Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats
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Central oxytocin (OT) modulates many social behaviors, including female rat sexual receptivity, quantified as the copulatory stance known as lordosis. The expression of the lordosis response is modulated by OT action in the ventromedial nucleus of the hypothalamus (VMH), as demonstrated by behavioral pharmacology experiments. However, the subcellular localization of OT in this brain region has been unclear. We tested the hypothesis that ovarian hormones reorganize OT-labeled pre- or postsynaptic elements in the fiber complex lateral to the VMH by using immunoelectron microscopy. OT immunolabeling occurred in axonal boutons identified by the presence of small, clear synaptic vesicles and double labeling with the presynaptic markers synaptophysin and vesicular glutamate transporter 2. OT immunoreactivity also was observed in dendritic profiles, verified with double labeling for the dendrite-specific marker microtubule-associated protein 2. Ovarian hormones did not alter the density of axonal boutons; however, estradiol treatment reduced the density of dendritic profiles by 34%. This effect was reversed when progesterone was given subsequent to estradiol. The effect of estradiol treatment was specific to dendrites that lacked OT immunostaining; the density of OT-labeled dendritic profiles remained constant during estradiol treatment. With the estradiol-induced exit of non-OT-labeled dendritic profiles, the remaining OT-labeled dendritic profiles experienced an increase in their number of synaptic contacts. Thus, hormone treatments that mimic the 4-day rat estrous cycle provoke a chemically coded reorganization of dendrite innervation in the fiber plexus lateral to the VMH that may underlie the hormone-specific effect of OT on reproductive behavior.
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Electron microscopic analysis has revealed dense core vesicles containing AVP- and OT-ir in terminals located in synaptic regions of brain areas such as the habenula, lateral septum, amygdala, supraoptic nuclei, ventromedial hypothalamus, and the nucleus of the solitary tract.
“For example, electron microscopic analysis has revealed dense core vesicles containing AVP- and OT-ir in terminals located in synaptic regions of brain areas such as the habenula, lateral septum, amygdala, supraoptic nuclei, ventromedial hypothalamus and the nucleus of the solitary tract [98; 99; 100; 101; 102; 103; 104].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [101]
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New regulators in oxytocin and vasopressin release : role of the endolysosomal two-pore channels
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- Authors
- Griffin, G. D., Ferri‐Kolwicz, S. L., Reyes, B. A. S., Van Bockstaele, E. J., & Flanagan‐Cato, L. M.
- Affiliations
- University of Pennsylvania (US)
- Thomas Jefferson University (US)
- Corresponding author
- Griffin, Gerald D.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 2010-07-26
- Volume
- 518
- Issue
- 22
- Pages
- 4531-4545
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- PMC
- PMC4323080
- OpenAlex
- W2158029907
- Cited by
- 56
- References
- 73
- Citations by year
- 2025: 2 · 2024: 2 · 2022: 4 · 2021: 5 · 2020: 9 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 3 · 2014: 7 · 2013: 3 · 2012: 6
- FWCI
- 6.09
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5t32mh017168-34)
- National Institute of Mental Health (TG-MH017168, R01MH064371, MH64371, T32 MH-017168)
- National Institute on Drug Abuse (R01DA009082)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin, ventromedial hypothalamus, ovarian hormones, estradiol, progesterone, dendritic reorganization, synaptic remodeling, lordosis, sexual receptivity, female reproductive behavior, axonal boutons, synaptophysin, vesicular glutamate transporter 2, MAP2, estrous cycle, immunoelectron microscopy
- MeSH terms
- Animals, Dendrites, Estradiol, Female, Hormones, Microtubule-Associated Proteins, Neurons, Ovariectomy, Oxytocin, Progestins, Progesterone, Synapses, Ventromedial Hypothalamic Nucleus, Microscopy, Immunoelectron, Synaptophysin, Rats, Sprague-Dawley, Vesicular Glutamate Transport Protein 2, Rats
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