Enriched housing enhances recovery of limb placement ability and reduces aggrecan-containing perineuronal nets in the rat somatosensory cortex after experimental stroke.
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Stroke causes life long disabilities where few therapeutic options are available. Using electrical and magnetic stimulation of the brain and physical rehabilitation, recovery of brain function can be enhanced even late after stroke. Animal models support this notion, and housing rodents in an enriched environment (EE) several days after experimental stroke stimulates lost brain function by multisensory mechanisms. We studied the dynamics of functional recovery of rats with a lesion to the fore and hind limb motor areas induced by photothrombosis (PT), and with subsequent housing in either standard (STD) or EE. In this model, skilled motor function is not significantly enhanced by enriched housing, while the speed of recovery of sensori-motor function substantially improves over the 9-week study period. In particular, this stroke lesion completely obliterates the fore and hind limb placing ability when visual and whisker guidance is prevented, a deficit that persists for up to 9 weeks of recovery, but that is markedly restored within 2 weeks by enriched housing. Enriched housing after stroke also leads to a significant loss of perineuronal net (PNN) immunoreactivity; detection of aggrecan protein backbone with AB1031 antibody was decreased by 13-22%, and labelling of a glycan moiety of aggrecan with Cat-315 antibody was reduced by 25-30% in the peri-infarct area and in the somatosensory cortex, respectively. The majority of these cells are parvalbumin/GABA inhibitory interneurons that are important in sensori-information processing. We conclude that damage to the fore and hind limb motor areas provides a model of loss of limb placing response without visual guidance, a deficit also seen in more than 50% of stroke patients. This loss is amenable to recovery induced by multiple sensory stimulation and correlates with a decrease in aggrecan-containing PNNs around inhibitory interneurons. Modulating the PNN structure after ischemic damage may provide new therapies enhancing tactile/proprioceptive function after stroke.
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Rats housed in enriched environments following ischemic damage exhibited faster neurological recovery compared to rats placed in standard housing.
“recent findings in rodent stroke models indicate that rats housed in enriched environments following ischemic damage exhibited faster neurological recovery compared to rats placed in standard housing (Madinier et al., 2014; Quattromani et al., 2018).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Madinier et al., 2014
Ischemia-induced damage of PNs in rat neocortices was analyzed by Bidmon et al. (1998) and by Wieloch's research group using a similar animal model.
“Using a similar animal model, ischemia-induced damage of PNs in rat neocortices was analyzed by Bidmon et al. (1998) and by Wieloch’s research group (Madinier et al., 2014; Quattromani et al., 2017).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Madinier et al., 2014
Abolished and decomposed PNs were reported for other animal models of experimentally induced stroke in neocortices of rats.
“Based on WFA staining, abolished and decomposed PNs were also reported for other animal models of experimentally induced stroke in neocortices of rats (Hobohm et al., 2005; Karetko-Sysa et al., 2011; Madinier et al., 2014; Quattromani et al., 2017).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Madinier et al., 2014
Following cortical photothrombotic stroke in rats, enriched housing after ischemia induction reduced perineuronal nets.
“Following cortical photothrombotic stroke in rats, enriched housing after ischemia induction reduced PNs, modulated activity and mRNA expression of ECM proteases and their inhibitors, accompanied by enhanced recovery of limb placement ability (Madinier et al., 2014; Quattromani et al., 2017).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Madinier et al., 2014
Following cortical photothrombotic stroke in rats, enriched housing after ischemia induction modulated activity and mRNA expression of extracellular matrix proteases and their inhibitors.
“Following cortical photothrombotic stroke in rats, enriched housing after ischemia induction reduced PNs, modulated activity and mRNA expression of ECM proteases and their inhibitors, accompanied by enhanced recovery of limb placement ability (Madinier et al., 2014; Quattromani et al., 2017).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Madinier et al., 2014
Following cortical photothrombotic stroke in rats, enriched housing after ischemia induction was accompanied by enhanced recovery of limb placement ability.
“Following cortical photothrombotic stroke in rats, enriched housing after ischemia induction reduced PNs, modulated activity and mRNA expression of ECM proteases and their inhibitors, accompanied by enhanced recovery of limb placement ability (Madinier et al., 2014; Quattromani et al., 2017).”
From Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep (2017) · cites this paper as Madinier et al., 2014
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Cites
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468 · see citing works
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938 · see citing works
Neuromorphic Silicon Neuron Circuits
Indiveri, G., Linares-Barranco, B., Hamilton, T. J., André, V. S., Etienne‐Cummings, R., Delbrück, T., Liu, S., Dudek, P., Hafliger, P. D., Renaud, S., et al. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00073 · Cited by 1,836 · see citing works
Mechanisms, challenges and opportunities in stroke
Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1106 · Cited by 1,783 · see citing works
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Nithianantharajah, J., & Hannan, A. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1970 · Cited by 1,771 · see citing works
A Semiautomated Method for Measuring Brain Infarct Volume
Swanson, R., Morton, M. T., Tsao-Wu, G., Savalos, R. A., Davidson, C., & Sharp, F. (1990) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.1990.47 · Cited by 1,727 · see citing works
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Organization of motor and somatosensory neocortex in the albino rat
Hall, R. D., & Lindholm, E. P. (1974) · Brain Research · doi:10.1016/0006-8993(74)90076-6 · Cited by 897 · see citing works
Measurement of motor recovery after stroke. Outcome assessment and sample size requirements.
Duncan, P. W., Goldstein, L. B., Matchar, D. B., Divine, G., & Feussner, J. R. (1992) · Stroke · doi:10.1161/01.str.23.8.1084 · Cited by 746 · see citing works
Freund, T. F., & Katona, I. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.012 · Cited by 656 · see citing works
Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642 · see citing works
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632 · see citing works
Effects of environmental enrichment on gene expression in the brain
Rampon, C., Jiang, C. H., Dong, H., Tang, Y., Lockhart, D. J., Schultz, P. G., Tsien, J. Z., & Hu, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12880 · Cited by 614 · see citing works
Biernaskie, J. A., & Corbett, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-05272.2001 · Cited by 608 · see citing works
Cellular and molecular mechanisms of neural repair after stroke: making waves
Carmichael, S. T. (2006) · Annals of Neurology · doi:10.1002/ana.20845 · Cited by 595 · see citing works
Outcome and time course of recovery in stroke. Part I: Outcome. The Copenhagen stroke study
Jørgensen, H. S., Nakayama, H., Raaschou, H. O., Vive-Larsen, J., Støier, M., & Olsen, T. S. (1995) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(95)80567-2 · Cited by 538 · see citing works
Behavioral Tests After Intracerebral Hemorrhage in the Rat
Hua, Y., Schallert, T. J., Keep, R. F., Wu, J., Hoff, J. T., & Xi, G. (2002) · Stroke · doi:10.1161/01.str.0000032302.91894.0f · Cited by 510 · see citing works
Perineuronal nets: past and present
Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01298-3 · Cited by 497 · see citing works
Sale, A., Maya Vetencourt, J. F., Medini, P., Cenni, M. C., Baroncelli, L., De Pasquale, R., & Maffei, L. (2007) · Nature Neuroscience · doi:10.1038/nn1899 · Cited by 492 · see citing works
Carmichael, S. T., Archibeque, I., Luke, L., Nolan, T., Momiy, J., & Li, S. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.01.004 · Cited by 421 · see citing works
The effects of early experience on problem-solving at maturity
Hebb, D. O. (1947) · American Psychologist · Cited by 421 · see citing works
The perineuronal net and the control of CNS plasticity
Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373 · see citing works
Ryck, M. D., Reempts, J. V., Borgers, M. J., Wauquier, A., & Janssen, P. A. J. (1989) · Stroke · doi:10.1161/01.str.20.10.1383 · Cited by 352 · see citing works
Mechanisms of neural plasticity following brain injury
Wieloch, T. W., & Nikolich, K. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.05.011 · Cited by 352 · see citing works
Self-citationAggrecan Glycoforms Contribute to the Molecular Heterogeneity of Perineuronal Nets
Matthews, R. T., Kelly, G. M., Zerillo, C. A., Gray, G., Tiemeyer, M., & Hockfield, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07536.2002 · Cited by 341 · see citing works
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
Hockly, E., Cordery, P., Woodman, B., Mahal, A., van Dellen, A., Blakemore, C., Lewis, C., Hannan, A., & Bates, G. (2002) · Annals of Neurology · doi:10.1002/ana.10094 · Cited by 326 · see citing works
Environment Influences Functional Outcome of Cerebral Infarction in Rats
Ohlsson, A.-L., & Johansson, B. B. (1995) · Stroke · doi:10.1161/01.str.26.4.644 · Cited by 324 · see citing works
Restivo, L., Ferrari, F., Passino, E., Sgobio, C., Bock, J., Oostra, B. A., Bagni, C., & Ammassari-Teule, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504984102 · Cited by 299 · see citing works
Schäbitz, W.-R., Berger, C., Kollmar, R., Seitz, M., Tanay, E., Kiessling, M., Schwab, S., & Sommer, C. (2004) · Stroke · doi:10.1161/01.str.0000119754.85848.0d · Cited by 283 · see citing works
Sensory Deprivation Alters Aggrecan and Perineuronal Net Expression in the Mouse Barrel Cortex
McRae, P. A., Rocco, M. M., Kelly, G., Brumberg, J. C., & Matthews, R. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5425-06.2007 · Cited by 272 · see citing works
Hockfield, S., Kalb, R. G., Zaremba, S., & Fryer, H. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.049 · Cited by 271 · cited 1× · see citing works
“PNNs are found in most CNS regions, and appear to stabilize synapses [45,46].”
BackgroundJohansson, B. B., & Belichenko, P. V. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200201000-00011 · Cited by 253 · see citing works
Targeting the neural extracellular matrix in neurological disorders
Soleman, S., Filippov, M. A., Dityatev, A., & Fawcett, J. W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.050 · Cited by 244 · see citing works
Arendash, G. W., Garcia, M. F., Costa, D. A., Cracchiolo, J. R., Wefes, I., & Potter, H. (2004) · Neuroreport · doi:10.1097/01.wnr.0000137183.68847.4e · Cited by 237 · see citing works
Multiphasic roles for matrix metalloproteinases after stroke
ROSELL, A., & LO, E. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.001 · Cited by 215 · see citing works
Impaired limb position sense after stroke: A quantitative test for clinical use
Carey, L. M., Oke, L. E., & Matyas, T. A. (1996) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(96)90192-6 · Cited by 213 · see citing works
Bézard, E., Doveró, S., Belin, D., Duconger, S., Jackson-Lewis, V. R., Przedborski, S., Piazza, P. V., Gross, C. E., & Jaber, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-10999.2003 · Cited by 209 · see citing works
Perineuronal net formation and structure in aggrecan knockout mice
Giamanco, K. A., Morawski, M., & Matthews, R. T. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.08.032 · Cited by 207 · see citing works
Lander, C., Kind, P., Maleski, M., & Hockfield, S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-06-01928.1997 · Cited by 195 · see citing works
Motor areas of the cerebral cortex.
Donoghue, J. P., & Sanes, J. N. (1994) · PubMed · Cited by 186 · see citing works
Non-invasive brain stimulation in neurological diseases
Schulz, R., Gerloff, C. P., & Hummel, F. C. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.05.016 · Cited by 182 · see citing works
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke
Ruscher, K., Shamloo, M., Rickhag, M., Ladunga, I., Soriano, L., Gisselsson, L., Toresson, H., Ruslim-Litrus, L., Oksenberg, D., Urfer, R., et al. (2011) · Brain · doi:10.1093/brain/awq367 · Cited by 176 · see citing works
Self-citationA surface antigen expressed by a subset of neurons in the vertebrate central nervous system.
Hockfield, S. J., & McKay, R. D. G. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.18.5758 · Cited by 175 · see citing works
Automated quantitative gait analysis in animal models of movement disorders
Vandeputte, C., Taymans, J., Casteels, C., Coun, F., Ni, Y., Laere, K. V., & Baekelandt, V. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-92 · Cited by 169 · see citing works
The Brain’s Extracellular Matrix and Its Role in Synaptic Plasticity
Frischknecht, R., & Gundelfinger, E. D. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_7 · Cited by 156 · see citing works
Improvement After Constraint-Induced Movement Therapy
Kitago, T., Liang, J., Huang, V. S., Hayes, S. M., Simon, P., Tenteromano, L., Lazar, R. M., Marshall, R. S., Mazzoni, P., Lennihan, L., et al. (2012) · Neurorehabilitation and neural repair · doi:10.1177/1545968312452631 · Cited by 155 · see citing works
Ha¨rtig, W., Brauer, K., Bigl, V., & Bru¨ckner, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)91452-4 · Cited by 147 · see citing works
An Enriched Environment Improves Sensorimotor Function Post-Ischemic Stroke
Janssen, H., Bernhardt, J., Collier, J., Sena, E., McElduff, P., Attia, J., Pollack, M., Howells, D., Nilsson, M., Calford, M., et al. (2010) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968310372092 · Cited by 143 · see citing works
Long-term behavioral assessment of function in an experimental model for ischemic stroke
Encarnacion, A., Horie, N., Keren‐Gill, H., Bliss, T. M., Steinberg, G. K., & Shamloo, M. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.01.010 · Cited by 140 · see citing works
Trends in Stroke Prevalence Between 1973 and 1991 in the US Population 25 to 74 Years of Age
Muntner, P., Garrett, E., Klag, M. J., & Coresh, J. (2002) · Stroke · doi:10.1161/01.str.0000015031.57955.d1 · Cited by 139 · see citing works
Aggrecan: Beyond cartilage and into the brain
Morawski, M., Brückner, G., Arendt, T., & Matthews, R. T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.01.010 · Cited by 136 · see citing works
Guimaraes, A., Zaremba, S., & Hockfield, S. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03014.1990 · Cited by 128 · see citing works
Experience-dependent plasticity and modulation of growth regulatory molecules at central synapses
Foscarin, S., Ponchione, D., Pajaj, E., Leto, K., Gawlak, M., Wilczynski, G. M., Rossi, F., & Carulli, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016666 · Cited by 128 · see citing works
Soleman, S., Yip, P. K., Duricki, D. A., & Moon, L. D. F. (2012) · Brain · doi:10.1093/brain/aws027 · Cited by 123 · see citing works
Kövesdi, E., Gyorgy, A. B., Kwon, S.-K. C., Wingo, D., Kamnaksh, A., Long, J. B., Kasper, C. E., & Agoston, D. V. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00042 · Cited by 114 · see citing works
New modalities of brain stimulation for stroke rehabilitation
Edwardson, M. A., Lucas, T. H., Carey, J. R., & Fetz, E. E. (2012) · Experimental Brain Research · doi:10.1007/s00221-012-3315-1 · Cited by 109 · see citing works
Plasticity in the Injured Brain
Overman, J. J., & Carmichael, S. T. (2013) · The Neuroscientist · doi:10.1177/1073858413491146 · Cited by 108 · see citing works
Hobohm, C., Günther, A., Grosche, J., Roßner, S., Schneider, D., & Brückner, G. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20459 · Cited by 103 · see citing works
From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology
Viapiano, M. S., & Matthews, R. T. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.08.007 · Cited by 101 · see citing works
Hill, J. J., Jin, K., Mao, X., Xie, L., & Greenberg, D. A. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1205697109 · Cited by 99 · see citing works
Müller, H. D., Hanumanthiah, K. M., Diederich, K., Schwab, S., Schäbitz, W., & Sommer, C. (2008) · Stroke · doi:10.1161/strokeaha.107.495069 · Cited by 95 · see citing works
Lendvai, D., Morawski, M., Négyessy, L., Gáti, G., Jäger, C., Baksa, G., Glasz, T., Attems, J., Tanila, H., Arendt, T., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-012-1042-0 · Cited by 93 · see citing works
Neocortical localization of tactile/proprioceptive limb placing reactions in the rat
Ryck, M. D., Reempts, J. V., Duytschaever, H., Deuren, B. V., & Clincke, G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90112-m · Cited by 93 · see citing works
Wang, Y., Bontempi, B., Hong, S. M., Mehta, K. M., Weinstein, P. R., Abrams, G., & Liu, J. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.82 · Cited by 90 · see citing works
Ballermann, M. A., Metz, G. A. S., McKenna, J. E., Klassen, F., & Whishaw, I. Q. (2001) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(01)00326-0 · Cited by 88 · see citing works
Gherardini, L. M., Gennaro, M., & Pizzorusso, T. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht217 · Cited by 86 · see citing works
Back seat driving: hindlimb corticospinal neurons assume forelimb control following ischaemic stroke
Starkey, M. L., Bleul, C., Zörner, B., Lindau, N. T., Mueggler, T., Rudin, M., & Schwab, M. E. (2012) · Brain · doi:10.1093/brain/aws270 · Cited by 85 · see citing works
Moon, S.-K., Alaverdashvili, M., Cross, A. R., & Whishaw, I. Q. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.021 · Cited by 84 · see citing works
Jones, T. A., & Schallert, T. J. (1992) · Behavioural Brain Research · doi:10.1016/s0166-4328(05)80306-7 · Cited by 81 · see citing works
Martínez‐Cué, C., Rueda, N., García, E., Davisson, M. T., Schmidt, C., & Flórez, J. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.04.016 · Cited by 80 · see citing works
Diño, M. R., Harroch, S., Hockfield, S. J., & Matthews, R. T. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.07.054 · Cited by 76 · see citing works
Gene Expression Profiling in the Intact and Injured Brain Following Environmental Enrichment
Keyvani, K., Sachser, N., Witte, O. W., & Paulus, W. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.6.598 · Cited by 71 · see citing works
Harris, N. G., Mironova, Y. A., Hovda, D. A., & Sutton, R. L. (2010) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181cb5bee · Cited by 70 · see citing works
Dahlqvist, P. M., Rönnbäck, A., Risedal, A., Nergårdh, R., Johansson, I., Seckl, J. R., Johansson, B. B., & Olsson, T. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00195-7 · Cited by 69 · see citing works
Shanina, E., Schallert, T. J., Witte, O. W., & Redecker, C. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.016 · Cited by 68 · see citing works
Harris, N. G., Carmichael, S. T., Hovda, D. A., & Sutton, R. L. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22115 · Cited by 62 · see citing works
Ruscher, K., Johannesson, E., Brugiere, E., Erickson, A., Rickhag, M., & Wieloch, T. W. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.96 · Cited by 61 · see citing works
Self-citationCarey, L. M., Abbott, D. F., Harvey, M. R., Puce, A., Seitz, R. J., & Donnan, G. A. (2011) · Neurorehabilitation and neural repair · doi:10.1177/1545968310395777 · Cited by 59 · see citing works
Jablonka, J., Burnat, K., Witte, O. W., & Kossut, M. M. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.074 · Cited by 53 · see citing works
Enriched environment promotes efficiency of compensatory movements after cerebral ischemia in rats
Knieling, M. R. N., Metz, G. A. S., Antonow‐Schlorke, I., & Witte, O. W. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.004 · Cited by 52 · see citing works
Tissue Microenvironments within Functional Cortical Subdivisions Adjacent to Focal Stroke
Katsman, D., Zheng, J., Spinelli, K., & Carmichael, S. T. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000084252.20114.be · Cited by 52 · see citing works
Sigler, A., Goroshkov, A. V., & Murphy, T. H. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.12.015 · Cited by 51 · see citing works
Karetko-Sysa, M., Skangiel-Kramska, J., & Nowicka, D. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.05.022 · Cited by 45 · see citing works
Motor dysfunction in a photothrombotic focal ischaemia model
Wood, N. I., Sopesén, B., Roberts, J. C., Pambakian, P. S., Rothaul, A. L., Hunter, A. J., & Hamilton, T. C. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00237-5 · Cited by 38 · see citing works
Diederich, K., Quennet, V., Bauer, H., Müller, H. D., Wersching, H., Schäbitz, W., Minnerup, J., & Sommer, C. (2011) · Stroke · doi:10.1161/strokeaha.111.622159 · Cited by 33 · see citing works
Photothrombotic Lesions of the Rat Cortex Impair Acquisition of the Water Maze
Rogers, D. C., & Hunter, A. J. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00430-3 · Cited by 32 · see citing works
The effect of stress on stroke recovery in a photothrombotic stroke animal model
Jin, Z., Wu, J., Oh, S., Kim, K.-W., & Shin, B. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.081 · Cited by 28 · see citing works
Inácio, A. R. L., Ruscher, K., & Wieloch, T. W. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.015 · Cited by 28 · see citing works
Self-citationNeurophysiological and Anatomical Plasticity in the Adult Sensorimotor Cortex
Dancause, N. (2006) · Reviews in the Neurosciences · doi:10.1515/revneuro.2006.17.6.561 · Cited by 22 · see citing works
Lenzlinger, P. M., Saatman, K. E., Hoover, R. C., Cheney, J. A., Bareyre, F. M., Raghupathi, R., Arnold, L. D., & McIntosh, T. K. (2004) · PubMed · Cited by 19 · see citing works
Intracarotid administration of human bone marrow mononuclear cells in rat photothrombotic ischemia
Minnerup, J., Seeger, F. H., Kuhnert, K., Diederich, K., Schilling, M., Dimmeler, S., & Schäbitz, W. (2010) · Experimental & Translational Stroke Medicine · doi:10.1186/2040-7378-2-3 · Cited by 16 · see citing works
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The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170 · see citing works
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
Is Environmental Enrichment Ready for Clinical Application in Human Post-stroke Rehabilitation?
McDonald, M. W., Hayward, K. S., Rosbergen, I. C. M., Jeffers, M. S., & Corbett, D. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00135 · Cited by 145 · see citing works
Zhao, L., & Willing, A. E. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.01.004 · Cited by 135 · see citing works
Livingston‐Thomas, J. M., Nelson, P. A., Karthikeyan, S., Antonescu, S., Jeffers, M. S., Marzolini, S., & Corbett, D. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0423-9 · Cited by 121 · see citing works
Hakon, J., Quattromani, M. J., Sjölund, C., Tomasevic, G., Carey, L. M., Lee, J., Ruscher, K., Wieloch, T. W., & Bauer, A. Q. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.11.022 · Cited by 97 · see citing works
Self-citationBozzelli, P. L., Alaiyed, S., Kim, E., Villapol, S., & Conant, K. E. (2018) · Neural Plasticity · doi:10.1155/2018/5735789 · Cited by 90 · see citing works
Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke
Talhada, D., Santos, C. R. A., Gonçalves, I., & Ruscher, K. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01103 · Cited by 83 · see citing works
Self-citationYew, W. P., Djukic, N. D., Jayaseelan, J. S. P., Walker, F. R., Roos, K. A. A., Chataway, T., Muyderman, H., & Sims, N. R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1379-y · Cited by 80 · see citing works
Releasing Addiction Memories Trapped in Perineuronal Nets
Lasek, A. W., Chen, H., & Chen, W.-Y. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.12.004 · Cited by 71 · see citing works
Enriched housing promotes post-stroke neurogenesis through calpain 1-STAT3/HIF-1α/VEGF signaling
Wu, X., Liu, S., Hu, Z., Zhu, G., Zheng, G., & Wang, G. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.02.018 · Cited by 69 · see citing works
Jeffers, M. S., & Corbett, D. (2018) · Stroke · doi:10.1161/strokeaha.118.020814 · Cited by 66 · see citing works
Slaker, M. L., Jorgensen, E. T., Hegarty, D. M., Liu, X., Kong, Y., Zhang, F., Linhardt, R. J., Brown, T. E., Aicher, S. A., & Sorg, B. A. (2018) · eneuro · doi:10.1523/eneuro.0221-18.2018 · Cited by 64 · see citing works
Shinozaki, M., Iwanami, A., Fujiyoshi, K., Tashiro, S., Kitamura, K., Shibata, S., Fujita, H., Nakamura, M., & Okano, H. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.07.005 · Cited by 64 · see citing works
Update on Perineuronal Net Staining With Wisteria floribunda Agglutinin (WFA)
Härtig, W., Meinicke, A., Michalski, D., Schob, S., & Jäger, C. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.851988 · Cited by 60 · see citing works
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Zeiler, S. R. (2019) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-019-0927-x · Cited by 60 · see citing works
Zhang, X., Chen, X., Lin, J., Xiong, Y., Liao, W., & Wan, Q. (2016) · Brain Research · doi:10.1016/j.brainres.2016.11.001 · Cited by 59 · see citing works
Slaker, M. L., Barnes, J., Sorg, B. A., & Grimm, J. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168256 · Cited by 57 · see citing works
Chen, J., Yuan, Y. J., Yuan, Y., Zhang, Y., Fan, X.-P., Yuan, S., Zhang, J., & Yao, S. (2017) · Cell Death Discovery · doi:10.1038/cddiscovery.2017.54 · Cited by 58 · see citing works
Zhang, Y., Xu, D., Qi, H., Yuan, Y., Liu, H. Q., Yao, S., Yuan, S., & Zhang, J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.030 · Cited by 58 · see citing works
Differential regulation of perineuronal nets in the brain and spinal cord with exercise training
Smith, C. C., Mauricio, R., Nobre, L., Marsh, B., Wüst, R. C. I., Rossiter, H. B., & Ichiyama, R. M. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.12.005 · Cited by 57 · see citing works
Mu, J., Bakreen, A., Juntunen, M., Korhonen, P., Oinonen, E., Cui, L., Myllyniemi, M., Zhao, S., Miettinen, S., & Jolkkonen, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00235 · Cited by 52 · see citing works
Härtig, W., Mages, B., Aleithe, S., Nitzsche, B., Altmann, S., Barthel, H., Krueger, M., & Michalski, D. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00015 · Cited by 53 · see citing works
Hakon, J., Ruscher, K., Romner, B., & Tomasevic, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120074 · Cited by 52 · see citing works
Self-citationExpression of aggrecan components in perineuronal nets in the mouse cerebral cortex
Ueno, H., Fujii, K., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Aoki, S., Okamoto, M., Ishihara, T., & Takao, K. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.01.002 · Cited by 47 · see citing works
Ueno, H., Suemitsu, S., Okamoto, M., Matsumoto, Y., & Ishihara, T. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.041 · Cited by 45 · see citing works
Kaushik, R., Morkovin, E. I., Schneeberg, J., Confettura, A. D., Kreutz, M. R., Senkov, O., & Dityatev, A. E. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00411 · Cited by 38 · see citing works
Extracellular matrix modulation is driven by experience-dependent plasticity during stroke recovery.
Quattromani, M. J., Pruvost, M., Guerreiro, C., Backlund, F., Englund, E., Aspberg, A., Jaworski, T., Hakon, J., Ruscher, K., Kaczmarek, L., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0461-2 · Cited by 39 · see citing works
Self-citationBice, A. R., Xiao, Q., Kong, J., Yan, P., Rosenthal, Z. P., Kraft, A. W., Smith, K. P., Wieloch, T. W., Lee, J., Culver, J. P., et al. (2022) · eLife · doi:10.7554/elife.68852 · Cited by 36 · see citing works
Self-citationWalter, J., Kovalenko, O., Younsi, A., Grutza, M., Unterberg, A. W., & Zweckberger, K. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112680 · Cited by 38 · see citing works
Neural ECM in regeneration and rehabilitation
Yang, S., Kwok, J. C. F., & Fawcett, J. W. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00008-6 · Cited by 37 · see citing works
Sánchez-Ventura, J., Giménez‐Llort, L., Penas, C., & Udina, E. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113533 · Cited by 36 · see citing works
From molecules to behavior: Implications for perineuronal net remodeling in learning and memory
Sanchez, B., Kraszewski, P., Lee, S., & Cope, E. C. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16036 · Cited by 37 · see citing works
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Corbett, D., Nguemeni, C., & Gomez-Smith, M. (2014) · Cerebrovascular Diseases · doi:10.1159/000368887 · Cited by 36 · see citing works
Fucà, E., Guglielmotto, M., Boda, E., Rossi, F., Leto, K., & Buffo, A. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.02.005 · Cited by 30 · see citing works
Quattromani, M. J., Hakon, J., Rauch, U., Bauer, A. Q., & Wieloch, T. W. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.011 · Cited by 25 · see citing works
Self-citationWalter, H. L., Pikhovych, A., Endepols, H., Rotthues, S., Bärmann, J., Backes, H., Hoehn, M., Wiedermann, D., Neumaier, B., Fink, G. R., et al. (2022) · Neurorehabilitation and neural repair · doi:10.1177/15459683221124116 · Cited by 25 · see citing works
Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity
Hakon, J., Quattromani, M. J., Sjölund, C., Talhada, D., Kim, B., Moyanova, S. G., Mastroiacovo, F., Menna, L. D., Olsson, R., Englund, E. M., et al. (2023) · Brain · doi:10.1093/brain/awad293 · Cited by 25 · see citing works
Self-citationTimotius, I. K., Canneva, F., Minakaki, G., Moceri, S., Plank, A.-C., Casadei, N., Rieß, O., Winkler, J., Klucken, J., Eskofier, B. M., et al. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108367 · Cited by 21 · see citing works
The Effects of Early Exercise on Motor, Sense, and Memory Recovery in Rats With Stroke
Yang, L., Zhang, J., Deng, Y., & Zhang, P. (2016) · American Journal of Physical Medicine & Rehabilitation · doi:10.1097/phm.0000000000000670 · Cited by 20 · see citing works
Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure
Lépine, M., Douceau, S., Devienne, G. F., Prunotto, P., Lenoir, S., Regnauld, C., Pouettre, E., Piquet, J., Lebouvier, L., Hommet, Y., et al. (2022) · BMC Biology · doi:10.1186/s12915-022-01419-8 · Cited by 19 · see citing works
Barios, J. A., Pisarchyk, L., Fernandez-Garcia, L., Barrio, L. C., Ramos, M., Martínez‐Murillo, R., & González‐Nieto, D. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15606139 · Cited by 18 · see citing works
Kyyriäinen, J., Bolkvadze, T., Koivisto, H., Lipponen, A., Pérez, L. O., Ndode‐Ekane, X. E., Tanila, H., & Pitkänen, A. (2019) · Epilepsy Research · doi:10.1016/j.eplepsyres.2019.02.009 · Cited by 16 · see citing works
Härtig, W., Appel, S., Suttkus, A., Grosche, J., & Michalski, D. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.09.004 · Cited by 15 · see citing works
Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells
Hirono, M., Karube, F., & Yanagawa, Y. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.661899 · Cited by 14 · see citing works
van Lieshout, E. C., Boonzaier, J., Pel, A. J., Heijningen, C. L. V., Vink, J. J. T., Visser‐Meily, J. M. A., van Tilborg, G. A. F., & Dijkhuizen, R. M. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211005022 · Cited by 13 · see citing works
Richards, T. M., Sharma, P., Kuang, A., Whitty, D., Ahmed, Z., & Shah, P. K. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6152 · Cited by 11 · see citing works
Oppici, L., Bērziņa, G., Hestetun-Mandrup, A. M., Løvstad, M., Opheim, A. I., Pacheco, M. M., Rafsten, L., Sunnerhagen, K. S., & Rudd, J. R. (2025) · Translational Stroke Research · doi:10.1007/s12975-025-01335-3 · Cited by 10 · see citing works
Yuan, S., Shi, J., Tang, X., Deng, B., Wu, Z., Qiu, B., Lin, S., Ji, C., Wang, L., Cui, S., et al. (2023) · eNeuro · doi:10.1523/eneuro.0234-23.2023 · Cited by 10 · see citing works
Yew, W. P., Djukic, N. D., Jayaseelan, J. S. P., Kaidonis, X., Kremer, K. L., Choy, F. C., Woodman, R. J., Koblar, S. A., & Sims, N. R. (2021) · Cell Transplantation · doi:10.1177/0963689720984437 · Cited by 10 · see citing works
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Padawer-Curry, J. A., Bowen, R. M., Jarang, A., Wang, X., Lee, J., & Bauer, A. Q. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2926-0_11 · Cited by 9 · see citing works
Walter, J., Mende, J., Hutagalung, S., Grutza, M., Younsi, A., Zheng, G., Unterberg, A., & Zweckberger, K. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265448 · Cited by 5 · see citing works
Sullivan, E. D. K., Dannenhoffer, C. A., Sutherland, E. B., Vidrascu, E. M., Gómez‐A, A., Boettiger, C. A., & Robinson, D. L. (2024) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15395 · Cited by 6 · see citing works
Mastroiacovo, F., Zinni, M., Mascio, G., Bruno, V., Battaglia, G., Pansiot, J., Imbriglio, T., Mairesse, J., Baud, O., & Nicoletti, F. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.668877 · Cited by 6 · see citing works
Jakovljević, A., Stamenković, V., Poleksić, J., Hamad, M. I. K., Reiss, G., Jakovčevski, I., & Anđjus, P. R. (2024) · Biomolecules · doi:10.3390/biom14040508 · Cited by 6 · see citing works
Yew, W. P., Djukic, N. D., Jayaseelan, J. S. P., Woodman, R. J., Muyderman, H., & Sims, N. R. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02208-w · Cited by 6 · see citing works
Nie, L., He, J., Wang, J., Wang, R., Huang, L., Jia, L., Kim, Y. T., BHAWAL, U. K., Fan, X., Zille, M., et al. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2024.tb00290.x · Cited by 5 · see citing works
Regulation of CNS Plasticity Through the Extracellular Matrix
Warren, P. M., Dickens, S., Gigout, S., Fawcett, J. W., & Kwok, J. C. F. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190635374.013.11 · Cited by 5 · see citing works
Nie, L., He, J., Wang, J., Wang, R., Huang, L., Jia, L., Kim, Y. T., BHAWAL, U. K., Fan, X., Zille, M., et al. (2023) · Comprehensive physiology · doi:10.1002/cphy.c230007 · Cited by 15 · see citing works
Houlton, J., Zubkova, O. V., & Clarkson, A. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094817 · Cited by 4 · see citing works
Post-Stroke Recovery in Relation to Parvalbumin-Positive Interneurons and Perineuronal Nets
Kuhl, L. M., Jeffers, M. S., Hristozov, N., Karthikeyan, S., McDonald, M. W., Hufnagel, A., Carter, A., Dancause, N., & Corbett, D. (2025) · Neurorehabilitation and neural repair · doi:10.1177/15459683241309567 · Cited by 3 · see citing works
Ueno, H., Kitano, E., Mori, S., Takahashi, Y., Murakami, S., Wani, K., Matsumoto, Y., Okamoto, M., & Ishihara, T. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.10.012 · Cited by 3 · see citing works
Milman, N., McGuire, N. M., Loeung, J., Bueno-Júnior, L. S., Tinsley, C. E., Bronstein, H., Kelly, F. D., Wickham, P. T., Ghimire, A., Johnson, Z. V., et al. (2025) · Cerebral Cortex · doi:10.1093/cercor/bhaf321 · Cited by 3 · see citing works
Sabzalizadeh, M., Afarinesh, M. R., Derakhshani, A., & Sheibani, V. (2023) · PubMed Central · doi:10.22074/cellj.2023.2007586.1373 · Cited by 3 · see citing works
Parambath, S. K., Krishna, N., & Krishnamurthy, R. G. (2025) · Biogerontology · doi:10.1007/s10522-025-10232-z · Cited by 3 · see citing works
Neurorehabilitation for upper limb recovery after stroke
van Lieshout, E. C. (2021) · doi:10.33540/420 · Cited by 2 · see citing works
A Novel In Vivo Model for Multiplexed Analysis of Callosal Connections upon Cortical Damage
González-Manteiga, A., Navarro-González, C., Sebestyén, V. E., Saborit-Torres, J. M., Talhada, D., de la Iglesia-Vayá, M., Ruscher, K., & Fazzari, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158224 · Cited by 1 · see citing works
Self-citationCamprubí-Ferrer, L., Kolbay, Ö. K., Quattromani, M. J., Wieloch, T. W., Ruscher, K., & Deierborg, T. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70028 · Cited by 1 · see citing works
Self-citationJiang, Y., Tetlow, A. M., Lin, Y., Ji, C., Ader, J., Laborc, K. F., Mar, A. C., Pan, R., Kong, X., Congdon, E. E., et al. (2026) · Science Translational Medicine · doi:10.1126/scitranslmed.aea4205 · Cited by 2 · see citing works
Performing Enriched Environment Studies to Improve Functional Recovery
Talhada, D., & Ruscher, K. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-2926-0_24 · Cited by 1 · see citing works
Self-citationJiang, Y., Tetlow, A. M., Lin, Y., Ji, C., Laborc, K. F., Mar, A. C., Pan, R., Kong, X., Congdon, E. E., & Sigurdsson, E. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.30.662446 · Cited by 1 · see citing works
THE THEORY AND PRACTICE OF RELAY TYPE INSTRUMENTS BASED ON RADIOACTIVE ISOTOPES
Shumilovskii, N. N., Yanushkovskii, V. A., & Taksar, I. M. (1959) · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
Housing in an Enriched Environment: A Tool to Study Functional Recovery After Experimental Stroke
Ruscher, K., & Wieloch, T. W. (2016) · Neuromethods · doi:10.1007/978-1-4939-5620-3_8
Self-citationBernhardt, J. A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733704137.793550246
The role of perineuronal nets in post-stroke neuroplasticity and functional reorganization
Aderinto, N., Abraham, I. C., Kwape, J. M., Gaur, A., Akanbi, C. A., Oyeniyi, D. T., Babalola, A. E., Babalola, D. O., Adeyeye, J., Bukky, S. O., et al. (2025) · Next research. · doi:10.1016/j.nexres.2025.101060
Yew, W. P., Djukic, N. D., Jayaseelan, J. S. P., Woodman, R. J., Muyderman, H., & Sims, N. R. (2021) · Figshare · doi:10.6084/m9.figshare.15087476
Lépine, M., Douceau, S., Devienne, G. F., Prunotto, P., Lenoir, S., Regnauld, C., Pouettre, E., Piquet, J., Lebouvier, L., Hommet, Y., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21285731
Mastroiacovo, F., Notartomaso, S., Moyanova, S. G., Llebaria, A., Gómez‐Santacana, X., Bucci, D., Bruno, V., Battaglia, G., Ruscher, K., Bauer, A. Q., et al. (2026) · Stroke · doi:10.1161/strokeaha.125.054261
Self-citationAhmed, A. K., Feghali, J., Shih, Y.-C., Miller, J., Yazigi, E., Hansen, L. J., Khalifeh, J. M., Reddy, S. C., Xu, R., Caplan, J. M., et al. (2026) · Neurocritical Care · doi:10.1007/s12028-026-02491-6
Douceau, S. (2020) · theses.fr (ABES) · doi:10.70675/6f1007f2z8468z4365zb07dz7d863bf32cd5
Teichert, M., Gull, S., Herrmann, K., Urbach, A., Frahm, C., Chung, H., Gaser, C., Holthoff, K., Reichenbach, J. R., Witte, O. W., et al. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.124.039816
Lin, C.-Y., Chan, H. H. N., Lin, J., Trent, D., Baker, K. B., & Lee, Y.-S. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112091
- Authors
- Madinier, A., Quattromani, M. J., Sjölund, C., Ruscher, K., & Wieloch, T.
- Affiliations
- Lund University (SE)
- Corresponding author
- Wieloch, Tadeusz
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-03-24
- Volume
- 9
- Issue
- 3
- Pages
- e93121
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3963994
- OpenAlex
- W1973274270
- Cited by
- 82
- References
- 93
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 2 · 2023: 8 · 2022: 8 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 13 · 2017: 7 · 2016: 7 · 2015: 3 · 2014: 3
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Lund University Publications (Lund University) (submittedVersion, other-oa)
- Funders
- Crafoordska Stiftelsen
- Vetenskapsrådet (201024, 2011-02684, 2011-02652)
- Greta och Johan Kocks stiftelser
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- environmental enrichment, stroke recovery, perineuronal nets, aggrecan, somatosensory cortex, sensorimotor function, parvalbumin interneurons, photothrombosis, stroke rehabilitation, multisensory stimulation
- MeSH terms
- Animals, Hindlimb, Male, Nerve Net, Proprioception, Somatosensory Cortex, Rats, Sprague-Dawley, Stroke, Rats, Aggrecans, Touch Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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