Structure-function relationships behind the phenomenon of cognitive resilience in neurology: insights for neuroscience and medicine.
Open accessAbstract
The phenomenon of cognitive resilience, that is, the dynamical preservation of normal functions despite neurological disorders, demonstrates that cognition can be highly robust to devastating brain injury. Here, cognitive resilience is considered across a range of neurological conditions. Simple computational models of structure-function relationships are used to discuss hypotheses about the neural mechanisms of resilience. Resilience expresses functional redundancies in brain networks and suggests a process of dynamic rerouting of brain signals. This process is underlined by a global renormalization of effective connectivity, capable of restoring information transfer between spared brain structures via alternate pathways. Local mechanisms of synaptic plasticity mediate the renormalization at the lowest level of implementation, but it is also driven by top-down cognition, with a key role of self-awareness in fostering resilience. The presence of abstraction layers in brain computation and networking is hypothesized to account for the renormalization process. Future research directions and challenges are discussed regarding the understanding and control of resilience based on multimodal neuroimaging and computational neuroscience. The study of resilience will illuminate ways by which the brain can overcome adversity and help inform prevention and treatment strategies. It is relevant to combating the negative neuropsychological impact of aging and fostering cognitive enhancement.
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The FoC must be virtual, in roughly the sense of Virtual Reality.
“This strongly suggests that it must also be virtual, in roughly the sense in which the word is used in “Virtual Reality””
From The Projective Consciousness Model and Phenomenal Selfhood (2018) · cites this paper as Rudrauf, 2014
Section 3.8 proposes that the mind is a virtual entity, and Section 3.7 describes an internally rendered space that frames experience of the world and self. These passages support a qualified sense of virtual experience, but the paper presents virtualization as a hypothesis, not a necessity, and does not explicitly equate it with the sense used in “Virtual Reality.” Page numbers were not available in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe brain is a kind of biological computer, among the other things it is.
“The brain does indeed seem to be a kind of biological computer, among the other things it is (see Rudrauf, 2014).”
From The Projective Consciousness Model and Phenomenal Selfhood (2018) · cites this paper as Rudrauf, 2014
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- Authors
- Rudrauf, D.
- Affiliations
- Inserm (FR)
- Corresponding author
- Rudrauf, David
- ORCID
- Rudrauf, David
- Venue
- Advances in Neuroscience
- Publisher
- Wiley
- Published
- 2014-08-04
- Volume
- 2014
- Pages
- 1-28
- ISSN
- 2314-789X (ISSN-L)
- 2356-6787
- OpenAlex
- W2031042133
- Cited by
- 74
- References
- 143
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 5 · 2022: 4 · 2021: 39 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 3
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Advances in Neuroscience (publishedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Keywords
- cognitive resilience, structure-function relationship, brain injury, functional redundancy, effective connectivity, synaptic plasticity, self-awareness, abstraction layer, brain computation, cognitive aging, cognitive enhancement, cognitive modeling
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