Characterization of Small RNAs in Aplysia Reveals a Role for miR-124 in Constraining Synaptic Plasticity through CREB
Open accessAbstract
Memory storage and memory-related synaptic plasticity rely on precise spatiotemporal regulation of gene expression. To explore the role of small regulatory RNAs in learning-related synaptic plasticity, we carried out massive parallel sequencing to profile the small RNAs of Aplysia californica. We identified 170 distinct miRNAs, 13 of which were novel and specific to Aplysia. Nine miRNAs were brain enriched, and several of these were rapidly downregulated by transient exposure to serotonin, a modulatory neurotransmitter released during learning. Further characterization of the brain-enriched miRNAs revealed that miR-124, the most abundant and well-conserved brain-specific miRNA, was exclusively present presynaptically in a sensory-motor synapse where it constrains serotonin-induced synaptic facilitation through regulation of the transcriptional factor CREB. We therefore present direct evidence that a modulatory neurotransmitter important for learning can regulate the levels of small RNAs and present a role for miR-124 in long-term plasticity of synapses in the mature nervous system.
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MicroRNA present at high levels in the brain regulate neuronal and synaptic plasticity.
“miRNA present at high levels in the brain regulate neuronal and synaptic plasticity.”
From Epigenetic mechanisms of major depression: Targeting neuronal plasticity (2018) · cites this paper as [136]
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MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
(2008) · doi:10.1038/nrg2290 · Cited by 5,199 · see citing works
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
Reinhart, B. J., Slack, F. J., Basson, M., Pasquinelli, A. E., Bettinger, J. C., Rougvie, A. E., Horvitz, H. R., & Ruvkun, G. (2000) · Nature · doi:10.1038/35002607 · Cited by 4,989 · see citing works
Identification of Novel Genes Coding for Small Expressed RNAs
Lagos-Quintana, M., Rauhut, R., Lendeckel, W., & Tuschl, T. (2001) · Science · doi:10.1126/science.1064921 · Cited by 4,956 · see citing works
Self-citationMicroarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., Bartel, D. P., Linsley, P. S., & Johnson, J. M. (2005) · Nature · doi:10.1038/nature03315 · Cited by 4,755 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
The molecular biology of memory storage: a dialogue between genes and synapses
Kandel, E. R. (2001) · Science · doi:10.1126/science.1067020 · Cited by 3,917 · see citing works
Self-citationA Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626 · see citing works
Self-citationArgonaute HITS-CLIP decodes microRNA–mRNA interaction maps
Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. (2009) · Nature · doi:10.1038/nature08170 · Cited by 1,791 · see citing works
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Farh, K. K.-H., Grimson, A., Jan, C., Lewis, B. P., Johnston, W. K., Lim, L. P., Burge, C. B., & Bartel, D. P. (2005) · Science · doi:10.1126/science.1121158 · Cited by 1,484 · see citing works
Selective Blockade of MicroRNA Processing by Lin28
Viswanathan, S. R., Daley, G. Q., & Gregory, R. I. (2008) · Science · doi:10.1126/science.1154040 · Cited by 1,442 · see citing works
Makeyev, E. V., Zhang, J., Carrasco, M. A., & Maniatis, T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.015 · Cited by 1,395 · see citing works
Relief of microRNA-Mediated Translational Repression in Human Cells Subjected to Stress
Bhattacharyya, S. N., Habermacher, R., Martiné, U., Closs, E. I., & Filipowicz, W. (2006) · Cell · doi:10.1016/j.cell.2006.04.031 · Cited by 1,332 · see citing works
The Small RNA Profile during Drosophila melanogaster Development
Aravin, A. A., Lagos‐Quintana, M., Yalçın, A., Zavolan, M., Marks, D. S., Snyder, B., Gaasterland, T., Meyer, J., & Tuschl, T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00228-4 · Cited by 960 · see citing works
Self-citationLin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
Heo, I., Joo, C., Cho, J., Ha, M., Han, J., & Kim, V. N. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.09.014 · Cited by 947 · see citing works
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works
Impey, S., Obrietan, K. H., Wong, S. T., Poser, S., Yano, S., Wayman, G. A., Deloulme, J., Chan, G. C. ‐., & Storm, D. R. (1998) · Neuron · doi:10.1016/s0896-6273(00)80602-9 · Cited by 889 · see citing works
Rybak‐Wolf, A., Fuchs, H. R., Smirnova, L., Brandt, C., Pohl, E. E., Nitsch, R., & Wulczyn, F. G. (2008) · Nature Cell Biology · doi:10.1038/ncb1759 · Cited by 788 · see citing works
Montarolo, P. G., Goelet, P., Castellucci, V. F., Morgan, J., Kandel, E. R., & Schacher, S. (1986) · Science · doi:10.1126/science.3775383 · Cited by 769 · see citing works
Self-citationA microRNA controlling left/right neuronal asymmetry in Caenorhabditis elegans
Johnston, R. J., & Hobert, O. (2003) · Nature · doi:10.1038/nature02255 · Cited by 760 · see citing works
Dash, P. K., Hochner, B., & Kandel, E. R. (1990) · Nature · doi:10.1038/345718a0 · Cited by 747 · see citing works
Self-citationEarly origins and evolution of microRNAs and Piwi-interacting RNAs in animals
Grimson, A., Srivastava, M., Fahey, B., Woodcroft, B. J., Chiang, H. R., King, N., Degnan, B. M., Rokhsar, D. S., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07415 · Cited by 725 · see citing works
Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia
Kupfermann, I., Castellucci, V. F., Pinsker, H. M., & Kandel, E. R. (1970) · Science · doi:10.1126/science.167.3926.1743 · Cited by 658 · see citing works
Self-citationBarco, A., Alarcon, J. M., & Kandel, E. (2002) · Cell · doi:10.1016/s0092-8674(02)00657-8 · Cited by 595 · see citing works
Self-citationRuby, J. G., Stark, E., Johnston, W. K., Kellis, M., Bartel, D. P., & Lai, E. C. (2007) · Genome Research · doi:10.1101/gr.6597907 · Cited by 591 · see citing works
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development
Visvanathan, J., Lee, S., Lee, B., Lee, J. W., & Lee, S.-K. (2007) · Genes & Development · doi:10.1101/gad.1519107 · Cited by 579 · see citing works
Martin, K. C., Michael, D., Rose, J. C., Barad, M., Casadio, A., Zhu, H., & Kandel, E. R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80330-x · Cited by 545 · see citing works
Self-citationC/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
Alberini, C. M., Ghirardl, M., Metz, R., & Kandel, E. R. (1994) · Cell · doi:10.1016/0092-8674(94)90386-7 · Cited by 523 · see citing works
Self-citationIdentification of microRNAs and other small regulatory RNAs using cDNA library sequencing
Hafner, M., Landgraf, P., Ludwig, J., Rice, A., Ojo, T., Lin, C. P., Holoch, D., Lim, C., & Tuschl, T. (2007) · Methods · doi:10.1016/j.ymeth.2007.09.009 · Cited by 480 · see citing works
Self-citationSynaptic Protein Synthesis Associated with Memory Is Regulated by the RISC Pathway in Drosophila
Ashraf, S. I., McLoon, A. L., Sclarsic, S. M., & Kunes, S. M. (2006) · Cell · doi:10.1016/j.cell.2005.12.017 · Cited by 446 · see citing works
Post-transcriptional regulation of microRNA expression
Obernosterer, G., Leuschner, P. J. F., Alenius, M., & Martinez, J. (2006) · RNA · doi:10.1261/rna.2322506 · Cited by 391 · see citing works
Castellucci, V. F., Kandel, E. R., Schwartz, J. H., Wilson, F. D., Nairn, A. C., & Greengard, P. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7492 · Cited by 383 · see citing works
Self-citationBartsch, D., Casadio, A., Karl, K. A., Serodio, P., & Kandel, E. R. (1998) · Cell · doi:10.1016/s0092-8674(00)81752-3 · Cited by 373 · see citing works
Self-citationHegde, A. N., Inokuchi, K., Pei, W., Casadio, A., Ghirardi, M., Chain, D. G., Martin, K. C., Kandel, E. R., & Schwartz, J. H. (1997) · Cell · doi:10.1016/s0092-8674(00)80188-9 · Cited by 359 · see citing works
Self-citationPosttranscriptional Regulation of miRNAs Harboring Conserved Terminal Loops
Michlewski, G., Guil, S., Semple, C. A. M., & Cáceres, J. F. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.013 · Cited by 337 · see citing works
Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry
Moroz, L. L., Edwards, J. R., Puthanveettil, S. V., Kohn, A. B., Ha, T. J., Heyland, A., Knudsen, B., Sahni, A., Yu, F., Liu, L., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.052 · Cited by 323 · see citing works
Self-citationThe developmental miRNA profiles of zebrafish as determined by small RNA cloningPreprint
Chen, P., Manninga, H., Slanchev, K., Chien, M., Russo, J. J., Ju, J., Sheridan, R., John, B., Marks, D. S., Gaidatzis, D., et al. (2005) · Genes & Development · doi:10.1101/gad.1310605 · Cited by 323 · see citing works
Self-citationSchacher, S., & Proshansky, E. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-12-02403.1983 · Cited by 279 · see citing works
The birth and death of microRNA genes in Drosophila
Lü, J., Shen, Y., Wu, Q., Kumar, S., He, B., Shi, S., Carthew, R. W., Wang, S. M., & Wu, C. (2008) · Nature Genetics · doi:10.1038/ng.73 · Cited by 249 · see citing works
RNA Trafficking and Local Protein Synthesis in Dendrites: An Overview
Martin, K. C., & Zukin, R. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1801-06.2006 · Cited by 218 · see citing works
Fine-tuning neural gene expression with microRNAs
Schratt, G. M. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.05.015 · Cited by 159 · see citing works
The evolution and functional diversification of animal microRNA genes
Liu, N., Okamura, K., Tyler, D. M., Phillips, M. D., Chung, W., & Lai, E. C. (2008) · Cell Research · doi:10.1038/cr.2008.278 · Cited by 153 · see citing works
Structure and Mechanism of RNA Ligase
Ho, C. K., Wang, L., Lima, C. D., & Shuman, S. (2004) · Structure · doi:10.1016/j.str.2004.01.011 · Cited by 148 · see citing works
Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons.
Sacktor, T. C., & Schwartz, J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.5.2036 · Cited by 100 · see citing works
Puthanveettil, S. V., Monje, F. J., Miniaci, M. C., Choi, Y., Karl, K. A., Khandros, E., Gawinowicz, M. A., Sheetz, M. P., & Kandel, E. R. (2008) · Cell · doi:10.1016/j.cell.2008.11.003 · Cited by 88 · see citing works
Self-citationLiu, R.-Y., Fioravante, D., Shah, S., & Byrne, J. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3848-07.2008 · Cited by 73 · see citing works
miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
Cheng, L.-C., Pastrana, E., Tavazoie, M., & Doetsch, F. (2009) · Nature Neuroscience · doi:10.1038/nn.2294
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Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · see citing works
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Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works
An updated role of microRNA-124 in central nervous system disorders: a review
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- Authors
- Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., & Kandel, E.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Turin (IT)
- Memorial Sloan Kettering Cancer Center (US)
- Columbia University (US)
- Corresponding author
- Tuschl, Thomas
- Kandel, Eric
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 63
- Issue
- 6
- Pages
- 803-817
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2875683
- OpenAlex
- W2059222949
- Cited by
- 406
- References
- 52
- Citations by year
- 2026: 2 · 2025: 16 · 2024: 16 · 2023: 18 · 2022: 15 · 2021: 17 · 2020: 24 · 2019: 20 · 2018: 16 · 2017: 29 · 2016: 26 · 2015: 26 · 2014: 36 · 2013: 40 · 2012: 37
- FWCI
- 14.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- Italian Academy for Advanced Studies in America, Columbia University
- National Institute of Mental Health (R01MH075026, F30MH086267)
- National Human Genome Research Institute (P50HG002806)
- National Institute of General Medical Sciences (P01GM073047)
- National Institute of Neurological Disorders and Stroke (R01NS060762)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- microRNA, miR-124, Aplysia californica, synaptic plasticity, CREB, serotonin, sensory-motor synapses, presynaptic modulation, memory storage, novel miRNAs, long-term plasticity, small regulatory RNAs
- MeSH terms
- Analysis of Variance, Animals, Aplysia, Central Nervous System, Dose-Response Relationship, Drug, Enzyme Inhibitors, Molecular Biology, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Protein Binding, Serotonin, Synapses, Time Factors, Oligonucleotides, Antisense, Kinesins, Cyclic AMP Response Element-Binding Protein, Evolution, Molecular, Excitatory Postsynaptic Potentials, MicroRNAs, Ubiquitin Thiolesterase
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