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Cited by 541

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Disulfiram treatment of alcoholism. A Veterans Administration cooperative study

Richard K. Fuller·1986·JAMA
DOI 10.1001/jama.256.11.1449
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Abstract

We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250 mg of disulfiram (202 men); 1 mg of disulfiram (204 men), a control for the threat of the disulfiram-ethanol reaction; or no disulfiram (199 men), a control for the counseling that all received. Bimonthly treatment assessments were done for one year. Relative/ friend interviews and blood and urine ethanol analyses were used to corroborate patients' reports. There were no significant differences among the groups in total abstinence, time to first drink, employment, or social stability. Among the patients who drank and had a complete set of assessment interviews, those in the 250-mg disulfiram group reported significantly fewer drinking days (49.0 ±8.4) than those in the 1-mg (75.4±11.9) or the no-disulfiram (86.5 ± 13.6) groups. There was a significant relationship between adherence to drug regimen and complete abstinence in all groups. We conclude that disulfiram may help reduce drinking frequency after relapse, but does not enhance counseling in aiding alcoholic patients to sustain continuous abstinence or delay the resumption of drinking. (JAMA1986;256:1449-1455)

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Metadata

Authors
Fuller, R. K.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
1986-09-19
Volume
256
Issue
11
Pages
1449
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.256.11.1449
OpenAlex
W4236852867
Cited by
541
References
0
FWCI
11.21
Type
journal article
Language
en
Open access
closed

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