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Cited by 229Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease

de la Monte, Suzanne M.·1989·Annals of Neurology
DOI 10.1002/ana.410250506
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Abstract

Morphometric analysis of standardized gross cerebral slices from 16 patients with end-stage Alzheimer's disease (AD), 14 controls without neuropathological lesions or neurological disease, and 4 neurologically intact nondemented patients with histopathological lesions of AD was used to measure cross-sectional areas of cerebral cortex, white matter, subcortical nuclei, and the ventricular system. In AD, there was global cerebral atrophy of both cortex and white matter, selective atrophy of the amygdala and hippocampus, and ex vacuo hydrocephalus. In addition, in half the cases of AD, white matter atrophy was associated with overt histopathological evidence of patchy rarefaction of fibers and gliosis. Patients with preclinical AD had prominent and selective shrinkage of white matter comparable to that observed in AD, yet their cortical areas were normal. These observations suggest that white matter degeneration is an intrinsic component of AD. Moreover, its presence in preclinical AD where cortical atrophy is not evident indicates that cytoskeletal abnormalities associated with axonal degeneration may precede and perhaps cause the cortical atrophy observed in clinically manifested AD.

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Crossref · 10.1002/ana.410250506

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Citations

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Research works printed but not linked: 3

  1. Terry RD, 1983, The neurology of aging, 51
  2. Skullured K, 1985, Variations in the size of the human brain. Influence of age, sex, body length, body mass index, alcoholism, Alzheimer changes, and cerebral atherosclerosis, Acta Neurol Scand [Suppl], 102, 1
  3. George AE, 1981, Parenchymal CT correlates of senile dementia (Alzheimer's disease): loss of grey‐white matter discriminability, AJNR, 2, 205

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Metadata

Authors
de la Monte, S. M.
Venue
Annals of Neurology
Publisher
Wiley
Published
1989-05
Volume
25
Issue
5
Pages
450-459
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.410250506
OpenAlex
W2062125611
Cited by
229
References
33
Citations by year
2025: 2 · 2024: 1 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 9
FWCI
8.46
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5639 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG05134-03)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, brain atrophy, preclinical Alzheimer's disease, white matter atrophy, cortical atrophy, hippocampal atrophy, amygdala atrophy, gliosis, axonal degeneration, cytoskeletal abnormalities, brain ventricles, subcortical nuclei
MeSH terms
Alzheimer Disease, Atrophy, Humans

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