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Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

Humbert, Patrick, Russell, Sarah, Richardson, Helena·2003·BioEssays
DOI 10.1002/bies.10286
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Abstract

Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been identified as tumour suppressor genes in Drosophila, mutations of which cause similar phenotypes, involving disruption of cell polarity and neoplastic overgrowth of tissues. The molecular mechanisms by which Dlg, Scrib and Lgl proteins regulate cell proliferation are not clear, but there is some evidence that epithelial polarisation is required for this regulation. Dlg, Scrib and Lgl are highly conserved between human and Drosophila, and we discuss evidence that these proteins also play a role in cancer progression in humans. BioEssays 25:542–553, 2003. © 2003 Wiley Periodicals, Inc.

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Cited by

Metadata

Authors
Humbert, P., Russell, S., & Richardson, H.
Venue
BioEssays
Publisher
Wiley
Published
2003-05-19
Volume
25
Issue
6
Pages
542-553
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
DOI
10.1002/bies.10286
OpenAlex
W2090678693
Cited by
297
References
4
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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