The impact of momentary pain and fatigue on physical activity in women with osteoarthritis
Open accessAbstract
Objective: To examine the daily life patterns of both pain and fatigue symptoms and objective physical activity (using ambulatory monitoring) in women with symptomatic lower extremity osteoarthritis (OA), and to evaluate how momentary symptoms impact physical activity levels. Methods: Sixty women age ≥55 years (40 with knee or hip OA and 20 matched controls) participated in an observational study involving 2 laboratory visits and a 5‐day home data collection period. During the home period physical activity levels were assessed continuously, and symptoms were inputted 6 times a day into an enhanced accelerometer at prespecified time points. Results: In the OA group as compared with the control group over the 5‐day period, average physical activity was significantly lower (P = 0.02) and peak physical activity tended to be lower (P = 0.06). Although pain and fatigue overall were of moderate severity in this cohort, fatigue escalated throughout each day. In a hierarchical linear model, fatigue was most strongly associated with physical activity (β = −30.1, P < 0.0001). Pain was more weakly associated with physical activity and in the direction opposite to what was hypothesized (β = 16.9, P = 0.04). Conclusion: Momentary reports of fatigue negatively predicted physical activity levels and were much more strongly related to physical activity than momentary pain. In order to help women with knee or hip OA manage symptoms and become more physically active, it may be important to emphasize fatigue management.
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The single-item measures used to assess momentary symptoms have not been validated.
“Use of single item measures that have not been validated to assess momentary symptoms is a limitation of this study.”
From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [81]
The ‘Subjective measures collected by the Actiwatch-S’ section describes momentary pain and fatigue ratings, supporting the use of single-item symptom measures. The Discussion identifies the 0–4 scale’s limited comparability with other studies, but does not say the symptom measures were unvalidated; it discusses Actiwatch-S validity separately. No page numbers were available in our copy. (LLM, conf=0.78)
Experimental — accuracy not yet measuredThere are no standard, validated ecological momentary assessment measures of the symptoms examined in this study.
“to our knowledge there are no standard, validated EMA measures of the symptoms examined in this study.”
From Ecological momentary assessment of pain, fatigue, depressive, and cognitive symptoms reveals significant daily variability in multiple sclerosis (2017) · cites this paper as [81]
The Subjective measures section describes the study’s 0–4 momentary pain and fatigue ratings, and the Discussion says this scale was chosen to reduce respondent burden rather than using the more common 0–10 scale. Neither passage says that standard, validated EMA measures of these symptoms do not exist; searches for validated EMA measures and symptom-scale validity found no such statement in our copy. Page numbers were not available. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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“adults will develop symptomatic knee OA in their lifetime.(24) Being physically active is one of the most effective nonpharmacological treatments of chronic pain,(2,11) and has also been recommended to improve the overall health and prevent a large number of chronic diseases by the Physical Activity Guidelines for Ame…”
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Effect of Aromatase Inhibitor Therapy on Sleep and Activity Patterns in Early-stage Breast Cancer
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Self-citationAll Fatigue is Not Created Equal
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Self-citationThe physiological benefits of sitting less and moving more: Opportunities for future research
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A multidisciplinary and multidimensional intervention for patients with hand osteoarthritis
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Fatigability as a function of physical activity energy expenditure in older adults
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A review and synthesis of correlates of fatigue in osteoarthritis
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Ambulatory Monitoring as a Measure of Disability in Chronic Low Back Pain Populations
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Activity pacing: what are we measuring and how does that relate to intervention?
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Measuring Physical Activity in Spinal Cord Injury Using Wrist-Worn Accelerometers
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Self-citationVitality and the course of limitations in activities in osteoarthritis of the hip or knee
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Self-citationAging, Fatigue, and Fatigability: Implications for Occupational and Physical Therapists
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Associations of Midlife to Late Life Fatigue With Physical Performance and Strength in Early Old Age
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Pain Resilience: Issues of Modeling Dynamic Adaptation in Chronic Pain
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Role of physical activity in the management and assessment of rheumatoid arthritis patients
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Impact of Disease Activity on Physical Activity in Patients With Psoriatic Arthritis
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- Authors
- Murphy, S. L., Smith, D. M., Clauw, D. J., & Alexander, N. B.
- Affiliations
- University of Michigan (US)
- Venue
- Arthritis Care & Research
- Publisher
- Wiley
- Published
- 2008-05-30
- Volume
- 59
- Issue
- 6
- Pages
- 849-856
- ISSN
- 0893-7524 (ISSN-L)
- 1529-0123
- PMC
- PMC3046423
- OpenAlex
- W2045799657
- Cited by
- 134
- References
- 48
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 12 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 5 · 2013: 12 · 2012: 14
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Arthritis Care & Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- American College of Rheumatology Research and Education Foundation
- National Institute on Aging (K24 AG 109675)
- National Center for Research Resources (M01RR000042)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K01HD045293)
- National Center for Medical Rehabilitation Research
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Keywords
- osteoarthritis, physical activity, fatigue, pain, women, lower extremity osteoarthritis, knee osteoarthritis, hip osteoarthritis, ambulatory monitoring, accelerometry, older women
- MeSH terms
- Aged, Aged, 80 and over, Fatigue, Female, Humans, Middle Aged, Motor Activity, Osteoarthritis, Pain, Osteoarthritis, Hip, Linear Models, Osteoarthritis, Knee
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