Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance

Edland, S. D.; Silverman, J. M.; Peskind, E. R.; Tsuang, D.; Wijsman, E.; Morris, J. C.

doi:10.1212/wnl.47.1.254

Cited by 145Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchGenetic Associations and Epidemiology

Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance

Edland, S. D., Silverman, J. M., Peskind, E. R., Tsuang, D., Wijsman, E., Morris, J. C.·1996·Neurology

DOI 10.1212/wnl.47.1.254

Open this paper in CoChat — free account

Abstract

This study tests the hypothesis of maternal inheritance of AD in families of 118 subjects with this disorder enrolled in The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The parental generation included 24 subjects with dementia. Using the Cox proportional hazards model, we found the age-adjusted mother-to-father relative risk to be 2.8 (95% CI, 1.1 to 7.7). Among a subset of 10 families with one affected parent and at least two affected siblings, the ratio of affected mothers-to-fathers was 9:1. These findings support recent studies that found a high mother-to-father ratio among affected parents of subjects with AD. Together, these results suggest maternal inheritance of AD and are consistent with several hypotheses regarding the genetic nature of AD.

Integrity signals

Registry

Crossref · 10.1212/wnl.47.1.254

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Both mothers and fathers contribute to their offspring's AD risk, but mothers contribute more because mtDNA is maternally inherited.
“In this respect, both mothers and fathers contribute to their offspring's AD risk, but because mitochondrial DNA (mtDNA) is maternally inherited mothers contribute more.”
From The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives (2014) · cites this paper as [113]
Cognitively normal, middle-aged individuals with AD mothers have a higher risk of developing AD than middle-aged individuals with AD fathers or no AD-affected parents.
“Cognitively normal, middle-aged individuals with AD mothers, who have a higher risk of developing AD than middle aged individuals with AD fathers or no AD-affected parents [131], have relatively low platelet COX activities [132].”
From Brain aging, Alzheimer's disease, and mitochondria (2011) · cites this paper as [131]

Neurosurgical horizons in Parkinson's disease
Goetz, C. G., Long, M. R. D., Penn, R. D., & Bakay, R. A. E. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.1 · Cited by 405 · see citing works
Megadose corticosteroids in multiple sclerosis
Kupersmith, M. J., Kaufman, D., Paty, D. W., Ebers, G. C., McFarland, H., Johnson, K., Reingold, S. C., & Whitaker, J. N. (1994) · Neurology · doi:10.1212/wnl.44.1.1 · Cited by 386 · see citing works
Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei.
Trask, B. J., Massa, H. F., Kenwrick, S. J., & Gitschier, J. M. (1991) · PubMed · Cited by 220 · see citing works
[New material and information about the History of the plants of New Spain by Francisco Hernandez].
Jm, L. P., & Tomás, J. P. (1994) · PubMed · Cited by 167 · see citing works
A comparison of familial and sporadic Alzheimer's disease
Duara, R., Lopez-Alberola, R. F., Barker, W. W., Loewenstein, D. A., Zatinsky, M., Eisdorfer, C. E., & Weinberg, G. B. (1993) · Neurology · doi:10.1212/wnl.43.7.1377 · Cited by 122 · see citing works
Segregation analysis reveals evidence of a major gene for Alzheimer disease.
Farrer, L. A., Myers, R. H., Connor, L., Cupples, L. A., & Growdon, J. H. (1991) · PubMed · Cited by 82 · see citing works
Increased risk of familial late-onset Alzheimer's disease in women
Payami, H., Montee, K. R., Grimslid, H., Shattuc, S., & Kaye, J. A. (1996) · Neurology · doi:10.1212/wnl.46.1.126 · Cited by 38 · see citing works
A Radiation Hybrid Map of Human Chromosome 11q22-q23 Containing the Ataxia-Telangiectasia Disease Locus
Richard, C. W., Cox, D., Kapp, L. N., Murnane, J. P., Cornélis, F., Julier, C., Lathrop, M. G., & James, M. R. (1993) · Genomics · doi:10.1006/geno.1993.1275 · Cited by 25 · see citing works
Hepatitis C and its sequelae: the biology of hepatitis C virus and implications for its control.
Purcell, R. H. (1995) · PubMed · Cited by 4 · see citing works
Announcement
Paykel, E. S. (1995) · Psychological Medicine · doi:10.1017/s0033291700028026 · Cited by 3 · see citing works

Flagged first, then by citations

Sorted by citations

Mitochondrial Dysfunction in Neurodegenerative Diseases
Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806 · see citing works
Mitochondria, oxidative stress and neurodegeneration
Federico, A., Cardaioli, E., Pozzo, P. D., Formichi, P., Gallus, G. N., & Radi, E. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.05.030 · Cited by 790 · see citing works
The Alzheimer’s disease mitochondrial cascade hypothesis: progress and perspectives
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.010 · Cited by 786 · see citing works
A “mitochondrial cascade hypothesis” for sporadic Alzheimer’s disease
Swerdlow, R. H., & Khan, S. M. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.12.045 · Cited by 758 · see citing works
Mitochondrial dysfunction in neurodegenerative diseases
Beal, M. F. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00114-5 · Cited by 608 · see citing works
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis
Swerdlow, R. H., Burns, J. M., & Khan, S. M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100339 · Cited by 562 · see citing works
“This phenomenon persists after correcting for increased female longevity and higher rates of AD among women [40].”
BackgroundResult
The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease
Monzio Compagnoni, G., Di Fonzo, A., Corti, S., Comi, G. P., Bresolin, N., & Masliah, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01926-1 · Cited by 378 · see citing works
Mitochondria in Neurodegeneration: Acute Ischemia and Chronic Neurodegenerative Diseases
Fiskum, G. M., Murphy, A. N., & Beal, M. F. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199904000-00001 · Cited by 351 · see citing works
RETRACTED: Mutations in mitochondrial cytochrome <i>c</i> oxidase genes segregate with late-onset Alzheimer disease
Davis, R. E., Miller, S., Herrnstadt, C., Ghosh, S. S., Fahy, E., Shinobu, L. A., Galasko, D., Thal, L. J., Beal, M. F., Howell, N., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4526 · Cited by 341 · see citing works
Retracted
Brain aging, Alzheimer's disease, and mitochondria
Swerdlow, R. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.012 · Cited by 306 · see citing works
“Cognitively normal, middle-aged individuals with AD mothers, who have a higher risk of developing AD than middle aged individuals with AD fathers or no AD-affected parents [131], have relatively low platelet COX activities [132].”
Background
Insulin Resistance and Alzheimer’s Disease: Bioenergetic Linkages
Neth, B., & Craft, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00345 · Cited by 263 · see citing works
A Long Journey into Aging, Brain Aging, and Alzheimer’s Disease Following the Oxidative Stress Tracks
Mecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 256 · see citing works
Pathogenesis of Alzheimer's disease.
Swerdlow, R. H. (2007) · PubMed Central · Cited by 236 · see citing works
Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
Mosconi, L., Brys, M., Switalski, R., Mistur, R., Glodzik, L., Pirraglia, E., Tsui, W., De Santi, S., & de Leon, M. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705036104 · Cited by 237 · see citing works
Amyloid burden and neural function in people at risk for Alzheimer's Disease
Johnson, S. C., Christian, B. T., Okonkwo, O. C., Oh, J. M., Harding, S., Xu, G., Hillmer, A. T., Wooten, D. W., Murali, D., Barnhart, T. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.028 · Cited by 218 · see citing works
The Alzheimer's disease mitochondrial cascade hypothesis: an update
Swerdlow, R. H., & Khan, S. M. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.011 · Cited by 206 · see citing works
The role of mitochondrial dysfunction in age-related diseases
Lane, R. K., Hilsabeck, T., & Rea, S. L. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.021 · Cited by 205 · see citing works
Mitochondria and Cell Bioenergetics: Increasingly Recognized Components and a Possible Etiologic Cause of Alzheimer's Disease
Swerdlow, R. H. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4149 · Cited by 203 · see citing works
Mitochondria in Neurodegeneration
Lezi, E., & Swerdlow, R. H. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-2869-1_12 · Cited by 204 · see citing works
Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease
Mosconi, L., Mistur, R., Switalski, R., Brys, M., Glodzik, L., Rich, K., Pirraglia, E., Tsui, W., De Santi, S., & de Leon, M. J. (2009) · Neurology · doi:10.1212/01.wnl.0000333247.51383.43 · Cited by 188 · see citing works
Role of mitochondrial homeostasis and dynamics in Alzheimer's disease
Selfridge, J. E., E, L., Lu, J., & Swerdlow, R. H. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.057 · Cited by 175 · see citing works
Mitochondrial involvement in Alzheimer’s disease
Bonilla, E., Tanji, K., Hirano, M., Vu, T., DiMauro, S., & Schon, E. A. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00165-0 · Cited by 165 · see citing works
Mitochondrial DNA mutations in neurodegeneration
Keogh, M. J., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.015 · Cited by 163 · see citing works
Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia
Coskun, P. E., Wyrembak, J., Derbereva, O., Melkonian, G., Doran, E. W., Lott, I. T., Head, E., Cotman, C. W., & Wallace, D. C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100351 · Cited by 158 · see citing works
The role of mitochondria in neurodegenerative diseases
Filosto, M., Scarpelli, M., Cotelli, M. S., Vielmi, V., Todeschini, A., Gregorelli, V., Tonin, P., Tomelleri, G., & Padovani, A. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6104-z · Cited by 140 · see citing works
Current Concepts in the Pathogenesis of Alzheimer’s Disease
Carr, D. B., Goate, A., Phil, D., & Morris, J. C. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00262-3 · Cited by 140 · see citing works
Increased fibrillar amyloid-β burden in normal individuals with a family history of late-onset Alzheimer’s
Mosconi, L., Rinne, J. O., Tsui, W. H., Berti, V., Li, Y., Wang, H., Murray, J., Scheinin, N., Någren, K., Williams, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914141107 · Cited by 135 · see citing works
Ovarian hormone loss induces bioenergetic deficits and mitochondrial β-amyloid
Yao, J., Irwin, R. W., Chen, S., Hamilton, R., Cadenas, E., & Brinton, R. D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.001 · Cited by 133 · see citing works
Mitochondrial DNA analysis: polymorphisms and pathogenicity
Chinnery, P. F., Howell, N., Andrews, R. M., & Turnbull, D. M. (1999) · Journal of Medical Genetics · doi:10.1136/jmg.36.7.505 · Cited by 128 · see citing works
White matter is altered with parental family history of Alzheimer's disease
Bendlin, B. B., Ries, M. L., Canu, E., Sodhi, A., Lazar, M., Alexander, A. L., Carlsson, C. M., Sager, M. A., Asthana, S., & Johnson, S. C. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2009.11.003 · Cited by 124 · see citing works
Mitochondria in Alzheimer's disease
Swerdlow, R. H., & Kish, S. J. (2002) · International review of neurobiology · doi:10.1016/s0074-7742(02)53013-0 · Cited by 126 · see citing works
Mitochondrial dysfunction and Alzheimer's disease
Maruszak, A., & Żekanowski, C. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.004 · Cited by 123 · see citing works
Phylogenetic analysis of the mitochondrial genome indicates significant differences between patients with Alzheimer disease and controls in a French-Canadian founder population.
Chagnon, P., Gee, M., Filion, M., Robitaille, Y., Belouchi, M., & Gauvreau, D. (1999) · American journal of medical genetics · doi:10.1002/(sici)1096-8628(19990702)85:1 · Cited by 128 · see citing works
Shift in brain metabolism in late onset Alzheimer’s disease: Implications for biomarkers and therapeutic interventions
Yao, J., Rettberg, J. R., Klosinski, L. P., Cadenas, E., & Brinton, R. D. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.005 · Cited by 124 · see citing works
Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease
Wilkins, H., & Swerdlow, R. H. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150827095102 · Cited by 122 · see citing works
The Neurodegenerative Mitochondriopathies
Swerdlow, R. H. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1095 · Cited by 112 · see citing works
Mitochondria, Cybrids, Aging, and Alzheimer's Disease
Swerdlow, R. H., Koppel, S., Weidling, I., Hayley, C., Ji, Y., & Wilkins, H. M. (2017) · Progress in Molecular Biology and Translational Science · doi:10.1016/bs.pmbts.2016.12.017 · Cited by 106 · see citing works
Insight into the genetic etiology of Alzheimer's disease: A comprehensive review of the role of rare variants
Hoogmartens, J., Cacace, R., & Broeckhoven, C. V. (2021) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12155 · Cited by 101 · see citing works
Reduced gray matter volume in normal adults with a maternal family history of Alzheimer disease
Honea, R. A., Swerdlow, R. H., Vidoni, E. D., Goodwin, J., & Burns, J. M. (2010) · Neurology · doi:10.1212/wnl.0b013e3181c918cb · Cited by 106 · see citing works
Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration
Wilkins, H. M., Weidling, I. W., Ji, Y., & Swerdlow, R. H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00508 · Cited by 102 · see citing works
Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis
Weidling, I. W., & Swerdlow, R. H. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113321 · Cited by 100 · see citing works
Relative risk for Alzheimer disease based on complete family history
Cannon‐Albright, L., Foster, N. L., Schliep, K. C., Farnham, J. M., Teerlink, C. C., Kaddas, H. K., Tschanz, J. T., Corcoran, C., & Kauwe, J. S. K. (2019) · Neurology · doi:10.1212/wnl.0000000000007231 · Cited by 100 · see citing works
Reduced mitochondria cytochrome oxidase activity in adult children of mothers with Alzheimer's disease
Mosconi, L., de Leon, M., Murray, J., E, L., Lu, J., Javier, E., McHugh, P., & Swerdlow, R. H. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110866 · Cited by 97 · see citing works
Mitochondrial Dysfunction in Idiopathic Parkinson Disease
Parker, W. D., & Swerdlow, R. H. (1998) · The American Journal of Human Genetics · doi:10.1086/301812 · Cited by 97 · see citing works
Ovariectomy Induces a Shift in Fuel Availability and Metabolism in the Hippocampus of the Female Transgenic Model of Familial Alzheimer's
Ding, F., Yao, J., Zhao, L., Mao, Z., Chen, S., & Brinton, R. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059825 · Cited by 90 · see citing works
Use of Cytoplasmic Hybrid Cell Lines for Elucidating the Role of Mitochondrial Dysfunction in Alzheimer's Disease and Parkinson's Disease
Ghosh, S. S., Swerdlow, R. H., Miller, S. W., Sheeman, B., Parker, W. D., & DAVIS, R. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07825.x · Cited by 91 · see citing works
mtDNA mutations and common neurodegenerative disorders
Howell, N., Elson, J. L., Chinnery, P. F., & Turnbull, D. M. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.08.012 · Cited by 90 · see citing works
Maternal transmission of Alzheimer's disease: prodromal metabolic phenotype and the search for genes
Mosconi, L., Berti, V., Swerdlow, R. H., Pupi, A., Duara, R., & de Leon, M. (2010) · Human Genomics · doi:10.1186/1479-7364-4-3-170 · Cited by 85 · see citing works
The mitochondrial hypothesis: Dysfunction, bioenergetic defects, and the metabolic link to Alzheimer's disease
Swerdlow, R. H. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.01.008 · Cited by 88 · see citing works
The Alzheimer’s Disease Mitochondrial Cascade Hypothesis: A Current Overview
Swerdlow, R. H. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221286 · Cited by 83 · see citing works
Recent developments in the molecular genetics of mitochondrial disorders
Graeber, M. B., & Müller, U. (1998) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)00295-5 · Cited by 79 · see citing works
Epigenetic studies in Alzheimer's disease: Current findings, caveats, and considerations for future studies
Lunnon, K., & Mill, J. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32201 · Cited by 78 · see citing works
Association of parental dementia with cognitive and brain MRI measures in middle-aged adults
Debette, S., Wolf, P. A., Beiser, A., Au, R., Himali, J. J., Pikula, A., Auerbach, S. H., DeCarli, C. S., & Seshadri, S. S. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c67833 · Cited by 77 · see citing works
Inhibition by R(+) or S(–) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH‐SY5Y neuroblastoma
Abramova, N. N., Cassarino, D. S., Khan, S. M., Painter, T. W., & Bennett, J. P. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10127 · Cited by 74 · see citing works
Preventive effect of melatonin against brain mitochondria DNA damage, lipid peroxidation and seizures induced by kainic acid
Mohanan, P. V., & Yamamoto, H. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00475-1 · Cited by 73 · see citing works
Genetic risk factors in Alzheimer's disease.
Tilley, L. A., Morgan, K., & Kalsheker, N. A. (1998) · Molecular Pathology · doi:10.1136/mp.51.6.293 · Cited by 71 · see citing works
Structural neuroimaging in preclinical dementia: From microstructural deficits and grey matter atrophy to macroscale connectomic changes
Mak, E., Gabel, S., Mirette, H., Su, L., Williams, G. B., Waldman, A., Wells, K., Ritchie, K., Ritchie, C., & O’Brien, J. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.001 · Cited by 71 · see citing works
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents
Mosconi, L., Rinne, J. O., Tsui, W. H., Murray, J., Li, Y., Glodzik, L., McHugh, P. F., Williams, S., Cummings, M., Pirraglia, E., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.03.002 · Cited by 67 · see citing works
Evidence for parent of origin effect in late-onset Alzheimer disease
Bassett, S. S., Avramopoulos, D., & Fallin, D. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.10648 · Cited by 66 · see citing works
mtDNA Mutations That Cause Optic Neuropathy: How Do We Know?
Howell, N., Smejkal, C. B., Jamieson, R. V., Marenda, D. R., & Mackey, D. A. (1998) · The American Journal of Human Genetics · doi:10.1086/301675 · Cited by 65 · see citing works
Mitochondrial Microheteroplasmy and a Theory of Aging and Age-Related Disease
Smigrodzki, R. M., & Khan, S. M. (2005) · Rejuvenation Research · doi:10.1089/rej.2005.8.172 · Cited by 62 · see citing works
Apolipoprotein E ϵ4 Allele and Familial Aggregation of Alzheimer Disease
Martinez, M. M., Campion, D., Brice, A., Hannequin, D., Dubois, B., Didierjean, O., Michon, A., Thomas-Antérion, C., Puel, M., Frébourg, T., et al. (1998) · Archives of Neurology · doi:10.1001/archneur.55.6.810 · Cited by 63 · see citing works
Effect of α-ketoglutarate and oxaloacetate on brain mitochondrial DNA damage and seizures induced by kainic acid in mice
Yamamoto, H., & Mohanan, P. V. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(03)00114-0 · Cited by 61 · see citing works
Mitochondrial Dysfunction and Stress Responses in Alzheimer’s Disease
Weidling, I. W., & Swerdlow, R. H. (2019) · Biology · doi:10.3390/biology8020039 · Cited by 56 · see citing works
Structural brain changes in normal individuals with a maternal history of Alzheimer's
Berti, V., Mosconi, L., Glodzik, L., Li, Y., Murray, J., De Santi, S., Pupi, A., Tsui, W., & De Leon, M. J. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.01.001 · Cited by 58 · see citing works
Mitochondria and Alzheimer’s Disease: the Role of Mitochondrial Genetic Variation
Ridge, P. G., & Kauwe, J. S. K. (2018) · Current Genetic Medicine Reports · doi:10.1007/s40142-018-0132-2 · Cited by 57 · see citing works
Ganglioside GT1B and melatonin inhibit brain mitochondrial DNA damage and seizures induced by kainic acid in mice
Yamamoto, H., & Mohanan, P. V. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04083-0 · Cited by 57 · see citing works
Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing
Turner, C., & Schapira, A. H. V. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-1249-3_19 · Cited by 56 · see citing works
Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease
Ray, W. J., Ashall, F., & Goate, A. (1998) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01229-5 · Cited by 55 · see citing works
Effects of ApoE4 and maternal history of dementia on hippocampal atrophy
Andrawis, J. P., Hwang, K. S., Green, A. E., Kotlerman, J., Elashoff, D., Morra, J. H., Cummings, J. L., Toga, A. W., Thompson, P. M., & Apostolova, L. G. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.020 · Cited by 54 · see citing works
Brain imaging of cognitively normal individuals with 2 parents affected by late-onset AD
Mosconi, L., Murray, J., Tsui, W. H., Li, Y., Spector, N. C., Goldowsky, A. M., Williams, S., Osorio, R. S., McHugh, P. F., Glodzik, L., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000181 · Cited by 51 · see citing works
Mitochondrial Genomic Analysis of Late Onset Alzheimer’s Disease Reveals Protective Haplogroups H6A1A/H6A1B: The Cache County Study on Memory in Aging
Ridge, P. G., Maxwell, T. J., Corcoran, C. D., Norton, M. C., Tschanz, J. T., O’Brien, E., Kerber, R. A., Cawthon, R., Munger, R. G., & Kauwe, J. S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045134 · Cited by 52 · see citing works
Triad of Risk for Late Onset Alzheimer’s: Mitochondrial Haplotype, APOE Genotype and Chromosomal Sex
Wang, Y., & Brinton, R. D. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00232 · Cited by 52 · see citing works
Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection
Wilkins, H., Carl, S. M., Greenlief, A. C. S., Festoff, B. W., & Swerdlow, R. H. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00311 · Cited by 48 · see citing works
Mitochondrial DNA Sequence Variation Associated with Dementia and Cognitive Function in the Elderly
Tranah, G. J., The Health, A. A. B. C. S., Nalls, M. A., Katzman, S. M., Yokoyama, J. S., Lam, E. T., Zhao, Y., Mooney, S. D., Thomas, F., Newman, A. B., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120466 · Cited by 50 · see citing works
Variability of age at onset in siblings with familial Alzheimer disease
Gómez-Tortosa, E., Barquero, M. S., Barón, M., Sainz, M. J., Manzano, S., Payno, M., Ros, R., Almaraz, C., Gómez-Garré, P., & Jiménez-Escrig, A. (2007) · Archives of Neurology · doi:10.1001/archneur.64.12.1743 · Cited by 47 · see citing works
Oxidative stress and amyloid-beta pathology in normal individuals with a maternal history of Alzheimer's
Mosconi, L., Glodzik, L., Mistur, R., McHugh, P., Rich, K. E., Javier, E., Williams, S., Pirraglia, E., De Santi, S., Mehta, P. D., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.011 · Cited by 46 · see citing works
Genetic basis of Alzheimer's dementia: role of mtDNA mutations
Grazina, M. M., Pratas, J., Silva, F., Oliveira, S. A., Santana, I. J., & Oliveira, C. R. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00225.x · Cited by 44 · see citing works
Comparing Brain Amyloid Deposition, Glucose Metabolism, and Atrophy in Mild Cognitive Impairment with and without a Family History of Dementia
Mosconi, L., Initiative, A. D. N., Andrews, R. D., & Matthews, D. C. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121867 · Cited by 43 · see citing works
No evidence of association between common European mitochondrial DNA variants in Alzheimer, Parkinson, and migraine in the Spanish population
Fachal, L., Mosquera‐Miguel, A., Pástor, P., Ortega‐Cubero, S., Lorenzo, E., Durán, A. O., Toriello, M., Quintáns, B., Camiña-Tato, M., Sesar, Á., et al. (2014) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32276 · Cited by 42 · see citing works
Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans
Tranah, G. J., Yokoyama, J. S., Katzman, S. M., Nalls, M. A., Newman, A. B., Harris, T. B., Cesari, M., Manini, T. M., Schork, N. J., Cummings, S. R., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.023 · Cited by 40 · see citing works
Exploratory analysis of mtDNA haplogroups in two Alzheimer's longitudinal cohorts
Swerdlow, R. H., Hui, D., Chalise, P., Sharma, P., Wang, X., Andrews, S. J., Pa, J., Mahnken, J. D., Morris, J. K., Wilkins, H., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12119 · Cited by 39 · see citing works
Genetic of Alzheimer's Disease: A Narrative Review Article.
Khanahmadi, M., Farhud, D. D., & Malmir, M. (2015) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Using Biomarkers to Improve Detection of Alzheimer’s Disease
Biagioni, M. C., & Galvin, J. E. (2011) · Neurodegenerative Disease Management · doi:10.2217/nmt.11.11 · Cited by 34 · see citing works
New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders
Wilkins, H., & Morris, J. K. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612822666161230144517 · Cited by 34 · see citing works
Polymorphic variation in cytochrome oxidase subunit genes
Lu, J., Wang, K., Rodova, M., Esteves, R., Berry, D., E, L., Crafter, A., Barrett, M., Cardoso, S. M., Onyango, I., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100123 · Cited by 33 · see citing works
Long-Term Effect of Acetyl-L-Carnitine for Antiretroviral Toxic Neuropathy
Herzmann, C., Johnson, M. A., & Youle, M. S. (2005) · HIV Clinical Trials · doi:10.1310/ch1n-ybnu-g3cu-jbxr · Cited by 33 · see citing works
Further evidence of a maternal parent‐of‐origin effect on chromosome 10 in late‐onset Alzheimer's disease
Bassett, S. S., Avramopoulos, D., Perry, R. T., Wiener, H. W., Watson, B., Go, R. C. P., & Fallin, M. D. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30350 · Cited by 33 · see citing works
Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter
Furlong, R. A., Ho, L. W., Rubinsztein, J. S., Walsh, C., Paykel, E. S., & Rubinsztein, D. C. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 100 · see citing works
Linear Regression with a Randomly Censored Covariate: Application to an Alzheimer's Study
Atem, F., Qian, J., Maye, J. E., Johnson, K. A., & Betensky, R. A. (2016) · Journal of the Royal Statistical Society Series C (Applied Statistics) · doi:10.1111/rssc.12164 · Cited by 26 · see citing works
Ceramides may Play a Central Role in the Pathogenesis of Alzheimer’s Disease: a Review of Evidence and Horizons for Discovery
Kalkman, H. O., & Smigielski, L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04989-0 · Cited by 29 · see citing works
The Effects of Curcumin on Astrocytes in Common Neurodegenerative Conditions
Alameri, A. A., Ghanni, M. U., Ali, A., Singh, M., Al-Gazally, M. E., Almulla, A. F., Ramírez‐Coronel, A. A., Mustafa, Y. F., Gupta, R., Obaid, R. F., et al. (2023) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557523666230502143131 · Cited by 31 · see citing works
Mortality from hereditary cerebral haemorrhage with amyloidosis--Dutch type. The impact of sex, parental transmission and year of birth
Bornebroek, M. (1997) · Brain · doi:10.1093/brain/120.12.2243 · Cited by 24 · see citing works
Mitochondrial Genetic Variants and Alzheimer Disease: A Case-Control Study of the T4336C and G5460A Variants
Edland, S. D., Tobe, V. O., Rieder, M. J., Bowen, J. D., McCormick, W. C., Teri, L. L., Schellenberg, G. D., Larson, E. B., Nickerson, D. A., & Kukull, W. A. (2002) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-200201000-00001 · Cited by 23 · see citing works
Mitochondrial pathway polygenic risk scores are associated with Alzheimer's Disease
Paliwal, D., McInerney, T. W., Pa, J., Swerdlow, R. H., Easteal, S., Andrews, S. J., & Initiative, F. T. A. D. N. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.08.005 · Cited by 21 · see citing works
Cognitively normal individuals with AD parents may be at risk for developing aging-related cortical thinning patterns characteristic of AD
Reiter, K. E., Alpert, K. I., Cobia, D. J., Kwasny, M., Morris, J. C., Csernansky, J. G., & Wang, L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.083 · Cited by 21 · see citing works
Common defects of mitochondria and iron in neurodegeneration and diabetes (MIND): A paradigm worth exploring
Stroh, M. A., Swerdlow, R. H., & Zhu, H. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.11.022 · Cited by 20 · see citing works
In Vivo and in Vitro Effects of Melatonin or Ganglioside GT1B on L-Cysteine-Induced Brain Mitochondrial DNA Damage in Mice
Yamamoto, H. (2003) · Toxicological Sciences · doi:10.1093/toxsci/kfg089 · Cited by 19 · see citing works
Mitochondria: how eminent in ageing and neurodegenerative disorders?
Bamshad, C., Najafi-Ghalehlou, N., Pourmohammadi-Bejarpasi, Z., Tomita, K., Kuwahara, Y., Sato, T., Feizkhah, A., Roushnadeh, A. M., & Roudkenar, M. H. (2022) · Human Cell · doi:10.1007/s13577-022-00833-y · Cited by 19 · see citing works
Maternal imprinting on cognition markers of wild type and transgenic Alzheimer’s disease model mice
Zamarbide, M., Gil-Bea, F. J., Bannenberg, P., Martínez‐Pinilla, E., Sandoval, J., Franco, R., & Pérez‐Mediavilla, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-24710-7 · Cited by 17 · see citing works

P1‐232: Maternal Transmission of Alzheimer's Disease
Heggeli, K., Thomas, C. S., Crook, J. E., & Graff‐Radford, N. R. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.512
Maternal Transmission of Alzheimer Disease
Heggeli, K., Crook, J. E., Thomas, C. S., & Graff‐Radford, N. R. (2012) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318247d203 · Cited by 13 · see citing works
Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?
Lautenschlager, N. T., Cupples, L. A., Rao, V. S., Auerbach, S. A., Becker, R., Burke, J., Chui, H., Duara, R., Foley, E. J., Glatt, S. L., et al. (1996) · Neurology · doi:10.1212/wnl.46.3.641 · Cited by 298 · see citing works
Increased risk of Alzheimer's disease in mothers of adults with Down's syndrome
Schupf, N., Kapell, D., Lee, J. H., Schupf, N., Ottman, R., Mayeux, R. P., Lee, J. H., Ottman, R., Ottman, R., & Mayeux, R. P. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91398-6 · Cited by 104 · see citing works
Analysis of the monoamine oxidase A (MAOA) gene in bipolar affective disorder by association studies, meta-analyses, and sequencing of the promoter
Furlong, R. A., Ho, L. W., Rubinsztein, J. S., Walsh, C., Paykel, E. S., & Rubinsztein, D. C. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19990820)88:4 · Cited by 100 · see citing works

Authors: Edland, S. D., Silverman, J. M., Peskind, E. R., Tsuang, D., Wijsman, E., & Morris, J. C.
Affiliations: University of Washington (US)
ORCID: Edland, S. D.
Peskind, E. R.
Tsuang, D.
Wijsman, E.
Morris, J. C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-07
Volume: 47
Issue: 1
Pages: 254-256
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.47.1.254
OpenAlex: W2154744393
Cited by: 145
References: 10
Citations by year: 2026: 2 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 8
FWCI: 4.50
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG06790, AG 05136, U01AG006790, P50AG005136)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: Alzheimer's disease, dementia, maternal inheritance, familial aggregation, genetic risk
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Dementia, Female, Humans, Mothers, Risk Factors, Survival Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased risk of dementia in mothers of Alzheimer's disease cases: Evidence for maternal inheritance

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks