Cited by 517Physical Activity and HealthObesity, Physical Activity, DietMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Effect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial

Open access

Irwin, Melinda L., Yasui, Yutaka, Ulrich, Cornelia M., Bowen, Deborah, Rudolph, Rebecca E., Schwartz, Robert S., Yukawa, Michi, Aiello, Erin, Potter, John D., McTiernan, Anne·2003·JAMA

DOI 10.1001/jama.289.3.323

Open this paper in CoChat — free account Open PDF

Abstract

CONTEXT: The increasing prevalence of obesity is a major public health concern. Physical activity may promote weight and body fat loss. OBJECTIVE: To examine the effects of exercise on total and intra-abdominal body fat overall and by level of exercise. DESIGN: Randomized controlled trial conducted from 1997 to 2001. SETTING AND PARTICIPANTS: A total of 173 sedentary, overweight (body mass index > or =24.0 and >33% body fat), postmenopausal women aged 50 to 75 years who were living in the Seattle, Wash, area. INTERVENTION: Participants were randomly assigned to an intervention consisting of exercise facility and home-based moderate-intensity exercise (n = 87) or a stretching control group (n = 86). MAIN OUTCOME MEASURE: Changes in body weight and waist and hip circumferences at 3 and 12 months; total body, intra-abdominal, and subcutaneous abdominal fat at 12 months. RESULTS: Twelve-month data were available for 168 women. Women in the exercise group participated in moderate-intensity sports/recreational activity for a mean (SD) of 3.5 (1.2) d/wk for 176 (91) min/wk. Walking was the most frequently reported activity. Exercisers showed statistically significant differences from controls in baseline to 12-month changes in body weight (-1.4 kg; 95% confidence interval [CI], -2.5 to -0.3 kg), total body fat (-1.0%; 95% CI, -1.6% to -0.4%), intra-abdominal fat (-8.6 g/cm2; 95% CI, -17.8 to 0.9 g/cm2), and subcutaneous abdominal fat (-28.8 g/cm2); 95% CI, -47.5 to -10.0 g/cm2). A significant dose response for greater body fat loss was observed with increasing duration of exercise. CONCLUSIONS: Regular exercise such as brisk walking results in reduced body weight and body fat among overweight and obese postmenopausal women.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/jama.289.3.323

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Psychophysical bases of perceived exertion
BORG, G. A. V. (1982) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198205000-00012 · Cited by 16,580
Compendium of physical activities: an update of activity codes and MET intensities
AINSWORTH, B. E., HASKELL, W. L., WHITT, M. C., IRWIN, M. L., SWARTZ, A. M., STRATH, S. J., O???BRIEN, W. L., BASSETT, D. R., SCHMITZ, K. H., EMPLAINCOURT, P. O., et al. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009001-00009 · Cited by 8,497
Self-citation
Longitudinal Data Analysis for Discrete and Continuous Outcomes
Zeger, S. L., & Liang, K. (1986) · Biometrics · doi:10.2307/2531248 · Cited by 7,781
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
Physical Activity and Health: A Report of the Surgeon General
(1995) · PsycEXTRA Dataset · doi:10.1037/e525162010-001 · Cited by 5,488
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
A questionnaire for the assessment of leisure time physical activities
Taylor, H. L., Jacobs, D. R., Schucker, B., Knudsen, J., Leon, A. S., & Debacker, G. (1978) · Journal of Chronic Diseases · doi:10.1016/0021-9681(78)90058-9 · Cited by 1,848
Influences of cardiorespiratory fitness and other precursors on cardiovascular disease and all-cause mortality in men and women
Blair, S. N. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03540030039029 · Cited by 1,819
Impact of Overweight on the Risk of Developing Common Chronic Diseases During a 10-Year Period
Field, A. E., Coakley, E. H., Must, A., Spadano, J. L., Laird, N., Dietz, W. H., Rimm, E., & Colditz, G. A. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.13.1581 · Cited by 1,694

Flagged first, then by citations

Show all 35 references

Sorted by citations

Items 101–200 of 516

Strength training and adiposity in premenopausal women: Strong, Healthy, and Empowered study
Schmitz, K. H., Hannan, P. J., Stovitz, S. D., Bryan, C. J., Warren, M., & Jensen, M. D. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.3.566 · Cited by 116
Leisure-time physical activity and high-risk fat: a longitudinal population-based twin study
Leskinen, T., Sipilä, S., Alen, M., Cheng, S., Pietiläinen, K. H., Usenius, J.-P., Suominen, H., Kovanen, V, Kainulainen, H., Kaprio, J., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.170 · Cited by 107
Adiponectin: an adipokine with protective features against metabolic syndrome.
Esfahani, M., Movahedian, A., Baranchi, M., & Goodarzi, M. T. (2015) · Europe PMC (PubMed Central) · Cited by 111
Epidemiologic Methods in Physical Activity Studies
Lee, I. (2008) · doi:10.1093/acprof:oso/9780195183009.001.0001 · Cited by 110
Connecting Myokines and Metabolism
Ahima, R. S., & Park, H. K. (2015) · Endocrinology and Metabolism · doi:10.3803/enm.2015.30.3.235 · Cited by 111
Association of Lifestyle Factors With Abdominal Subcutaneous and Visceral Adiposity
Molenaar, E. A., Massaro, J. M., Jacques, P. F., Pou, K. M., Ellison, R. C., Hoffmann, U., Pencina, K. M., Shadwick, S. D., Vasan, R. S., O’Donnell, C. J., et al. (2008) · Diabetes Care · doi:10.2337/dc08-1382 · Cited by 113
“The reductions in SAT and VAT induced by physical activity may occur with concomitant weight loss (15,17), although results from several exercise studies demonstrated that reductions may also occur in the absence of weight loss (15).”
Obesity in the elderly: who should we be treating, and why, and how?
Kennedy, R. L., Chokkalingham, K., & Srinivasan, R. (2003) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200401000-00002 · Cited by 107
Physical activity and abdominal obesity in youth
Kim, Y., & Lee, S. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-066 · Cited by 107
Place of birth, duration of residence, neighborhood immigrant composition and body mass index in New York City
Park, Y., Neckerman, K. M., Quinn, J. W., Weiss, C. C., & Rundle, A. (2008) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-5-19 · Cited by 106
Recruiting and retaining breast cancer survivors into a randomized controlled exercise trial
Irwin, M. L., Cadmus, L. A., Alvarez-Reeves, M., O'Neil, M., Mierzejewski, E., Latka, R., Yu, H., DiPietro, L., Jones, B. A., Knobf, M. T., et al. (2008) · Cancer · doi:10.1002/cncr.23446 · Cited by 105
Self-citation
Physical Activity After Cancer: Physiologic Outcomes
McTiernan, A. (2004) · Cancer Investigation · doi:10.1081/cnv-120027581 · Cited by 102
Self-citation
Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects
Holt, H., Wild, S. H., Wood, P. J., Zhang, J.-L., Darekar, A., Dewbury, K. C., Poole, R., Holt, R. I. G., Phillips, D. I., & Byrne, C. D. (2005) · Diabetologia · doi:10.1007/s00125-005-0070-x · Cited by 100
“55 m/s, 2% gradient) [33].”
Nutrition and Exercise Interventions to Improve Body Composition for Persons with Overweight or Obesity Near Retirement Age: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Eglseer, D., Traxler, M., Embacher, S., Reiter, L., Schoufour, J. D., Weijs, P. J. M., Voortman, T., Boirie, Y., Cruz-Jentoft, A., & Bauer, S. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.001 · Cited by 102
ATP-Sensitive K+ Channel Knockout Compromises the Metabolic Benefit of Exercise Training, Resulting in Cardiac Deficits
Kane, G. C., Behfar, A., Yamada, S., Pérez-Terzic, C. M., O’Cochlain, F., Reyes, S., Dzeja, P. P., Miki, T., Seino, S., & Terzic, A. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s169 · Cited by 99
Physical activity in the treatment of obesity: beyond body weight reduction
Janiszewski, P. M., & Ross, R. (2007) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-018 · Cited by 97
“Approximately 20–25 min of daily physical activity was reported to significantly reduce VAT and ASAT in overweight postmenopausal women (Irwin et al. 2003) and obese postmenopausal women with diabetes (Giannopoulou et al.”
BackgroundInfluential
The Effects of Exercise on Food Intake and Body Fatness: A Summary of Published Studies
Elder, S. J., & Roberts, S. B. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00263.x · Cited by 95
High intensity, circuit-type integrated neuromuscular training alters energy balance and reduces body mass and fat in obese women: A 10-month training-detraining randomized controlled trial
Batrakoulis, A., Jamurtas, A. Z., Georgakouli, K., Draganidis, D., Deli, C. K., Παπανικολάου, Κ., Avloniti, A. A., Chatzinikolaou, A., Leontsini, D., Tsimeas, P. D., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202390 · Cited by 94
Moderate-Intensity Exercise Reduces the Incidence of Colds Among Postmenopausal Women
Chubak, J., McTiernan, A., Sorensen, B. E., Wener, M. H., Yasui, Y., Velasquez, M., Wood, B. L., Rajan, K. B., Wetmore, C. M., Potter, J. D., et al. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.06.033 · Cited by 92
Self-citation
Beneficios de la actividad física y riesgos del sedentarismo
Cenarruzabeitia, J. J. V., Hernández, J. A. M., & Martínez‐González, M. Á. (2003) · Medicina Clínica · doi:10.1016/s0025-7753(03)74054-8 · Cited by 105
Usual Physical Activity and Endogenous Sex Hormones in Postmenopausal Women: The European Prospective Investigation into Cancer–Norfolk Population Study
Chan, M.-F., Dowsett, M., Folkerd, E. J., Bingham, S. A., Wareham, N. J., Luben, R., Welch, A. A., & Khaw, K. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0745 · Cited by 90
Effects of dietary and exercise intervention on weight loss and body composition in obese postmenopausal women: a systematic review and meta-analysis
Cheng, C.-C., Hsu, C.-Y., & Liu, J.-F. (2018) · Menopause · doi:10.1097/gme.0000000000001085 · Cited by 89
Effects of Physical Activity on Cardiovascular and Noncardiovascular Outcomes in Older Adults
Sattelmair, J. R., Pertman, J. H., & Forman, D. E. (2009) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2009.07.004 · Cited by 88
Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women
Campbell, P. T., Wener, M. H., Sorensen, B. E., Wood, B. L., Chen-Levy, Z., Potter, J. D., McTiernan, A., & Ulrich, C. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01349.2007 · Cited by 87
Self-citation
Sleep, ghrelin, leptin and changes in body weight during a 1-year moderate-intensity physical activity intervention
Littman, A. J., Vitiello, M. V., Foster-Schubert, K., Ulrich, C. M., Tworoger, S. S., Potter, J. D., Weigle, D. S., & McTiernan, A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803438 · Cited by 86
Self-citation
Nutrition and Physical Activity and Chronic Disease Prevention: Research Strategies and Recommendations
Prentice, R. L., Willett, W. C., Greenwald, P., Alberts, D. S., Bernstein, L., Boyd, N. F., Byers, T., Clinton, S. K., Fraser, G. E., Freedman, L. S., et al. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh240 · Cited by 88
“For example, a recent exercise intervention trial (68) was conducted in 173 sedentary, overweight postmenopausal women randomly assigned to a moderate-intensity exercise program or to a control group, with outcomes that included sex hormone concentrations and body fat distribution ( 69 ,70).”
BackgroundSelf-citation
Physical Activity and Weight Management Across the Lifespan
Goldberg, J. H., & King, A. C. (2007) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.28.021406.144105 · Cited by 88
Visceral and Not Subcutaneous Abdominal Adiposity Reduction Drives the Benefits of a 1‐Year Lifestyle Modification Program
Borel, A., Nazare, J., Smith, J. D., Alméras, N., Tremblay, A., Bergeron, J., Poirier, P., & Després, J. (2012) · Obesity · doi:10.1038/oby.2011.396 · Cited by 84
Resting Energy Expenditure and Body Mass Changes in Women During Adjuvant Chemotherapy for Breast Cancer
Campbell, K. L., Lane, K. N., Martin, A. D., Gelmon, K. A., & McKenzie, D. C. (2007) · Cancer Nursing · doi:10.1097/01.ncc.0000265004.64440.5f · Cited by 82
Long-Term and Recent Recreational Physical Activity and Survival After Breast Cancer: The California Teachers Study
West-Wright, C. N., Henderson, K. D., Sullivan‐Halley, J., Ursin, G., Deapen, D., Neuhausen, S. L., Reynolds, P., Chang, E. T., Ma, H., & Bernstein, L. (2009) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-09-0538 · Cited by 81
“The exact mechanism by which physical activity lowers breast cancer risk remains unclear, but may involve altering menstrual cycle characteristics (13), influencing age at menarche (14), or affecting body size (15, 16), all of which are associated with endogenous estrogen exposure.”
Background
Frequent intentional weight loss is associated with lower natural killer cell cytotoxicity in postmenopausal women: possible long-term immune effects
Shade, E. D., Ulrich, C. M., Wener, M. H., Wood, B. L., Yasui, Y., LaCroix, K., Potter, J. D., & McTiernan, A. (2004) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2004.03.018 · Cited by 80
Self-citation
Social Media and Health Behavior Change
Laranjo, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-809269-9.00006-2 · Cited by 99
Associations among Circulating Sex Hormones, Insulin-Like Growth Factor, Lipids, and Mammographic Density in Postmenopausal Women
Aiello, E. J., Tworoger, S. S., Yasui, Y., Stanczyk, F. Z., Potter, J. D., Ulrich, C. M., Irwin, M. L., & McTiernan, A. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0920 · Cited by 79
Self-citation
Effects of a High vs Moderate Volume of Aerobic Exercise on Adiposity Outcomes in Postmenopausal Women
Friedenreich, C. M., Neilson, H. K., O’Reilly, R., Duha, A., Yasui, Y., Morielli, A. R., Adams, S. C., & Courneya, K. S. (2015) · JAMA Oncology · doi:10.1001/jamaoncol.2015.2239 · Cited by 78
Self-citation
Effect of Exercise and Pharmacological Interventions on Visceral Adiposity: A Systematic Review and Meta-analysis of Long-term Randomized Controlled Trials
Rao, S. G., Pandey, A., Garg, S. K., Park, B., Mayo, H., Després, J., Kumbhani, D. J., de Lemos, J. A., & Neeland, I. J. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2018.09.019 · Cited by 80
Effects of Exercise Interventions on Weight, Body Mass Index, Lean Body Mass and Accumulated Visceral Fat in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lee, H. S., & Lee, J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052635 · Cited by 91
“Batrakoulis (2018) [20] + ? ? ? + ? + Besnier (2015) [21] + + ? ? + ? + Blue (2018) [22] + + + ? + + + Coker (2009) [23] + ? ? ? + ? + Gepner (2018) [24] + + ? ? + + + Goodpaster (2010) [25] + ? ? ? + ? + Hunter (2010) [26] + + ? + + ? + Irving (2008) [27] + + ? ? + ? + Irwin (2003) [28] + + + ? + + + Johnson (2009) […”
Background
Weight Loss Strategies for Obese Adults: Personalized Weight Management Program vs. Standard Care
Byrne, N. M., Meerkin, J. D., Laukkanen, R. M. T., Ross, R., Fogelholm, M., & Hills, A. P. (2006) · Obesity · doi:10.1038/oby.2006.205 · Cited by 76
“(22) found a 2-kg weight loss in women was accompanied by a 7% reduction in visceral fat, Slentz et al.”
Background
Molecular Epidemiology of Physical Activity and Cancer
Rundle, A. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.227.14.1 · Cited by 75
Role of exercise training on cardiovascular disease in persons who have type 2 diabetes and hypertension
Stewart, K. J. (2004) · Cardiology Clinics · doi:10.1016/j.ccl.2004.06.007 · Cited by 72
“A recent randomized trial in sedentary, overweight, postmenopausal women, a group who is at high risk for diabetes, showed that exercise training without diet for 12 months resulted in a 4.2% loss in total body fat and a 6.9% loss of intra-abdominal visceral fat [145].”
BackgroundInfluential
Sitting time increases the overweight and obesity risk independently of walking time in elderly people from Spain
Gómez‐Cabello, A., Pedrero‐Chamizo, R., Olivares, P. R., Hernández-Perera, R., Marroyo, J. A. R., Mata, E., Aznar, S., Villa, G., Espino-Torón, L., Gusi, N., et al. (2012) · Maturitas · doi:10.1016/j.maturitas.2012.09.001 · Cited by 74
Effects of aerobic exercise and obesity phenotype on abdominal fat reduction in response to weight loss
Okura, T., Nakata, Y., Lee, D. J., Ohkawara, K., & Tanaka, K. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803013 · Cited by 72
Basal very low-density lipoprotein metabolism in response to exercise: Mechanisms of hypotriacylglycerolemia
Magkos, F. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.003 · Cited by 71
The effect of aerobic exercise on metabolic and inflammatory markers in breast cancer survivors—a pilot study
Guinan, E. M., Hussey, J. M., Broderick, J. M., Lithander, F. E., O’Donnell, D. M., Kennedy, M. J., & Connolly, E. (2013) · Supportive Care in Cancer · doi:10.1007/s00520-013-1743-5 · Cited by 72
“Higher-intensity aerobic exercise specifically targets visceral fat deposits [11, 45].”
The Utility of Physical Activity in the Management of Global Cardiometabolic Risk
Janiszewski, P. M., & Ross, R. (2009) · Obesity · doi:10.1038/oby.2009.382 · Cited by 73
A Reduced-Fat Diet and Aerobic Exercise in J apanese A mericans With Impaired Glucose Tolerance Decreases Intra-Abdominal Fat and Improves Insulin Sensitivity but not β-Cell Function
Carr, D. B., Utzschneider, K. M., Boyko, E. J., Asberry, P. J., Hull, R. L., Kodama, K., Callahan, H. S., Matthys, C. C., Leonetti, D. L., Schwartz, R. S., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.2.340 · Cited by 69
“Moreover, we found that the reductions in weight and IAF fat, but not percent body fat or abdominal SCF, were associated with the 24-month change in -cell function.”
ResultInfluentialSelf-citation
Effect of exercise intervention dosage on reducing visceral adipose tissue: a systematic review and network meta-analysis of randomized controlled trials
Chang, Y., Yang, H.-Y., & Shun, S. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00767-9 · Cited by 74
The Influence of Energetic Factors on Biomarkers of Postmenopausal Breast Cancer Risk
Neilson, H. K., Conroy, S. M., & Friedenreich, C. M. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0069-8 · Cited by 71
Moderate physical activity and breast cancer risk: the effect of menopausal status
Ángeles-Llerenas, A., Ortega-Olvera, C., Pérez‐Rodríguez, E., Esparza-Cano, J. P., Lazcano-Ponce, E. C., Romieu, I., & Torres-Mejı́a, G. (2010) · Cancer Causes & Control · doi:10.1007/s10552-009-9487-8 · Cited by 66
Effects of a Moderate Intensity Exercise Intervention on Estrogen Metabolism in Postmenopausal Women
Atkinson, C., Lampe, J. W., Tworoger, S. S., Ulrich, C. M., Bowen, D. J., Irwin, M. L., Schwartz, R. S., Rajan, B. K., Yasui, Y., Potter, J. D., et al. (2004) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.868.13.5 · Cited by 67
“Further details on all measurements have been published elsewhere (29).”
BackgroundResultInfluentialSelf-citation
Does home-based exercise improve body mass index in patients with type 2 diabetes?
Krousel-Wood, M. A., Berger, L., Jiang, X., Blonde, L., Myers, L., & Webber, L. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.08.028 · Cited by 62
Lifestyle Components and Primary Breast Cancer Prevention
Kruk, J. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.24.10543 · Cited by 64
Effects of high-intensity exercise training on body composition, abdominal fat loss, and cardiorespiratory fitness in middle-aged Korean females
Lee, M.-G., Park, K.-S., Kim, D.-U., Choi, S.-M., & Kim, H.-J. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h2012-084 · Cited by 63
Long‐term effect of exercise on improving fatty liver and cardiovascular risk factors in obese adults: A 1‐year follow‐up study
Zhang, H., Pan, L., Ma, Z., Chen, Z., Huang, Z., Sun, Q., Lü, Y., Han, C., Lin, M., Li, X., et al. (2016) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12809 · Cited by 63
Industry funding and the reporting quality of large long-term weight loss trials
Thomas, O., Thabane, L., Douketis, J. D., Chu, R., Westfall, A. O., & Allison, D. B. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.137 · Cited by 64
Randomized clinical trial: benefits of aerobic physical activity for 24 weeks in postmenopausal women with nonalcoholic fatty liver disease
Rezende, R. E. F., Duarte, S. M. B., Stefano, J. T., Roschel, H., Gualano, B., de Sá Pinto, A. L., Vezozzo, D. C. P., Carrilho, F. J., & Oliveira, C. P. (2016) · Menopause · doi:10.1097/gme.0000000000000647 · Cited by 62
Randomized trial of exercise in sedentary middle aged women: effects on quality of life
Bowen, D. J., Fesinmeyer, M. D., Yasui, Y., Tworoger, S. S., Ulrich, C. M., Irwin, M. L., Rudolph, R. E., LaCroix, K., Schwartz, R. R., & McTiernan, A. (2006) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-3-34 · Cited by 61
Self-citation
The Effect of Exercise on Obesity, Body Fat Distribution and Risk for Type 2 Diabetes
Goedecke, J. H., & Micklesfield, L. K. (2014) · Medicine and sport science/Medicine and sport · doi:10.1159/000357338 · Cited by 63
Achieving Equity in Physical Activity Participation
Hasson, R. E., BROWN, D. R., Dorn, J. M., Barkley, L. C., TORGAN, C. E., Whitt‐Glover, M. C., Ainsworth, B. E., & Keith, N. R. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001161 · Cited by 59
“The benefits of regular moderate- to vigorousintensity physical activity include improved weight control (18,34,42,43,63,78,79,88,107), mental health, and mood (52,102) as well as reduced disease risk (e.”
Background
Effect of Six Months Lifestyle Intervention in Japanese Men with Metabolic Syndrome: Randomized Controlled Trial
Nanri, A., Tomita, K., Matsushita, Y., Ichikawa, F., Yamamoto, M. L., Nagafuchi, Y., Kakumoto, Y., & Mizoue, T. (2012) · Journal of Occupational Health · doi:10.1539/joh.11-0238-oa · Cited by 58
Changing the Endpoints for Determining Effective Obesity Management
Ross, R., Blair, S., de Lannoy, L., Després, J.-P., & Lavie, C. J. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2014.10.002 · Cited by 55
The Effect of Aerobic and Resistance Training and Combined Exercise Modalities on Subcutaneous Abdominal Fat: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Yarizadeh, H., Eftekhar, R., Anjom-Shoae, J., Speakman, J. R., & Djafarian, K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa090 · Cited by 68
“According to the results of the influence analysis, 2 studies (31, 50) were outliers.”
BackgroundResult
ECSS position statement: Exercise and obesity
Fogelholm, M., Stallknecht, B. M., & van Baak, M. A. (2006) · European Journal of Sport Science · doi:10.1080/17461390600563085 · Cited by 58
“Furthermore, in postmenopausal women a 12-month training program ( /175 min/week of moderate intensity exercise) reduced abdominal subcutaneous (5%) as well as visceral (6%) fat significantly (Irwin et al., 2003).”
BackgroundInfluential
Effects of Aerobic Exercise Training on Estrogen Metabolism in Premenopausal Women: A Randomized Controlled Trial
Campbell, K. L., Westerlind, K. C., Harber, V. J., Bell, G. J., Mackey, J. R., & Courneya, K. S. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0784 · Cited by 56
Impact of different training modalities on anthropometric outcomes in patients with obesity: a systematic review and network meta-analysis.
Morze, J., Rücker, G., Danielewicz, A., Przybyłowicz, K., Neuenschwander, M., Schlesinger, S., & Schwingshackl, L. (2021) · Obesity Reviews · doi:10.1111/obr.13218 · Cited by 55
“Minimal intervention if the form of stretching exercise or lifestyle education was used as a comparator in three studies.(27,57,60) AET was delivered using aerobic machines (i.”
The effects of a lifestyle intervention program on physical outcomes, depression, and quality of life in adults with metabolic syndrome: A randomized clinical trial
Wang, Q., Chair, S. Y., & Wong, E. M. L. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.12.084 · Cited by 56
Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk
Jemtel, T. H. L., Samson, R., Milligan, G. P., Jaiswal, A., & Oparil, S. (2018) · Current Hypertension Reports · doi:10.1007/s11906-018-0880-0 · Cited by 56
Does IRISIN Have a BRITE Future as a Therapeutic Agent in Humans?
Irving, B. A., Still, C. D., & Argyropoulos, G. A. (2014) · Current Obesity Reports · doi:10.1007/s13679-014-0091-1 · Cited by 56
Evidence-based risk assessment and recommendations for physical activity clearance: diabetes mellitus and related comorbidities1This paper is one of a selection of papers published in this Special Issue, entitled Evidence-based risk assessment and recommendations for physical activity clearance, and has undergone the Journal’s usual peer review process.
Riddell, M. C., & Burr, J. F. (2011) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-063 · Cited by 54
“Prediabetes Reference Subjects Prescreened Supervised exercise No. of subjects exercised Study type Banzer et al. 2004 952 (250 DM, 702 no diabetes) Yes, medical history and physical evaluation Yes 250 Prospective intervention Lemaster et al. 2003 391 diabetic with a prior history of foot ulcer Yes NA 391 Prospective…”
BackgroundInfluential
Influence of a walking program on the metabolic risk profile of obese postmenopausal women
Roussel, M., Garnier, S., Lemoine, S., Gaubert, I., Charbonnier, L., Auneau, G., & Mauriège, P. (2009) · Menopause · doi:10.1097/gme.0b013e31818d4137 · Cited by 55
“The reduction in waist girth we reported also fits well with values noted in short-bout walkers after a 10-week program(12) and in women who exercised 3 days per week for 12 weeks.(14)”
Result
Exercise program affects body composition but not weight in postmenopausal women
Velthuis, M. J., Schuit, A. J., Peeters, P. H. M., & Monninkhof, E. M. (2009) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318197122a · Cited by 53
“Furthermore, two of these studies were conducted among overweight women, whereas we included women with a BMI between 22 and 40 kg/m(2) (mean, BMI 27 kg/m(2)).(17,18) One might hypothesize that in overweight women, a greater reduction in fat mass as a result of physical exercise might be expected, although we were not…”
Background
Low-Volume High-Intensity Interval Training Versus Moderate-Intensity Continuous Training on Body Composition, Cardiometabolic Profile, and Physical Capacity in Older Women
Boukabous, I., Marcotte‐Chénard, A., Amamou, T., Boulay, P., Brochu, M., Tessier, D., Dionne, I. J., & Riesco, É. (2019) · Journal of Aging and Physical Activity · doi:10.1123/japa.2018-0309 · Cited by 50
Long-Term Effect of Weight Regain Following Behavioral Weight Management Programs on Cardiometabolic Disease Incidence and Risk: Systematic Review and Meta-Analysis
Hartmann-Boyce, J., Theodoulou, A., Oke, J. L., Butler, A. R., Bastounis, A., Dunnigan, A., Byadya, R., Cobiac, L. J., Scarborough, P., Hobbs, F. D. R., et al. (2023) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.122.009348 · Cited by 53
EFFECT OF HIGH-INTENSITY INTERVAL TRAINING PROTOCOL ON ABDOMINAL FAT REDUCTION IN OVERWEIGHT CHINESE WOMEN: A RANDOMIZED CONTROLLED TRIAL
Zhang, H., Tong, T. K., Qiu, W., Wang, J., Nie, J., & He, Y. (2015) · Hrčak Portal of scientific journals of Croatia (University Computing Centre) · Cited by 50
Influence of demographic, physiologic, and psychosocial variables on adherence to a yearlong moderate-intensity exercise trial in postmenopausal women
Irwin, M. L., Tworoger, S. S., Yasui, Y., Rajan, B., McVarish, L., LaCroix, K., Ulrich, C. M., Bowen, D. J., Schwartz, R. S., Potter, J. D., et al. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.04.017 · Cited by 51
Self-citation
Using pedometers to increase physical activity in overweight and obese women: a pilot study
Pal, S., Cheng, C., Egger, G. J., Binns, C. W., & Donovan, R. J. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-309 · Cited by 51
“Walking, which is "self paced" is the most frequently reported physical activity and most preferred in the overweight and obese as it is low-impact with little risk of injury [12,36,37].”
Background
The role of adiponectin in cardiovascular disease
Peng, J., Chen, Q., & Wu, C. (2023) · Cardiovascular Pathology · doi:10.1016/j.carpath.2022.107514 · Cited by 56
Detrimental Changes in Health during Menopause: The Role of Physical Activity
Hulteen, R. M., Marlatt, K. L., Allerton, T. D., & Lovre, D. (2023) · International Journal of Sports Medicine · doi:10.1055/a-2003-9406 · Cited by 68
“treadmill walking or stationary bicycling for at least 45-min of moderate-intensity sessions, 5 days/week for 12 months) and losses in total body weight, fat mass, and intra-abdominal fat [21].”
Background
Exercise as the Cornerstone of Cardiovascular Prevention
Pérez, A. B. (2008) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(08)60166-8 · Cited by 52
The effect of physical activity and physical fitness on plasma adiponectin in adults with predisposition to metabolic syndrome
Ring‐Dimitriou, S., Paulweber, B., von DUVILLARD, S. P., Stadlmann, M., LeMura, L. M., Lang, J., & Müller, E. A. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0291-9 · Cited by 51
“These favorable responses may be elevated with regular physical activity because exercise has positive eVects on body composition, insulin sensitivity, and blood glucose levels (Borghouts et al. 1999; Eriksson et al. 1999; Ross et al. 2000; Tuomilehto et al. 2001; Irwin et al. 2003 ).”
Background
Effectiveness of weight loss interventions for obese older adults
Felix, H. C., & West, D. S. (2013) · American Journal of Health Promotion · doi:10.4278/ajhp.110617-lit-259 · Cited by 47
Designing trials of behavioral interventions to increase physical activity in patients with COPD: Insights from the chronic disease literature
Leidy, N. K., Kimel, M., Ajagbe, L., Kim, K. K., Hamilton, A. L., & Becker, K. (2013) · Respiratory Medicine · doi:10.1016/j.rmed.2013.11.011 · Cited by 48
Effects of physical exercise on health-related quality of life and blood lipids in perimenopausal women
Zhang, J., Chen, G., Lu, W., Yan, X., Zhu, S., Dai, Y., Xi, S., Chen, Y., & Bai, W. (2014) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000264 · Cited by 48
Does Regular Exercise without Weight Loss Reduce Insulin Resistance in Children and Adolescents?
Kim, Y., & Park, H.-N. (2013) · International Journal of Endocrinology · doi:10.1155/2013/402592 · Cited by 47
“Hindawi Publishing Corporation International Journal of Endocrinology Volume 2013, Article ID 402592, 10 pages http://dx.doi.org/10.1155/2013/402592”
BackgroundInfluential
Cardiovascular Risk and Disease Among Masters Endurance Athletes: Insights from the Boston MASTER (Masters Athletes Survey To Evaluate Risk) Initiative
Shapero, K. S., DeLuca, J. R., Contursi, M. E., Wasfy, M. M., Weiner, R. B., Lewis, G. D., Hutter, A. M., & Baggish, A. L. (2016) · Sports Medicine - Open · doi:10.1186/s40798-016-0053-0 · Cited by 47
Intervention Studies in Exercise and Cancer Prevention
McTiernan, A. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000093749.90499.63 · Cited by 45
Self-citation
The Effect of CYP19 and COMT Polymorphisms on Exercise‐Induced Fat Loss in Postmenopausal Women
Tworoger, S. S., Chubak, J., Aiello, E. J., Yasui, Y., Ulrich, C. M., Farin, F. M., Stapleton, P. L., Irwin, M. L., Potter, J. D., Schwartz, R. S., et al. (2004) · Obesity Research · doi:10.1038/oby.2004.119 · Cited by 45
Self-citation
Effects of exercise training on metabolic syndrome risk factors in post-menopausal women – A systematic review and meta-analysis of randomised controlled trials
Tan, A. S. Y., Thomas, R., Campbell, M. D., Prior, S. L., Bracken, R. M., & Churm, R. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.008 · Cited by 60
The relationship between active transportation and health
Schauder, S., & Foley, M. C. (2015) · Journal of Transport & Health · doi:10.1016/j.jth.2015.06.006 · Cited by 44
Effect of Exercise on Bone Mineral Density and Lean Mass in Postmenopausal Women
Chubak, J., Ulrich, C. M., Tworoger, S. S., Sorensen, B. E., Yasui, Y., Irwin, M. L., Stanczyk, F. Z., Potter, J. D., & McTiernan, A. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000227308.11278.d7 · Cited by 44
Self-citation
The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities
Yang, L., Courneya, K. S., & Friedenreich, C. M. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02748-x · Cited by 49
NAFLD, Estrogens, and Physical Exercise: The Animal Model
Lavoie, J.-M., & Pighon, A. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2012/914938 · Cited by 43
“Longitudinal and cross-sectional studies have shown that physical activities, such as moderate-intensity sports/recreational activity or biking and walking for transportation are associated with lower body fat and less central adiposity in postmenopausal women [81, 94, 95].”
Background
The effect of two different health messages on physical activity levels and health in sedentary overweight, middle-aged women
Pal, S., Cheng, C., & Ho, S. S. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-204 · Cited by 43
“Self paced walking is the most common physical activity reported by overweight and obese individuals and is preferred due to its low-impact nature and reduced risk of injury [8,36,37].”
Background
Ejercicio, piedra angular de la prevención cardiovascular
Pérez, A. B. (2008) · Revista Española de Cardiología · doi:10.1157/13119996 · Cited by 51
Lifestyle correlates of anthropometric estimates of body adiposity in an Italian middle-aged and elderly population: a covariance analysis
Leite, M. L. C., & Nicolosi, A. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803239 · Cited by 40
Physical Activity in Relation to Mammographic Density in the Dutch Prospect-European Prospective Investigation into Cancer and Nutrition Cohort
Suijkerbuijk, K. P. M., van Duijnhoven, F. J. B., van Gils, C. H., van Noord, P. A. H., Peeters, P. H. M., Friedenreich, C. M., & Monninkhof, E. M. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0569 · Cited by 39
Effects of endurance training on cardiorespiratory fitness and substrate partitioning in postmenopausal women
Zarins, Z. A., Wallis, G. A., Faghihnia, N., Johnson, M. L., Fattor, J. A., Horning, M. A., & Brooks, G. A. (2009) · Metabolism · doi:10.1016/j.metabol.2009.04.018 · Cited by 41
The Dose–Response Effects of Aerobic Exercise on Body Composition and Breast Tissue among Women at High Risk for Breast Cancer: A Randomized Trial
Brown, J. C., Despina Kontos, B., Schnall, M. D., Wu, S., & Schmitz, K. H. (2016) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-15-0408 · Cited by 39
Study design and methods for the Breast Cancer and Exercise Trial in Alberta (BETA)
Friedenreich, C. M., MacLaughlin, S., Neilson, H. K., Stanczyk, F. Z., Yasui, Y., Duha, A., Lynch, B. M., Kallal, C., & Courneya, K. S. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-919 · Cited by 39
“Two comparable trials in postmenopausal women [10,24] observed similar effects of an exercise intervention on hypothesized breast cancer biomarkers as well as some suggestion of a dose–response effect with stronger improvements in some biomarkers when exercise exceeded 195 minutes/week [24-26] or 130 minutes/week [12,…”
BackgroundResultSelf-citation
State of the science: a focus on physical activity.
Hills, A. P., & Byrne, N. M. (2006) · PubMed · Cited by 37
Randomized Controlled Trials of Physical Activity and Breast Cancer Prevention
Irwin, M. L. (2006) · Exercise and Sport Sciences Reviews · doi:10.1249/01.jes.0000240026.15126.ca · Cited by 37
Self-citation
Selecting exercise regimens and strains to modify obesity and diabetes in rodents: an overview
Ghosh, S., Golbidi, S., Werner, I., Verchere, C. B., & Laher, I. (2010) · Clinical Science · doi:10.1042/cs20090389 · Cited by 37

Authors: Irwin, M. L., Yasui, Y., Ulrich, C. M., Bowen, D., Rudolph, R. E., Schwartz, R. S., Yukawa, M., Aiello, E., Potter, J. D., & McTiernan, A.
Affiliations: Yale University (US)
University of Washington (US)
Corresponding author: McTiernan, Anne
ORCID: Irwin, Melinda L.
Yasui, Yutaka
Ulrich, Cornelia M.
Bowen, Deborah
Yukawa, Michi
Potter, John D.
McTiernan, Anne
Venue: JAMA
Publisher: American Medical Association (AMA)
Published: 2003-01-15
Volume: 289
Issue: 3
Pages: 323
ISSN: 0002-9955 (ISSN-L)
0098-7484
DOI: 10.1001/jama.289.3.323
OpenAlex: W2110141259
Cited by: 517
References: 35
Citations by year: 2026: 4 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 12 · 2021: 16 · 2020: 17 · 2019: 8 · 2018: 16 · 2017: 15 · 2016: 26 · 2015: 19 · 2014: 24 · 2013: 29 · 2012: 28
FWCI: 20.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JAMA (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (R01-69334)
National Institute on Aging (AG1094)
National Cancer Institute (T32 CA09661, T32CA009661)
National Center for Research Resources (M01-RR 00037, M01RR000037)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: physical activity, postmenopausal women, intra-abdominal fat, total body fat, subcutaneous abdominal fat, obesity, overweight, weight loss, moderate-intensity exercise, home-based exercise, walking, waist circumference, dose-response relationship, sedentary women
MeSH terms: Abdomen, Adipose Tissue, Aged, Body Composition, Female, Humans, Middle Aged, Obesity, Weight Loss, Exercise, Body Mass Index, Postmenopause

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effect of Exercise on Total and Intra-abdominal Body Fat in Postmenopausal Women: A Randomized Controlled Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks