Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain
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Although the cognitive impairment in Alzheimer’s disease (AD) is believed to be caused by amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs), several postmortem studies have reported cognitive normal subjects with AD brain pathology. As the mechanism underlying these discrepancies has not been clarified, we focused the neuroprotective role of astrocytes. After examining 47 donated brains, we classified brains into 3 groups, no AD pathology with no dementia (N-N), AD pathology with no dementia (AD-N), and AD pathology with dementia (AD-D), which represented 41%, 21%, and 38% of brains, respectively. No differences were found in the accumulation of Aβ plaques or NFTs in the entorhinal cortex (EC) between AD-N and AD-D. Number of neurons and synaptic density were increased in AD-N compared to those in AD-D. The astrocytes in AD-N possessed longer or thicker processes, while those in AD-D possessed shorter or thinner processes in layer I/II of the EC. Astrocytes in all layers of the EC in AD-N showed enhanced GLT-1 expression in comparison to those in AD-D. Therefore these activated forms of astrocytes with increased GLT-1 expression may exert beneficial roles in preserving cognitive function, even in the presence of Aβ and NFTs.
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An increase in SLC1A2 expression in EC astrocytes has been associated with resilience to AD pathology.
“an increase in SLC1A2 expression in EC astrocytes has been associated with resilience to AD pathology37”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [37]
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Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540 · see citing works
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056 · see citing works
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
Mirra, S. S., Heyman, A., McKeel, D., Sumi, S. M., Crain, B. J., Brownlee, L. M., Vogel, F. S., Hughes, J. P., Belle, G. V., Berg, L., et al. (1991) · Neurology · doi:10.1212/wnl.41.4.479 · Cited by 4,961 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,068 · see citing works
Phases of Aβ-deposition in the human brain and its relevance for the development of AD
Thal, D. R., Rüb, U., Orantes, M., & Braak, H. (2002) · Neurology · doi:10.1212/wnl.58.12.1791 · Cited by 3,490 · see citing works
Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0127-z · Cited by 3,172 · see citing works
Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-011-0910-3 · Cited by 2,992 · see citing works
Katz, S. (1963) · JAMA · doi:10.1001/jama.1963.03060120024016 · Cited by 2,421 · see citing works
Localization of neuronal and glial glutamate transporters
Rothstein, J. D., Martin, L. J., Levey, A. I., Dykes‐Hoberg, M., Jin, L., Wu, D. M., Nash, N. R., & Kuncl, R. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90038-8 · Cited by 1,703 · see citing works
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Doody, R. S., Thomas, R. G., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., Raman, R., Sun, X., Aisen, P. S., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312889 · Cited by 1,668 · see citing works
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434 · see citing works
(2001) · The Lancet · doi:10.1016/s0140-6736(00)03589-3 · Cited by 1,338 · see citing works
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225 · see citing works
Tau in Alzheimer Disease and Related Tauopathies
Iqbal, K., Liu, F., Gong, C., & Grundke, I. (2010) · Current Alzheimer Research · doi:10.2174/156720510793611592 · Cited by 1,122 · see citing works
Neurotoxicity of Amyloid -Protein: Synaptic and Network Dysfunction
Mucke, L., & Selkoe, D. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006338 · Cited by 1,000 · see citing works
Astrocyte reactivity and reactive astrogliosis: costs and benefits
Pekny, M., & Pekna, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00041.2013 · Cited by 934 · see citing works
Du, A. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.4.441 · Cited by 719 · see citing works
The dual role of astrocyte activation and reactive gliosis
Pekny, M., Wilhelmsson, U., & Pekna, M. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2013.12.071 · Cited by 666 · see citing works
M. Tucker, A., & Stern, Y. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745320 · Cited by 561 · see citing works
Alzheimer's disease: synaptic dysfunction and Aβ
Shankar, G. M., & Walsh, D. M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-48 · Cited by 522 · see citing works
Danysz, W., & Parsons, C. G. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02057.x · Cited by 500 · see citing works
Glei, D. A., Landau, D. A., Goldman, N., Chuang, Y., Rodrı́guez, G., & Weinstein, M. (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi049 · Cited by 493 · see citing works
Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease
Masliah, E., Hansen, L., Alford, M., Deteresa, R., & Mallory, M. (1996) · Annals of Neurology · doi:10.1002/ana.410400512 · Cited by 476 · see citing works
Human astrocytes: structure and functions in the healthy brain
Vasile, F., Dossi, E., & Rouach, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1383-5 · Cited by 428 · see citing works
Healthy Aging and Dementia: Findings from the Nun Study
Snowdon, D. A. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_2-200309021-00014 · Cited by 412 · see citing works
The role of astroglia in neuroprotection
Bélanger, M., & Magistretti, P. J. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/mbelanger · Cited by 396 · see citing works
Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology
Perez-Nievas, B. G., Stein, T. D., Tai, H.-C., Dols-Icardo, O., Scotton, T. C., Barroeta-Espar, I., Fernandez-Carballo, L., de Munain, E. L., Perez, J., Marquie, M., et al. (2013) · Brain · doi:10.1093/brain/awt171 · Cited by 387 · see citing works
Reactive Astrocytes As Therapeutic Targets for CNS Disorders
Hamby, M. E., & Sofroniew, M. V. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.003 · Cited by 367 · see citing works
Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology.
McCall, M. A., Gregg, R. G., Behringer, R. R., Brenner, M., Delaney, C. L., Galbreath, E. J., Zhang, C. L., Pearce, R. A., Chiu, S. Y., & Messing, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6361 · Cited by 349 · see citing works
Evidence for a wide extra-astrocytic distribution of S100B in human brain
Steiner, J. H., Bernstein, H., Bielau, H., Berndt, A., Brisch, R., Mawrin, C., Keilhoff, G., & Bogerts, B. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-2 · Cited by 282 · see citing works
Childhood mental ability and dementia
Whalley, L. J., Starr, J. M., Athawes, R. W. B., Hunter, D. C., Pattie, A., & Deary, I. J. (2000) · Neurology · doi:10.1212/wnl.55.10.1455 · Cited by 274 · see citing works
Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia
Zarow, C., Vinters, H. V., Ellis, W. G., Weiner, M. W., Mungas, D., White, L., & Chui, H. C. (2005) · Annals of Neurology · doi:10.1002/ana.20503 · Cited by 241 · see citing works
Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
Medeiros, R., & LaFerla, F. M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.007 · Cited by 236 · see citing works
Yassa, M. A., Muftuler, L. T., & Stark, C. E. L. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002113107 · Cited by 233 · see citing works
Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles
Andrade-Moraes, C. H., de Oliveira-Pinto, A. V., Castro-Fonseca, E., da Silva, C. G., Guimarães, D. M., Szczupak, D., Parente-Bruno, D. R., Carvalho, L. R. B., Polichiso, L., Valério‐Gomes, B., et al. (2013) · Brain · doi:10.1093/brain/awt273 · Cited by 213 · see citing works
GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model
Mookherjee, P., Green, P. S., Watson, G. S., Marques, M. A., Tanaka, K., Meeker, K. D., Meabon, J. S., Li, N., Zhu, P., Olson, V. G., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110503 · Cited by 164 · see citing works
Very low levels of education and cognitive reserve
Farfel, J. M., Nitríni, R., Suemoto, C. K., Grinberg, L. T., Ferretti‐Rebustini, R. E. D. L., Leite, R. E. P., Tampellini, E., Lima, L. C., Farias, D. S., Neves, R. C., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e3182a08f1b · Cited by 164 · see citing works
Zumkehr, J., Rodríguez‐Ortiz, C. J., Cheng, D., Kieu, Z., Wai, T., Hawkins, C., Kilian, J., Lim, S., Medeiros, R., & Kitazawa, M. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.005 · Cited by 152 · see citing works
Saur, L., Baptista, P. P. A., de Senna, P. N., Paim, M. F., do Nascimento, P. S., Ilha, J., Bagatini, P. B., Achaval, M., & Xavier, L. L. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0500-8 · Cited by 148 · see citing works
Clinicopathological analysis of dementia disorders in the elderly – An update
Jellinger, K. A. (2006) · Journal of Alzheimer s Disease · doi:10.3233/jad-2006-9s308 · Cited by 143 · see citing works
Immunohistochemical co-localization of S-100b and the glial fibrillary acidic protein in rat brain
Boyes, B. E., KiM, S. U., Lee, V., & Sung, S. C. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90050-3 · Cited by 137 · see citing works
Morphological changes in hippocampal astrocytes induced by environmental enrichment in mice
Viola, G. G., Rodrigues, L., Américo, J. C., Hansel, G., Vargas, R. S., Biasibetti, R., Swarowsky, A., Gonçalves, C. A., Xavier, L. L., Achaval, M., et al. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.007 · Cited by 114 · see citing works
Morimoto, K., Horio, J., Satoh, H., Sue, L. I., Beach, T. G., Arita, S., Tooyama, I., & Konishi, Y. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101815 · Cited by 104 · see citing works
Post-Mortem diagnosis of dementia by informant interview
Ferretti‐Rebustini, R. E. D. L., Damin, A. E., Brucki, S. M. D., Morillo, L. S., Perroco, T. R., Campora, F., Moreira, E. G., Balbino, E. S., Lima, M. D. C., Battela, C., et al. (2010) · Dementia & Neuropsychologia · doi:10.1590/s1980-57642010dn40200011 · Cited by 96 · see citing works
Phenotypic Conversions of “Protoplasmic” to “Reactive” Astrocytes in Alexander Disease
Sosunov, A. A., Guilfoyle, E., Wu, X., McKhann, G. M., & Goldman, J. E. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4506-12.2013 · Cited by 80 · see citing works
The Epidemiological Scale of Alzheimer’s Disease
Cornuțiu, G. (2015) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2106w · Cited by 70 · see citing works
Memory Formation Shaped by Astroglia
Zorec, R., Horvat, A., Vardjan, N., & Verkhratsky, A. (2015) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00056 · Cited by 70 · see citing works
Ferretti‐Rebustini, R. E. D. L., Balbinotti, M. A. A., Filho, W. J., Rebustini, F., Suemoto, C. K., Pasqualucci, C. A., Farfel, J. M., Leite, R. E. P., Grinberg, L. T., & Nitríni, R. (2015) · Revista da Escola de Enfermagem da USP · doi:10.1590/s0080-623420150000600010 · Cited by 52 · see citing works
Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2015) · PLOS ONE · doi:10.1371/journal.pone.0118463 · Cited by 52 · see citing works
Choi, M., Ahn, S., Yang, E.-J., Kim, H.-J., Chong, Y. H., & Kim, H. (2016) · Molecular Brain · doi:10.1186/s13041-016-0253-z · Cited by 47 · see citing works
Wang, X., Zhang, M., Yang, S.-W., Li, W., Ren, S., Zhang, J., & Zhang, F. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.05.053 · Cited by 33 · see citing works
Şovrea, A. S., & Boşca, A. B. (2013) · Journal of Molecular Psychiatry · doi:10.1186/2049-9256-1-18 · Cited by 22 · see citing works
Influence of socio-demographic, clinical and functional factors on the severity of dementia
Marra, T. A., Pereira, D. A. G., Faria, C. D. C. D. M., Tirado, M. G. A., & Pereira, L. S. M. (2010) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2010.11.001 · Cited by 11 · see citing works
[Clinical Dementia Rating (CDR)].
Sugishita, M., & Furukawa, K. (2011) · PubMed · Cited by 4 · see citing works
Price (1999) · doi:10.1002/1531-8249(199903)45:3
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Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Armada‐Moreira, A., Gomes, J. I., Pina, C. C., Savchak, O. K., Gonçalves‐Ribeiro, J., Rei, N., Pinto, S., Morais, T. P., Martins, R. S., Ribeiro, F. F., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00090 · Cited by 323 · see citing works
Beyond the GFAP-Astrocyte Protein Markers in the Brain
Jurga, A. M., Paleczna, M., Kadluczka, J., & Kuter, K. Z. (2021) · Biomolecules · doi:10.3390/biom11091361 · Cited by 319 · see citing works
Neuroinflammation in Alzheimer’s Disease
Onyango, I. G., Jauregui, G. V., Čarná, M., Bennett, J. P., & Stokin, G. B. (2021) · Biomedicines · doi:10.3390/biomedicines9050524 · Cited by 330 · see citing works
Deciphering the astrocyte reaction in Alzheimer's disease
Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282 · see citing works
Andersen, J. V., Schousboe, A., & Verkhratsky, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102331 · Cited by 259 · see citing works
Nakano, M., Kubota, K., Kobayashi, E., Chikenji, T., Saito, Y., Konari, N., & Fujimiya, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-67460-1 · Cited by 224 · see citing works
Self-citationIntersection of pathological tau and microglia at the synapse
Vogels, T., Murgoci, A.-N., & Hromádka, T. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0754-y · Cited by 197 · see citing works
Astrocyte senescence promotes glutamate toxicity in cortical neurons
Limbad, C., Oron, T. R., Alimirah, F., Davalos, A. R., Tracy, T. E., Gan, L., Desprez, P.-Y., & Campisi, J. (2020) · PLOS ONE · doi:10.1371/journal.pone.0227887 · Cited by 183 · see citing works
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System
Malik, A. R., & Willnow, T. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225671 · Cited by 170 · see citing works
Microglia and Astrocyte Function and Communication: What Do We Know in Humans?
Garland, E. F., Hartnell, I. J., & Boche, D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.824888 · Cited by 165 · see citing works
Is Alzheimer’s Disease Risk Modifiable?
Serrano‐Pozo, A., & Growdon, J. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad181028 · Cited by 157 · see citing works
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease
Serrano-Pozo, A., Li, H., Li, Z., Muñoz-Castro, C., Jaisa-aad, M., Healey, M. A., Welikovitch, L. A., Jayakumar, R., Bryant, A. G., Noori, A., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01791-4 · Cited by 140 · see citing works
Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131 · see citing works
Verkhratsky, A., Augusto‐Oliveira, M., Pivoriūnas, A., Popov, A., Brazhe, A., & Semyanov, A. V. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02465-3 · Cited by 108 · see citing works
SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models
Kwon, O., Song, J., Yang, Y., Kim, S., Kim, J. Y., Seok, M., Hwang, I., Yu, J., Karmacharya, J., Maeng, H., et al. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202013076 · Cited by 110 · see citing works
Cai, Y., Zhang, Y., Leng, S., Ma, Y., Jiang, Q., Wen, Q., Ju, S., & Hu, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106426 · Cited by 111 · see citing works
Dysregulation of Astrocyte–Neuronal Communication in Alzheimer’s Disease
Nanclares, C., Baraibar, A. M., Araque, A., & Kofuji, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157887 · Cited by 96 · see citing works
Merlo, S., Spampinato, S. F., & Sortino, M. A. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13050 · Cited by 78 · see citing works
de Vries, L. E., Huitinga, I., Kessels, H. W. H. G., Swaab, D. F., & Verhaagen, J. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00719-7 · Cited by 82 · see citing works
Viejo, L., Noori, A., Merrill, E., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12753 · Cited by 69 · see citing works
Friend or Foe? Defining the Role of Glutamate in Aging and Alzheimer’s Disease
Cox, M. F., Hascup, E. R., Bartke, A., & Hascup, K. N. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.929474 · Cited by 70 · see citing works
Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease
Hanslik, K. L., Marino, K. M., & Ulland, T. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.718324 · Cited by 68 · see citing works
The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review
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Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease
Dejakaisaya, H., Kwan, P., & Jones, N. C. (2021) · Epilepsia · doi:10.1111/epi.16918 · Cited by 62 · see citing works
Pajarillo, E. A. B., Johnson, J., Rizor, A., Nyarko‐Danquah, I., Adinew, G. M., Bornhorst, J., Stiboller, M., Schwerdtle, T., Son, D., Aschner, M., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.015552 · Cited by 51 · see citing works
Astillero‐Lopez, V., González-Rodríguez, M., Villar‐Conde, S., Flores‐Cuadrado, A., Martı́nez-Marcos, A., Úbeda‐Bañón, I., & Saiz‐Sánchez, D. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12580 · Cited by 51 · see citing works
Bioactive human Alzheimer brain soluble Aβ: pathophysiology and therapeutic opportunities
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Nakano, M., Kubota, K., Hashizume, S., Kobayashi, E., Chikenji, T., Saito, Y., & Fujimiya, M. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100149 · Cited by 45 · see citing works
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Comparative neuropathology in aging primates: A perspective
Freire‐Cobo, C., Edler, M. K., Varghese, M., Munger, E. L., Laffey, J., Raia, S., In, S. S., Wicinski, B. A., Medalla, M., Perez, S. E., et al. (2021) · American Journal of Primatology · doi:10.1002/ajp.23299 · Cited by 45 · see citing works
Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?
Staurenghi, E., Giannelli, S., Testa, G., Sottero, B., Leonarduzzi, G., & Gamba, P. (2021) · Antioxidants · doi:10.3390/antiox10121890 · Cited by 44 · see citing works
The glutamatergic system in Alzheimer’s disease: a systematic review with meta-analysis
Soares, C., Ros, L. U. D., Machado, L. S., da Rocha, A. S., Lazzarotto, G., Carello‐Collar, G., Bastiani, M. A. D., Ferrari‐Souza, J. P., Lussier, F. Z., Souza, D. O., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02473-0 · Cited by 47 · see citing works
Astrocytic lipid metabolism determines susceptibility to diet-induced obesity
Varela, L., Kim, J. G., Fernández‐Tussy, P., Aryal, B. K., Liu, Z. W., Fernandez-Hernando, C. F., & Horváth, T. L. (2021) · Science Advances · doi:10.1126/sciadv.abj2814 · Cited by 44 · see citing works
Muñoz-Castro, C., Noori, A., Magdamo, C. G., Li, Z., Marks, J. D., Frosch, M. P., Das, S., Hyman, B. T., & Serrano-Pozo, A. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02383-4 · Cited by 41 · see citing works
Bouvier, D. S., Fixemer, S., Heurtaux, T., Jeannelle, F., Frauenknecht, K. B. M., & Mittelbronn, M. G. A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.814889 · Cited by 41 · see citing works
Review of Alzheimer’s disease drugs and their relationship with neuron-glia interaction
Ajenikoko, M., Ajagbe͓, A., Onigbinde, O., Okesina, A., & Tijani, A. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.11.005 · Cited by 29 · see citing works
Stanca, S., Rossetti, M., & Bongioanni, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813880 · Cited by 34 · see citing works
Fontana, I. C., de Souza, D. G., Souza, D. O., Gee, A. D., Zimmer, E. R., & Bongarzone, S. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01572 · Cited by 34 · see citing works
Liu, X., Li, Y., Huang, L., Kuang, Y., Wu, X., Ma, X., Zhao, B., & Lan, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1450704 · Cited by 33 · see citing works
Control of complex behavior by astrocytes and microglia
Ortinski, P. I., Reissner, K. J., Turner, J. R., Anderson, T. L., & Scimemi, A. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104651 · Cited by 30 · see citing works
EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review
Wood, O. W. G., Yeung, J. H. Y., Faull, R. L. M., & Kwakowsky, A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.952096 · Cited by 29 · see citing works
Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R
Beltran-Lobo, P., Reid, M. J., Jiménez-Sánchez, M., Verkhratsky, A., Perez‐Nievas, B. G., & Noble, W. J. (2022) · Essays in Biochemistry · doi:10.1042/ebc20220079 · Cited by 28 · see citing works
Xia, Y., Ma, T., Ji, J., Zhang, L., Wang, Y., Wu, J., Ding, J., Han, X., & Li, D. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.110698 · Cited by 25 · see citing works
Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity
Sha, L., Chen, T., Deng, Y., Du, T., Ma, K., Zhu, W., Shen, Y., & Xu, Q. (2020) · Theranostics · doi:10.7150/thno.44721 · Cited by 25 · see citing works
McCarty, M. F., DiNicolantonio, J. J., & Lerner, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042140 · Cited by 26 · see citing works
Astroglial contribution to tau-dependent neurodegeneration
Sidoryk‐Wȩgrzynowicz, M., & Strużyńska, L. (2019) · Biochemical Journal · doi:10.1042/bcj20190506 · Cited by 26 · see citing works
Modeling Neurological Disorders with Human Pluripotent Stem Cell-Derived Astrocytes
Suga, M., Kondo, T., & Inoue, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20163862 · Cited by 27 · see citing works
Kuo, Y.-M., Hsu, P.-C., Hung, C., Hu, Y.-Y., Huang, Y., Gan, Y., Lin, C.-H., Shie, F., Chang, W., Kao, L., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01669-8 · Cited by 22 · see citing works
Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity
Koller, E. J., & Chakrabarty, P. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00151 · Cited by 22 · see citing works
Tau pathology in the dorsal raphe may be a prodromal indicator of Alzheimer’s disease
Pierson, S. R., Fiock, K. L., Wang, R., Balasubramanian, N., Reinhardt, J., Khan, K. M., James, T. D., Hunter, M. L., Cooper, B. J., Williamsen, H. R., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02664-9 · Cited by 25 · see citing works
Gao, J., Liu, L., Liu, C., Fan, S., Liu, L., Liu, S., Xian, X., & Li, W. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.580772 · Cited by 21 · see citing works
Abo-Zaid, O. A., Sallam, M. W., & Ahmed, E. S. A. (2022) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2022.26 · Cited by 24 · see citing works
Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders
Kumar, M., Nguyen, T. P. N., Milanese, M., & Bonanno, G. (2022) · Biomolecules · doi:10.3390/biom12030344 · Cited by 18 · see citing works
Xia, Y., Chen, J., Ma, T., Meng, X., Han, X., & Li, D. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.154437 · Cited by 17 · see citing works
Music compensates for altered gene expression in age-related cognitive disorders
Gómez‐Carballa, A., Navarro, L., Pardo‐Seco, J., Bello, X., Pischedda, S., Viz-Lasheras, S., Camino‐Mera, A., Currás-Tuala, M. J., Ferreirós-Vidal, I., Mallah, N., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-48094-5 · Cited by 17 · see citing works
Hashizume, S., Nakano, M. H., Kubota, K., Sato, S., Himuro, N., Kobayashi, E., Takaoka, A., & Fujimiya, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-01318-y · Cited by 16 · see citing works
Self-citationHuffels, C. F. M., Osborn, L. M., Cappaert, N. L. M., & Hol, E. M. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25042 · Cited by 13 · see citing works
Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation
Ma, Y., McClatchy, D. B., Martínez‐Bartolomé, S., Bamberger, C., & Yates, J. R. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00645 · Cited by 10 · see citing works
Williams, C. J. A., Malte, C. L., Malte, H., Bertelsen, M. F., & Wang, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-74014-y · Cited by 13 · see citing works
Potential Mechanism of Cellular Uptake of the Excitotoxin Quinolinic Acid in Primary Human Neurons
Braidy, N., Alicajic, H., Pow, D. V., Smith, J. R., Jugder, B., Brew, B. J., Nicolazzo, J. A., & Guillemin, G. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02046-6 · Cited by 12 · see citing works
The role of hippocampal glial glutamate transporter (GLT‐1) in morphine‐induced behavioral responses
Saeedi, N., Darvishmolla, M., Tavassoli, Z., Davoudi, S., Heysieattalab, S., Hosseinmardi, N., Janahmadi, M., & Behzadi, G. (2021) · Brain and Behavior · doi:10.1002/brb3.2323 · Cited by 11 · see citing works
Astrocyte Reactivity in Alzheimer’s Disease: Therapeutic Opportunities to Promote Repair
Mirzaei, N., Davis, N., Chau, T. W., & Sastre, M. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211029164106 · Cited by 11 · see citing works
Developmental dynamics of the single nucleus regulatory landscape of pig hippocampus
Yang, S., Chen, D., Xie, L., Zou, X., Xiao, Y., Rao, L., Yao, T., Zhang, Q., Cai, L., Huang, F., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2345-2 · Cited by 11 · see citing works
Liu, H., Tan, A. Y. S., Mehrabi, N. F., Turner, C. P., Curtis, M. A., Faull, R. L. M., Dragunow, M., Singh‐Bains, M. K., & Smith, A. M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106749 · Cited by 11 · see citing works
Involvement of astrocyte senescence in Alzheimer's disease
Tüzer, F., & Torres, C. A. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102594 · Cited by 10 · see citing works
Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s diseasePreprint
Serrano‐Pozo, A., Li, Z., Woodbury, M. E., Muñoz‐Castro, C., Wachter, A., Jayakumar, R., Bryant, A. G., Noori, A., Welikovitch, L. A., Hu, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.03.518999 · Cited by 10 · see citing works
İlgün, A., & Çakır, T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04965-8 · Cited by 11 · see citing works
The Implication of Glial Metabotropic Glutamate Receptors in Alzheimer’s Disease
de Lima, I. B. Q., & Ribeiro, F. M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x20666211223140303 · Cited by 9 · see citing works
High Mobility Group Box 1 Ameliorates Cognitive Impairment in the 3×Tg-AD Mouse Model
Zhang, J. C., Hua, X., Gu, J., Chen, F., Gu, J., Gong, C., Liu, F., & Dai, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191110 · Cited by 7 · see citing works
Williams, C. J. A., Hansen, K., Williams, N., Jakobsen, S. R., Pedersen, C., Bertelsen, M. F., & Wang, T. (2021) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2021.111036 · Cited by 7 · see citing works
Astrocyte–Neuron Interactions in Alzheimer’s Disease
Muñoz‐Castro, C., & Serrano‐Pozo, A. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-64839-7_14 · Cited by 7 · see citing works
Lee, J.-W., & Cho, J. (2025) · Journal of Veterinary Science · doi:10.4142/jvs.24259 · Cited by 7 · see citing works
Duffield, M. D., Patel, A., Mortensen, O. V., Schnur, D. M., Gonzalez-Suarez, A. D., Torres‐Salazar, D., & Fontana, A. C. K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104792 · Cited by 6 · see citing works
Perrin, F., Anderson, L. C., Mitchell, S. P. C., Sinha, P., Turchyna, Y., Maesako, M., Houser, M. C., Zhang, C. M., Wagner, S. L., Tanzi, R. E., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01876-y · Cited by 6 · see citing works
Wood, O. W. G., Yeung, J. H. Y., Palpagama, T. H., Turner, C. P., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.12.027 · Cited by 4 · see citing works
Glutamate Transporter 1 as a Novel Negative Regulator of Amyloid β
Sinha, P., Turchyna, Y., Mitchell, S., Sadek, M., Armagan, G., Perrin, F., Maesako, M., & Berezovska, O. (2024) · Cells · doi:10.3390/cells13191600 · Cited by 3 · see citing works
Mariani, M. M., Mojziszek, K., Curley, E., & Thornton, J. E. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.104631 · Cited by 3 · see citing works
Chen, H., Zheng, K., Qiu, M. S., & Yang, J. (2023) · Developmental Neurobiology · doi:10.1002/dneu.22929 · Cited by 3 · see citing works
Findley, C. A., McFadden, S., Hill, T., Peck, M. R., Quinn, K., Hascup, K. N., & Hascup, E. R. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240795 · Cited by 3 · see citing works
Is EAAT2 a potential therapeutic intervention target for Alzheimer’s disease?
Kwakowsky, A., Wood, O. G., & Yeung, J. Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.363834 · Cited by 3 · see citing works
Hashizume, S., Nakano, M. H., Kubota, K., Kobayashi, E., & Fujimiya, M. (2021) · Research Square · doi:10.21203/rs.3.rs-199928/v1 · Cited by 1 · see citing works
Self-citationGlial-derived mitochondrial signals impact neuronal proteostasis and agingPreprint
Bar‐Ziv, R., Dutta, N., Hruby, A. J., Sukarto, E., Averbukh, M., Alcala, A., Henderson, H. R., Durieux, J., Tronnes, S. U., Ahmad, Q., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549924 · Cited by 1 · see citing works
Tuning gene expression to music: the compensatory effect of music on age-related cognitive disordersPreprint
Gómez‐Carballa, A., Navarro, L., Pardo‐Seco, J., Bello, X., Pischedda, S., Viz-Lasheras, S., Camino‐Mera, A., Currás-Tuala, M. J., Ferreirós-Vidal, I., Mallah, N., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.12.557408 · Cited by 1 · see citing works
Minbay, Z., Gören, B., & Eyigör, Ö. (2020) · Uludağ Üniversitesi Tıp Fakültesi Dergisi · doi:10.32708/uutfd.824431
Verkhratsky, A. (2021) · Ageing & Longevity · doi:10.47855/jal9020-2021-1-6
Astrocyte and microglial aging
Peterson, T. A., & MacLean, A. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00024-x
Human induced pluripotent stem cell–derived astrocytes progenitors as discovery platforms
Taga, A., & Maragakis, N. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85545-7.00005-3
Customer Loyalty in E-Business.
Raggad, B. G., & Lawler, J. E. (2003) · International Conference on Enterprise Information Systems
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00005-5
Nervous System, Neurons, and Metabolism
Konukoğlu, D. (2024) · doi:10.69860/nobel.9786053359166.1
Inflammaging, Neuroinflammation, and Synaptic Damage in Alzheimer's Disease
Carnevale, L. N., & Lipton, S. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95702-1.00491-7
Hétérogénéité de la réactivité astrocytaire dans la maladie d'Alzheimer
Guillemaud, O. (2020) · theses.fr (ABES) · doi:10.70675/038d98c5z55ccz4754z9af9z417e3826d282
Pradhan, L. K., & Gao, X. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1013131
Li, Y., Liu, S., & 蓝娇 (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1915244
Dynamic contributions of astrocytes in Alzheimer’s disease
Guo, F., Li, T., & He, X. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116032
- Authors
- Kobayashi, E., Nakano, M., Kubota, K., Himuro, N., Mizoguchi, S., Chikenji, T., Otani, M., Mizue, Y., Nagaishi, K., & Fujimiya, M.
- Affiliations
- Sapporo Medical University (JP)
- Corresponding author
- Fujimiya, Mineko
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-01-26
- Volume
- 8
- Issue
- 1
- Pages
- 1712-1712
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5786045
- OpenAlex
- W2792811901
- Cited by
- 98
- References
- 63
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 14 · 2023: 9 · 2022: 19 · 2021: 20 · 2020: 18 · 2019: 8 · 2018: 3
- FWCI
- 8.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (16K19317)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, astrocytes, GLT-1, glutamate transporters, astrocyte activation, entorhinal cortex, amyloid plaques, neurofibrillary tangles, dementia, synaptic density, neuroprotection, astrocyte morphology
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Astrocytes, Brain, Cognition Disorders, Female, Humans, Male, Amyloid beta-Peptides, Neurofibrillary Tangles, Excitatory Amino Acid Transporter 2, Glutamate Plasma Membrane Transport Proteins
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