The impact of amyloid‐beta and tau on prospective cognitive decline in older individuals
Open accessAbstract
Objectives: Amyloid‐beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at postmortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline in normal aging and preclinical Alzheimer's disease (AD) remains to be fully elucidated. Methods: One hundred thirty‐seven older individuals (age = 76.3 ± 6.22 years) participating in the Harvard Aging Brain Study underwent Aβ ( 11 C‐Pittsburgh compound B) and tau ( 18 F‐flortaucipir) positron emission tomography (PET) with prospective neuropsychological assessments following PET imaging (mean number of cognitive visits = 2.8 ± 1.1). Tau and Aβ PET measures were assessed in regions of interest (ROIs) as well as vertex‐wise map analyses. Cognitive change was evaluated with Memory and Executive Function composites. Results: Higher levels of Aβ and tau were both associated with greater memory decline, but not with change in executive function. Higher cortical Aβ was associated with higher tau levels in all ROIs, independent of age, and very elevated levels of tau were observed primarily in clinically normal with elevated Aβ. A significant interaction between tau and Aβ was observed in both ROI and map‐level analyses, such that rapid prospective memory decline was observed in participants who had high levels of both pathologies. Interpretation: Our results are consistent with the supposition that both Aβ and tau are necessary for memory decline in the preclinical stages of AD. These findings may be relevant for disambiguating aging and early cognitive manifestations of AD, and to inform secondary prevention trials in preclinical AD. Ann Neurol 2019;00:1–3 ANN NEUROL 2019;85:181–193.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Entorhinal cortex tau deposition predicts cognitive decline.
“The regional specificity of these findings aligns with evidence that entorhinal cortex is a site of preclinical neuropathological tau deposition that is elevated for APOE4 carriers [37] and predicts cognitive decline [38], and which undergoes accelerated atrophy in preclinical AD [39].”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [38]
The Results report that greater entorhinal cortex tau was associated with greater decline in the memory composite. The Discussion qualifies this finding: tau-related memory decline was evident only in the Aβ-positive group. The unqualified claim does not convey that condition, and the paper did not find a significant association with executive-function decline. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123 · see citing works
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155 · see citing works
Self-citationImaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., Shaw, L. M., Vemuri, P., Wiste, H. J., Weigand, S. D., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70291-0 · Cited by 4,396 · see citing works
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 1× · see citing works
“Autopsy reports suggest that tau deposition in the entorhinal cortex (EC) is nearly ubiquitous in advanced aging, whereas spread into the surrounding temporal neocortex is less commonly observed among CN older individuals, particularly in the absence of substantial Aβ pathology.(18) It remains unclear whether EC tau a…”
BackgroundPreclinical Alzheimer’s Disease: Definition, Natural History, and Diagnostic Criteria
Dubois, B., Hampel, H., Feldman, H. H., Scheltens, P., Aisen, P., Andrieu, S., Bakardjian, H., Benali, H., Bertram, L., Blennow, K., et al. (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.02.002 · Cited by 1,925 · see citing works
Self-citationFrequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656 · see citing works
Primary age-related tauopathy (PART): a common pathology associated with human aging
Crary, J. F., Trojanowski, J. Q., Schneider, J. A., Abisambra, J. F., Abner, E. L., Alafuzoff, I., Arnold, S. E., Attems, J., Beach, T. G., Bigio, E. H., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1349-0 · Cited by 1,467 · see citing works
PET Imaging of Tau Deposition in the Aging Human Brain
Schöll, M., Lockhart, S. N., Schonhaut, D. R., O’Neil, J. P., Janabi, M., Ossenkoppele, R., Baker, S. L., Vogel, J. W., Faria, J., Schwimmer, H. D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.028 · Cited by 1,214 · see citing works
Tau positron emission tomographic imaging in aging and early <scp>A</scp> lzheimer disease
Johnson, K. A., Schultz, A., Betensky, R. A., Becker, J. A., Sepulcre, J., Rentz, D., Mormino, E., Chhatwal, J., Amariglio, R., Papp, K., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24546 · Cited by 986 · see citing works
Self-citationJin, M., Shepardson, N., Yang, T., Chen, G., Walsh, D., & Selkoe, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017033108 · Cited by 876 · see citing works
The A4 Study: Stopping AD Before Symptoms Begin?
Sperling, R. A., Rentz, D. M., Johnson, K. A., Karlawish, J. H., Donohue, M., Salmon, D. P., & Aisen, P. S. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007941 · Cited by 756 · see citing works
Self-citationThe Evolution of Preclinical Alzheimer’s Disease: Implications for Prevention Trials
Sperling, R., Mormino, E., & Johnson, K. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.038 · Cited by 725 · see citing works
Self-citationEarly Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
Chien, D. T., Szardenings, A. K., Bahri, S., Walsh, J. C., Mu, F., Xia, C. A., Shankle, W. R., Lerner, A. J., Su, M., Elizarov, A. M., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130098 · Cited by 676 · see citing works
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807
Chien, D. T., Bahri, S., Szardenings, A. K., Walsh, J. C., Mu, F., Su, M.-Y., Shankle, W. R., Elizarov, A., & Kolb, H. C. (2013) · Journal of Alzheimer's Disease · doi:10.3233/jad-122059 · Cited by 651 · see citing works
Marquié, M., Normandin, M. D., Vanderburg, C. R., Costantino, I. M., Bien, E. A., Rycyna, L. G., Klunk, W. E., Mathis, C. A., Ikonomovic, M. D., Debnath, M. L., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24517 · Cited by 615 · see citing works
Self-citationBateman, R. J., Aisen, P. S., De Strooper, B., Fox, N. C., Lemere, C. A., Ringman, J. M., Salloway, S., Sperling, R. A., Windisch, M., & Xiong, C. (2010) · Alzheimer's Research & Therapy · doi:10.1186/alzrt59 · Cited by 573 · see citing works
Self-citationPreclinical Alzheimer's disease and its outcome: a longitudinal cohort study
Vos, S. J., Xiong, C., Visser, P. J., Jasielec, M. S., Hassenstab, J., Grant, E. A., Cairns, N. J., Morris, J. C., Holtzman, D. M., & Fagan, A. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70194-7 · Cited by 564 · see citing works
Donohue, M. C., Sperling, R. A., Petersen, R., Sun, C.-K., Weiner, M. W., Aisen, P. S., & Initiative, F. T. A. D. N. (2017) · JAMA · doi:10.1001/jama.2017.6669 · Cited by 452 · see citing works
Self-citationIn vivo staging of regional amyloid deposition
Grothe, M. J., Barthel, H., Sepulcre, J., Dyrba, M., Sabri, O., Teipel, S. J., Initiative, F. T. A. D. N., Initiative, A. D. N., Weiner, M., Aisen, P., et al. (2017) · Neurology · doi:10.1212/wnl.0000000000004643 · Cited by 440 · see citing works
Self-citationMormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Amariglio, R. E., Rentz, D. M., Johnson, K. A., & Sperling, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.2031 · Cited by 328 · see citing works
Self-citationGreve, D. N., Salat, D. H., Bowen, S., Izquierdo‐Garcia, D., Schultz, A. P., Catana, C., Becker, J. A., Svarer, C., Knudsen, G. M., Sperling, R. A., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.042 · Cited by 312 · see citing works
Self-citationWidespread brain tau and its association with ageing, Braak stage and Alzheimer’s dementia
Lowe, V. J., Wiste, H. J., Senjem, M. L., Weigand, S. D., Therneau, T. M., Boeve, B. F., Josephs, K. A., Fang, P., Pandey, M. K., Murray, M. E., et al. (2017) · Brain · doi:10.1093/brain/awx320 · Cited by 302 · see citing works
Wang, L. Y., Benzinger, T. L. S., Su, Y., Christensen, J. J., Friedrichsen, K. A., Aldea, P., McConathy, J., Cairns, N. J., Fagan, A. M., Morris, J. C., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2078 · Cited by 295 · see citing works
In vivo staging of regional amyloid deposition
Grothe, M. J., Barthel, H., Sepulcre, J., Dyrba, M., Sabri, O., Teipel, S. J., Stern, Y., & Initiative, A. D. N. (2022) · DZNE Pub · doi:10.7916/0vj1-4c02 · Cited by 294 · see citing works
Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease
Mormino, E. C., Betensky, R. A., Hedden, T., Schultz, A. P., Ward, A. M., Huijbers, W., Rentz, D. M., Johnson, K. A., Sperling, R. A., & For the Alzheimer's Disease Neuroimaging Initiative, T. A. I. B. A. L. F. S. O. A. (2014) · Neurology · doi:10.1212/wnl.0000000000000431 · Cited by 290 · see citing works
Self-citationEntorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging
Maaß, A., Lockhart, S. N., Harrison, T. M., Bell, R. K., Mellinger, T. J., Swinnerton, K. N., Baker, S. L., Rabinovici, G. D., & Jagust, W. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2028-17.2017 · Cited by 288 · see citing works
Rowe, C. C., Bourgeat, P., Ellis, K. A., Brown, B., Lim, Y. Y., Mulligan, R., Jones, G., Maruff, P., Woodward, M., Price, R., et al. (2013) · Annals of Neurology · doi:10.1002/ana.24040 · Cited by 222 · see citing works
Burnham, S. C., Bourgeat, P., Doré, V., Savage, G., Brown, B., Laws, S., Maruff, P., Salvado, O., Ames, D., Martins, R. N., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30125-9 · Cited by 207 · see citing works
Mormino, E. C., Papp, K. V., Rentz, D. M., Donohue, M., Amariglio, R. E., Quiroz, Y. T., Chhatwal, J. P., Marshall, G. A., Donovan, N. J., Jackson, J., et al. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2017.01.018 · Cited by 200 · see citing works
Self-citationPetersen, R. C., Wiste, H. J., Weigand, S. D., Rocca, W. A., Roberts, R. O., Mielke, M. M., Lowe, V. J., Knopman, D. S., Pankratz, V. S., Machulda, M. M., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2015.3098 · Cited by 196 · see citing works
Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease
Hyman, B. T. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.70 · Cited by 192 · see citing works
Josephs, K. A., Murray, M. E., Tosakulwong, N., Whitwell, J. L., Knopman, D. S., Machulda, M. M., Weigand, S. D., Boeve, B. F., Kantarci, K., Petrucelli, L., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1681-2 · Cited by 166 · see citing works
Ushering in the study and treatment of preclinical Alzheimer disease
Langbaum, J. B. S., Fleisher, A., Chen, K., Ayutyanont, N., Lopera, F. J., Quiroz, Y. T., Caselli, R. J., Tariot, P. N., & Reiman, E. M. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.107 · Cited by 145 · see citing works
Self-citationFluorodeoxyglucose metabolism associated with tau‐amyloid interaction predicts memory decline
Hanseeuw, B. J., Betensky, R. A., Schultz, A. P., Papp, K. V., Mormino, E. C., Sepulcre, J., Bark, J. S., Cosio, D. M., LaPoint, M., Chhatwal, J. P., et al. (2017) · Annals of Neurology · doi:10.1002/ana.24910 · Cited by 140 · see citing works
Self-citationHypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change
Soldan, A., Pettigrew, C. A., Cai, Q., Wang, M., Moghekar, A., O’Brien, R., Selnes, O. A., & Albert, M. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0194 · Cited by 117 · see citing works
Tau‐PET uptake: Regional variation in average SUVR and impact of amyloid deposition
Vemuri, P., Lowe, V. J., Knopman, D. S., Senjem, M. L., Kemp, B. J., Schwarz, C. G., Przybelski, S. A., Machulda, M. M., Petersen, R. C., & Jack, C. R. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.12.010 · Cited by 117 · see citing works
Aβ-amyloid and Tau Imaging in Dementia
Villemagne, V. L., Doré, V., Bourgeat, P., Burnham, S. C., Laws, S., Salvado, O., Masters, C. L., & Rowe, C. C. (2017) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2016.09.006 · Cited by 110 · see citing works
Lim, Y., Snyder, P., Pietrzak, R., Ukiqi, A., Villemagne, V., Ames, D., Salvado, O., Bourgeat, P., Martins, R., Masters, C., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.dadm.2015.11.003 · Cited by 107 · see citing works
Association of Longitudinal Cognitive Decline With Amyloid Burden in Middle-aged and Older Adults
Farrell, M. E., Kennedy, K. M., Rodrigue, K. M., Wig, G. S., Bischof, G. N., Rieck, J. R., Chen, X., Festini, S. B., Devous, M. D., & Park, D. C. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0892 · Cited by 102 · see citing works
Teichmann, M., Epelbaum, S., Samri, D., Lévy, M., Michon, A., Hampel, H. J., Lamari, F., & Dubois, B. (2017) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.12.014 · Cited by 86 · see citing works
Amyloid and tau PET demonstrate region-specific associations in normal older people
Lockhart, S. N., Schöll, M., Baker, S. L., Ayakta, N., Swinnerton, K. N., Bell, R. K., Mellinger, T. J., Shah, V. D., O’Neil, J. P., Janabi, M., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.051 · Cited by 79 · see citing works
Schindler, S. E., Jasielec, M. S., Weng, H., Hassenstab, J. J., Grober, E. H., McCue, L. M., Morris, J. C., Holtzman, D. M., Xiong, C., & Fagan, A. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.04.004 · Cited by 77 · see citing works
18 F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal
Lee, C. M., Jacobs, H. I. L., Marquié, M., Becker, J. A., Andrea, N. V., Jin, D. S., Schultz, A. P., Frosch, M. P., Gómez‐Isla, T., Sperling, R. A., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170840 · Cited by 76 · see citing works
Self-citationRentz, D. M., Mormino, E. C., Papp, K. V., Betensky, R. A., Sperling, R. A., & Johnson, K. A. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9640-4 · Cited by 72 · see citing works
Self-citationMormino, E. C., Papp, K. V., Rentz, D. M., Schultz, A. P., LaPoint, M. R., Amariglio, R. E., Hanseeuw, B. J., Marshall, G. A., Hedden, T., Johnson, K. A., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2237 · Cited by 65 · see citing works
Self-citationMachulda, M. M., Hagen, C. E., Wiste, H. J., Mielke, M. M., Knopman, D. S., Roberts, R. O., Vemuri, P., Lowe, V. J., Jack, C. R., & Petersen, R. C. (2016) · The Clinical Neuropsychologist · doi:10.1080/13854046.2016.1241303 · Cited by 58 · see citing works
Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid
Clark, L. R., Berman, S. E., Norton, D., Koscik, R. L., Jonaitis, E. M., Blennow, K., Bendlin, B. B., Asthana, S., Johnson, S. C., Zetterberg, H., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005291 · Cited by 52 · see citing works
Memory performance is related to amyloid and tau pathology in the hippocampus
Reitz, C., Honig, L. S., Vonsattel, J. P., Tang, M.-X., & Mayeux, R. P. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.154146 · Cited by 45 · see citing works
Selective Tau Imaging: Der Stand der Dinge
Villemagne, V. L. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.117.198325 · Cited by 23 · see citing works
Anti-Correlated Cerebrospinal Fluid Biomarker Trajectories in Preclinical Alzheimer’s Disease
Gomar, J. J., Conejero-Goldberg, C., Davies, P., Goldberg, T. E., & Initiative, F. T. A. D. N. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150937 · Cited by 13 · see citing works
Price (1999) · doi:10.1002/1531-8249(199903)45:3
Flagged first, then by citations
Cited by
Sorted by citations
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
Jack, C. R., Andrews, J. S., Beach, T. G., Buracchio, T., Dunn, B., Graf, A., Hansson, O., Ho, C., Jagust, W., McDade, E., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13859 · Cited by 2,803 · see citing works
Self-citationSynergy between amyloid-β and tau in Alzheimer’s disease
Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242 · see citing works
Biomarkers for neurodegenerative diseases
Hansson, O. (2021) · Nature Medicine · doi:10.1038/s41591-021-01382-x · Cited by 1,159 · see citing works
Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group
Dubois, B., Villain, N., Frisoni, G. B., Rabinovici, G. D., Sabbagh, M., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00066-1 · Cited by 1,051 · see citing works
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0281-2 · Cited by 947 · see citing works
Self-citationInteraction between Aβ and Tau in the Pathogenesis of Alzheimer’s Disease
Zhang, H., Wei, W., Zhao, M., Ma, L., Jiang, X., Pei, H., Cao, Y., & Li, H. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.57078 · Cited by 689 · see citing works
Tau biomarkers in Alzheimer's disease: towards implementation in clinical practice and trials
Ossenkoppele, R., van der Kant, R., & Hansson, O. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00168-5 · Cited by 557 · see citing works
Ossenkoppele, R., Pichet Binette, A., Groot, C., Smith, R., Strandberg, O., Palmqvist, S., Stomrud, E., Tideman, P., Ohlsson, T., Jögi, J., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-02049-x · Cited by 496 · see citing works
Self-citationOssenkoppele, R., Smith, R., Mattsson-Carlgren, N., Groot, C., Leuzy, A., Strandberg, O., Palmqvist, S., Olsson, T., Jögi, J., Stormrud, E., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.1858 · Cited by 311 · see citing works
Association of Factors With Elevated Amyloid Burden in Clinically Normal Older Individuals
Sperling, R. A., Donohue, M., Raman, R., Sun, C., Yaari, R., Holdridge, K. C., Siemers, E., Johnson, K. A., Aisen, P. S. S., & for the A4 Study Team (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.0387 · Cited by 326 · see citing works
Self-citationAmyloid-beta peptide and tau protein crosstalk in Alzheimer’s disease
Villegas, S., Roda, A., Serra-Mir, G., Montoliu-Gaya, L., & Tiessler, L. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.332127 · Cited by 306 · see citing works
The AHEAD 3‐45 Study: Design of a prevention trial for Alzheimer's disease
Rafii, M. S., Sperling, R. A., Donohue, M. C., Zhou, J., Roberts, C., Irizarry, M. C., Dhadda, S., Sethuraman, G., Kramer, L. D., Swanson, C. J., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12748 · Cited by 291 · see citing works
Self-citationTherriault, J., Vermeiren, M. R., Servaes, S., Tissot, C., Ashton, N. J., Benedet, A. L., Karikari, T. K., Lantero‐Rodriguez, J., Brum, W. S., Lussier, F. Z., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.4485 · Cited by 268 · see citing works
Jacobs, H. I. L., Becker, J. A., Kwong, K. K., Engels, N., Prokopiou, P. C., Papp, K. V., Properzi, M. J., Hampton, O. L., Uquillas, F. D., Sanchez, J. S., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abj2511 · Cited by 222 · see citing works
Self-citationJack, C. R., Wiste, H. J., Botha, H., Weigand, S. D., Therneau, T. M., Knopman, D. S., Graff-Radford, J., Jones, D. T., Ferman, T. J., Boeve, B. F., et al. (2019) · Brain · doi:10.1093/brain/awz268 · Cited by 200 · see citing works
Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age
Betthauser, T. J., Koscik, R. L., Jonaitis, E. M., Allison, S. L., Cody, K. A., Erickson, C. M., Rowley, H. A., Stone, C. K., Mueller, K. D., Clark, L. R., et al. (2019) · Brain · doi:10.1093/brain/awz378 · Cited by 174 · see citing works
Predicting amyloid PET and tau PET stages with plasma biomarkers
Jack, C. R., Wiste, H. J., Algeciras‐Schimnich, A., Figdore, D. J., Schwarz, C. G., Lowe, V. J., Ramanan, V. K., Vemuri, P., Mielke, M. M., Knopman, D. S., et al. (2023) · Brain · doi:10.1093/brain/awad042 · Cited by 149 · see citing works
Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease
Cain, A., Taga, M., McCabe, C., Green, G. S., Hekselman, I., White, C. C., Lee, D. I., Gaur, P., Rozenblatt-Rosen, O., Zhang, F., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01356-x · Cited by 142 · see citing works
Self-citationGlobal quantitative analysis of the human brain proteome and phosphoproteome in Alzheimer’s disease
Ping, L., Kundinger, S. R., Duong, D. M., Yin, L., Gearing, M., Lah, J. J., Levey, A. I., & Seyfried, N. T. (2020) · Scientific Data · doi:10.1038/s41597-020-00650-8 · Cited by 127 · see citing works
Predicting future rates of tau accumulation on PET
Jack, C. R., Wiste, H. J., Weigand, S. D., Therneau, T. M., Lowe, V. J., Knopman, D. S., Botha, H., Graff-Radford, J., Jones, D. T., Ferman, T. J., et al. (2020) · Brain · doi:10.1093/brain/awaa248 · Cited by 117 · see citing works
Tau deposition is associated with functional isolation of the hippocampus in aging
Harrison, T. M., Maaß, A., Adams, J. N., Du, R., Baker, S. L., & Jagust, W. J. (2019) · Nature Communications · doi:10.1038/s41467-019-12921-z · Cited by 106 · see citing works
Hammond, T. C., Xing, X., Wang, C., Ma, D., Nho, K. T., Crane, P. K., Elahi, F. M., Ziegler, D. A., Liang, G., Cheng, Q. S., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-1079-x · Cited by 113 · see citing works
Guo, T., Korman, D., Baker, S. L., Landau, S. M., & Jagust, W. J. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.029 · Cited by 100 · see citing works
Amyloid duration is associated with preclinical cognitive decline and tau PET
Koscik, R. L., Betthauser, T. J., Jonaitis, E. M., Allison, S. L., Clark, L. R., Hermann, B. P., Cody, K. A., Engle, J. W., Barnhart, T. E., Stone, C. K., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12007 · Cited by 99 · see citing works
O’Dell, R. S., Mecca, A. P., Chen, M.-K., Naganawa, M., Toyonaga, T., Lu, Y., Godek, T. A., Harris, J. E., Bartlett, H. H., Banks, E. R., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00742-y · Cited by 104 · see citing works
Ossenkoppele, R., Salvadó, G., Janelidze, S., Binette, A. P., Bali, D., Karlsson, L., Palmqvist, S., Mattsson, N., Stomrud, E., Therriault, J., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00835-z · Cited by 102 · see citing works
Local Sleep and Alzheimer’s Disease Pathophysiology
Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97 · see citing works
Social Engagement and Amyloid-β-Related Cognitive Decline in Cognitively Normal Older Adults
Biddle, K. D., Uquillas, F. D., Jacobs, H. I. L., Zide, B. S., Kirn, D. R., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Donovan, N. J. (2019) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2019.05.005 · Cited by 90 · see citing works
Self-citationBuckley, R. F., Mormino, E. C., Chhatwal, J. P., Schultz, A. P., Rabin, J. S., Rentz, D. M., Acar, D., Properzi, M. J., Dumurgier, J., Jacobs, H. I. L., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.02.019 · Cited by 89 · see citing works
Self-citationYoung, C. B., Winer, J. R., Younes, K., Cody, K. A., Betthauser, T. J., Johnson, S. C., Schultz, A., Sperling, R. A., Greicius, M. D., Cobos, I., et al. (2022) · JAMA Neurology · doi:10.1001/jamaneurol.2022.0676 · Cited by 79 · see citing works
Self-citationENGAGE and EMERGE: Truth and consequences?
Kuller, L. H., & López, O. L. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12286 · Cited by 85 · see citing works
Synaptic dysfunction in early phases of Alzheimer's Disease
Pelucchi, S., Gardoni, F., Luca, M. D., & Marcello, E. E. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00022-9 · Cited by 88 · see citing works
Boccalini, C., Ribaldi, F., Hristovska, I., Arnone, A., Peretti, D. E., Mu, L., Scheffler, M., Perani, D., Frisoni, G. B., & Garibotto, V. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13355 · Cited by 82 · see citing works
Ullah, R., Park, T. J., Huang, X., & Kim, M. O. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101451 · Cited by 78 · see citing works
Association of Digital Clock Drawing With PET Amyloid and Tau Pathology in Normal Older Adults
Rentz, D. M., Papp, K. V., Mayblyum, D. V., Sanchez, J. S., Klein, H., Souillard‐Mandar, W., Sperling, R. A., & Johnson, K. A. (2021) · Neurology · doi:10.1212/wnl.0000000000011697 · Cited by 77 · see citing works
Self-citationAnti-amyloid-β protein agents for the treatment of Alzheimer’s disease: an update on emerging drugs
Lozupone, M., Solfrizzi, V., D’Urso, F., Di Gioia, I., Sardone, R., Dibello, V., Stallone, R., Liguori, A., Ciritella, C., Daniele, A., et al. (2020) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2020.1808621 · Cited by 77 · see citing works
Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer’s disease
Cody, K. A., Langhough, R. E., Zammit, M. D., Clark, L. R., Chin, N. A., Christian, B. T., Betthauser, T. J., & Johnson, S. C. (2024) · Brain · doi:10.1093/brain/awae116 · Cited by 67 · see citing works
Chhatwal, J. P., Schultz, A. P., Dang, Y., Ostaszewski, B., Liu, L., Yang, H.-S., Johnson, K. A., Sperling, R. A., & Selkoe, D. J. (2020) · Nature Communications · doi:10.1038/s41467-020-19543-w · Cited by 60 · see citing works
Self-citationKim, B., Elzinga, S. E., Henn, R. E., McGinley, L. M., & Feldman, E. L. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104541 · Cited by 66 · see citing works
Tau pathology in cognitively normal older adults
Ziontz, J., Bilgel, M., Shafer, A. T., Moghekar, A., Elkins, W., Helphrey, J. H., Gómez, G., June, D., McDonald, M. A., Dannals, R. F., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.07.007 · Cited by 65 · see citing works
Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
Mormino, E. C., Toueg, T. N., Azevedo, E. C., Castillo, J. B., Guo, W., Nadiadwala, A., Corso, N. K., Hall, J. N., Fan, A. P., Trelle, A. N., et al. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04923-7 · Cited by 65 · see citing works
Self-citationThe complex pathway between amyloid β and cognition: implications for therapy
Jagust, W. J., Teunissen, C. E., & DeCarli, C. S. (2023) · The Lancet Neurology · doi:10.1016/s1474-4422(23)00128-x · Cited by 63 · see citing works
Sanchez, J. S., Hanseeuw, B. J., Lopera, F., Sperling, R. A., Baena, A., Bocanegra, Y., Aguillon, D., Guzmán-Vélez, E., Pardilla-Delgado, E., Ramirez-Gomez, L., et al. (2021) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00765-5 · Cited by 58 · see citing works
Self-citationTowards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease
Ossenkoppele, R., & Hansson, O. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12356 · Cited by 62 · see citing works
Knopman, D. S., Lundt, E. S., Therneau, T. M., Albertson, S. M., Gunter, J. L., Senjem, M. L., Schwarz, C. G., Mielke, M. M., Machulda, M. M., Boeve, B. F., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2020.3921 · Cited by 61 · see citing works
Normal Pressure Hydrocephalus Associated with Alzheimer's Disease
Müller‐Schmitz, K., Krasavina‐Loka, N., Yardimci, T., Lipka, T., Kolman, A. G. J., Robbers, S., Menge, T., Kujovic, M., & Seitz, R. J. (2020) · Annals of Neurology · doi:10.1002/ana.25847 · Cited by 61 · see citing works
AI-driven fusion of multimodal data for Alzheimer’s disease biomarker assessment
Jasodanand, V. H., Kowshik, S. S., Puducheri, S., Romano, M. F., Xu, L., Au, R., & Kolachalama, V. B. (2025) · Nature Communications · doi:10.1038/s41467-025-62590-4 · Cited by 70 · see citing works
Tau‐PET is superior to phospho‐tau when predicting cognitive decline in symptomatic AD patients
Smith, R., Cullen, N. C., Pichet Binette, A., Leuzy, A., Blennow, K., Zetterberg, H., Klein, G., Borroni, E., Ossenkoppele, R., Janelidze, S., et al. (2023) · Alzheimer's & Dementia · doi:10.1002/alz.12875 · Cited by 60 · see citing works
True ultra-low-dose amyloid PET/MRI enhanced with deep learning for clinical interpretation
Chen, K. T., Toueg, T. N., Koran, M. E. I., Davidzon, G., Zeineh, M., Holley, D., Gandhi, H., Halbert, K., Boumis, A., Kennedy, G., et al. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05151-9 · Cited by 59 · see citing works
Self-citationRegional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults
Chen, X., Cassady, K. E., Adams, J. N., Harrison, T. M., Baker, S. L., & Jagust, W. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2111-20.2020 · Cited by 58 · see citing works
Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis
Bocancea, D. I., Svenningsson, A. L., van Loenhoud, A. C., Groot, C., Barkhof, F., Strandberg, O. T., Smith, R. A., Initiative, A. D. N., Weiner, M. W., Aisen, P., et al. (2023) · Brain · doi:10.1093/brain/awad100 · Cited by 57 · see citing works
Self-citationLiu, W., Li, J., Yang, M., Ke, X., Dai, Y., Lin, H., Wang, S., Chen, L., & Tao, J. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-00994-w · Cited by 56 · see citing works
Lu, M., Pontecorvo, M. J., Devous, M. D., Arora, A. K., Galante, N., McGeehan, A., Devadanam, C., Salloway, S. P., Doraiswamy, P. M., Curtis, C., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2020.5505 · Cited by 56 · see citing works
Self-citationWiner, J. R., Morehouse, A. B., Fenton, L. E., Harrison, T. M., Ayangma, L., Reed, M. E., Kumar, S., Baker, S. L., Jagust, W. J., & Walker, M. P. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-21.2021 · Cited by 52 · see citing works
Montal, V., Diez, I., Kim, C.-M., Orwig, W., Bueichekú, E., Gutiérrez-Zúñiga, R., Bejanin, A., Pegueroles, J., Dols-Icardo, O., Vannini, P., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abn7273 · Cited by 52 · see citing works
Self-citationAlexander, C., Parsaee, A., & Vasefi, M. (2023) · Biology · doi:10.3390/biology12111453 · Cited by 51 · see citing works
Generalization of deep learning models for ultra-low-count amyloid PET/MRI using transfer learning
Chen, K. T., Schürer, M., Ouyang, J., Koran, M. E. I., Davidzon, G., Mormino, E. C., Tiepolt, S., Hoffmann, K., Sabri, O., Zaharchuk, G., et al. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04897-6 · Cited by 48 · see citing works
Self-citationTime between milestone events in the Alzheimer's disease amyloid cascade
Insel, P. S., Donohue, M., Berron, D., Hansson, O., & Mattsson, N. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117676 · Cited by 48 · see citing works
Advances in Brain Amyloid Imaging
Krishnadas, N., Villemagne, V. L., Doré, V., & Rowe, C. C. (2021) · Seminars in Nuclear Medicine · doi:10.1053/j.semnuclmed.2020.12.005 · Cited by 48 · see citing works
Rodriguez‐Vieitez, E., Montal, V., Sepulcre, J., Lois, C., Hanseeuw, B. J., Vilaplana, E., Schultz, A. P., Properzi, M. J., Scott, M. R., Amariglio, R. E., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01290-z · Cited by 47 · see citing works
Self-citationSex differences in off-target binding using tau positron emission tomography
Smith, R. A., Strandberg, O. T., Leuzy, A., Betthauser, T. J., Johnson, S. C., Pereira, J. B., & Hansson, O. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102708 · Cited by 46 · see citing works
Slater, C., & Wang, Q. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.397 · Cited by 43 · see citing works
Das, S. R., Xie, L., Wisse, L. E. M., Vergnet, N., Ittyerah, R., Cui, S., Yushkevich, P. A., Wolk, D. A., & Initiative, A. D. N. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2019.05.009 · Cited by 45 · see citing works
Neuroimaging of Alzheimer’s disease: focus on amyloid and tau PET
Matsuda, H., Yoko, S., & Sato, N. (2019) · Japanese Journal of Radiology · doi:10.1007/s11604-019-00867-7 · Cited by 40 · see citing works
Wolters, E. E., Dodich, A., Boccardi, M., Corre, J., Drzezga, A. E., Hansson, O., Nordberg, A. K., Frisoni, G. B., Garibotto, V., & Ossenkoppele, R. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-05118-w · Cited by 47 · see citing works
Scott, M. R., Hampton, O. L., Buckley, R. F., Chhatwal, J. P., Hanseeuw, B. J., Jacobs, H. I. L., Properzi, M. J., Sanchez, J. S., Johnson, K. A., Sperling, R. A., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116991 · Cited by 44 · see citing works
Self-citationWolters, E. E., Ossenkoppele, R., Verfaillie, S. C. J., Coomans, E. M., Timmers, T., Visser, D., Tuncel, H., Golla, S. S. V., Windhorst, A. D., Boellaard, R., et al. (2020) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-020-04758-2 · Cited by 43 · see citing works
Speech pause distribution as an early marker for Alzheimer’s disease
Pastoriza-Domínguez, P., Torre, I. G., Diéguez-Vide, F., Gómez‐Ruiz, I., Geladó, S., López, J. B., Ávila, A., Matías‐Guiu, J. A., Pytel, V., & Hernández-Fernändez, A. (2021) · Speech Communication · doi:10.1016/j.specom.2021.11.009 · Cited by 42 · see citing works
Schwarz, C. G., Therneau, T. M., Weigand, S. D., Gunter, J. L., Lowe, V. J., Przybelski, S. A., Senjem, M. L., Botha, H., Vemuri, P., Kantarci, K., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118259 · Cited by 41 · see citing works
Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults
Vogt, N. M., Hunt, J. F. V., Adluru, N., Ma, Y., Hulle, C. A. V., Dean, D., Kecskemeti, S., Chin, N. A., Carlsson, C. M., Asthana, S., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12364 · Cited by 41 · see citing works
Hampton, O. L., Buckley, R. F., Manning, L. K., Scott, M. R., Properzi, M. J., Peña-Gómez, C., Jacobs, H. I. L., Chhatwal, J. P., Johnson, K. A., Sperling, R. A., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102407 · Cited by 41 · see citing works
Self-citationGroot, C., Doré, V., Robertson, J. S., Burnham, S. C., Savage, G. R., Ossenkoppele, R., Rowe, C. C., & Villemagne, V. L. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.09.017 · Cited by 41 · see citing works
Tau positron emission tomography in preclinical Alzheimer’s disease
Insel, P. S., Young, C. B., Aisen, P. S. S., Johnson, K. A., Sperling, R. A., Mormino, E. C., & Donohue, M. (2022) · Brain · doi:10.1093/brain/awac299 · Cited by 40 · see citing works
Self-citationTesting the amyloid cascade hypothesis: Prevention trials in autosomal dominant Alzheimer disease
Levin, J., Vöglein, J., Quiroz, Y. T., Bateman, R. J., Ghisays, V., Lopera, F., McDade, E., Reiman, E., Tariot, P. N., & Morris, J. C. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12624 · Cited by 40 · see citing works
Self-citationWhite matter lesions may be an early marker for age-related cognitive decline
Morrison, C., Dadar, M., Villeneuve, S., Collins, D. L., & Initiative, A. D. N. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103096 · Cited by 38 · see citing works
Multi-cellular communities are perturbed in the aging human brain and Alzheimer’s disease
Cain, A., Taga, M., McCabe, C., Green, G., Hekselman, I., White, C. C., Lee, D. I., Gaur, P., Rozenblatt-Rosen, O., Zhang, F., et al. (2020) · doi:10.1101/2020.12.22.424084 · Cited by 143 · see citing works
Self-citationArias, J. F., Brum, W. S., Salvadó, G., Therriault, J., Servaes, S., Wang, Y., Aumont, É., Rahmouni, N., Macedo, A. C., Quispialaya, K. M., et al. (2025) · Brain · doi:10.1093/brain/awaf033 · Cited by 40 · see citing works
Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
Karthika, V., Sridharan, B., Nam, J. W., Kim, D., & Lim, H. G. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02406-7 · Cited by 38 · see citing works
New Pathways Identify Novel Drug Targets for the Prevention and Treatment of Alzheimer’s Disease
Penke, B., Szűcs, M., & Bogár, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065383 · Cited by 39 · see citing works
Amyloid and Tau PET Imaging of Alzheimer Disease and Other Neurodegenerative Conditions
Rowley, P. A., Samsonov, A. A., Betthauser, T. J., Pirasteh, A., Johnson, S. C., & Eisenmenger, L. B. (2020) · Seminars in Ultrasound CT and MRI · doi:10.1053/j.sult.2020.08.011 · Cited by 36 · see citing works
Barthélemy, N. R., Toth, B., Manser, P. T., Sanabria-Bohórquez, S., Teng, E., Keeley, M., Bateman, R. J., Weimer, R. M., & Wildsmith, K. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210677 · Cited by 33 · see citing works
Infection and inflammation: New perspectives on Alzheimer's disease
Whitson, H. E., Colton, C. A., Khoury, J. B. E., Gate, D., Goate, A., Heneka, M. T., Kaddurah‐Daouk, R., Klein, R. S., Shinohara, M. L., Sisodia, S. S., et al. (2022) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2022.100462 · Cited by 33 · see citing works
Self-citationKrance, S. H., Cogo‐Moreira, H., Rabin, J. S., Black, S. E., & Swardfager, W. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1056-19.2019 · Cited by 34 · see citing works
Self-citationIndividuals with Alzheimer's disease and low tau burden: Characteristics and implications
Landau, S. M., Lee, J., Murphy, A., Ward, T. J., Harrison, T. M., Baker, S. L., DeCarli, C. S., Harvey, D. J., Tosun, D., Weiner, M. W., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13609 · Cited by 33 · see citing works
Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology
Han, F., Lee, J., Chen, X., Ziontz, J., Ward, T. J., Landau, S. M., Baker, S. L., Harrison, T. M., Jagust, W. J., & Initiative, A. D. N. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14296 · Cited by 42 · see citing works
Amyloid pathology but notAPOEε4 status is permissive for tau-related hippocampal dysfunction
Düzel, E., Ziegler, G., Berron, D., Maaß, A., Schütze, H., Cárdenas‐Blanco, A., Glanz, W., Metzger, C. D., Dobisch, L., Reuter, M., et al. (2021) · Brain · doi:10.1093/brain/awab405 · Cited by 30 · see citing works
Evaluation of [ 18 F]-JNJ-64326067-AAA tau PET tracer in humans
Baker, S. L., Provost, K., Thomas, W., Whitman, A., Janabi, M., Schmidt, M. E., Timmers, M., Kolb, H. C., Rabinovici, G. D., & Jagust, W. J. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x211031035 · Cited by 32 · see citing works
CSF Alzheimer Disease Biomarkers
Greenberg, B., Pettigrew, C. A., Soldan, A., Wang, J., Wang, M., Darrow, J. A., Albert, M., & Moghekar, A. (2022) · Neurology · doi:10.1212/wnl.0000000000200953 · Cited by 32 · see citing works
Teng, E., Manser, P. T., Bohorquez, S. M. S., Wildsmith, K. R., Pickthorn, K., Baker, S. L., Ward, M. E., Kerchner, G. A., & Weimer, R. M. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00937-x · Cited by 31 · see citing works
Speech patterns during memory recall relates to early tau burden across adulthood
Young, C. B., Smith, V., Karjadi, C., Grogan, S., Ang, T. F. A., Insel, P. S., Henderson, V. W., Sumner, M., Poston, K. L., Au, R., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13731 · Cited by 27 · see citing works
Self-citationComparing PET and MRI Biomarkers Predicting Cognitive Decline in Preclinical Alzheimer Disease
Mayblyum, D. V., Becker, J. A., Jacobs, H. I. L., Buckley, R. F., Schultz, A. P., Sepulcre, J., Sanchez, J. S., Rubinstein, Z. B., Katz, S. R., Moody, K. A., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012108 · Cited by 29 · see citing works
Self-citationSmith, G. S., Workman, C. I., Protas, H. D., Su, Y., Savonenko, A. V., Kuwabara, H., Gould, N. F., Kraut, M. A., Joo, J. H., Nandi, A., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01539-9 · Cited by 29 · see citing works
Gabrielli, M., Tozzi, F., Verderio, C., & Origlia, N. (2022) · Cells · doi:10.3390/cells12010063 · Cited by 31 · see citing works
Burnham, S. C., Iaccarino, L., Pontecorvo, M. J., Fleisher, A., Lu, M., Collins, E. C., & Devous, M. D. (2023) · Brain Communications · doi:10.1093/braincomms/fcad305 · Cited by 29 · see citing works
Wang, Z.-T., Shen, X.-N., Ma, Y.-H., Ou, Y.-N., Dong, P. Q., Tan, P. L., & Yu, P. J.-T. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.10.078 · Cited by 28 · see citing works
Seo, E. H., Lim, H. J., Yoon, H., Choi, K. Y., Lee, J. J., Park, J. Y., Choi, S. H., Kim, H., Kim, B. C., & Lee, K. H. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00909-1 · Cited by 26 · see citing works
Age-, sex-, and pathology-related variability in brain structure and cognition
Bachmann, D., Buchmann, A., Studer, S. T., Saake, A., Rauen, K., Zuber, I., Gruber, E., Nitsch, R. M., Höck, C., Gietl, A. F., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02572-6 · Cited by 28 · see citing works
Panza, F., Dibello, V., Sardone, R., Zupo, R., Castellana, F., Leccisotti, I., Moretti, M. C., Altamura, M., Bellomo, A., Daniele, A., et al. (2025) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2025.2463963 · Cited by 27 · see citing works
Beyond the amyloid cascade: An update of Alzheimer's disease pathophysiology
Gouilly, D., Rafiq, M., Nogueira, L., Salabert, A., Payoux, P., Péran, P., & Pariente, J. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2022.12.006 · Cited by 27 · see citing works
The Effects of Amyloid and Tau on Functional Network Connectivity in Older Populations
Wales, R. M., & Leung, H.-C. (2021) · Brain Connectivity · doi:10.1089/brain.2020.0902 · Cited by 26 · see citing works
- Authors
- Sperling, R. A., Mormino, E. C., Schultz, A. P., Betensky, R. A., Papp, K. V., Amariglio, R. E., Hanseeuw, B. J., Buckley, R., Chhatwal, J., Hedden, T., Marshall, G. A., Quiroz, Y. T., Donovan, N. J., Jackson, J., Gatchel, J. R., Rabin, J. S., Jacobs, H., Yang, H., Properzi, M., Kirn, D. R., Rentz, D. M., & Johnson, K. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Corresponding author
- Sperling, Reisa A.
- ORCID
- Sperling, Reisa A.
- Mormino, Elizabeth C.
- Schultz, Aaron P.
- Betensky, Rebecca A.
- Papp, Kathryn V.
- Amariglio, Rebecca E.
- Hanseeuw, Bernard J.
- Buckley, Rachel
- Chhatwal, Jasmeer
- Hedden, Trey
- Marshall, Gad A.
- Quiroz, Yakeel T.
- Donovan, Nancy J.
- Jackson, Jonathan
- Gatchel, Jennifer R.
- Rabin, Jennifer S.
- Jacobs, Heidi
- Yang, Hyun‐Sik
- Properzi, Michael
- Rentz, Dorene M.
- Johnson, Keith A.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2019-01-21
- Volume
- 85
- Issue
- 2
- Pages
- 181-193
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC6402593
- OpenAlex
- W2905538154
- Cited by
- 286
- References
- 52
- Citations by year
- 2026: 22 · 2025: 57 · 2024: 42 · 2023: 29 · 2022: 29 · 2021: 52 · 2020: 38 · 2019: 17
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- National Institute on Aging (K24 AG035007, P01AG036694)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- amyloid-beta, tau protein, preclinical Alzheimer's disease, cognitive decline, memory decline, executive function, tau PET, normal aging, older adults, secondary prevention
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography, Cognitive Dysfunction, Memory, Episodic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
