Cited by 134Physical Activity and HealthMusculoskeletal pain and rehabilitationOsteoarthritis Treatment and Mechanisms

The impact of momentary pain and fatigue on physical activity in women with osteoarthritis

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Murphy, Susan L., Smith, Dylan M., Clauw, Daniel J., Alexander, Neil B.·2008·Arthritis Care & Research

Abstract

Objective: To examine the daily life patterns of both pain and fatigue symptoms and objective physical activity (using ambulatory monitoring) in women with symptomatic lower extremity osteoarthritis (OA), and to evaluate how momentary symptoms impact physical activity levels. Methods: Sixty women age ≥55 years (40 with knee or hip OA and 20 matched controls) participated in an observational study involving 2 laboratory visits and a 5‐day home data collection period. During the home period physical activity levels were assessed continuously, and symptoms were inputted 6 times a day into an enhanced accelerometer at prespecified time points. Results: In the OA group as compared with the control group over the 5‐day period, average physical activity was significantly lower (P = 0.02) and peak physical activity tended to be lower (P = 0.06). Although pain and fatigue overall were of moderate severity in this cohort, fatigue escalated throughout each day. In a hierarchical linear model, fatigue was most strongly associated with physical activity (β = −30.1, P < 0.0001). Pain was more weakly associated with physical activity and in the direction opposite to what was hypothesized (β = 16.9, P = 0.04). Conclusion: Momentary reports of fatigue negatively predicted physical activity levels and were much more strongly related to physical activity than momentary pain. In order to help women with knee or hip OA manage symptoms and become more physically active, it may be important to emphasize fatigue management.

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  • The single-item measures used to assess momentary symptoms have not been validated.

    “Use of single item measures that have not been validated to assess momentary symptoms is a limitation of this study.”

    From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [81]

    The ‘Subjective measures collected by the Actiwatch-S’ section describes momentary pain and fatigue ratings, supporting the use of single-item symptom measures. The Discussion identifies the 0–4 scale’s limited comparability with other studies, but does not say the symptom measures were unvalidated; it discusses Actiwatch-S validity separately. No page numbers were available in our copy. (LLM, conf=0.78)

    Experimental — accuracy not yet measured
  • There are no standard, validated ecological momentary assessment measures of the symptoms examined in this study.

    “to our knowledge there are no standard, validated EMA measures of the symptoms examined in this study.”

    From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [81]

    The Subjective measures section describes the study’s 0–4 momentary pain and fatigue ratings, and the Discussion says this scale was chosen to reduce respondent burden rather than using the more common 0–10 scale. Neither passage says that standard, validated EMA measures of these symptoms do not exist; searches for validated EMA measures and symptom-scale validity found no such statement in our copy. Page numbers were not available. (LLM, conf=0.72)

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1 of the 48 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Meenan RF, Callahan LF, Helmick CG. The National Arthritis Action Plan: a public health strategy for a looming epidemic [editorial]. Arthritis Care Res 1999;12:79 -81.
  2. Kahn EB, Ramsey LT, Brownson RC, Heath GW, Howze EH, Powell KE, et al. The effectiveness of interventions to increase physical activity: a systematic review. Am J Prev Med 2002; 22(4 Suppl):73-107.

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Authors
Murphy, S. L., Smith, D. M., Clauw, D. J., & Alexander, N. B.
Affiliations
University of Michigan (US)
Venue
Arthritis Care & Research
Publisher
Wiley
Published
2008-05-30
Volume
59
Issue
6
Pages
849-856
ISSN
  • 0893-7524 (ISSN-L)
  • 1529-0123
OpenAlex
W2045799657
Cited by
134
References
48
Citations by year
2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 12 · 2012: 14
FWCI
7.02
Type
journal article
Language
en
Open access
Locations
  • Arthritis Care & Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
  • American College of Rheumatology Research and Education Foundation
  • National Institute on Aging (K24 AG 109675)
  • National Center for Research Resources (M01RR000042)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (K01HD045293)
  • National Center for Medical Rehabilitation Research
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords
osteoarthritis, physical activity, fatigue, pain, women, lower extremity osteoarthritis, knee osteoarthritis, hip osteoarthritis, ambulatory monitoring, accelerometry, older women
MeSH terms
Aged, Aged, 80 and over, Fatigue, Female, Humans, Middle Aged, Motor Activity, Osteoarthritis, Pain, Osteoarthritis, Hip, Linear Models, Osteoarthritis, Knee

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