Cited by 136Neuroscience and Neural EngineeringSilk-based biomaterials and applicationsElectrospun Nanofibers in Biomedical Applications

The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.

Silk as a Multifunctional Biomaterial Substrate for Reduced Glial Scarring around Brain‐Penetrating Electrodes

Open access

Tien, Lee W., Wu, Fan, Tang‐Schomer, Min D., Yoon, Euisik, Omenetto, Fiorenzo G., Kaplan, David L.·2013·Advanced Functional Materials

DOI 10.1002/adfm.201203716

Open this paper in CoChat — free account Open PDF

Abstract

The reliability of chronic, brain‐penetrating electrodes must be improved for these ‐neural recording technologies to be viable in widespread clinical applications. One approach to improving electrode reliability is to reduce the foreign body response at the probe‐tissue interface. In this work, silk fibroin is investigated as a candidate material for fabricating mechanically dynamic neural probes with enhanced biocompatibility compared to traditional electrode materials. Silk coatings are applied to flexible cortical electrodes to produce devices that transition from stiff to flexible upon hydration. Theoretical modeling and in vitro testing show that the silk coatings impart mechanical properties sufficient for the electrodes to penetrate brain tissue. Further, it is demonstrated that silk coatings may reduce some markers of gliosis in an in vitro model and that silk can encapsulate and release the gliosis‐modifying enzyme chondroitinase ABC. This work establishes a basis for future in vivo studies of silk‐based brain‐penetrating electrodes, as well as the use of silk materials for other applications in the central nervous system where gliosis must be controlled.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1002/adfm.201203716

Cites

75 of 75 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Silk-based biomaterials
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
Self-citation
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue
Farndale, R. W., Buttle, D. J., & Barrett, A. J. (1986) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(86)90306-5 · Cited by 3,309
Materials fabrication from Bombyx mori silk fibroin
Rockwood, D. N., Preda, R. C., Yücel, T., Wang, X., Lovett, M. L., & Kaplan, D. L. (2011) · Nature Protocols · doi:10.1038/nprot.2011.379 · Cited by 3,149
Self-citation
Response of brain tissue to chronically implanted neural electrodes
Polikov, V. S., Tresco, P. A., & Reichert, W. M. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.08.015 · Cited by 1,896
Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics
Kim, D.-H., Viventi, J., Amsden, J. J., Xiao, J., Vigeland, L., Kim, Y.-S., Blanco, J. A., Panilaitis, B., Frechette, E. S., Contreras, D., et al. (2010) · Nature Materials · doi:10.1038/nmat2745 · Cited by 1,721
Self-citation
CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure
Fitch, M. T., & Silver, J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.014 · Cited by 1,007
Brain responses to micro-machined silicon devices
Szarowski, D. H., Andersen, M. D., Retterer, S. T., Spence, A. J., Isaacson, M. S., Craighead, H. G., Turner, J. N., & Shain, W. G. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03023-3 · Cited by 811
In vivo degradation of three-dimensional silk fibroin scaffolds
Wang, Y., Rudym, D., Walsh, A., Abrahamsen, L., Kim, H.-J., Kim, H. S., Kirker‐Head, C. A., & Kaplan, D. L. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.05.002 · Cited by 788
Self-citation
The inflammatory responses to silk films in vitro and in vivo
Meinel, L., Hofmann, S., Karageorgiou, V., Kirker‐Head, C. A., McCool, J., Gronowicz, G., Zichner, L., Langer, R., Vunjak‐Novakovic, G., & Kaplan, D. L. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.02.047 · Cited by 785
Self-citation
Water-insoluble silk films with silk I structure
Lu, Q., Hu, X., Wang, X., Kluge, J. A., Lu, S., Cebe, P., & Kaplan, D. L. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.10.041 · Cited by 654
Self-citation

Flagged first, then by citations

Show all 75 references

Research works printed but not linked: 3

T.Suzuki K.Mabuchi S.Takeuchi inProc. First International IEEE EMBS Conference on Neural Engineering2003; pp.154–156.
Y.Zhong G. C.McConnell J. D.Ross S. P.DeWeerth R. V.Bellamkonda in2nd International IEEE EMBS Conference on Neural Engineering 2005 pp.522–525.
F.Wu M.Im E.Yoon in16th International Solid‐State Sensors Actuators and Microsystems Conference (TRANSDUCERS) 2011 pp.966–969.

Sorted by citations

Glial responses to implanted electrodes in the brain
Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642
Current and Novel Polymeric Biomaterials for Neural Tissue Engineering
Boni, R., Ali, A., Shavandi, A., & Clarkson, A. N. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0491-8 · Cited by 439
Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
Jorfi, M., Skousen, J. L., Weder, C., & Capadona, J. R. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/1/011001 · Cited by 384
Tools for Probing Local Circuits: High-Density Silicon Probes Combined with Optogenetics
Buzsáki, G., Stark, E., Berényi, A., Khodagholy, D., Kipke, D. R., Yoon, E., & Wise, K. D. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.028 · Cited by 337
Self-citation
Soft Materials in Neuroengineering for Hard Problems in Neuroscience
Jeong, J.-W., Shin, G., Park, S. I., Yu, K. J., Xu, L., & Rogers, J. A. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.035 · Cited by 333
Dealing with the Foreign‐Body Response to Implanted Biomaterials: Strategies and Applications of New Materials
Zhang, D., Chen, Q., Shi, C., Chen, M., Ma, K., Wan, J., & Liu, R. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202007226 · Cited by 306
3D in vitro modeling of the central nervous system
Hopkins, A. M., DeSimone, E. K., Chwalek, K., & Kaplan, D. L. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.11.003 · Cited by 234
Self-citation
A review on mechanical considerations for chronically-implanted neural probes
Lecomte, A., Descamps, E., & Bergaud, C. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aa8b4f · Cited by 205
DARPA-funded efforts in the development of novel brain–computer interface technologies
Miranda, R. A., Casebeer, W. D., Hein, A. M., Judy, J. W., Krotkov, E., Laabs, T. L., Manzo, J. E., Pankratz, K., Pratt, G. A., Sanchez, J. C., et al. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.07.019 · Cited by 185
Flexible, Penetrating Brain Probes Enabled by Advances in Polymer Microfabrication
Weltman, A., Yoo, J. J., & Meng, E. F. (2016) · Micromachines · doi:10.3390/mi7100180 · Cited by 192
Rapid evaluation of the durability of cortical neural implants using accelerated aging with reactive oxygen species
Takmakov, P. A., Ruda, K., Phillips, K. S., Isayeva, I. S., Krauthamer, V., & Welle, C. G. (2015) · Journal of Neural Engineering · doi:10.1088/1741-2560/12/2/026003 · Cited by 183
Flexible, multifunctional neural probe with liquid metal enabled, ultra-large tunable stiffness for deep-brain chemical sensing and agent delivery
Wen, X., Wang, B., Huang, S., Liu, T. “., Lee, M., Chung, P., Chow, Y. T., Huang, I.-W., Monbouquette, H. G., Maidment, N. T., et al. (2019) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2019.01.060 · Cited by 162
Ultra-thin flexible polyimide neural probe embedded in a dissolvable maltose-coated microneedle
Xiang, Z., Yen, S.-C., Xue, N., Sun, T., Tsang, W. M., Zhang, S., Liao, L., Thakor, N. V., & Lee, C. (2014) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/24/6/065015 · Cited by 157
Soft, Flexible Freestanding Neural Stimulation and Recording Electrodes Fabricated from Reduced Graphene Oxide
Apollo, N. V., Maturana, M. I., Tong, W., Nayagam, D. A. X., Shivdasani, M. N., Foroughi, J., Wallace, G. G., Prawer, S., Ibbotson, M. R., & Garrett, D. J. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201500110 · Cited by 156
Nanofabricated Ultraflexible Electrode Arrays for High‐Density Intracortical Recording
Wei, X., Luan, L., Zhao, Z., Li, X., Zhu, H., Potnis, O., & Xie, C. (2018) · Advanced Science · doi:10.1002/advs.201700625 · Cited by 149
Implantable intracortical microelectrodes: reviewing the present with a focus on the future
Wang, Y., Yang, X., Zhang, X., Wang, Y., & Pei, W. (2023) · Microsystems & Nanoengineering · doi:10.1038/s41378-022-00451-6 · Cited by 147
A review of electrodes for the electrical brain signal recording
Im, C., & Seo, J.-M. (2016) · Biomedical Engineering Letters · doi:10.1007/s13534-016-0235-1 · Cited by 141
Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine
Balakrishnan, G., Song, J., Mou, C., & Bettinger, C. J. (2021) · Advanced Materials · doi:10.1002/adma.202106787 · Cited by 135
Curcumin-releasing mechanically adaptive intracortical implants improve the proximal neuronal density and blood–brain barrier stability
Potter, K. A., Jorfi, M., Householder, K. T., Foster, E. J., Weder, C., & Capadona, J. R. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.01.018 · Cited by 127
Biocompatible silk step-index optical waveguides
Applegate, M. B., Perotto, G., Kaplan, D. L., & Omenetto, F. G. (2015) · Biomedical Optics Express · doi:10.1364/boe.6.004221 · Cited by 118
Self-citation
Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes
Calia, A. B., Masvidal‐Codina, E., Smith, T., Schaefer, N., Rathore, D., Rodríguez-Lucas, E., Illa, X., de la Cruz, J. M., del Corro, E., Prats‐Alfonso, E., et al. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-01041-9 · Cited by 121
Silk and PEG as means to stiffen a parylene probe for insertion in the brain: toward a double time-scale tool for local drug delivery
Lecomte, A., Castagnola, V, Descamps, E., Dahan, L., Blatché, M. C., Dinis, T. M., Leclerc, E., Egles, C., & Bergaud, C. (2015) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/25/12/125003 · Cited by 110
Recent development of implantable and flexible nerve electrodes
Shi, Y., Liu, R., He, L. M., Feng, H., Li, Y., & Li, Z. (2020) · Smart Materials in Medicine · doi:10.1016/j.smaim.2020.08.002 · Cited by 93
Neural tissue-microelectrode interaction: Brain micromotion, electrical impedance, and flexible microelectrode insertion
Sharafkhani, N., Kouzani, A. Z., Adams, S. D., Long, J. M., Lissorgues, G., Rousseau, L., & Orwa, J. O. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109388 · Cited by 86
Injectable Biomedical Devices for Sensing and Stimulating Internal Body Organs
Jung, Y. H., Kim, J. U., Lee, J. S., Shin, J. H., Jung, W., Ok, J., & Kim, T. (2020) · Advanced Materials · doi:10.1002/adma.201907478 · Cited by 88
Synthetic Engineering of Spider Silk Fiber as Implantable Optical Waveguides for Low-Loss Light Guiding
Qiao, X., Qian, Z., Li, J., Sun, H., Han, Y. F., Xia, X., Zhou, J., Wang, C., Wang, Y., & Wang, C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b01752 · Cited by 84
Multimaterial and multifunctional neural interfaces: from surface-type and implantable electrodes to fiber-based devices
Sung, C., Jeon, W., Nam, K. S., Kim, Y., Butt, H., & Park, S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00872a · Cited by 87
A Parylene Neural Probe Array for Multi-Region Deep Brain Recordings
Wang, X., Weltman, A., Xu, H., Slingsby-Smith, Z., Lecomte, A., Scholten, K., Song, D. B., & Meng, E. F. (2020) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2020.3000235 · Cited by 87
Silk-Backed Structural Optimization of High-Density Flexible Intracortical Neural Probes
Wu, F., Tien, L. W., Chen, F., Berke, J. D., Kaplan, D. L., & Yoon, E. (2015) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2014.2375326 · Cited by 80
Self-citation
Surface-Functionalized Silk Fibroin Films as a Platform To Guide Neuron-like Differentiation of Human Mesenchymal Stem Cells
Manchineella, S., Thrivikraman, G., Basu, B., & Govindaraju, T. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b06403 · Cited by 74
Film‐Based Implants for Supporting Neuron–Electrode Integrated Interfaces for The Brain
Tang‐Schomer, M. D., Hu, X., Hronik‐Tupaj, M., Tien, L. W., Whalen, M. J., Omenetto, F. G., & Kaplan, D. L. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201303196 · Cited by 71
Self-citation
Advances in Carbon-Based Microfiber Electrodes for Neural Interfacing
Hejazi, M., Tong, W., Ibbotson, M. R., Prawer, S., & Garrett, D. J. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.658703 · Cited by 77
A comparison of insertion methods for surgical placement of penetrating neural interfaces
Thielen, B., & Meng, E. F. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abf6f2 · Cited by 78
Flexible and Implantable Polyimide Aptamer-Field-Effect Transistor Biosensors
Zhao, C., Man, T., Cao, Y. F., Weiss, P. S., Monbouquette, H. G., & Andrews, A. M. (2022) · ACS Sensors · doi:10.1021/acssensors.2c01909 · Cited by 61
Neural Probes for Chronic Applications
Kook, G., Lee, S., Lee, H., Cho, I., & Lee, H. J. (2016) · Micromachines · doi:10.3390/mi7100179 · Cited by 61
Progress and challenges of implantable neural interfaces based on nature-derived materials
Riva, E. R., & Micera, S. (2021) · Bioelectronic Medicine · doi:10.1186/s42234-021-00067-7 · Cited by 59
A Review: Research Progress of Neural Probes for Brain Research and Brain–Computer Interface
Luo, J., Xue, N., & Chen, J. (2022) · Biosensors · doi:10.3390/bios12121167 · Cited by 63
Integration of 2D and 3D Thin Film Glassy Carbon Electrode Arrays for Electrochemical Dopamine Sensing in Flexible Neuroelectronic Implants
VanDersarl, J. J., Mercanzini, A., & Renaud, P. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201402934 · Cited by 57
A Removable Insertion Shuttle for Ultraflexible Neural Probe Implantation with Stable Chronic Brain Electrophysiological Recording
Zhang, S., Wang, C., Gao, H., Yu, C., Yan, Q., Lu, Y., Tao, Z., Linghu, C., Chen, Z., Xu, K., et al. (2020) · Advanced Materials Interfaces · doi:10.1002/admi.201901775 · Cited by 56
Engineering strategies towards overcoming bleeding and glial scar formation around neural probes
Otte, E., Vlachos, A., & Asplund, M. (2022) · Cell and Tissue Research · doi:10.1007/s00441-021-03567-9 · Cited by 54
Microfabricated Probes for Studying Brain Chemistry: A Review
Ngernsutivorakul, T., White, T. S., & Kennedy, R. T. (2018) · ChemPhysChem · doi:10.1002/cphc.201701180 · Cited by 52
Gels, jets, mosquitoes, and magnets: a review of implantation strategies for soft neural probes
Apollo, N. V., Murphy, B. B., Prezelski, K., Driscoll, N., Richardson, A. G., Lucas, T. H., & Vitale, F. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abacd7 · Cited by 47
The Neuroinflammatory Response to Nanopatterning Parallel Grooves into the Surface Structure of Intracortical Microelectrodes
Ereifej, E. S., Smith, C. S., Meade, S. M., Chen, K., Feng, H., & Capadona, J. R. (2017) · Advanced Functional Materials · doi:10.1002/adfm.201704420 · Cited by 45
Dextran as a Resorbable Coating Material for Flexible Neural Probes
Kil, D., Carmona, M. B., Ceyssens, F., Deprez, M., Brancato, L., Nuttin, B., Balschun, D., & Puers, R. (2019) · Micromachines · doi:10.3390/mi10010061 · Cited by 41
Control of neural probe shank flexibility by fluidic pressure in embedded microchannel using PDMS/PI hybrid substrate
Rezaei, S., Xu, Y., & Pang, S. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220258 · Cited by 42
Surface biotechnology for refining cochlear implants
Tan, F., Walshe, P., Viani, L. G., & Al‐Rubeai, M. (2013) · Trends in biotechnology · doi:10.1016/j.tibtech.2013.09.001 · Cited by 40
Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system
Thompson, C. H., Riggins, T. E., Patel, P. R., Chestek, C. A., Li, W., & Purcell, E. K. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab7030 · Cited by 38
Engineering and commercialization of human-device interfaces, from bone to brain
Tate, M. L. K., Detamore, M. S., Capadona, J. R., Woolley, A. J., & Knothe, U. R. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.03.038 · Cited by 40
Multimodal neural probes for combined optogenetics and electrophysiology
Tian, H., Xu, K., Zou, L., & Fang, Y. Z. (2021) · iScience · doi:10.1016/j.isci.2021.103612 · Cited by 41
Silk: A bio-derived coating for optical fiber sensing applications
Khalid, A., Peng, L., Arman, A., Warren-Smith, S. C., Schartner, E. P., Sylvia, G. M., Hutchinson, M. R., Ebendorff‐Heidepriem, H., McLaughlin, R. A., Gibson, B. C., et al. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.127864 · Cited by 38
Distributed implantation of a flexible microelectrode array for neural recording
Wei, C., Wang, Y., Pei, W., Han, X., Lin, L., Liu, Z., Ming, G., Chen, R., Wu, P., Yang, X., et al. (2022) · Microsystems & Nanoengineering · doi:10.1038/s41378-022-00366-2 · Cited by 38
Toward Nontransient Silk Bioelectronics: Engineering Silk Fibroin for Bionic Links
Patil, A. C., Xiong, Z., & Thakor, N. V. (2020) · Small Methods · doi:10.1002/smtd.202000274 · Cited by 37
Electrodeposited silk coatings for bone implants
Elia, R., Michelson, C. D., Perera, A. L., Brunner, T. F., Harsono, M., Leisk, G. G., Kugel, G., & Kaplan, D. L. (2014) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33351 · Cited by 36
Self-citation
Designing Silk Biomaterials toward Better Future Healthcare: The Development and Application of Silk‐Based Implantable Electronic Devices in Clinical Diagnosis and Therapy
Lv, Q., Li, Q., Cao, P., Wei, C., Li, Y., Wang, Z., & Wang, L. (2024) · Advanced Materials · doi:10.1002/adma.202411946 · Cited by 35
A review on 3D printing functional brain model
Samanipour, R., Tahmooressi, H., Nejad, H. R., Hirano, M., Shin, S. R., & Hoorfar, M. (2022) · Biomicrofluidics · doi:10.1063/5.0074631 · Cited by 37
Mechanics Strategies for Implantation of Flexible Neural Probes
Zhang, S., Wang, C., Linghu, C., Wang, S., & Song, J. (2020) · Journal of Applied Mechanics · doi:10.1115/1.4047858 · Cited by 34
Development and Characterization of a Sucrose Microneedle Neural Electrode Delivery System
Apollo, N. V., Jiang, J. L., Cheung, W., Baquier, S. H., Lai, A., Mirebedini, A., Foroughi, J., Wallace, G. G., Shivdasani, M. N., Prawer, S., et al. (2017) · Advanced Biosystems · doi:10.1002/adbi.201700187 · Cited by 34
In vitro and in vivo characterization of SU-8 flexible neuroprobe: From mechanical properties to electrophysiological recording
Huang, S.-H., Lin, S., & Chen, J. J. (2014) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2014.06.005 · Cited by 33
Overcoming failure: improving acceptance and success of implanted neural interfaces
Dalrymple, A. N., Jones, S. T., Fallon, J. B., Shepherd, R. K., & Weber, D. J. (2025) · Bioelectronic Medicine · doi:10.1186/s42234-025-00168-7 · Cited by 38
Degradable, silyl ether thiol–ene networks
Ware, T. H., Jennings, A. R., Bassampour, Z. S., Simon, D., Son, D. Y., & Voit, W. (2014) · RSC Advances · doi:10.1039/c4ra06997h · Cited by 32
The role of inflammation on the functionality of intracortical microelectrodes
Gaire, J., Lee, H. C., Hilborn, N., Ward, R., Regan, M., & Otto, K. J. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aae4b6 · Cited by 35
Stiffness tunable implanted electrode enabled by magnetic liquid metal for wireless hyperthermia
Sun, X., Guo, R., Yuan, B., Wang, H., Duan, M., Yang, Y., Zhu, X., Wang, X., Chen, S., Cheng, J., et al. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101495 · Cited by 30
Bioactive polymer-enabled conformal neural interface and its application strategies
Hu, Z., Niu, Q., Hsiao, B. S., Yao, X., & Zhang, Y. (2022) · Materials Horizons · doi:10.1039/d2mh01125e · Cited by 30
Silk electrogel coatings for titanium dental implants
Elia, R., Michelson, C. D., Perera, A. L., Harsono, M., Leisk, G. G., Kugel, G., & Kaplan, D. L. (2014) · Journal of Biomaterials Applications · doi:10.1177/0885328214561536 · Cited by 29
Self-citation
Wafer-Scale Multilayer Fabrication for Silk Fibroin-Based Microelectronics
Kook, G., Jeong, S., Kim, S. H., Kim, M. K., Lee, S., Cho, I.-J., Choi, N., & Lee, H. J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b13170 · Cited by 28
Dissolvable Base Scaffolds Allow Tissue Penetration of High‐Aspect‐Ratio Flexible Microneedles
Yagi, S., Yamagiwa, S., Kubota, Y., Sawahata, H., Numano, R., Imashioya, T., Oi, H., Ishida, M., & Kawano, T. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500305 · Cited by 28
Brown Recluse Spider's Nanometer Scale Ribbons of Stiff Extensible Silk
Schniepp, H. C., Koebley, S. R., & Vollrath, F. W. (2013) · Advanced Materials · doi:10.1002/adma.201302740 · Cited by 26
Polymer hydration and stiffness at biointerfaces and related cellular processes
Kerch, G. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.08.012 · Cited by 27
Progress in Research of Flexible MEMS Microelectrodes for Neural Interface
Tang, L., Wang, M., Tian, H., Kang, X., Hong, W., & Liu, J. (2017) · Micromachines · doi:10.3390/mi8090281 · Cited by 23
The effects of electrical stimulation on glial cell behaviour
Tsui, C. T., Lal, P., Fox, K. V. R., Churchward, M. A., & Todd, K. G. (2022) · BMC Biomedical Engineering · doi:10.1186/s42490-022-00064-0 · Cited by 25
Characterization of the Optical Properties of Turbid Media by Supervised Learning of Scattering Patterns
Hassaninia, I., Bostanabad, R., Chen, W., & Mohseni, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-15601-4 · Cited by 22
A novel assembly method for 3-dimensional microelectrode array with micro-drive
Wang, M., Ji, B., Gu, X., Guo, Z., Wang, X., Yang, B. T., Li, C., & Liu, J. (2018) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2018.02.147 · Cited by 22
Film interface for drug testing for delivery to cells in culture and in the brain
Tang‐Schomer, M. D., Kaplan, D. L., & Whalen, M. J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.02.052 · Cited by 22
Self-citation
Natural based reusable materials for microfluidic substrates: The silk road towards sustainable portable analytical systems
Brito‐Pereira, R., Macedo, A. S., Ribeiro, C., Cardoso, V. F., & Lanceros-Méndez, S. (2022) · Applied Materials Today · doi:10.1016/j.apmt.2022.101507 · Cited by 21
Flexible‐Device Injector with a Microflap Array for Subcutaneously Implanting Flexible Medical Electronics
Song, K., Kim, J., Cho, S., Kim, N., Jung, D., Choo, H., & Lee, J. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800419 · Cited by 21
Flexible deep brain neural probes based on a parylene tube structure
Zhao, Z., Kim, E. H., Luo, H., Zhang, J., & Xu, Y. P. (2017) · Journal of Micromechanics and Microengineering · doi:10.1088/1361-6439/aa9d61 · Cited by 20
The past, present, and future of in vivo -implantable recording microelectrodes: the neural interfaces
Liu, K., Zhang, H., Hu, M., Li, Z., Xu, K., Chen, D., Cui, W., Lv, C., Ding, R., Geng, X., et al. (2024) · Materials Advances · doi:10.1039/d3ma01105d · Cited by 23
Implanting mechanics of PEG/DEX coated flexible neural probe: impacts of fabricating methods
Zhang, W., Zhou, X., He, Y., Xu, L., & Xie, J. (2021) · Biomedical Microdevices · doi:10.1007/s10544-021-00552-5 · Cited by 18
Intrinsically Soft Implantable Electronics for Long‐term Biosensing Applications
Lee, S. H., Lee, H., Lee, S., Kim, D., Kim, H. J., & Sunwoo, S. (2025) · Advanced Sensor Research · doi:10.1002/adsr.202500002 · Cited by 18
Bioengineered Silk Gene Delivery System for Nuclear Targeting
Yiğit, S., Tokareva, O. S., Varone, A., Georgakoudi, I., & Kaplan, D. L. (2014) · Macromolecular Bioscience · doi:10.1002/mabi.201400113 · Cited by 17
Self-citation
The state-of-the-art of invasive brain-computer interfaces in humans: a systematic review and individual patient meta-analysis
Lim, M. J. R., Lo, Y. T., Tan, Y. Y., Lin, H.-Y., Wang, Y., Tan, D., Wang, E., Ma, Y. Y. N., Ng, J. J. W., Jefree, R. A., et al. (2025) · Journal of Neural Engineering · doi:10.1088/1741-2552/adb88e · Cited by 18
Silk coating as a novel delivery system and reversible adhesive for stiffening and shaping flexible probes
Metallo, C., & Trimmer, B. A. (2015) · Journal of Biological Methods · doi:10.14440/jbm.2015.41 · Cited by 17
Glial cells, but not neurons, exhibit a controllable response to a localized inflammatory microenvironment in vitro
Sommakia, S., Rickus, J. L., & Otto, K. J. (2014) · Frontiers in Neuroengineering · doi:10.3389/fneng.2014.00041 · Cited by 15
Fabrication of a Multilayer Implantable Cortical Microelectrode Probe to Improve Recording Potential
Liu, X., Bibineyshvili, Y., Robles, D. A., Boreland, A. J., Margolis, D. J., Shreiber, D. I., & Zahn, J. D. (2021) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2021.3092230 · Cited by 14
Effect of silk fibroin protein hydrolysis on biochemistry, gelation kinetics, and NF-kB bioactivity in vitro
Lawrence, B. D., & Infanger, D. W. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132702 · Cited by 15
Types of biomaterials useful in brain repair
Ali, M. A., & Bhuiyan, M. H. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105034 · Cited by 14
Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications
Guo, B., Ye, F., Wang, M., Cheng, Y., Ji, B., Chen, Y., & Wang, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111528 · Cited by 14
Flexible Neural Probes with Optical Artifact-Suppressing Modification and Biofriendly Polypeptide Coating
Wang, M., Ye, F., Li, L., Wen, F., Guo, B., Jin, M., Xu, J., Zhou, Y., Kang, X., Ji, B., et al. (2022) · Micromachines · doi:10.3390/mi13020199 · Cited by 13
Polymer‐Incorporated Mechanically Compliant Carbon Nanotube Microelectrode Arrays for Multichannel Neural Signal Recording
Roh, H., Kim, K., Kim, C., Kim, M. J., Kim, M., Sim, S., Kim, J., Ok, J. G., & Im, M. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202509630 · Cited by 13
Instructive proteins for tissue regeneration
Guarino, V., Benfenati, V., Maya, I. C., Saracino, E., Zamboni, R., & Ambrosio, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100979-6.00002-1 · Cited by 11
Design and material for a patternable polysiloxane acrylate-based penetrating intracortical neural probe
Jung, W., Heo, C., Kim, J. U., Jeong, C., Ryu, H., Park, B., Suh, M., & Kim, T. (2021) · Journal of Micromechanics and Microengineering · doi:10.1088/1361-6439/abdb78 · Cited by 11
Silkworm Gut Fiber of Bombyx mori as an Implantable and Biocompatible Light-Diffusing Fiber
Cenís, J. L., Aznar‐Cervantes, S. D., Pérez, A. A. L., Rojo, M., Muñoz, J., Meseguer‐Olmo, L., & Arenas, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071142 · Cited by 10
Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces
Yan, Z., Gao, W., Duan, Y.-Y., Zhou, H., Ni, C., Huang, L., & Ye, Z. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.06.014 · Cited by 13
A polymer neural probe with tunable flexibility
Ejserholm, F., Vastesson, A., Haraldsson, T., van der Wijngaart, W., Schouenborg, J., Wallman, L., & Bengtsson, M. (2013) · International IEEE/EMBS Conference on Neural Engineering · doi:10.1109/ner.2013.6696028 · Cited by 9
Bioresorbable Insertion Aids for Brain Implantable Flexible Probes: A Comparative Study on Silk Fibroin, Alginate, and Disaccharides
Cerezo‐Sánchez, M., McGlynn, E., Bartoletti, S., Yalagala, B. P., Garofani, B. C., Capodiferro, A., Russell, E., Palazzolo, G., Walton, F., Curia, G., et al. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200117 · Cited by 8
Cortical Network Synchrony Under Applied Electrical Field in vitro
Tang‐Schomer, M. D., Jackvony, T. N., & Santaniello, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00630 · Cited by 8
Self-citation
Flexible parylene-thread bioprobe and the sewing method for in vivo neuronal recordings
Yamashita, K., Sawahata, H., Yamagiwa, S., Morikawa, Y., Numano, R., Koida, K., & Kawano, T. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.127835 · Cited by 8
Stiffness‐Tunable Neurotentacles for Minimally Invasive Implantation and Long‐Term Neural Activity Recordings
Wang, Y., Xu, X., Yang, X., Tang, R., Chen, Y., Zang, S., Wang, Y., Liang, J., & Pei, W. (2025) · Advanced Science · doi:10.1002/advs.202505100 · Cited by 8
Electrogelated drug-embedded silk/gelatin/rGO degradable electrode for anti-inflammatory applications in brain-implant systems
Lin, Z.-K., Lin, J.-S., Chen, Z.-H., Cheng, H.-W., Huang, W.-C., & Chen, S.-Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02715e · Cited by 7
Neural cell cultures to study spinal cord injury
McCanney, G. A., Whitehead, M. J., McGrath, M. A., Lindsay, S. L., & Barnett, S. C. (2017) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2018.10.005 · Cited by 7

Authors: Tien, L. W., Wu, F., Tang‐Schomer, M. D., Yoon, E., Omenetto, F. G., & Kaplan, D. L.
Affiliations: Tufts University (US)
University of Michigan (US)
Corresponding author: Kaplan, David L.
ORCID: Wu, Fan
Tang‐Schomer, Min D.
Omenetto, Fiorenzo G.
Kaplan, David L.
Venue: Advanced Functional Materials
Publisher: Wiley
Published: 2013-01-24
Volume: 23
Issue: 25
Pages: 3185-3193
ISSN: 1616-301X (ISSN-L)
1616-3028
DOI: 10.1002/adfm.201203716
OpenAlex: W2021310862
Cited by: 136
References: 75
Citations by year: 2026: 7 · 2025: 9 · 2024: 7 · 2023: 9 · 2022: 12 · 2021: 15 · 2020: 14 · 2019: 4 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 10 · 2014: 14 · 2013: 4
FWCI: 6.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Functional Materials (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Institutes of Health (EB002520)
Air Force Office of Scientific Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: silk fibroin, glial scar, gliosis, foreign body reaction, neural recording, hydrogel coating, chondroitinase ABC, enzyme encapsulation, biocompatibility, mechanical properties

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Silk as a Multifunctional Biomaterial Substrate for Reduced Glial Scarring around Brain‐Penetrating Electrodes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks