Oxytocin in the ventromedial hypothalamic nucleus reduces feeding and acutely increases energy expenditure
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Central oxytocin reduces food intake and increases energy expenditure. The ventromedial hypothalamic nucleus (VMN) is associated with energy balance and contains a high density of oxytocin receptors. We hypothesized that oxytocin in the VMN is a negative regulator of energy balance acting to reduce feeding and increase energy expenditure. To test this idea, oxytocin or vehicle was injected directly into the VMN of Sprague-Dawley rats during fasted and nonfasted conditions. Energy expenditure (via indirect calorimetry) and spontaneous physical activity (SPA) were recorded simultaneously. Animals were also exposed to a conditioned taste aversion test, to determine whether oxytocin's effects on food intake were associated with malaise. When food was available during testing, oxytocin-induced elevations in energy expenditure lasted for 1 h, after which overall energy expenditure was reduced. In the absence of food during the testing period, oxytocin similarly increased energy expenditure during the first hour, but differences in 12-h energy expenditure were eliminated, implying that the differences may have been due to the thermic effects of feeding (digestion, absorption, and metabolic processing). Oxytocin acutely elevated SPA and reduced feeding at doses that did not cause a conditioned taste aversion during both the fed and fasted states. Together, these data suggest that oxytocin in the VMN promotes satiety and acutely elevates energy expenditure and SPA and implicates the VMN as a relevant site for the antiobesity effects of oxytocin.
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Oxytocin induces weight loss in rodents, and this effect may be related to increased energy expenditure and lipolysis in addition to appetite suppression.
“Oxytocin induces weight loss in rodents, and this effect may be related to increased energy expenditure and lipolyis in addition to appetite suppression(6, 7, 8, 9, 10, 11).”
From Oxytocin reduces caloric intake in men (2015) · cites this paper as [8]
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- Authors
- Noble, E. E., Billington, C. J., Kotz, C. M., & Wang, C.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Wang, ChuanFeng
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2014-09-15
- Volume
- 307
- Issue
- 6
- Pages
- R737-R745
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- PMC
- PMC4166752
- OpenAlex
- W1972127276
- Cited by
- 102
- References
- 67
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 12 · 2023: 8 · 2022: 4 · 2021: 13 · 2020: 6 · 2019: 7 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 8 · 2014: 3
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK083250)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, ventromedial hypothalamus, energy expenditure, dietary intake, energy balance, spontaneous physical activity, conditioned taste aversion, satiety, thermic effect of feeding, anti-obesity, fasting
- MeSH terms
- Animals, Dose-Response Relationship, Drug, Eating, Energy Metabolism, Fasting, Feeding Behavior, Injections, Intraventricular, Male, Motor Activity, Oxytocin, Satiety Response, Time Factors, Ventromedial Hypothalamic Nucleus, Rats, Sprague-Dawley, Anti-Obesity Agents, Rats
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