Cited by 229Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease

de la Monte, Suzanne M.·1989·Annals of Neurology

DOI 10.1002/ana.410250506

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Abstract

Morphometric analysis of standardized gross cerebral slices from 16 patients with end-stage Alzheimer's disease (AD), 14 controls without neuropathological lesions or neurological disease, and 4 neurologically intact nondemented patients with histopathological lesions of AD was used to measure cross-sectional areas of cerebral cortex, white matter, subcortical nuclei, and the ventricular system. In AD, there was global cerebral atrophy of both cortex and white matter, selective atrophy of the amygdala and hippocampus, and ex vacuo hydrocephalus. In addition, in half the cases of AD, white matter atrophy was associated with overt histopathological evidence of patchy rarefaction of fibers and gliosis. Patients with preclinical AD had prominent and selective shrinkage of white matter comparable to that observed in AD, yet their cortical areas were normal. These observations suggest that white matter degeneration is an intrinsic component of AD. Moreover, its presence in preclinical AD where cortical atrophy is not evident indicates that cytoskeletal abnormalities associated with axonal degeneration may precede and perhaps cause the cortical atrophy observed in clinically manifested AD.

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The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Diagnosis of Alzheimer's Disease
Khachaturian, Z. S. (1985) · Archives of Neurology · doi:10.1001/archneur.1985.04060100083029 · Cited by 2,499
Observations on the brains of demented old people
Tomlinson, B. E., Blessed, G., & Roth, M. (1970) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(70)90063-8 · Cited by 2,084
Cholinergic innervation of cortex by the basal forebrain: Cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (Substantia innominata), and hypothalamus in the rhesus monkey
Mesulam, M. ‐., Mufson, E. J., Levey, A. I., & Wainer, B. H. (1983) · Journal of Comparative Neurology · doi:10.1002/cne.902140206 · Cited by 1,962
Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques
Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., Renbing, X., & Peck, A. (1988) · Annals of Neurology · doi:10.1002/ana.410230206 · Cited by 1,225
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014
Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.
Pearson, R. C., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., & Powell, T. P. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.13.4531 · Cited by 987
MALARIAL DIABETES
Rau, L. (1948) · The Lancet · doi:10.1016/s0140-6736(48)91789-9 · Cited by 828

Show all 33 references

Research works printed but not linked: 3

Terry RD, 1983, The neurology of aging, 51
Skullured K, 1985, Variations in the size of the human brain. Influence of age, sex, body length, body mass index, alcoholism, Alzheimer changes, and cerebral atherosclerosis, Acta Neurol Scand [Suppl], 102, 1
George AE, 1981, Parenchymal CT correlates of senile dementia (Alzheimer's disease): loss of grey‐white matter discriminability, AJNR, 2, 205

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Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease
ETIENNE, D., Kraft, J., Ganju, N., Gómez‐Isla, T., Gemelli, B., Hyman, B. T., Hedley‐Whyte, E. T., Wands, J. R., & de la Monte, S. M. (1998) · Journal of Alzheimer s Disease · doi:10.3233/jad-1998-1205 · Cited by 73
Relationships Between Diabetes and Cognitive Impairment
de la Monte, S. M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.006 · Cited by 73
Amyloid β peptide-induced corpus callosum damage and glial activation in vivo
Jantaratnotai, N., Ryu, J. K., Kim, S. U., & McLarnon, J. G. (2003) · Neuroreport · doi:10.1097/00001756-200308060-00005 · Cited by 86
Association between Alzheimer’s disease pathogenesis and early demyelination and oligodendrocyte dysfunction
Sun, X.-H., Dong, Y.-X., Zhang, H.-Y., Li, H.-Y., Liu, P.-H., & Sui, Y. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.232486 · Cited by 67
Cognitive correlates of cerebral white matter changes
de Groot, J. C., de Leeuw, F., & Breteler, M. M. B. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_5 · Cited by 66
A Scoping Review of Cognitive Training in Neurodegenerative Diseases via Computerized and Virtual Reality Tools: What We Know So Far
Lasaponara, S., Marson, F., Doricchi, F., & Cavallo, M. (2021) · Brain Sciences · doi:10.3390/brainsci11050528 · Cited by 72
Executive Function: The Core Feature of Dementia?
Voss, S. E., & Bullock, R. A. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000079202 · Cited by 69
Aberrant GAP-43 gene expression in Alzheimer's disease.
de la Monte, S. M., Ng, S., & Hsu, D. (1995) · Europe PMC (PubMed Central) · Cited by 66
Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer’s Disease
Cantero, J. L., Atienza, M., Lage, C., Záborszky, L., Vilaplana, E., López‐García, S., Pozueta, A., Rodríguez‐Rodríguez, E., Blesa, R., Alcolea, D. A., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz224 · Cited by 65
Immunocytochemical characterization of glial fibrillary tangles in Alzheimer's disease brain.
Nishimura, M., Tomimoto, H., Suenaga, T., Namba, Y., Ikeda, K., Akiguchi, I., & Kimura, J. (1995) · Europe PMC (PubMed Central) · Cited by 65
Intracranial compartment volumes in patients with enlarged ventricles assessed by magnetic resonance—based image processing
Matsumae, M., Kikinis, R., Mórocz, I. Á., Lorenzo, A. V., Albert, M., Black, P. M., & Jolesz, F. A. (1996) · Journal of neurosurgery · doi:10.3171/jns.1996.84.6.0972 · Cited by 64
Measurement of global brain atrophy in alzheimer's disease with unsupervised segmentation of spin-echo MRI studies
Brunetti, A., Postiglione, A., Tedeschi, E., Ciarmiello, A., Quarantelli, M., Covelli, E. M., Milan, G., Larobina, M., Soricelli, A., Sodano, A., et al. (2000) · Journal of Magnetic Resonance Imaging · doi:10.1002/(sici)1522-2586(200003)11:3 · Cited by 31
Structural Magnetic Resonance Image Averaging in Schizophrenia
Wolkin, A., Rusinek, H., Vaid, G., Arena, L., Lafargue, T., Sanfilipo, M. P., Loneragan, C., Lautin, A., & Rotrosen, J. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.8.1064 · Cited by 60
Cingulum fiber diffusivity and CSF T-tau in patients with subjective and mild cognitive impairment
Stenset, V. T. V., Bjørnerud, A., Fjell, A. M., Walhovd, K. B., Hofoss, D., Due‐Tønnessen, P., Gjerstad, L., & Fladby, T. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.014 · Cited by 61
The Full Spectrum of Alzheimer’s Disease Is Rooted in Metabolic Derangements That Drive Type 3 Diabetes
de la Monte, S. M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_4 · Cited by 59
THE HIPPOCAMPUS IN AGING AND ALZHEIMER'S DISEASE
de Leon, M. J., Convit, A. J., DeSanti, S., Golomb, J. B., Tarshish, C. Y., Rusinek, H., Bobinski, M., Ince, C., Miller, D. C., Wı́sniewski, H. M., et al. (1995) · Neuroimaging Clinics of North America · doi:10.1016/s1052-5149(25)00272-2 · Cited by 59
Clinical correlates of high signal lesions on magnetic resonance imaging in Alzheimer's disease
Bennett, D. A., Gilley, D. W., Wilson, R. S., Huckman, M. S., & Fox, J. H. (1992) · Journal of Neurology · doi:10.1007/bf00839137 · Cited by 58
Hypertension and Related Factors in the Etiology of Alzheimer's Disease
Skoog, I. G., & Gustafson, D. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04796.x · Cited by 58
Functional connectivity of white matter as a biomarker of cognitive decline in Alzheimer’s disease
Gao, Y., Sengupta, A., Li, M., Zu, Z., Rogers, B. P., Anderson, A. W., Ding, Z., Gore, J. C., & Initiative, A. D. N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0240513 · Cited by 58
Heat shock protein (hsx70) mRNA expression in human brain: effects of neurodegenerative disease and agonal state
Harrison, P. J., PROCTER, A. W., Exworthy, T., Roberts, G. W., Najlerahim, A., BARTON, A. J. L., & Pearson, R. C. A. (1993) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1993.tb00400.x · Cited by 54
Normal brain aging and Alzheimer's disease are associated with lower cerebral pH: an in vivo histidine 1H-MR spectroscopy study
Lyros, E., Ragoschke-Schumm, A., Kostopoulos, P., Sehr, A., Backens, M., Kalampokini, S., Decker, Y., Lesmeister, M., Liu, Y., Reith, W., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.11.012 · Cited by 48
Animal-Assisted and Pet-Robot Interventions for Ameliorating Behavioral and Psychological Symptoms of Dementia: A Systematic Review and Meta-Analysis
Park, S., Bak, A., Kim, S., Nam, Y., Kim, H., Yoo, D.-H., & Moon, M. (2020) · Biomedicines · doi:10.3390/biomedicines8060150 · Cited by 44
Increased levels of neuronal thread protein in cerebrospinal fluid of patients with Alzheimer's disease
de la Monte, S. M., Volicer, L., Hauser, S. L., & Wands, J. R. (1992) · Annals of Neurology · doi:10.1002/ana.410320606 · Cited by 50

Authors: de la Monte, S. M.
Venue: Annals of Neurology
Publisher: Wiley
Published: 1989-05
Volume: 25
Issue: 5
Pages: 450-459
ISSN: 0364-5134 (ISSN-L)
1531-8249
DOI: 10.1002/ana.410250506
OpenAlex: W2062125611
Cited by: 229
References: 33
Citations by year: 2025: 2 · 2024: 1 · 2023: 8 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 8 · 2018: 12 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 10 · 2012: 9
FWCI: 8.46
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5639 d)
Locations: Annals of Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG05134-03)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, brain atrophy, preclinical Alzheimer's disease, white matter atrophy, cortical atrophy, hippocampal atrophy, amygdala atrophy, gliosis, axonal degeneration, cytoskeletal abnormalities, brain ventricles, subcortical nuclei
MeSH terms: Alzheimer Disease, Atrophy, Humans

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Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer’s disease

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