Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Measuring inconsistency in meta-analyses

Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin

(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)

The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group (2004) · Human Reproduction · doi:10.1093/humrep/deh098 · Cited by 6,138

Amenorrhea associated with bilateral polycystic ovaries

Stein, I. F., & Leventhal, M. L. (1935) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30642-6 · Cited by 2,121

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., et al. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.09.024 · Cited by 1,976

Thiazolidinediones

Yki-Järvinen, H. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041001 · Cited by 1,830

The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria

March, W. A., Moore, V. M., Willson, K. J., Phillips, D. I. W., Norman, R. J., & Davies, M. J. (2010) · Human Reproduction · doi:10.1093/humrep/dep399 · Cited by 1,799

Metformin—mode of action and clinical implications for diabetes and cancer

Pernicova, I., & Korbonits, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.256 · Cited by 1,393

Maternal Morbid Obesity and the Risk of Adverse Pregnancy Outcome

Cedergren, M. (2004) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000107291.46159.00 · Cited by 1,352

Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis

Gillies, C. L., Abrams, K. R., Lambert, P. C., Cooper, N. J., Sutton, A. J., Hsu, R. T., & Khunti, K. (2007) · BMJ · doi:10.1136/bmj.39063.689375.55 · Cited by 1,171

Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome

Legro, R. S., Barnhart, H. X., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., McGovern, P. G., Cataldo, N. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063971 · Cited by 1,027

Prevalence and Characteristics of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Apridonidze, T., Essah, P. A., Iuorno, M. J., & Nestler, J. E. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1045 · Cited by 931

Improvement in Endocrine and Ovarian Function during Dietary Treatment of Obese Women with Polycystic Ovary Syndrome

Kiddy, D. S., Hamilton‐Fairley, D., Bush, A., Short, F., Anyaoku, V., Reed, M. J., & Franks, S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02909.x · Cited by 921

Effects of Metformin on Spontaneous and Clomiphene-Induced Ovulation in the Polycystic Ovary Syndrome

Nestler, J. E., Jakubowicz, D. J., Evans, W. S., & Pasquali, R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199806253382603 · Cited by 781

Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp

Stepto, N. K., Cassar, S., Joham, A. E., Hutchison, S. K., Harrison, C. L., Goldstein, R. F., & Teede, H. J. (2013) · Human Reproduction · doi:10.1093/humrep/des463 · Cited by 747

Decreases in Ovarian Cytochrome P450c17α Activity and Serum Free Testosterone after Reduction of Insulin Secretion in Polycystic Ovary Syndrome

Nestler, J. E., & Jakubowicz, D. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608293350902 · Cited by 743

Lifestyle changes in women with polycystic ovary syndrome

Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725

Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials

Lago, R. M., Singh, P. P., & Nesto, R. W. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61514-1 · Cited by 710

The management of anovulatory infertility in women with polycystic ovary syndrome: An analysis of the evidence to support the development of global who guidance

Balen, A. H., Morley, L. C., Misso, M., Franks, S., Legro, R. S., Wijeyaratne, C. N., Stener-Victorin, E., Fauser, B. C. J. M., Norman, R. J., & Teede, H. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw025 · Cited by 705

Prevalence and Predictors of the Metabolic Syndrome in Women with Polycystic Ovary Syndrome

Ehrmann, D. A., Liljenquist, D. R., Kasza, K., Azziz, R., Legro, R. S., & Ghazzi, M. N. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1329 · Cited by 703

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Tang, T., Lord, J. M., Norman, R. J., Yasmin, E., & Balen, A. H. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053.pub5 · Cited by 698

Metformin Effects on Clinical Features, Endocrine and Metabolic Profiles, and Insulin Sensitivity in Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled 6-Month Trial, followed by Open, Long-Term Clinical Evaluation1

Moghetti, P., Castello, R., Negri, C., Tosi, F., Perrone, F., Caputo, M., Zanolin, E., & Muggeo, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6293 · Cited by 660

Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome

Pasquali, R., Gambineri, A., Biscotti, D., Vicennati, V., Gagliardi, L., Colitta, D., Fiorini, S., Cognigni, G. E., Filicori, M., & Morselli-Labate, A. M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.8.6738 · Cited by 635

The insulin-sensitizing agent troglitazone improves metabolic and reproductive abnormalities in the polycystic ovary syndrome

Dunaif, A. E., Scott, D., Finegood, D. T., Quintana, B., & Whitcomb, R. W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.9.8784087 · Cited by 561

Obesity and reproductive disorders in women

Pasquali, R. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg024 · Cited by 549

Health care-related economic burden of the polycystic ovary syndrome during the reproductive life Span

Azziz, R., Marin, C., Hoq, L., Badamgarav, E., & Song, P. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0628 · Cited by 537

Troglitazone Improves Ovulation and Hirsutism in the Polycystic Ovary Syndrome: A Multicenter, Double Blind, Placebo-Controlled Trial1

Azziz, R., Ehrmann, D. A., Legro, R. S., Whitcomb, R. W., Hanley, R. M., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7375 · Cited by 537

Ovulatory and Metabolic Effects of d-Chiro-Inositol in the Polycystic Ovary Syndrome

Nestler, J. E., Jakubowicz, D. J., Reamer, P., Gunn, R. D., & Allan, G. (1999) · New England Journal of Medicine · doi:10.1056/nejm199904293401703 · Cited by 518

The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study

Ford, E. S. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.12.022 · Cited by 501

Lean Women with Polycystic Ovary Syndrome Respond to Insulin Reduction with Decreases in Ovarian P450c17 Activity and Serum Androgens

Nestler, J. E., & Jakubowicz, D. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4431 · Cited by 398

Troglitazone Improves Ovulation and Hirsutism in the Polycystic Ovary Syndrome: A Multicenter, Double Blind, Placebo-Controlled Trial

Azziz, R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.4.1626 · Cited by 379

Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome

Tang, T. H., Norman, R. J., Balen, A. H., & Lord, J. M. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053 · Cited by 369

Ovarian Function and Metabolic Factors in Women with Oligomenorrhea Treated with Metformin in a Randomized Double Blind Placebo-Controlled Trial

Fleming, R., Hopkinson, Z. E., Wallace, A. M., Greer, I. A., & Sattar, N. A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8261 · Cited by 366

Metformin increases the ovulatory rate and pregnancy rate from clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone

Vandermolen, D. T., Ratts, V. S., Evans, W. S., Stovall, D. W., Kauma, S. W., & Nestler, J. E. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01675-7 · Cited by 356

Prevalence and Characteristics of the Polycystic Ovary Syndrome in Overweight and Obese Women

Álvarez‐Blasco, F., Botella-Carretero, J. I., Millán, J. L. S., & Escobar-Morreale, H. F. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.19.2081 · Cited by 352

Combined lifestyle modification and metformin in obese patients with polycystic ovary syndrome. A randomized, placebo-controlled, double-blind multicentre study

Tang, T., Glanville, J., Hayden, C. J., White, D., Barth, J. H., & Balen, A. H. (2006) · Human Reproduction · doi:10.1093/humrep/dei311 · Cited by 335

Clinical manifestations and insulin resistance (IR) in polycystic ovary syndrome (PCOS) among South Asians and Caucasians: is there a difference?

Wijeyaratne, C. N., Balen, A. H., Barth, J. H., & Belchetz, P. E. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01603.x · Cited by 315

The Finnish Diabetes Prevention Study

Uusitupa, M. I. J., Louheranta, A. M., Lindström, J., Valle, T. T., Sundvall, J., Eriksson, J. G., & Tuomilehto, J. O. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500001070 · Cited by 312

Menstrual Cyclicity After Metformin Therapy in Polycystic Ovary Syndrome

M, E., Acosta, A., & Mendoza, S. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00296-2 · Cited by 305

Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women

Crave, J. C., Fimbel, S., Lejeune, H., Cugnardey, N., Déchaud, H., & Pugeat, M. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.7.7608255 · Cited by 301

Effects of metformin and rosiglitazone, alone and in combination, in nonobese women with polycystic ovary syndrome and normal indices of insulin sensitivity

Baillargeon, J.-P., Jakubowicz, D. J., Iuorno, M. J., Jakubowicz, S., & Nestler, J. E. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.127 · Cited by 300

Lifestyle changes in women with polycystic ovary syndrome

Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292

The relationship of insulin insensitivity to menstrual pattern in women with hyperandrogenism and polycystic ovaries

Robinson, S., Kiddy, D. S., Gelding, S. V., Willis, D., Niththyananthan, R., Bush, A., Johnston, D. G., & Franks, S. (1993) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1993.tb02376.x · Cited by 282

Effect of clomifene citrate plus metformin and clomifene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomised double blind clinical trial

Moll, E., Bossuyt, P., Korevaar, J., Lambalk, C., & van der Veen, F. (2006) · British medical journal · doi:10.1136/bmj.38867.631551.55 · Cited by 280

Prospective parallel randomized, double-blind, double-dummy controlled clinical trial comparing clomiphene citrate and metformin as the first-line treatment for ovulation induction in nonobese anovulatory women with polycystic ovary syndrome

Palomba, S., Orio, F., Falbo, A., Manguso, F., Russo, T., Cascella, T., Tolino, A., Carmina, E., Colao, A., & Zullo, F. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0110 · Cited by 279

A randomized, 48-week, placebo-controlled trial of intensive lifestyle modification and/or metformin therapy in overweight women with polycystic ovary syndrome: A pilot study

Hoeger, K. M., Kochman, L., Wixom, N., Craig, K., Miller, R. K., & Guzick, D. S. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2004.02.104 · Cited by 278

Restoration of Reproductive Potential by Lifestyle Modification in Obese Polycystic Ovary Syndrome: Role of Insulin Sensitivity and Luteinizing Hormone

Huber-Buchholz, M.-M. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.4.1470 · Cited by 269

Metformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene citrate-resistant women with polycystic ovary syndrome

Koçak, M., Çalışkan, E., ŞİMŞİR, Ç., & Haberal, A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02941-7 · Cited by 267

Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome

Leo, V. D., Marca, A. L., Ditto, A., Morgante, G., & Cianci, A. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00208-3 · Cited by 266

Endocrine and Metabolic Effects of Metformin Versus Ethinyl Estradiol-Cyproterone Acetate in Obese Women with Polycystic Ovary Syndrome: A Randomized Study

Morin-Papunen, L. C., Vauhkonen, I., Koivunen, R. M., Ruokonen, A., Martikainen, H. K., & Tapanainen, J. S. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6792 · Cited by 261

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome

Tso, L. O., Costello, M., Albuquerque, L. E. T., Andriolo, R. B., & Macedo, C. R. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006105.pub3 · Cited by 255

Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome

Diamanti‐Kandarakis, E., Christakou, C. D., Kandaraki, E., & Economou, F. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0733 · Cited by 251

Effect of the Insulin Sensitizer Pioglitazone on Insulin Resistance, Hyperandrogenism, and Ovulatory Dysfunction in Women with Polycystic Ovary Syndrome

Brettenthaler, N., Geyter, C. D., Huber, P., & Keller, U. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031737 · Cited by 247

Metformin improves pregnancy and live-birth rates in women with polycystic ovary syndrome (PCOS): a multicenter, double-blind, placebo-controlled randomized trial

Morin-Papunen, L., Rantala, A. S., Unkila-Kallio, L., Tiitinen, A., Hippeläinen, M., Perheentupa, A., Tinkanen, H., Bloigu, R., Puukka, K., Ruokonen, A., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3061 · Cited by 243

A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome

Costello, M. F., & Eden, J. A. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04554-5 · Cited by 224

Leptin Concentrations in the Polycystic Ovary Syndrome

Mantzoros, C. S., Dunaif, A. E., & Flier, J. S. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.6.4017 · Cited by 201

Insulin-sensitising drugs versus the combined oral contraceptive pill for hirsutism, acne and risk of diabetes, cardiovascular disease, and endometrial cancer in polycystic ovary syndrome

Costello, M. F., Shrestha, B., Eden, J., Johnson, N., & Moran, L. J. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005552.pub2 · Cited by 197

Troglitazone-induced liver failure: a case study

Graham, D. J., Green, L., Senior, J. R., & Nourjah, P. A. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01529-2 · Cited by 188

Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene-resistant polycystic ovaries: a randomized, double-blinded placebo-controlled trial

Ng, E. H. Y. (2001) · Human Reproduction · doi:10.1093/humrep/16.8.1625 · Cited by 183

Co-administration of metformin during rFSH treatment in patients with clomiphene citrate-resistant polycystic ovarian syndrome: a prospective randomized trial

Yaralı́, H. (2002) · Human Reproduction · doi:10.1093/humrep/17.2.289 · Cited by 171

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)—relationship to newly identified mitochondrial pyruvate carrier proteins

Colca, J. R., McDonald, W. G., Cavey, G. S., Cole, S. L., Holewa, D. D., Brightwell-Conrad, A. S., Wolfe, C. L., Wheeler, J. S., Coulter, K. R., Kilkuskie, P. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061551 · Cited by 171

Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome1

Jakubowicz, D. J., Seppälä, M. T., Jakubowicz, S., Rodriguez-Armas, O., Rivas-Santiago, A., Koistinen, H. K., Koistinen, R., & Nestler, J. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.3.7295 · Cited by 164

Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin

Maciel, G. A. R., Soares, J. M., Motta, E. L. A., Haidar, M. A., de Lima, G. R., & Baracat, E. C. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.08.012 · Cited by 161

Untitled work

(2009) · PubMed · Cited by 160

Endocrine and Metabolic Effects of Metformin Versus Ethinyl Estradiol-Cyproterone Acetate in Obese Women with Polycystic Ovary Syndrome: A Randomized Study

Morin-Papunen, L. C. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.9.3161 · Cited by 157

Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study

Elter, K., İmir, G., & Durmuşoğlu, F. (2002) · Human Reproduction · doi:10.1093/humrep/17.7.1729 · Cited by 152

Health-related quality of life in women with polycystic ovary syndrome, a self-administered questionnaire, was validated

Guyatt, G. H., Weaver, B., Cronin, L., Dooley, J. A., & Azziz, R. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2003.10.018 · Cited by 151

First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis

Cassina, M., Donà, M., Di Gianantonio, E., Litta, P., & Clementi, M. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu022 · Cited by 143

The effects of metformin with lifestyle therapy in polycystic ovary syndrome: a randomized double-blind study

Ladson, G., Dodson, W. C., Sweet, S. D., Archibong, A. E., Kunselman, A. R., Demers, L. M., Williams, N. I., Coney, P., & Legro, R. S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.12.002 · Cited by 138

Lean Women With Polycystic Ovary Syndrome Respond to Insulin Reduction With Decreases in Ovarian P450c17 alpha Activity and Serum Androgens

Nestler, J. E., & Jakubowicz, D. J. (1998) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199805000-00018 · Cited by 133

Early Effects of Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomized, Double-Blind, Placebo-Controlled Trial

Eisenhardt, S., Schwarzmann, N., Henschel, V., Germeyer, A., von Wolff, M., Hamann, A., & Strowitzki, T. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1994 · Cited by 130

Insulin Reduction with Metformin Increases Luteal Phase Serum Glycodelin and Insulin-Like Growth Factor-Binding Protein 1 Concentrations and Enhances Uterine Vascularity and Blood Flow in the Polycystic Ovary Syndrome

Jakubowicz, D. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.3.1126 · Cited by 130

Aromatase inhibitors for subfertile women with polycystic ovary syndrome

Franik, S., Kremer, J. A. M., Nelen, W. L. D. M., & Farquhar, C. M. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010287.pub2 · Cited by 125

Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.

Gerli, S., Mignosa, M., & Renzo, G. C. D. (2003) · PubMed · Cited by 125

Additive Effects of Insulin-Sensitizing and Anti-Androgen Treatment in Young, Nonobese Women with Hyperinsulinism, Hyperandrogenism, Dyslipidemia, and Anovulation

Ibáñez, L., Valls, C., Ferrer, A., Ong, K. K., Dunger, D. B., & de Zegher, F. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.6.8568 · Cited by 120

An assessment of lifestyle modification versus medical treatment with clomiphene citrate, metformin, and clomiphene citrate–metformin in patients with polycystic ovary syndrome

Karimzadeh, M. A., & Javedani, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.02.078 · Cited by 118

Consensus on infertility treatment related to polycystic ovary syndrome.

Hong, K. (2008) · Human Reproduction · doi:10.1093/humrep/dem426 · Cited by 117

The Effect of Metformin on Fat Distribution and the Metabolic Syndrome in Women With Polycystic Ovary Syndrome–A Randomised, Double-Blind, Placebo-Controlled Trial

Lord, J., Thomas, R., Fox, B., Acharya, U., & Wilkin, T. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00966.x · Cited by 113

The Pregnancy in Polycystic Ovary Syndrome Study: baseline characteristics of the randomized cohort including racial effects

Legro, R. S., Myers, E. R., Barnhart, H. X., Carson, S. A., Diamond, M. P., Carr, B. R., Schlaff, W. D., Coutifaris, C., McGovern, P. G., Cataldo, N. A., et al. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.03.037 · Cited by 111

Prevalence of the metabolic syndrome and its components in Brazilian women with polycystic ovary syndrome

Soares, E. M. M., Azevedo, G. D., Gadelha, R. G. N., Lemos, T. M. A. M., & Maranhão, T. M. O. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.03.081 · Cited by 106

Comparison of clomiphene citrate, metformin, or the combination of both for first-line ovulation induction, achievement of pregnancy, and live birth in Asian women with polycystic ovary syndrome: a randomized controlled trial

Zain, M. M., Jamaluddin, R., Ibrahim, A., & Norman, R. J. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.002 · Cited by 106

Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Tang, T. H., Lord, J. M., Norman, R. J., Yasmin, E., & Balen, A. H. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053.pub4 · Cited by 104

Clomiphene citrate, metformin or both as first‐step approach in treating anovulatory infertility in patients with polycystic ovary syndrome (PCOS): a systematic review of head‐to‐head randomized controlled studies and meta‐analysis

Palomba, S., Pasquali, R., Orio, F., & Nestler, J. E. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03369.x · Cited by 103

Soluble CD36 and Risk Markers of Insulin Resistance and Atherosclerosis Are Elevated in Polycystic Ovary Syndrome and Significantly Reduced During Pioglitazone Treatment

Glintborg, D., Højlund, K., Andersen, M., Henriksen, J. E., Beck‐Nielsen, H., & Handberg, A. (2008) · Diabetes Care · doi:10.2337/dc07-1424 · Cited by 103

The effect of metformin on hirsutism in polycystic ovary syndrome

Kelly, C., & Gordon, D. (2002) · European Journal of Endocrinology · doi:10.1530/eje.0.1470217 · Cited by 102

Efficacy of metformin in obese and non-obese women with polycystic ovary syndrome: a randomized, double-blinded, placebo-controlled cross-over trial

Trolle, B., Flyvbjerg, A., Kesmodel, U., & Lauszus, F. F. (2007) · Human Reproduction · doi:10.1093/humrep/dem271 · Cited by 91

Untitled work

(2011) · PubMed · Cited by 91

Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study

Rautio, K., Tapanainen, J. S., Ruokonen, A., & Morin-Papunen, L. C. (2006) · Human Reproduction · doi:10.1093/humrep/dei505 · Cited by 88

Troglitazone decreases adrenal androgen levels in women with polycystic ovary syndrome

Azziz, R., Ehrmann, D. A., Legro, R. S., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(02)04914-2 · Cited by 87

Short-Term Intervention with Liraglutide Improved Eating Behavior in Obese Women with Polycystic Ovary Syndrome

Jensterle, M., Kocjan, T., Kravos, N. A., Pfeifer, M., & Janez, A. (2015) · Endocrine Research · doi:10.3109/07435800.2014.966385 · Cited by 86

Psychological parameters in the reproductive phenotypes of polycystic ovary syndrome

Moran, L., Deeks, A. A., Gibson‐Helm, M. E., & Teede, H. J. (2012) · Human Reproduction · doi:10.1093/humrep/des114 · Cited by 86

Clinical, metabolic, and endocrine parameters in response to metformin and lifestyle intervention in women with polycystic ovary syndrome: a randomized, double-blind, and placebo control trial

Fux Otta, C., Wior, M., Iraci, G. S., Kaplan, R., Torres, D., Gaido, M. I., & Wyse, E. P. (2010) · Gynecological Endocrinology · doi:10.3109/09513590903215581 · Cited by 85

Clinical, Metabolic and Endocrine Parameters in Response to Metformin in Obese Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind and Placebo-Controlled Trial

Chou, K. H., Corleta, H. V. E., Capp, E., & Spritzer, P. M. (2003) · Hormone and Metabolic Research · doi:10.1055/s-2003-39056 · Cited by 85

A randomized controlled trial of the efficacy of rosiglitazone and clomiphene citrate versus metformin and clomiphene citrate in women with clomiphene citrate–resistant polycystic ovary syndrome

Rouzi, A. A., & Ardawi, M. S. M. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.07.1312 · Cited by 82

Plasma homocysteine in polycystic ovary syndrome: does it correlate with insulin resistance and ethnicity?

Wijeyaratne, C. N., Nirantharakumar, K., Balen, A. H., Barth, J. H., Sheriff, R., & Belchetz, P. E. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02019.x · Cited by 82

Metformin versus clomiphene citrate for infertility in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis

Misso, M. L., Costello, M. F., Garrubba, M., Wong, J., Hart, R., Rombauts, L., Melder, A. M., Norman, R. J., & Teede, H. J. (2013) · Human Reproduction Update · doi:10.1093/humupd/dms036 · Cited by 81

Prevalence of the Metabolic Syndrome in German Women with Polycystic Ovary Syndrome

Hahn, S., Tan, S., Sack, S., Kimmig, R., Quadbeck, B., Mann, K., & Janssen, O. E. (2007) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2007-967093 · Cited by 80

PCOSMIC: a multi-centre randomized trial in women with PolyCystic Ovary Syndrome evaluating Metformin for Infertility with Clomiphene

JOHNSON, N. P., Stewart, A., Falkiner, J., Farquhar, C. M., Milsom, S. R., Singh, V. P., Okonkwo, Q. L., & Buckingham, K. (2010) · Human Reproduction · doi:10.1093/humrep/deq100 · Cited by 78

Progression to impaired glucose tolerance or type 2 diabetes mellitus in polycystic ovary syndrome: a controlled follow-up study

Celik, C., Taşdemir, N., Abalı, R., Baştu, E., & Yılmaz, M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.12.050 · Cited by 74

Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome

Khorram, O., Helliwell, J. P., Katz, S., Bonpane, C. M., & Jaramillo, L. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.042 · Cited by 73

Metabolic and Hormonal Changes Induced by Pioglitazone in Polycystic Ovary Syndrome: A Randomized, Placebo-Controlled Clinical Trial

Aroda, V. R., Ciaraldi, T. P., Burke, P., Mudaliar, S., Clopton, P., Phillips, S., Chang, R. J., & Henry, R. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1133 · Cited by 71

Predictive value of glucose–insulin ratio in PCOS and profile of women who will benefit from metformin therapy: Obese, lean, hyper or normoinsulinemic?

Önalan, G., Göktolga, Ü., Ceyhan, T., Bağış, T., Önalan, R., & Pabuçcu, R. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.05.010 · Cited by 71

Metformin does not enhance ovulation induction in clomiphene resistant polycystic ovary syndrome in clinical practice

Sturrock, N. D. C., Lannon, B. M., & Fay, T. N. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2002.01575.x · Cited by 70

Total and high molecular weight (HMW) adiponectin levels and measures of glucose and lipid metabolism following pioglitazone treatment in a randomized placebo‐controlled study in polycystic ovary syndrome

Glintborg, D., Frystyk, J., Højlund, K., Andersen, K. K., Henriksen, J. E., Hermann, A. P., Hagen, C., Flyvbjerg, A., & Andersen, M. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03015.x · Cited by 69

Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome

Glintborg, D., Hermann, A. P., Andersen, M., Hagen, C., Beck‐Nielsen, H., Veldhuis, J. D., & Henriksen, J. E. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.12.067 · Cited by 68

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome

Bordewijk, E. M., Nahuis, M. J., Costello, M., van der Veen, F., Tso, L. O., Mol, B. W., & van Wely, M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009090.pub2 · Cited by 65

The effects of metformin on insulin resistance, clomiphene-induced ovulation and pregnancy rates in women with polycystic ovary syndrome

Şahin, Y., Yirmibeş, Ü., Keleştimur, F., & Aygen, E. (2004) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2003.09.036 · Cited by 61

Ultra‐short metformin pretreatment for clomiphene citrate‐resistant polycystic ovary syndrome

Hwu, Y., Lin, S., Huang, W. Y., Lin, M., & Lee, R. K. K. (2005) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2005.04.004 · Cited by 60

Minimal Response of Circulating Lipids in Women with Polycystic Ovary Syndrome to Improvement in Insulin Sensitivity with Troglitazone

Legro, R. S., Azziz, R., Ehrmann, D. A., Fereshetian, A. G., O’Keefe, M., & Ghazzi, M. N. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030044 · Cited by 60

Metformin versus lifestyle changes in treating women with polycystic ovary syndrome

Curi, D. D. G., Fonseca, A. M., Marcondes, J. A. M., Almeida, J. A. M., Bagnoli, V. R., Soares, J. M., & Baracat, E. C. (2012) · Gynecological Endocrinology · doi:10.3109/09513590.2011.583957 · Cited by 60

Prevalence of the metabolic syndrome in Asian women with polycystic ovary syndrome: Using the International Diabetes Federation criteria

Weerakiet, S., Bunnag, P., Phakdeekitcharoen, B., Wansumrith, S., Chanprasertyothin, S., Jultanmas, R., & Thakkinstian, A. (2007) · Gynecological Endocrinology · doi:10.1080/09513590701214158 · Cited by 59

Metformin effects on ovarian ultrasound appearance and steroidogenic function in normal-weight normoinsulinemic women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

Romualdi, D., Giuliani, M., Cristello, F., Fulghesu, A. M., Selvaggi, L., Lanzone, A., & Guido, M. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.114 · Cited by 58

Definition of insulin resistance using the homeostasis model assessment (HOMA-IR) in IVF patients diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria

Alebić, M. Š., Bulum, T., Stojanović, N., & Duvnjak, L. S. (2014) · Endocrine · doi:10.1007/s12020-014-0182-5 · Cited by 56

Polycystic ovary syndrome and fat distribution: The central issue?

Lord, J. M., & Wilkin, T. J. (2002) · Human Fertility · doi:10.1080/1464727022000198952 · Cited by 55

Correction of Insulin Resistance and Hyperandrogenism in Polycystic Ovary Syndrome By Combined Rosiglitazone and Clomiphene Citrate Therapy

Shobokshi, A., & Shaarawy, M. (2003) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(02)00260-5 · Cited by 54

Does adding metformin to clomifene citrate lead to higher pregnancy rates in a subset of women with polycystic ovary syndrome?

Moll, E., Korevaar, J. C., Bossuyt, P. M., & van der Veen, F. (2008) · Human Reproduction · doi:10.1093/humrep/den182 · Cited by 48

Mitochondrial Inhibitor as a New Class of Insulin Sensitizer

Zhang, Y., & Ye, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.010 · Cited by 47

A retrospective study of the pregnancy, delivery and neonatal outcome in overweight versus normal weight women with polycystic ovary syndrome

Frène, V. D., Vansteelandt, S., T'Sjoen, G. G., Gerris, J., Somers, S., Vercruysse, L., & Sutter, P. D. (2014) · Human Reproduction · doi:10.1093/humrep/deu154 · Cited by 47

The effect of metformin plus clomiphene citrate on ovulation and pregnancy rates in clomiphene-resistant women with polycystic ovary syndrome

Malkawi, H. Y., & Qublan, H. S. (2002) · Saudi Medical Journal · doi:10.15537/1658-3175.1726 · Cited by 46

Is Metformin Indicated as Primary Ovulation Induction Agent in Women with PCOS? A Systematic Review and Meta-Analysis

Siebert, T. I., Viola, M. I., Steyn, D. W., & Kruger, T. F. (2012) · Gynecologic and Obstetric Investigation · doi:10.1159/000335253 · Cited by 46

Twenty years of ovulation induction with metformin for PCOS; what is the best available evidence?

Hashim, H. A. (2015) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2015.09.015 · Cited by 45

Effects of metformin and clomiphene citrate on ovarian vascularity in patients with polycystic ovary syndrome

Palomba, S., Orio, F., Falbo, A. I., Russo, T., Tolino, A., & Zullo, F. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.035 · Cited by 45

Does metformin affect the ovarian response to gonadotropins for in vitro fertilization treatment in patients with polycystic ovary syndrome and reduced ovarian reserve? A randomized controlled trial

Palomba, S., Falbo, A. I., Cello, A. D., Cappiello, F., Tolino, A., & Zullo, F. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.020 · Cited by 45

Retinol-Binding Protein 4 in Polycystic Ovary Syndrome—Association with Steroid Hormones and Response to Pioglitazone Treatment

Aigner, E. S., Bachofner, N., Klein, K., Geyter, C. D., Hohla, F., Patsch, W., & Datz, C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2156 · Cited by 44

Pioglitazone Treatment Increases Spontaneous Growth Hormone (GH) Secretion and Stimulated GH Levels in Polycystic Ovary Syndrome

Glintborg, D., Støving, R. K., Hagen, C., Hermann, A. P., Frystyk, J., Veldhuis, J. D., Flyvbjerg, A., & Andersen, M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0615 · Cited by 43

Type 2 diabetes and polycystic ovary syndrome

Legro, R. S. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.04.010 · Cited by 40

Clomiphene citrate, metformin or a combination of both as the first line ovulation induction drug for Asian Indian women with polycystic ovarian syndrome: A randomized controlled trial

Kar, S., & Sanchita, S. (2015) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.170373 · Cited by 37

The Insulin-Sensitizing Agent Troglitazone Improves Metabolic and Reproductive Abnormalities in the Polycystic Ovary Syndrome

Dunaif, A. E., Scott, D., Finegood, D. T., Quintana, B., & Whitcomb, R. W. (1997) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-199702000-00016 · Cited by 32

Rosiglitazone treatment alleviates inflammation and improves liver function in overweight women with polycystic ovary syndrome: a randomized placebo-controlled study

Rautio, K., Tapanainen, J. S., Ruokonen, A., & Morin-Papunen, L. C. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.05.061 · Cited by 29

Does metformin induce ovulation in normoandrogenic anovulatory women?

Carmina, E., & Løbo, R. A. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.05.030 · Cited by 29

The effect of administration of metformin on lipid profile changes andinsulin resistance in patients with polycystic ovary syndrome

Karimzadeh, M. A., Eftekhar, M., Taheripanah, R., Tayebi, N., Sakhavat, L., & Zare, F. (2007) · TSpace (University of Toronto) · Cited by 25

Evaluating the equivalence of clomiphene citrate with and without metformin in ovulation induction in PCOS patients

Siebert, T., Kruger, T., & Lombard, C. J. (2009) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-009-9304-z · Cited by 24

Ovulation induction with clomiphene citrate and metformin in women with polycystic ovary syndrome.

Leanza, V., Coco, L., Grasso, F., Leanza, G., Zarbo, G., & Palumbo, M. A. (2014) · PubMed · Cited by 22

Efficacy of combined metformin-clomiphene citrate in comparison with clomiphene citrate alone in infertile women with polycystic ovarian syndrome (PCOS).

Ayaz, A., Alwan, Y., & Farooq, M. U. (2013) · PubMed Central · Cited by 21

Metformin effects on clomifene-induced ovulation in the polycystic ovary syndrome.

Ayed, B. B., Mlik, S. D. D., Arab, H. B., Trabelsi, H., Chahtour, H., Mathlouthi, N., Dhuib, M., Kassis, M., Saiidane, D., Trabelsi, K., et al. (2009) · PubMed · Cited by 20

Analysis of factors predicting success of metformin and clomiphene treatment for women with infertility owing to PCOS-related ovulation dysfunction in a randomised controlled trial

JOHNSON, N. P., Bontekoe, S., & Stewart, A. W. (2011) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2011.01295.x · Cited by 18

Extended-Release Metformin Does Not Reduce the Clomiphene Citrate Dose Required to Induce Ovulation in Polycystic Ovary Syndrome

Cataldo, N. A., Barnhart, H. X., Legro, R. S., Myers, E. R., Schlaff, W. D., Carr, B. R., Diamond, M. P., Carson, S. A., Steinkampf, M. P., Coutifaris, C., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0287 · Cited by 17

[Study on treatment of hyperandrogenism and hyperinsulinism in polycystic ovary syndrome with Chinese herbal formula "tiangui fang"].

Hou, J., Yu, J., & Wei, M. (2000) · PubMed · Cited by 16

Health-related quality of life in women with newly diagnosed polycystic ovary syndrome randomized between clomifene citrate plus metformin or clomifene citrate plus placebo

Moll, E., van Wely, M., Lambalk, C. B., Bossuyt, P. M., & van der Veen, F. (2012) · Human Reproduction · doi:10.1093/humrep/des310 · Cited by 16

Metformin-clomiphene citrate vs. clomiphene citrate alone: Polycystic ovarian syndrome

Farooq, M., Ayaz, A., & Alwan, Y. (2013) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.112372 · Cited by 16

Efficacy of Metformin in Obese and Non-obese Women With Polycystic Ovary Syndrome: A Randomized, Double-Blinded, Placebo-Controlled Cross-Over Trial

Trolle, B., Flyvbjerg, A., Kesmodel, U., & Lauszus, F. F. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000300471.31456.ea · Cited by 14

Clomiphene citrate alone, in combination with metformin or in combination with pioglitazone as first line therapy in induction of ovulation in infertile women with polycystic ovary syndrome, a randomized controlled trial

Abuelghar, W. M., Elkady, O. S., & Khamees, A. A. (2013) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2013.05.002 · Cited by 12

The reproductive and metabolic effect of rosiglitazone on Chinese women with polycystic ovarian syndrome—a double-blind randomized placebo-controlled study

Lam, P. M., Tam, W. H., Ronald, C. W., Cheung, L. P., Tsui, M. H. Y., Tong, P. C. Y., Chow, F. C. C., Lam, C. W. K., Chan, M. H. M., Chan, J. C. N., et al. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.05.085 · Cited by 12

Infertility in Practice

Balen, A. H. (2014) · CRC Press eBooks · doi:10.1201/b16081 · Cited by 12

Metformin-therapy Effects in 50 Clomiphene Citrate Resistant PCOS Patients

Farzadi, L., & ., S. Z. S. M. (2006) · Journal of Medical Sciences(Faisalabad) · doi:10.3923/jms.2006.765.771 · Cited by 11

Does metformin augment the ovulation inducing effects of clomiphene in non-obese women with polycystic ovary syndrome?

Chaudhury, K., Chaudhury, S., & Chowdhury, S. (2008) · PubMed · Cited by 9

Characteristics of polycystic ovary syndrome with and without insulin resistance and the role of insulinsensitizing drug (metformin) in its management

Refaie, A., Ibrahim, G., & Oash, S. A. (2005) · TSpace (University of Toronto) · Cited by 9

[Indication of metformin in the management of hormonal dysfunction secondary to polycystic ovarian syndrome: prospective comparative study of 63 cases].

Boudhrâa, K., Jellouli, M. A., Amri, M., Farhat, M., Torkhani, F., & Gara, M. F. (2010) · PubMed · Cited by 8

Co-administration of metformin during recombinant follicle stimulating hormone (recombinant FSH) treatment using the low-dose step-up protocol in patients with clomiphene citrate resistant polycystic ovary syndrome (PCOS): a prospective randomized trial.

Yaralı́, H., Yýldýz, B. O., Demi̇rol, A., Zeyneloğlu, H. B., Yigit, N., & Bükülmez, O. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02126-4 · Cited by 6

A randomized, placebo-controlled study of the influence of instant-release metformin on response to clomiphene citrate and time to conception in polycystic ovary syndrome

Williams, C. D., Pastore, L. M., Shelly, W. B., Bailey, A. P., Baras, D. C., & Bateman, B. G. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.07.1076 · Cited by 6

Metabolic risks of the lean PCOS woman

Kar, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.848 · Cited by 5

Effect of Metformin and Clomiphene Citrate in Improving Fertility in Subfertile Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial

Begum, H., Chowdhury, T., Begum, F., Begum, S. N., Kabir, N., & Haque, M. A. (2016) · Bangladesh Journal of Obstetrics & Gynaecology · doi:10.3329/bjog.v29i1.30438 · Cited by 5

Insulin sensitizing agent (metformin) improves clinical pregnancy rate in clomiphene citrate resistant polycystic ovarian syndrome patients with acanthosis nigricans

Salman, S. A., Farghaly, T., Attallah, D. A. A., Abdel-Hafeez, H. A., & Shaaban, O. M. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.475 · Cited by 1

Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline

Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919

Lifestyle changes in women with polycystic ovary syndrome

Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725

Ovulation: Parallels With Inflammatory Processes

Duffy, D. M., Ko, C. J., Jo, M., Brännström, M., & Curry, T. E. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00075 · Cited by 530

Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

Fekadu, S., Alemayehu, E., Dewil, R., & der Bruggen, B. V. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.11.072 · Cited by 525

Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics

Glueck, C. J., & Goldenberg, N. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.002 · Cited by 442

In women with polycystic ovary syndrome, oligoamenorrhea and subfertility, what are the effects of insulin-sensitizing drugs (metformin, rosiglitazone, pioglitazone, d-chiro-inositol)?

Ahmad, G. (2014) · Cochrane Clinical Answers · doi:10.1002/cca.284 · Cited by 1

For women with polycystic ovary syndrome, oligomenorrhea, and subfertility, what are the effects of insulin-sensitizing drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol)?

Ahmad, G. (2018) · Cochrane Clinical Answers · doi:10.1002/cca.1975

Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome

Tang, T. H., Norman, R. J., Balen, A. H., & Lord, J. M. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003053 · Cited by 369

Efficacy Of Insulin Sensitizers Metformin, Pioglitazone And Combination Myo-Inositol (MI) Plus D-Chiroinositol (DCI) Plus Folic Acid In Women With Polycystic Ovary Syndrome: A RCT

Dr. Urooj Zafar, D. A. Z. (2023) · Journal of Pharmaceutical Negative Results · doi:10.47750/pnr.2023.14.03.385

[Polycystic ovary syndrome: treatment with insulin-sensitizing agents].

Barbosa, S. L.-S., Rodien, P., & Rohmer, V. (2002) · PubMed · Cited by 6