The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
Open accessAbstract
With a political debate about the potential risks and benefits of cannabis use as a backdrop, the wave of legalization and liberalization initiatives continues to spread. Four states (Colorado, Washington, Oregon, and Alaska) and the District of Columbia have passed laws that legalized cannabis for recreational use by adults, and 23 others plus the District of Columbia now regulate cannabis use for medical purposes. These policy changes could trigger a broad range of unintended consequences, with profound and lasting implications for the health and social systems in our country. Cannabis use is emerging as one among many interacting factors that can affect brain development and mental function. To inform the political discourse with scientific evidence, the literature was reviewed to identify what is known and not known about the effects of cannabis use on human behavior, including cognition, motivation, and psychosis.
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“It manifests as a reduce motivation to engage in everyday activities such as a diminished desire to study or work, engage in social or recreational activities people who use cannabis frequently [32].”
From Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits (2025) · cites this paper as [32]
In the citing paper
“Specifically, chronic cannabis users have smaller volumes of the orbitofrontal cortex, a brain region implicated in motivation, and the hippocampus, a brain area implicated in stress, learning and memory [32].”
From Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits (2025) · cites this paper as [32]
In the citing paper
“Cannabis users and people intoxicated with THC had altered function in the same regions and in brain striatal areas implicated in reward processing.”
From Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits (2025) · cites this paper as [32]
In the citing paper
“Specifically, chronic cannabis users have smaller volumes of the orbitofrontal cortex, a brain region implicated in motivation, and the hippocampus, a brain area implicated in stress, learning and memory [32].”
From Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits (2025) · cites this paper as [32]
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Self-citation
Metadata
- Authors
- Volkow, N. D., Swanson, J. M., Evins, A. E., DeLisi, L. E., Meier, M. H., Gonzalez, R., Bloomfield, M. A. P., Curran, H. V., & Baler, R.
- Affiliations
- National Institutes of Health (US)
- University of California, Irvine (US)
- Harvard University (US)
- Arizona State University (US)
- Center for Children and Families, Department of Psychology, Florida International University, Miami
- Hammersmith Hospital (GB)
- University College London (GB)
- National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland
- ORCID
- Venue
- JAMA Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2016-03-01
- Volume
- 73
- Issue
- 3
- Pages
- 292
- ISSN
- 2168-622X (ISSN-L)
- OpenAlex
- W2264173627
- Cited by
- 867
- References
- 77
- Citations by year
- 2026: 46 · 2025: 85 · 2024: 64 · 2023: 85 · 2022: 81 · 2021: 87 · 2020: 105 · 2019: 102 · 2018: 97 · 2017: 74 · 2016: 40
- FWCI
- 84.45
- Type
- journal article
- Language
- en
- Open access
- green
- discovery.ucl.ac.uk
- Locations
- JAMA Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Funders
- FORUM Pharmaceuticals
- National Institute for Health and Care Research (CL-2015-18-005, ACF-2014-18-010)
- British Medical Association
- National Institutes of Health
- Medical Research Council (MR/K015524/1)
- National Institute on Drug Abuse (R01DA021576, R01DA021245, R01DA030992)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- cannabis use, recreational cannabis legalization, medical cannabis, cognition, motivation, psychosis, brain development, mental health, cannabis policy
- MeSH terms
- Adult, Behavior, Cannabis, Marijuana Abuse, Cognition, Humans, Legislation, Drug, Motivation, Psychoses, Substance-Induced, United States
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