The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
Abstract
Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the course of several neurological disorders. Environmentally enriched mice may actually mimic human disease more accurately. We found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal littermates, maximal enrichment was required to induce a marked improvement in behavioral tests. Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468
Apoptosis in neurodegenerative disorders
Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434
Evans, D. A., Hebert, L. E., Beckett, L. A., Scherr, P. A., Albert, M. S., Chown, M. J., Pilgrim, D. M., & Taylor, J. O. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550230066019 · Cited by 435
Cited by
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771
Self-citationMolecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease
Zuccato, C., Valenza, M., & Cattaneo, E. (2010) · Physiological Reviews · doi:10.1152/physrev.00041.2009 · Cited by 848
Duan, W., Guo, Z., Jiang, H., Ware, M., Li, X.-J., & Mattson, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0536856100 · Cited by 428
Laviola, G., Hannan, A. J., Macrì, S., Solinas, M., & Jaber, M. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.05.001 · Cited by 300
Self-citationEpigenetic influence of social experiences across the lifespan
Champagne, F. A. (2010) · Developmental Psychobiology · doi:10.1002/dev.20436 · Cited by 273
Pang, T. Y. C., Stam, N. C., Nithianantharajah, J., Howard, M. L., & Hannan, A. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.04.013 · Cited by 265
Self-citationHannan, A. J. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12102 · Cited by 240
Self-citationInoculation stress hypothesis of environmental enrichment.
Crofton, E. J., Zhang, Y., & Green, T. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.017 · Cited by 206
Kondo, M., Gray, L. J., Pelka, G. J., Christodoulou, J., Tam, P. P. L., & Hannan, A. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06305.x · Cited by 190
Self-citationThe pathogenic mechanisms of polyglutamine diseases and current therapeutic strategies
Bauer, P. O., & Nukina, N. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06302.x · Cited by 178
Laboratory environments and rodents' behavioural needs: a review
Balcombe, J. P. (2006) · Laboratory Animals · doi:10.1258/002367706777611488 · Cited by 176
Paulsen, J. S., Nance, M., Kim, J.-I., Carlozzi, N. E., Panegyres, P. K., Erwin, C., Goh, A., McCusker, E., & Williams, J. K. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.08.003 · Cited by 168
Environmental enrichment and the sensory brain: The role of enrichment in remediating brain injury
Alwis, D. S., & Rajan, R. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00156 · Cited by 129
Busse, M., Quinn, L., Debono, K., Jones, K., Collett, J., Playle, R., Kelly, M., Simpson, S., Backx, K., Wasley, D., et al. (2013) · Journal of Neurologic Physical Therapy · doi:10.1097/npt.0000000000000016 · Cited by 97
Madinier, A., Quattromani, M. J., Sjölund, C., Ruscher, K., & Wieloch, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093121 · Cited by 82
Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice
Li, M., Huang, Y., Ma, A. A. K., Lin, E., & Diamond, M. I. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.011 · Cited by 68
Effects of chronic stress on the onset and progression of Huntington’s disease in transgenic mice
Mo, C., Renoir, T., & Hannan, A. J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.008 · Cited by 46
Self-citationDecanalization, brain development and risk of schizophrenia
McGrath, J. J., Hannan, A. J., & Gibson, G. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.16 · Cited by 45
Self-citationTurner, K. M., & Burne, T. H. J. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00097 · Cited by 16
“This neurodegenerative condition has a genetic cause, yet mice housed in enriched cages show delayed onset and progression of both the motor and cognitive deficits compared to standard housed controls (Hockly et al., 2002; Nithianantharajah and Hannan, 2006; Pang et al., 2006).”
Background
Metadata
- Authors
- Hockly, E., Cordery, P. M., Woodman, B., Mahal, A., Van Dellen, A., Blakemore, C., Lewis, C. M., Hannan, A. J., & Bates, G. P.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2002-01-31
- Volume
- 51
- Issue
- 2
- Pages
- 235-242
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W1972251644
- Cited by
- 330
- References
- 5
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
