Localization of oxytocin receptor messenger ribonucleic acid in the rat brain.
Abstract
The expression of oxytocin receptor (OT-R) mRNA in the rat central nervous system was examined by in situ hybridization histochemistry using cRNA probe. Wide distribution of cells expressing OT-R mRNA was observed not only in the hypothalamus, but also in other regions. There were high levels of OT-R mRNA in the anterior olfactory nuclei, tenia tecta, olfactory tubercle, rostral most region of the frontal cortex, piriform cortex, layers 2 and 3 of the neocortex, bed nucleus of the stria terminalis, anterior medial preoptic nucleus (AV3V region), magnocellular preoptic nucleus, supraoptic nucleus, paraventricular hypothalamic nucleus, retrochiasmatic nucleus, ventromedial hypothalamic nucleus, paraventricular thalamic nucleus, central amygdaloid nucleus, medial amygdaloid nucleus, posterior cortical amygdaloid nucleus, amygdalohippocampal area, subiculum, prepositus hypoglossal nucleus, and dorsal motor nucleus of vagus. In most regions of the brain, our findings concurred with those obtained by receptor binding autoradiography using a ligand specific to OT. However, in the inferior olive nucleus, OT-R mRNA was not detected despite an abundance of binding sites showed by receptor binding autography. Despite this discrepancy OT appears to have central nervous system functions in addition to its hormonal functions.
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In rodents, high concentrations of OXTR mRNA are found in the hypothalamus, amygdala, olfactory bulb, ventral pallidum, and dorsal vagal nucleus.
“Seminal animal work using histochemistry and immunohistochemistry revealed high concentrations of OXTR mRNA in the hypothalamus, amygdala, olfactory bulb, ventral pallidum, and the dorsal vagal nucleus in rodents7,8.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [7]
Oxytocin receptors are widespread throughout the hypothalamus.
“oxytocin receptors are widespread throughout the hypothalamus (Yoshimura et al., 1993).”
From The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior (2022) · cites this paper as Yoshimura et al., 1993
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Self-citation
- Authors
- Yoshimura, R., Kiyama, H., Kimura, T., Araki, T., Maeno, H., Tanizawa, O., & Tohyama, M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1993-09
- Volume
- 133
- Issue
- 3
- Pages
- 1239-1246
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2142834656
- Cited by
- 161
- References
- 29
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 4 · 2015: 6 · 2014: 10 · 2013: 8 · 2012: 2
- FWCI
- 9.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin receptor, mRNA localization, rat brain, hypothalamus, anterior olfactory nucleus, bed nucleus of the stria terminalis, amygdala, preoptic nucleus, inferior olive, receptor binding sites
- MeSH terms
- Animals, Autoradiography, Brain Chemistry, Cerebral Cortex, Female, Hypothalamus, RNA, Messenger, Telencephalon, Tissue Distribution, RNA Probes, Gene Expression, Rats, Wistar, In Situ Hybridization, Receptors, Vasopressin, Receptors, Oxytocin, Rats
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