Cited by 867Cannabis and Cannabinoid ResearchSchizophrenia research and treatmentPsychedelics and Drug Studies

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Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review

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Volkow, Nora D., Swanson, James M., Evins, A. Eden, DeLisi, Lynn E., Meier, Madeline H., Gonzalez, Raul, Bloomfield, Michael A. P., Curran, H. Valerie, Baler, Ruben·2016·JAMA Psychiatry

DOI 10.1001/jamapsychiatry.2015.3278

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Abstract

With a political debate about the potential risks and benefits of cannabis use as a backdrop, the wave of legalization and liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, and Alaska) and the District of Columbia have passed laws that legalized cannabis for recreational use by adults, and 23 others plus the District of Columbia now regulate cannabis use for medical purposes. These policy changes could trigger a broad range of unintended consequences, with profound and lasting implications for the health and social systems in our country. Cannabis use is emerging as one among many interacting factors that can affect brain development and mental function. To inform the political discourse with scientific evidence, the literature was reviewed to identify what is known and not known about the effects of cannabis use on human behavior, including cognition, motivation, and psychosis.

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What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Endocannabinoid-Mediated Control of Synaptic Transmission
Kano, M., Ohno‐Shosaku, T., Hashimotodani, Y., Uchigashima, M., & Watanabe, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00019.2008 · Cited by 1,595
Persistent cannabis users show neuropsychological decline from childhood to midlife
Meier, M. H., Caspi, A., Ambler, A., Harrington, H., Houts, R., Keefe, R. S. E., McDonald, K., Ward, A., Poulton, R., & Moffitt, T. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206820109 · Cited by 1,523
Self-citation
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Caspi, A., Moffitt, T. E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.026 · Cited by 1,409
Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study.
Arseneault, L., Cannon, M., Poulton, R., Murray, R., Caspi, A., & Moffitt, T. E. (2002) · BMJ · doi:10.1136/bmj.325.7374.1212 · Cited by 1,399
Cannabis and schizophrenia. A longitudinal study of Swedish conscripts
Andréasson, S., Engström, A., Allebeck, P., & Rydberg, U. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92620-1 · Cited by 1,166
Apathy: a neuropsychiatric syndrome
Marin, R. S. (1991) · Journal of Neuropsychiatry · doi:10.1176/jnp.3.3.243 · Cited by 1,088
The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis
D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Wu, Y.-T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300496 · Cited by 1,024
Cannabis use and psychosis: A longitudinal population-based study
van Os, J. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf043 · Cited by 928

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The Science of Marijuana
Iversen, L. L. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328240.001.0001 · Cited by 230
Cannabis-associated psychosis: Neural substrate and clinical impact
Murray, R. M., Englund, A., Abi‐Dargham, A., Lewis, D. A., Forti, M. D., Davies, C., Sherif, M. A., McGuire, P. K., & D’Souza, D. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.018 · Cited by 210
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“It manifests as a reduce motivation to engage in every-day activities such as a diminished desire to study or work, engage in social or recreational activities people who use cannabis frequently [32].”
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Self-citation
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Self-citation
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Terry‐McElrath, Y. M., O’Malley, P. M., Johnston, L. D., Bray, B. C., Patrick, M. E., & Schulenberg, J. E. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.11.021 · Cited by 78
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Choi, N. G., DiNitto, D. M., & Marti, C. N. (2017) · American Journal on Addictions · doi:10.1111/ajad.12598 · Cited by 77
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Self-citation

Authors: Volkow, N. D., Swanson, J. M., Evins, A. E., DeLisi, L. E., Meier, M. H., Gonzalez, R., Bloomfield, M. A. P., Curran, H. V., & Baler, R.
Affiliations: National Institutes of Health (US)
University of California, Irvine (US)
Harvard University (US)
Arizona State University (US)
Center for Children and Families, Department of Psychology, Florida International University, Miami
Hammersmith Hospital (GB)
University College London (GB)
National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland
ORCID: Volkow, Nora D.
Swanson, James M.
Evins, A. Eden
DeLisi, Lynn E.
Meier, Madeline H.
Bloomfield, Michael A. P.
Curran, H. Valerie
Venue: JAMA Psychiatry
Publisher: American Medical Association (AMA)
Published: 2016-03-01
Volume: 73
Issue: 3
Pages: 292
ISSN: 2168-622X (ISSN-L)
DOI: 10.1001/jamapsychiatry.2015.3278
OpenAlex: W2264173627
Cited by: 867
References: 77
Citations by year: 2026: 46 · 2025: 85 · 2024: 64 · 2023: 85 · 2022: 81 · 2021: 87 · 2020: 105 · 2019: 102 · 2018: 97 · 2017: 74 · 2016: 40
FWCI: 84.45
Type: journal article
Language: en
Open access: green
discovery.ucl.ac.uk
Locations: JAMA Psychiatry (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Research Bank (Australian Catholic University) (submittedVersion)
Funders: FORUM Pharmaceuticals
National Institute for Health and Care Research (CL-2015-18-005, ACF-2014-18-010)
British Medical Association
National Institutes of Health
Medical Research Council (MR/K015524/1)
National Institute on Drug Abuse (R01DA021576, R01DA021245, R01DA030992)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: cannabis use, recreational cannabis legalization, medical cannabis, cognition, motivation, psychosis, brain development, mental health, cannabis policy
MeSH terms: Adult, Behavior, Cannabis, Marijuana Abuse, Cognition, Humans, Legislation, Drug, Motivation, Psychoses, Substance-Induced, United States

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Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review

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