Cited by 41Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsAdvanced Neuroimaging Techniques and Applications

Enriched environment increases the myelinated nerve fibers of aged rat corpus callosum

Zhao, Yuan‐Yu, Shi, Xiao‐Yan, Qiu, Xuan, Lu, Wei, Yang, Shu, Li, Chen, Chen, Lin, Zhang, Lei +2 more·2012·The Anatomical Record

Abstract

In this study, the effect of enriched environment (EE) on the spatial learning of aged rats was examined, and then the effects of EE on the aged corpus callosum (CC) were investigated by means of the modern stereological methods. We found that EE significantly improved the spatial learning of aged rats. The CC volume, the total volume of the myelinated fibers and total volume of the myelin sheaths in the CC, the total length of the myelinated fibers in the CC of enriched rats were significantly increased when compared to standard rats. The increase of the myelinated fibers in enriched rat CC might provide one of the structural bases for the enrichment-related improvement of the spatial learning. This study provided, to the best of our knowledge, the first evidence of environmental enrichment-induced increases of the CC and the myelinated fibers in the CC of aged rats.

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Crossref · 10.1002/ar.22446

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Authors
Zhao, Y., Shi, X., Qiu, X., Lu, W., Yang, S., Li, C., Chen, L., Zhang, L., Cheng, G., & Tang, Y.
Affiliations
Chongqing Medical University (CN)
Corresponding author
Tang, Yong
Venue
The Anatomical Record
Publisher
Wiley
Published
2012-03-19
Volume
295
Issue
6
Pages
999-1005
ISSN
  • 1932-8486 (ISSN-L)
  • 1932-8494
OpenAlex
W1964478258
Cited by
41
References
46
Citations by year
2025: 3 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3
FWCI
1.40
Type
journal article
Language
en
Open access
closed
Locations
  • The Anatomical Record (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
environmental enrichment, corpus callosum, myelinated axons, myelin sheath, aging, spatial learning, aged rats, axon growth
MeSH terms
Aging, Animals, Animal Husbandry, Corpus Callosum, Environment, Female, Housing, Animal, Nerve Fibers, Myelinated, Swimming, Rats, Sprague-Dawley, Maze Learning, Rats

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