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Cited by 278

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Endogenous amyloid‐β is necessary for hippocampal synaptic plasticity and memory

Puzzo, Daniela, Privitera, Lucia, Fa', Mauro, Staniszewski, Agnieszka, Hashimoto, Gakuji, Aziz, Fahad, Sakurai, Mikako, Ribe, Elena M., Troy, Carol M., Mercken, Marc, Jung, Sonia S., Palmeri, Agostino, Arancio, Ottavio·2011·Annals of Neurology
DOI 10.1002/ana.22313PMC PMC4071456
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Abstract

Objective: The goal of this study was to investigate the role of endogenous amyloid‐β peptide (Aβ) in healthy brain. Methods: Long‐term potentiation (LTP), a type of synaptic plasticity that is thought to be associated with learning and memory, was examined through extracellular field recordings from the CA1 region of hippocampal slices, whereas behavioral techniques were used to assess contextual fear memory and reference memory. Amyloid precursor protein (APP) expression was reduced through small interfering RNA (siRNA) technique. Results: We found that both antirodent Aβ antibody and siRNA against murine APP reduced LTP as well as contextual fear memory and reference memory. These effects were rescued by the addition of human Aβ 42, suggesting that endogenously produced Aβ is needed for normal LTP and memory. Furthermore, the effect of endogenous Aβ on plasticity and memory was likely due to regulation of transmitter release, activation of α7‐containing nicotinic acetylcholine receptors, and Aβ 42 production. Interpretation: Endogenous Aβ 42 is a critical player in synaptic plasticity and memory within the normal central nervous system. This needs to be taken into consideration when designing therapies aiming at reducing Aβ levels to treat Alzheimer disease. Ann Neurol 2011;

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Metadata

Authors
Puzzo, D., Privitera, L., Fa', M., Staniszewski, A., Hashimoto, G., Aziz, F., Sakurai, M., Ribe, E. M., Troy, C. M., Mercken, M., Jung, S. S., Palmeri, A., & Arancio, O.
Venue
Annals of Neurology
Publisher
Wiley
Published
2011-04-06
Volume
69
Issue
5
Pages
819-830
ISSN
  • 0364-5134
  • 1531-8249
DOI
10.1002/ana.22313
PMC
PMC4071456
Cited by
278
References
10
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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