorder During Effortful Emotion Regulation
Raschle, N. M., Fehlbaum, L. V., Menks, W. M., Martinelli, A., Prätzlich, M., Bernhard, A., Ackermann, K., Freitag, C. M., Brito, S. A. D., Fairchild, G. F., et al. (2019) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2019.05.003 · Cited by 32 · see citing works
Neuropsychological Subgroups of Emotion Processing in Youths With Conduct Disorder
Kohls, G., Fairchild, G. F., Bernhard, A., Martinelli, A., Smaragdi, A., González-Madruga, K., Wells, A. E., Rogers, J. C., Pauli, R., Oldenhof, H., et al. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.585052 · Cited by 32 · see citing works
Behavioral and Emotional Disorders in Children and Their Anesthetic Implications
Reddy, S. K., & Deutsch, N. (2020) · Children · doi:10.3390/children7120253 · Cited by 31 · see citing works
Future directions for cognitive neuroscience in psychiatry: recommendations for biomarker design based on recent test re-test reliability work
Blair, J., Mathur, A., Haines, N., & Bajaj, S. (2022) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2022.101102 · Cited by 31 · see citing works
The Nature and Nurture of Callous-Unemotional Traits
Hyde, L. W., & Dotterer, H. L. (2022) · Current Directions in Psychological Science · doi:10.1177/09637214221121302 · Cited by 31 · see citing works
Antisocial pathways associated with substance use disorders: characterizing etiological underpinnings and implications for treatment
Brennan, G. M., Hyde, L. W., & Baskin-sommers, A. R. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.11.014 · Cited by 31 · see citing works
The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces
Aggensteiner, P.-M., Holz, N. E., Böttinger, B., Baumeister, S., Hohmann, S., Werhahn, J. E., Naaijen, J., Ilbegi, S., Glennon, J. C., Hoekstra, P. J., et al. (2020) · Psychological Medicine · doi:10.1017/s0033291720002111 · Cited by 30 · see citing works
Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior
Ibrahim, K., Kalvin, C. B., Li, F., He, G. S., Pelphrey, K. A., McCarthy, G., & Sukhodolsky, D. G. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100884 · Cited by 30 · see citing works
Amygdala activity to angry and fearful faces relates to bullying and victimization in adolescents
Swartz, J. R., Carranza, A. F., & Knodt, A. R. (2019) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsz084 · Cited by 29 · see citing works
Emotion processing in youths with conduct problems: an fMRI meta-analysis
Berluti, K., Ploe, M. L., & Marsh, A. A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02363-z · Cited by 29 · see citing works
Does Affective Theory of Mind Contribute to Proactive Aggression in Boys with Conduct Problems and Psychopathic Tendencies?
Gillespie, S. M., Kongerslev, M., Sharp, C., Bo, S., & Abu-Akel, A. M. (2018) · Child Psychiatry & Human Development · doi:10.1007/s10578-018-0806-8 · Cited by 29 · see citing works
Risk of Suicide Attempt among Adolescents with Conduct Disorder: A Longitudinal Follow-up Study
Wei, H.-T., Lan, W.-H., Hsu, J.-W., Bai, Y., Huang, K., Su, T., Li, C., Lin, W.-C., Chen, T., & Chen, M. (2016) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2016.06.057 · Cited by 28 · see citing works
The structural brain correlates of callous-unemotional traits in incarcerated male adolescents
Caldwell, B. M., Anderson, N. E., Harenski, K. A., Sitney, M. H., Caldwell, M. F., Rybroek, G. J. V., & Kiehl, K. A. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101703 · Cited by 29 · see citing works
Callous-unemotional traits and fearlessness: A cardiovascular psychophysiological perspective in two adolescent samples using virtual reality
Thomson, N. D., Gillespie, S. M., & Centifanti, L. C. M. (2019) · Development and Psychopathology · doi:10.1017/s0954579419001196 · Cited by 27 · see citing works
Dysfunction in differential reward-punishment responsiveness in conduct disorder relates to severity of callous-unemotional traits but not irritability
Zhang, R., Aloi, J. M., Bajaj, S., Bashford‐Largo, J., Lukoff, J., Schwartz, A., Elowsky, J., Dobbertin, M. D., Blair, K. S., & Blair, J. (2021) · Psychological Medicine · doi:10.1017/s0033291721003500 · Cited by 29 · see citing works
An ‘embedded brain’ approach to understanding antisocial behaviour
Viding, E. M., McCrory, E. J. P., Baskin-sommers, A. R., Brito, S. A. D., & Frick, P. J. (2023) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2023.08.013 · Cited by 28 · see citing works
An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits
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Authors: Blair, R. J. R., Leibenluft, E., & Pine, D. S.
Affiliations: National Institutes of Health (US)
ORCID: Leibenluft, Ellen
Pine, Daniel S.
Venue: New England Journal of Medicine
Publisher: Massachusetts Medical Society
Published: 2014-12-04
Volume: 371
Issue: 23
Pages: 2207-2216
ISSN: 0028-4793 (ISSN-L)
1533-4406
DOI: 10.1056/nejmra1315612
PMC: PMC6312699
OpenAlex: W2041104702
Cited by: 371
References: 75
Citations by year: 2026: 11 · 2025: 27 · 2024: 27 · 2023: 30 · 2022: 43 · 2021: 34 · 2020: 50 · 2019: 33 · 2018: 28 · 2017: 35 · 2016: 35 · 2015: 17
FWCI: 4.38
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: New England Journal of Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (Z99 MH999999)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: conduct disorder, callous-unemotional traits, youth, aggression, rule violations, substance abuse risk, criminal behavior, educational disruption, clinical features
MeSH terms: Adolescent, Amygdala, Antisocial Personality Disorder, Child, Child Behavior Disorders, Cognition Disorders, Decision Making, Empathy, Humans, Magnetic Resonance Imaging, Psychotherapy, Social Environment, Conduct Disorder

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