Enriched environment increases the myelinated nerve fibers of aged rat corpus callosum
Abstract
In this study, the effect of enriched environment (EE) on the spatial learning of aged rats was examined, and then the effects of EE on the aged corpus callosum (CC) were investigated by means of the modern stereological methods. We found that EE significantly improved the spatial learning of aged rats. The CC volume, the total volume of the myelinated fibers and total volume of the myelin sheaths in the CC, the total length of the myelinated fibers in the CC of enriched rats were significantly increased when compared to standard rats. The increase of the myelinated fibers in enriched rat CC might provide one of the structural bases for the enrichment-related improvement of the spatial learning. This study provided, to the best of our knowledge, the first evidence of environmental enrichment-induced increases of the CC and the myelinated fibers in the CC of aged rats.
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Environmental enrichment increases myelination of callosal fibres.
“Environmental enrichment, a less specific manipulation, has been shown to increase myelination of callosal fibres (Markham et al., 2009; Zhao et al., 2012).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Zhao et al., 2012
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“Environmental enrichment, a less specific manipulation, has been shown to increase myelination of callosal fibres (Markham et al., 2009; Zhao et al., 2012).”
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- Authors
- Zhao, Y., Shi, X., Qiu, X., Lu, W., Yang, S., Li, C., Chen, L., Zhang, L., Cheng, G., & Tang, Y.
- Affiliations
- Chongqing Medical University (CN)
- Corresponding author
- Tang, Yong
- Venue
- The Anatomical Record
- Publisher
- Wiley
- Published
- 2012-03-19
- Volume
- 295
- Issue
- 6
- Pages
- 999-1005
- ISSN
- 1932-8486 (ISSN-L)
- 1932-8494
- OpenAlex
- W1964478258
- Cited by
- 41
- References
- 46
- Citations by year
- 2025: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Anatomical Record (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- environmental enrichment, corpus callosum, myelinated axons, myelin sheath, aging, spatial learning, aged rats, axon growth
- MeSH terms
- Aging, Animals, Animal Husbandry, Corpus Callosum, Environment, Female, Housing, Animal, Nerve Fibers, Myelinated, Swimming, Rats, Sprague-Dawley, Maze Learning, Rats
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