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Cited by 147Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorCognitive Abilities and Testing

Animal neuropsychology: validation of the intra-dimensional extra-dimensional set shifting task for mice

GARNER, J, THOGERSON, C, WURBEL, H, MURRAY, J, MENCH, J·2006·Behavioural Brain Research
DOI 10.1016/j.bbr.2006.06.002
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Abstract

Research in animal neuropsychology is providing an exciting new generation of behavioral tests for mice that promise to overcome many of the limitations of current high-throughput testing, and provide direct animal homologues of clinically important measures in human research. Set shifting tasks are some of the best understood and widely used human neuropsychological tasks, with clinical relevance to traumatic brain injury, schizophrenia, autism, obsessive compulsive disorder, trichotillomania, and many other disorders. Here we report the first successful modification of a human set shifting neuropsychological task, the Intra-Dimensional Extra-Dimensional (IDED) task, for use with mice. We presented mice with a series of compound discrimination and reversal tasks where one stimulus dimension consistently cued reward. Task performance improved with a new set of compound stimuli, as did reversal performance--indicating the formation of a cognitive-attentional set. We then overtrained a subset of the mice, and presented control and overtrained mice with a new compound discrimination where a novel stimulus dimension cued reward. As is the case in human control subjects, control mice persisted in responding to the now-incorrect stimulus dimension, performing poorly on this extra-dimensional shift compared with the previous intra-dimensional shift, thereby validating the task as a measure of set shifting. Furthermore, overtrained mice were impaired on this extra-dimensional shift compared with controls, further validating the task. The advantages and disadvantages of the IDED task compared to high-throughput approaches are discussed.

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  • A digging-based foraging task is a naturalistic method to test behavioral flexibility and is rapidly learned by mice and rats.

    “A digging-based foraging task is a naturalistic method to test behavioral flexibility and is rapidly learned by mice and rats (Birrell and Brown, 2000; Garner et al., 2006; Kim and Ragozzino, 2005).”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Garner et al., 2006

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Authors
GARNER, J., THOGERSON, C., WURBEL, H., MURRAY, J., & MENCH, J.
Affiliations
  • Purdue University West Lafayette (US)
  • University of California, Davis (US)
Corresponding author
GARNER, J
ORCID
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
2006-10-02
Volume
173
Issue
1
Pages
53-61
ISSN
0166-4328 (ISSN-L)
DOI
10.1016/j.bbr.2006.06.002
OpenAlex
W2153232433
Cited by
147
References
49
Citations by year
2026: 5 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 9 · 2018: 14 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 12 · 2012: 11
FWCI
2.43
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R03MH063907, 5 R03 MH 63907-2)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
set-shifting, mice, cognitive flexibility, compound discrimination, reversal learning, overtraining
MeSH terms
Animals, Attention, Concept Formation, Discrimination, Psychological, Female, Male, Mice, Inbred C57BL, Neuropsychological Tests, Neuropsychology, Random Allocation, Reversal Learning, Set, Psychology, Mice

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