Plasma Natriuretic Peptides for Community Screening for Left Ventricular Hypertrophy and Systolic Dysfunction: The Framingham Heart Study
Abstract
CONTEXT: Several reports have suggested the usefulness of plasma brain natriuretic peptide (BNP) as a screening test for left ventricular hypertrophy (LVH) and systolic dysfunction (LVSD). Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women. OBJECTIVES: To examine the usefulness of natriuretic peptides for screening for elevated LV mass and LVSD in the community. DESIGN, SETTING, AND PARTICIPANTS: Community-based prospective cohort study of 3177 participants (1707 women) from the Framingham Study who attended a routine examination in 1995-1998. MAIN OUTCOME MEASURES: Receiver operating characteristic (ROC) curves, test sensitivity, specificity, positive and negative predictive values, and likelihood ratios for identifying elevated LV mass (sex-specific 90th percentile or higher of LV mass/[height](2)), LVSD (ejection fraction < or = 50% and/or fractional shortening <29%), and moderate to severe LVSD (ejection fraction < or = 40% and/or fractional shortening <22%) at different discrimination limits of plasma BNP and N-terminal proatrial natriuretic peptide (NT-ANP), with echocardiography as the criterion standard. RESULTS: The areas under the ROC curves for elevated LV mass or LVSD were at or below 0.75 for both peptides, were higher for men compared with women, and were similar for BNP and NT-ANP. The diagnostic performance of natriuretic peptides for LVSD improved in women but not…
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LVSD is frequently diagnosed only after patients develop symptomatic disease due to the lack of effective screening strategies.
“but LVSD is frequently diagnosed only after patients develop symptomatic disease due to the lack of effective screening strategies5–7.”
From Detection of left ventricular systolic dysfunction from single-lead electrocardiography adapted for portable and wearable devices (2023) · cites this paper as [6]
Cites
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305 · see citing works
The meaning and use of the area under a receiver operating characteristic (ROC) curve.
Hanley, J. A., & McNeil, B. J. (1982) · Radiology · doi:10.1148/radiology.143.1.7063747 · Cited by 21,856 · see citing works
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430 · see citing works
Hanley, J. A., & McNeil, B. J. (1983) · Radiology · doi:10.1148/radiology.148.3.6878708 · Cited by 7,016 · see citing works
(1997) · Archives of Internal Medicine · doi:10.1001/archinte.157.21.2413 · Cited by 6,345 · see citing works
Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911 · see citing works
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699 · see citing works
Self-citation(1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271003 · Cited by 3,725 · see citing works
Users' Guides to the Medical Literature
Jaeschke, R. (1994) · JAMA · doi:10.1001/jama.1994.03510330081039 · Cited by 2,220 · see citing works
AN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
Kannel, W. B., Feinleib, M., McNAMARA, P. M., Garrison, R. J., & Castelli, W. P. (1979) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112813 · Cited by 1,635 · see citing works
Biochemical detection of left-ventricular systolic dysfunction
McDonagh, T., Robb, S., Murdoch, D. R., Morton, J. J., Ford, I., Morrison, C., Tunstall‐Pedoe, H., McMurray, J. J. V., & Dargie, H. (1998) · The Lancet · doi:10.1016/s0140-6736(97)03034-1 · Cited by 958 · see citing works
Cowie, M., Struthers, A. D., Wood, D. A., Coats, A. J. S., Thompson, S. G., Poole-Wilson, P. A., & Sutton, G. C. (1997) · The Lancet · doi:10.1016/s0140-6736(97)06031-5 · Cited by 869 · see citing works
Omland, T., Aakvaag, A., Bonarjee, V., Caidahl, K., Lie, R. T., Nilsen, D. W. T., Sundsfjord, J., & Dickstein, K. (1996) · Circulation · doi:10.1161/01.cir.93.11.1963 · Cited by 698 · see citing works
Meta-analysis of Pap Test Accuracy
Fahey, M. T., Irwig, L., & Macaskill, P. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117485 · Cited by 690 · see citing works
Symptomatic and asymptomatic left-ventricular systolic dysfunction in an urban population
McDonagh, T. A., Morrison, C., Lawrence, A., Ford, I., Tunstall-Pedoe, H., McMurray, J. J. V., & Dargie, H. J. (1997) · The Lancet · doi:10.1016/s0140-6736(97)03033-x · Cited by 631 · see citing works
Yamamoto, K., Burnett, J. C. J., Jougasaki, M., Nishimura, R. A., Bailey, K. R., Saito, Y., Nakao, K., & Redfield, M. M. (1996) · Hypertension · doi:10.1161/01.hyp.28.6.988 · Cited by 518 · see citing works
Impact of age and sex on plasma natriuretic peptide levels in healthy adults
Wang, T. J., Larson, M. G., Levy, D. A., Leip, E. P., Benjamin, E. J., Wilson, P. W. F., Sutherland, P. A., Omland, T., & Vasan, R. S. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02464-5 · Cited by 471 · see citing works
Self-citationMaisel, A. S., Koon, J., Krishnaswamy, P., Kazenegra, R., Clopton, P., Gardetto, N. J., Morrisey, R., Garcia, A., Chiu, A., & DeMaria, A. N. (2001) · American Heart Journal · doi:10.1067/mhj.2001.113215 · Cited by 375 · see citing works
Fouad, F. M., Słomiński, J. M., & Tarazi, R. C. (1984) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(84)80289-2 · Cited by 357 · see citing works
When can a risk factor be used as a worthwhile screening test?
Wald, N., Hackshaw, A., & Frost, C. D. (1999) · BMJ · doi:10.1136/bmj.319.7224.1562 · Cited by 342 · see citing works
Lerman, A., Gibbons, R. J., Rodeheffer, R. J., Bailey, K. R., McKinley, L. J., Heublein, D. M., & Burnett, J. C. J. (1993) · The Lancet · doi:10.1016/0140-6736(93)93125-k · Cited by 312 · see citing works
Asada, J., & 渡邊, 潤. (2003) · Medical Entomology and Zoology · Cited by 251 · see citing works
Echocardiographic assessment of left ventricular hypertrophy
Reichek, N. (1982) · European Heart Journal · doi:10.1093/eurheartj/3.suppl_a.49 · Cited by 233 · see citing works
Davidson, N. C., Naas, A. A., Hanson, J., Kennedy, N. S. J., Coutie, W. J., & Struthers, A. D. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89176-x · Cited by 183 · see citing works
Luchner, A., Burnett, J. C. J., Jougasaki, M., Hense, H. W., Heid, I. M., Muders, F., Riegger, G. N. A. J., & Schunkert, H. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018080-00018 · Cited by 177 · see citing works
Percentage of Shortening of the Echocardiographic Left Ventricular Dimension
Quiñones, M. A., Pickering, E., & Alexander, J. K. (1978) · CHEST Journal · doi:10.1378/chest.74.1.59 · Cited by 152 · see citing works
Should we screen for asymptomatic left ventricular dysfunction to prevent heart failure?
McMurray, J. J. V., McDonagh, T., Davie, A. P., Cleland, J. G. F., Francis, C. M., & Morrison, C. E. (1998) · European Heart Journal · doi:10.1093/eurheartj/19.6.842 · Cited by 151 · see citing works
Ruling Out or Ruling In Disease with the Most sensitiue or Specific Diagnostic Test
Boyko, E. J. (1994) · Medical Decision Making · doi:10.1177/0272989x9401400210 · Cited by 124 · see citing works
Luchner, A. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(01)00510-7 · Cited by 116 · see citing works
Clinical criteria and biochemical markers for the detection of systolic dysfunction
Yamamoto, K., Burnett, J. C. J., Bermudez, E. A., Jougasaki, M., Bailey, K. R., & Redfield, M. M. (2000) · Journal of Cardiac Failure · doi:10.1054/jcaf.2000.9676 · Cited by 116 · see citing works
Enhancing and Evaluating Diagnostic Accuracy
Swets, J. A., Getty, D. J., Pickett, R. M., D’Orsi, C. J., Seltzer, S. E., & McNeil, B. J. (1991) · Medical Decision Making · doi:10.1177/0272989x9101100102 · Cited by 116 · see citing works
Smith, H. E. (2000) · BMJ · doi:10.1136/bmj.320.7239.906 · Cited by 98 · see citing works
McClure, S. J., Caruana, L., Davie, A. P., GOLDTHORP, S. L., & McMurray, J. J. V. (1998) · BMJ · doi:10.1136/bmj.317.7157.516 · Cited by 86 · see citing works
Predictive properties of serum prostate-specific antigen testing in a community setting.
Jacobsen, S. J., Bergstralh, E. J., Guess, H. A., Katusic, S. K., Klee, G. G., Oesterling, J. E., & Lieber, M. M. (1996) · PubMed · doi:10.1001/archinte.157.15.1765b · Cited by 66 · see citing works
Cupples, L. A. (1987) · Medical Entomology and Zoology · Cited by 64 · see citing works
Limited Echocardiography for Hypertensive Left Ventricular Hypertrophy
Sheps, S. G., & Frohlich, E. D. (1997) · Hypertension · doi:10.1161/01.hyp.29.2.560 · Cited by 51 · see citing works
Schirmer, H. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1396 · Cited by 43 · see citing works
Simplified Echocardiography in the Diagnosis of Heart Failure
Willenheimer, R. B., Israelsson, B. A., Cline, C. M. J., & Erhardt, L. (1997) · Scandinavian Cardiovascular Journal · doi:10.3109/14017439709058063 · Cited by 38 · see citing works
Remaley, A. T., Sampson, M. L., DeLeo, J. M., Remaley, N. A., Farsi, B. D., & ZWEIG, M. H. (1999) · Clinical Chemistry · doi:10.1093/clinchem/45.7.934 · Cited by 30 · see citing works
Suzuki, T., Yamaoki, K., NAKAJIMA, O., Yamazaki, T., Yamada, Y., Akioka, H., Yazaki, Y., & Nagai, R. (2000) · Japanese Heart Journal · doi:10.1536/jhj.41.205 · Cited by 25 · see citing works
Harrell, F., Jr. (1996) · doi:10.1002/(sici)1097-0258(19960229)15:4
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2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536 · see citing works
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult
Hunt, S. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.022 · Cited by 4,127 · see citing works
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.192065 · Cited by 3,712 · see citing works
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8807 · Cited by 3,304 · see citing works
Burden of Systolic and Diastolic Ventricular Dysfunction in the Community
Redfield, M. M., Jacobsen, S. J., Burnett, J. C. J., Mahoney, D. W., Bailey, K. R., & Rodeheffer, R. J. (2003) · JAMA · doi:10.1001/jama.289.2.194 · Cited by 2,989 · see citing works
WRITING COMMITTEE MEMBERS, Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M., Konstam, M. A., Mancini, D. M., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167586 · Cited by 2,251 · see citing works
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M. L., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T. B., Januzzi, J. L., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31829e8776 · Cited by 2,129 · see citing works
Plasma Natriuretic Peptide Levels and the Risk of Cardiovascular Events and Death
Wang, T. J., Larson, M. G., Levy, D. A., Benjamin, E. J., Leip, E. P., Omland, T., Wolf, P. A., & Vasan, R. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031994 · Cited by 1,527 · see citing works
Self-citationHunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.11.013 · Cited by 1,367 · see citing works
B-type natriuretic peptide in cardiovascular disease
de Lemos, J. A., McGuire, D. K., & Drazner, M. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13976-1 · Cited by 1,068 · see citing works
Artificial intelligence-enhanced electrocardiography in cardiovascular disease management
Siontis, K. C., Noseworthy, P. A., Attia, Z. I., & Friedman, P. A. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00503-2 · Cited by 914 · see citing works
State of the art: using natriuretic peptide levels in clinical practice
Maisel, A., Mueller, C., Adams, K., Anker, S. D., Aspromonte, N., Cleland, J. G. F., Cohen-Solal, A., Dahlstrom, U., DeMaria, A., Di Somma, S., et al. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.07.014 · Cited by 839 · see citing works
Mueller, C. E., McDonald, K., de Boer, R. A., Maisel, A. S., Cleland, J. G. F., Kozhuharov, N., Coats, A. J. S., Metra, M., Mebazaa, A., Ruschitzka, F. T., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1494 · Cited by 816 · see citing works
Galectin-3, a Marker of Cardiac Fibrosis, Predicts Incident Heart Failure in the Community
Ho, J. E., Liu, C., Lyass, A., Courchesne, P. L., Pencina, M. J., Vasan, R. S., Larson, M. G., & Levy, D. A. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.053 · Cited by 590 · see citing works
Self-citationArmenian, S. H., Hudson, M. M., Mulder, R. L., Chen, M. H., Constine, L. S., Dwyer, M., Nathan, P. C., Tissing, W. J. E., Shankar, S., Sieswerda, E., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(14)70409-7 · Cited by 570 · see citing works
Mant, J., Doust, J., Roalfe, A., Barton, P., Cowie, M., Glasziou, P., Mant, D., McManus, R., Holder, R., Deeks, J., et al. (2009) · Health Technology Assessment · doi:10.3310/hta13320 · Cited by 498 · see citing works
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2005) · Circulation · doi:10.1161/circulationaha.105.167587 · Cited by 461 · see citing works
Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis
Charpentier, J., Luyt, C. E., Fulla, Y., Vinsonneau, C., Cariou, A., Grabar, S., Dhainaut, J.-F., Mira, J. P., & Chiche, J. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000114827.93410.d8 · Cited by 429 · see citing works
Silver, M. A., Maisel, A. S., Yancy, C. W., McCullough, P. A., Burnett, J. C. J., Francis, G. S., Mehra, M. R., Peacock, W. F., Fonarow, G. C., Gibler, W. B., et al. (2004) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2004.03271.x · Cited by 358 · see citing works
Clerico, A., & Emdin, M. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.024760 · Cited by 332 · see citing works
A Systematic Review of the Diagnostic Accuracy of Natriuretic Peptides for Heart Failure
Doust, J. A., Glasziou, P., Pietrzak, E. R., & Dobson, A. J. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.18.1978 · Cited by 323 · see citing works
Lam, C. S. P., Lyass, A., Kraigher‐Krainer, E., Massaro, J. M., Lee, D. S., Ho, J. E., Levy, D. A., Redfield, M. M., Pieske, B. M., Benjamin, E. J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.979203 · Cited by 315 · see citing works
Self-citationTang, W. H. W., Francis, G. S., Morrow, D. A., Newby, L. K., Cannon, C. P., Jesse, R. L., Storrow, A. B., Christenson, R. H., Christenson, R. H., Apple, F. S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.185267 · Cited by 311 · see citing works
Hunt, S. A., Abraham, W. T., Chin, M. H., Feldman, A. M., Francis, G. S., Ganiats, T. G., Jessup, M. L., Konstam, M. A., MANCINI, D. M., Michl, K., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.08.023 · Cited by 308 · see citing works
70-year legacy of the Framingham Heart Study
Andersson, C., Johnson, A. D., Benjamin, E. J., Levy, D., & Vasan, R. S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0202-5 · Cited by 305 · see citing works
Self-citation2013 ACCF/AHA Guideline for the Management of Heart Failure: Executive Summary
Yancy, C. W., Jessup, M. L., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T. B., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.020 · Cited by 290 · see citing works
Normal values of B type natriuretic peptide in infants, children, and adolescents
Koch, A., & Singer, H. (2003) · Heart · doi:10.1136/heart.89.8.875 · Cited by 273 · see citing works
Plasma Brain Natriuretic Peptide to Detect Preclinical Ventricular Systolic or Diastolic Dysfunction
Redfield, M. M., Rodeheffer, R. J., Jacobsen, S. J., Mahoney, D. W., Bailey, K. R., & Burnett, J. C. J. (2004) · Circulation · doi:10.1161/01.cir.0000130845.38133.8f · Cited by 260 · see citing works
Clerico, A., Recchia, F. A., Passino, C., & Emdin, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00684.2005 · Cited by 257 · see citing works
Cardiac Hormones as Diagnostic Tools in Heart Failure
Ruskoaho, H. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0006 · Cited by 251 · see citing works
Rutten, F. H., Moons, K. G. M., Cramer, M. J., Grobbee, D. E., Zuithoff, N. P. A., Lammers, A.-W. J., & Hoes, A. W. (2005) · BMJ · doi:10.1136/bmj.38664.661181.55 · Cited by 238 · see citing works
The Epidemiology of Asymptomatic Left Ventricular Systolic Dysfunction: Implications for Screening
Wang, T. J., Levy, D., Benjamin, E. J., & Vasan, R. S. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-11-200306030-00012 · Cited by 229 · see citing works
Self-citationB-Type Natriuretic Peptide and Ischemia in Patients With Stable Coronary Disease
Bibbins-Domingo, K. B., Ansari, M. N., Schiller, N. B., Massie, B. M., & Whooley, M. A. (2003) · Circulation · doi:10.1161/01.cir.0000103681.04726.9c · Cited by 226 · see citing works
Genetic Variants Associated With Cardiac Structure and Function
Vasan, R. S., Glazer, N. L., Felix, J. F., Lieb, W., Wild, P. S., Felix, S. B., Watzinger, N., Larson, M. G., Smith, N. L., Dehghan, A., et al. (2009) · JAMA · doi:10.1001/jama.2009.978-a · Cited by 222 · see citing works
Self-citationRisk Factors for Heart Failure
Lawson, C. A., Zaccardi, F., Squire, I. B., Okhai, H., Davies, M. J., Huang, W., Mamas, M. A., Lam, C. S. P., Khunti, K., & Kadam, U. T. (2020) · Circulation Heart Failure · doi:10.1161/circheartfailure.119.006472 · Cited by 205 · see citing works
Current biochemistry, molecular biology, and clinical relevance of natriuretic peptides
Nishikimi, T., Kuwahara, K., & Nakao, K. (2011) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.01.002 · Cited by 199 · see citing works
Synthesis, secretion, function, metabolism and application of natriuretic peptides in heart failure
Fu, S., Ping, P., Wang, F., & Luo, L. (2018) · Journal of Biological Engineering · doi:10.1186/s13036-017-0093-0 · Cited by 199 · see citing works
10-Year Risk Equations for Incident Heart Failure in the General Population
Khan, S. S., Ning, H., Shah, S. J., Yancy, C. W., Carnethon, M. R., Berry, J. D., Mentz, R. J., O'Brien, E. C., Correa, A., Suthahar, N., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.02.057 · Cited by 199 · see citing works
B-type natriuretic peptides: a diagnostic breakthrough for clinicians.
McCullough, P. A., Omland, T., & Maisel, A. S. (2003) · PubMed · Cited by 196 · see citing works
Cardiac remodeling at the population level—risk factors, screening, and outcomes
Gjesdal, O., Bluemke, D. A., & Lima, J. A. C. (2011) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2011.154 · Cited by 194 · see citing works
Association of parental heart failure with risk of heart failure in offspring
Lee, D. S., Pencina, M. J., Benjamin, E. J., Wang, T. J., Levy, D., O'Donnell, C. J., Nam, B.-H., Larson, M. G., D'Agostino, R. B., & Vasan, R. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052948 · Cited by 191 · see citing works
Self-citationAssociations Among Androgens, Estrogens, and Natriuretic Peptides in Young Women
Chang, A. Y., Abdullah, S. M., Jain, T., Stanek, H. G., Das, S. R., McGuire, D. K., Auchus, R. J., & de Lemos, J. A. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.10.040 · Cited by 189 · see citing works
Heidenreich, P. A., Gubens, M. A., Fonarow, G. C., Konstam, M. A., Stevenson, L. W., & Shekelle, P. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.043 · Cited by 185 · see citing works
Influence of sex and hormone status on circulating natriuretic peptides
Lam, C. S. P., Cheng, S., Choong, K., Larson, M. G., Murabito, J. M., Newton-Cheh, C., Bhasin, S., McCabe, E. L., Miller, K. K., Redfield, M. M., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.03.042 · Cited by 181 · see citing works
Self-citationRichards, M., Nicholls, M. G., Espiner, E. A., Lainchbury, J. G., Troughton, R. W., Elliott, J. M., FRAMPTON, C. M. A., Crozier, I., Yandle, T. G., Doughty, R. N., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.085 · Cited by 170 · see citing works
Premature Atrial Contractions in the General Population
Conen, D., Adam, M., Roche, F., Barthélemy, J., Dietrich, D. F., Imboden, M., Künzli, N., von Eckardstein, A., Regenass, S., Hornemann, T., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.112300 · Cited by 166 · see citing works
Olsen, M. H., Hansen, T. W., Christensen, M. K., Gustafsson, F., Rasmussen, S. L., Wachtell, K., Borch‐Johnsen, K., Ibsen, H., Jørgensen, T., & Hildebrandt, P. R. (2005) · Hypertension · doi:10.1161/01.hyp.0000179575.13739.72 · Cited by 166 · see citing works
Evaluation of B-type natriuretic peptide (BNP) levels in normal and preeclamptic women
Resnik, J. L., Hong, C., Resnik, R. R., Kazanegra, R., Beede, J., Bhalla, V., & Maisel, A. S. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.12.006 · Cited by 161 · see citing works
von Bibra, H., & Sutton, M. S. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1682-3 · Cited by 156 · see citing works
Krum, H., & Abraham, W. T. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60236-1 · Cited by 158 · see citing works
Galasko, G. I. W., Lahiri, A., Barnes, S. C., Collinson, P. O., & Senior, R. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi410 · Cited by 157 · see citing works
N-Terminal Pro-Brain Natriuretic Peptide
Wang, A. Y.-M., Lam, C. W.-K., Yu, C., Wang, M., Chan, I. H.-S., Zhang, Y., Lui, S., & Sanderson, J. E. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121299 · Cited by 156 · see citing works
Arnold, J. M. O., Howlett, J. G., Dorian, P., Ducharme, A., Giannetti, N., Haddad, H. A., Heckman, G. A., Ignaszewski, A. P., Isaac, D., Jong, P., et al. (2007) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(07)70211-8 · Cited by 147 · see citing works
The natriuretic peptides in cardiovascular medicine
Munagala, V. K., BURNETTJR, J., & Redfield, M. M. (2004) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2004.07.002 · Cited by 151 · see citing works
Detection of Left Ventricular Systolic Dysfunction From Electrocardiographic Images
Sangha, V., Nargesi, A. A., Dhingra, L. S., Khunte, A., Mortazavi, B. J., Ribeiro, A. H., Banina, E., Adeola, O., Garg, N., Brandt, C. A., et al. (2023) · Circulation · doi:10.1161/circulationaha.122.062646 · Cited by 150 · see citing works
Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome
Schlueter, N., de Sterke, A., Willmes, D. M., Spranger, J., Jordan, J., & Birkenfeld, A. L. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.04.007 · Cited by 148 · see citing works
Clerico, A., Fontana, M., Zyw, L., Passino, C., & Emdin, M. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.075713 · Cited by 148 · see citing works
Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock*
Tung, R. H., García, C. M. C., Morss, A. M., Pino, R. M., Fifer, M. A., Thompson, B., Lewandrowski, K. B., Lee-Lewandrowski, E., & Januzzi, J. L. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000133694.28370.7f · Cited by 144 · see citing works
Screening for heart disease in diabetic subjects
Fang, Z. Y., Schull-Meade, R., Leano, R., Mottram, P. M., Prins, J. B., & Marwick, T. H. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.06.021 · Cited by 144 · see citing works
Muzammil, M. A., Javid, S., Afridi, A. K., Siddineni, R., Shahabi, M., Haseeb, M. A., Fariha, F., Kumar, S., Zaveri, S., & Nashwan, A. J. (2024) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2024.01.006 · Cited by 137 · see citing works
Velagaleti, R. S., Gona, P. N., Pencina, M. J., Aragam, J. R., Wang, T. J., Levy, D. A., D’Agostino, R. B., Lee, D. S., Kannel, W. B., Benjamin, E. J., et al. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.09.028 · Cited by 136 · see citing works
Self-citationLoke, I. W., Squire, I. B., Davies, J. E., & Ng, L. L. (2003) · European Journal of Heart Failure · doi:10.1016/s1388-9842(03)00108-9 · Cited by 135 · see citing works
Risk factors for heart failure
Kenchaiah, S., Narula, J., & Vasan, R. S. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.016 · Cited by 134 · see citing works
Self-citationGenome-wide association with select biomarker traits in the Framingham Heart Study
Benjamin, E. J., Dupuis, J., Larson, M. G., Lunetta, K. L., Booth, S. L., Govindaraju, D. R., Kathiresan, S., Keaney, J. F., Keyes, M. J., Lin, J., et al. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s11 · Cited by 125 · see citing works
Self-citationEwald, B. D., Ewald, D., Thakkinstian, A., & Attia, J. (2007) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2007.01454.x · Cited by 123 · see citing works
Natriuretic peptides in the diagnosis and management of heart failure
Felker, G. M. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.060236 · Cited by 122 · see citing works
Interpretation of B-type natriuretic peptide in cardiac disease and other comorbid conditions
Burke, M. A., & Cotts, W. (2007) · Heart Failure Reviews · doi:10.1007/s10741-007-9002-9 · Cited by 121 · see citing works
Electrocardiographic QRS Duration and the Risk of Congestive Heart Failure
Dhingra, R., Pencina, M. J., Wang, T. J., Nam, B., Benjamin, E. J., Levy, D. A., Larson, M. G., Kannel, W. B., D’Agostino, R. B., & Vasan, R. S. (2006) · Hypertension · doi:10.1161/01.hyp.0000217141.20163.23 · Cited by 121 · see citing works
Self-citationPre-Clinical Diabetic Cardiomyopathy: Prevalence, Screening, and Outcome
Kiencke, S., Handschin, R., von Dahlen, R., Muser, J., Rocca, H. B., Schumann, J., Felix, B., Berneis, K. K., & Rickenbacher, P. R. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq110 · Cited by 119 · see citing works
Galectin 3 and incident atrial fibrillation in the community
Ho, J. E., Yin, X., Levy, D. A., Vasan, R. S., Magnani, J. W., Ellinor, P. T., McManus, D. D., Lubitz, S. A., Larson, M. G., & Benjamin, E. J. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.02.009 · Cited by 118 · see citing works
Self-citationEarly detection of myocardial dysfunction and heart failure
de Couto, G., Ouzounian, M., & Liu, P. P. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2010.51 · Cited by 118 · see citing works
Ingelsson, E., SULLIVAN, L. M., Murabito, J. M., Fox, C. S., Benjamin, E. J., Polak, J. F., Meigs, J. B., Keyes, M. J., O’Donnell, C. J., Wang, T. J., et al. (2007) · Diabetes · doi:10.2337/db07-0078 · Cited by 113 · see citing works
Self-citationYeboah, J., Rodríguez, C. J., Stacey, B. R., Lima, J. A. C., Liu, S., Carr, J. J., Hundley, W. G., & Herrington, D. M. (2012) · Circulation · doi:10.1161/circulationaha.112.112201 · Cited by 113 · see citing works
Diagnosis of heart failure in primary care
Fonseca, C. (2006) · Heart Failure Reviews · doi:10.1007/s10741-006-9481-0 · Cited by 111 · see citing works
Natriuretic peptides: markers or modulators of cardiac hypertrophy?
GARDNER, D. (2003) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(03)00113-9 · Cited by 111 · see citing works
Dhingra, R., Gona, P., Benjamin, E. J., Wang, T. J., Aragam, J., D'Agostino, R. B., Kannel, W. B., & Vasan, R. S. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq106 · Cited by 108 · see citing works
Self-citationde Lemos, J. A., McGuire, D. K., Khera, A., Das, S. R., Murphy, S. A., Omland, T., & Drazner, M. H. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.12.017 · Cited by 103 · see citing works
Measuring plasma B-type natriuretic peptide in heart failure
Rodeheffer, R. J. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2004.03.082 · Cited by 103 · see citing works
Gout and the risk for incident heart failure and systolic dysfunction
Krishnan, E. (2012) · BMJ Open · doi:10.1136/bmjopen-2011-000282 · Cited by 101 · see citing works
Cowan, D. M., Fan, Q., Zou, Y., Shi, X., Chen, J., Aschner, M., Rosenthal, F. S., & Zheng, W. (2009) · Biomarkers · doi:10.1080/13547500902730672 · Cited by 101 · see citing works
Brain Natriuretic Peptide in the Management of Heart Failure
de Denus, S., Pharand, C., & Williamson, D. R. (2004) · CHEST Journal · doi:10.1378/chest.125.2.652 · Cited by 98 · see citing works
Oyama, M. A., Sisson, D. D., & Solter, P. F. (2007) · American Journal of Veterinary Research · doi:10.2460/ajvr.68.1.42 · Cited by 97 · see citing works
Tang, W. H. W., Francis, G. S., Morrow, D. A., Newby, L. K., Cannon, C. P., Jesse, R. L., Storrow, A. B., Christenson, R. H., Christenson, R. H., Apple, F. S., et al. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.07.002 · Cited by 97 · see citing works
Population Risk Prediction Models for Incident Heart Failure
Echouffo-Tcheugui, J. B., Greene, S. J., Papadimitriou, L., Zannad, F. M., Yancy, C. W., Gheorghiade, M., & Butler, J. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001896 · Cited by 96 · see citing works
Ng, L. L., Pathik, B., Loke, I. W., Squire, I. B., & Davies, J. E. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.09.020 · Cited by 95 · see citing works
Khunte, A., Sangha, V., Oikonomou, E. K., Dhingra, L. S., Aminorroaya, A., Mortazavi, B. J., Coppi, A., Brandt, C. A., Krumholz, H. M., & Khera, R. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00869-w · Cited by 95 · see citing works
Katz, D. H., Deo, R. C., Aguilar, F. G., Selvaraj, S., Martinez, E. E., Beussink‐Nelson, L., Kim, K. A., Peng, J., Irvin, M. R., Tiwari, H. K., et al. (2017) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-017-9739-z · Cited by 95 · see citing works
B-Type Natriuretic Peptide as a Biomarker Beyond Heart Failure: Speculations and Opportunities
McKie, P. M., & Burnett, J. C. J. (2005) · Mayo Clinic Proceedings · doi:10.4065/80.8.1029 · Cited by 95 · see citing works
Hammerer‐Lercher, A., Ludwig, W., Falkensammer, G., Müller, S., Neubauer, E., Puschendorf, B., Pachinger, O. M., & Mair, J. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2003.028316 · Cited by 94 · see citing works
Goetze, J. P., Møgelvang, R., Maage, L., Scharling, H., Schnohr, P., Søgaard, P., Rehfeld, J. F., & Jensen, J. S. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl406 · Cited by 93 · see citing works
Andersson, C., Nayor, M. G., Tsao, C. W., Levy, D. A., & Vasan, R. S. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.059 · Cited by 94 · see citing works
Self-citationRutten, F. H., Cramer, M. J., Zuithoff, N. P. A., Lammers, J. J., Verweij, W. M., Grobbee, D. E., & Hoes, A. W. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2007.01.010 · Cited by 92 · see citing works
The heart as an endocrine organ
Ogawa, T., & de Bold, A. J. (2014) · Endocrine Connections · doi:10.1530/ec-14-0012 · Cited by 91 · see citing works
Vinereanu, D., Lim, P. O., Frenneaux, M. P., & Fraser, A. G. (2004) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2004.07.014 · Cited by 91 · see citing works
B-Type Natriuretic Peptides and Echocardiographic Measures of Cardiac Structure and Function
Troughton, R. W., & Richards, M. (2009) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2008.12.006 · Cited by 87 · see citing works
Nadir, M. A., Rekhraj, S., Wei, L., Lim, T. K., Davidson, J., MacDonald, T. M., Lang, C. C., Dow, E., & Struthers, A. D. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.049 · Cited by 85 · see citing works
Emdin, M., Passino, C., Prontera, C., Fontana, M., Poletti, R., Gabutti, A., Mammini, C., Giannoni, A., Zyw, L., Zucchelli, G., et al. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.080234 · Cited by 84 · see citing works
Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study
Moreira, E. M., Gall, H. J., Leening, M. J. G., Lahousse, L., Loth, D. W., Krijthe, B. P., Jong, J. C. K., Brusselle, G., Albert Hofman, D., Stricker, B. H. C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130072 · Cited by 84 · see citing works
Novel markers for heart failure diagnosis and prognosis
Lee, D. S., & Vasan, R. S. (2005) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000161832.04952.6a · Cited by 81 · see citing works
Self-citation
- Authors
- Vasan, R. S., Benjamin, E. J., Larson, M. G., Leip, E. P., Wang, T. J., Wilson, P. W. F., & Levy, D.
- Affiliations
- Framingham Heart Study (US)
- Boston University (US)
- National Institutes of Health (US)
- ORCID
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2002-09-11
- Volume
- 288
- Issue
- 10
- Pages
- 1252
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2059920038
- Cited by
- 493
- References
- 42
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 10 · 2023: 14 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 16 · 2014: 14 · 2013: 20 · 2012: 29
- FWCI
- 27.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Heart, Lung, and Blood Institute (K24-HL-04334-01A1, N01‐HC25195, R01HL067288, K24HL004334, 1R01HL67288-01)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- natriuretic peptides, brain natriuretic peptide, N-terminal proatrial natriuretic peptide, left ventricular hypertrophy, left ventricular systolic dysfunction, left ventricular mass, cardiovascular screening, diagnostic performance, sex differences, Framingham Heart Study, echocardiography
- MeSH terms
- Echocardiography, Female, Humans, Male, Mass Screening, Middle Aged, Atrial Natriuretic Factor, Phenotype, Predictive Value of Tests, Prospective Studies, Protein Precursors, ROC Curve, Sensitivity and Specificity, Systole, Biomarkers, Likelihood Functions, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Natriuretic Peptide, Brain
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