The ventral striatopallidothalamic projection: I. The striatopallidal link originating in the striatal parts of the olfactory tubercle
Abstract
The projections from the striatal part of the olfactory tubercle were examined in rats, both with the aid of experimental silver impregnation methods following superficial laminar heat lesions of the tubercle and by the use of anterograde transport of Phaseolus vulgaris-leucoagglutinin (PHA-L) following injections of the lectin in the dense cell layer of the tubercle. Retrograde transport of fluorescent substances following injections of the tracer in the multiform layer of the tubercle were used to corroborate the results obtained by the anterograde transport and degeneration methods. The main and apparently only significant termination from the striatal cells in the olfactory tubercle is located immediately deep to the dense cell layer in areas that could be identified as part of the ventral pallidum on the basis of either the Nissl method or glutamate decarboxylase immunocytochemistry. Whereas a mediolateral topography is generally maintained by the ventral striatopallidal pathway originating in the dense cell layer, there is a considerable spread of the projection in the rostrocaudal direction. The dense projection field of the olfactory tubercle component of the ventral striatopallidal pathway permeates the ventrolateral part of the ventral pallidum, thereby complementing the termination of the accumbens projection to the more mediodorsal parts of the ventral pallidum.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The ventral striatum sends its major projection to the ventral pallidum.
“The ventral striatum sends its major projection to the ventral pallidum (Heimer et al., 1987; 1991; Zahm and Heimer, 1987; 1990; Zahm et al., 1987; O’Donnell et al., 1997; Usuda et al., 1998; Zhou et al., 2003).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Heimer et al., 1987
The lateral shell and lateral olfactory tubercle appear to project to the ventrolateral portion of the ventral pallidum.
“Similarly, the lateral shell and lateral olfactory tubercle appear to project to the ventrolateral portion of the ventral pallidum, including the lateral polymorph layer of the olfactory tubercle containing pallidal neurons (Heimer et al., 1987; 1991; Zahm and Heimer, 1987; 1990; O’Donnell et al., 1997; Usuda et al., 1998; Zhou et al., 2003).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Heimer et al., 1987
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy
Karnovsky, M. J., & Karnovsky, M. J. (1965) · The Journal of Cell Biology · Cited by 5,078 · see citing works
Stereotaxic mapping of the monoamine pathways in the rat brain
Ungerstedt, U. (1971) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.1971.tb10998.x · Cited by 3,819 · see citing works
Embedding in Epoxy Resins for Ultrathin Sectioning in Electron Microscopy
Richardson, K. C., Jarett, L., & Finke, E. H. (1960) · Stain Technology · doi:10.3109/10520296009114754 · Cited by 3,310 · see citing works
Fink, R., & Heimer, L. (1967) · Brain Research · doi:10.1016/0006-8993(67)90166-7 · Cited by 1,766 · see citing works
Self-citationFuxé, K. (1965) · PubMed · Cited by 1,544 · see citing works
Krettek, J. E., & Price, J. L. (1978) · Journal of Comparative Neurology · doi:10.1002/cne.901780204 · Cited by 1,293 · see citing works
Gerfen, C. R., & Sawchenko, P. E. (1984) · Brain Research · doi:10.1016/0006-8993(84)90940-5 · Cited by 1,203 · see citing works
Efferent connections and nigral afferents of the nucleus accumbens septi in the rat
Nauta, W. J. H., Smith, G. P., Faull, R. L. M., & Domesick, V. B. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90041-6 · Cited by 876 · see citing works
de Olmos, J. S., Hardy, H., & Heimer, L. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901810202 · Cited by 712 · see citing works
Self-citationHaberly, L. B., & Price, J. L. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901780408 · Cited by 680 · see citing works
The structure of the caudate nucleus of the cat: light and electron microscopy
Kemp, J. M., & Powell, T. P. S. (1971) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1971.0102 · Cited by 672 · see citing works
Dejerine, J. (1895) · Biblioteca Digital (Real Academia Nacional de Medicina) · Cited by 565 · see citing works
Cytochemical methods in neuroanatomy
Chan‐Palay, V., & Palay, S. L. (1982) · A.R. Liss eBooks · Cited by 562 · see citing works
Itoh, K., Konishi, A., Nomura, S., Mizuno, N., Nakamura, Y., & Sugimoto, T. (1979) · Brain Research · doi:10.1016/0006-8993(79)91013-8 · Cited by 541 · see citing works
Cholecystokinin innervation of the ventral striatum: A morphological and radioimmunological study
Záborszky, L., Alheid, G. F., Beinfeld, M. C., Eiden, L. E., Heimer, L., & Palkovits, M. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90302-1 · Cited by 489 · see citing works
Self-citationGroenewegen, H. J., & Russchen, F. T. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230303 · Cited by 447 · see citing works
Efferent connections of the ventral pallidum: Evidence of a dual striato pallidofugal pathway
Haber, S. N., Groenewegen, H. J., Grove, E. A., & Nauta, W. J. H. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350304 · Cited by 432 · see citing works
The Distribution of Adrenergic Nerve Fibres to the Blood Vessels in Skeletal Muscle
Fuxé, K., & Sedvall, G. (1965) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1965.tb04155.x · Cited by 419 · see citing works
Mogenson, G. J., Swanson, L. W., & Wu, M. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-01-00189.1983 · Cited by 410 · see citing works
Ribak, C. E., Vaughn, J. E., & Roberts, E. (1979) · The Journal of Comparative Neurology · doi:10.1002/cne.901870203 · Cited by 410 · see citing works
Ventral striatum and ventral pallidum
Heimer, L., Switzer, R. D., & Hoesen, G. W. V. (1982) · Trends in Neurosciences · doi:10.1016/0166-2236(82)90037-6 · Cited by 401 · see citing works
Self-citationZáborszky, L., Carlsen, J., Brashear, H. R., & Heimer, L. (1986) · The Journal of Comparative Neurology · doi:10.1002/cne.902430405 · Cited by 379 · see citing works
Self-citationValverde, F. (1965) · Harvard University Press eBooks · doi:10.4159/harvard.9780674864559 · Cited by 377 · see citing works
A note on the connections and development of the nucleus accumbens
Swanson, L. W., & Cowan, W. M. (1975) · Brain Research · doi:10.1016/0006-8993(75)90278-4 · Cited by 353 · see citing works
A Golgi study of the descending medial forebrain bundle
Millhouse, O. E. (1969) · Brain Research · doi:10.1016/0006-8993(69)90161-9 · Cited by 345 · see citing works
The morphology of the forebrain in amphibia and reptilia
Herrick, C. J. (1910) · Journal of Comparative Neurology and Psychology · doi:10.1002/cne.920200502 · Cited by 333 · see citing works
Ramifications of the globus pallidus in the rat as indicated by patterns of immunohistochemistry
Haber, S. N., & Nauta, W. J. H. (1983) · Neuroscience · doi:10.1016/0306-4522(83)90291-9 · Cited by 325 · see citing works
Heimer, L. (1968) · PubMed · Cited by 312 · see citing works
Self-citationThe Olfactory Cortex and the Ventral Striatum
Heimer, L. (1978) · Springer eBooks · doi:10.1007/978-1-4757-0716-8_7 · Cited by 283 · see citing works
Self-citationCrosby, E. C., & Humphrey, T. (1941) · The Journal of Comparative Neurology · doi:10.1002/cne.900740209 · Cited by 275 · see citing works
Single Neostriatal Efferent Axons in the Globus Pallidus: A Light and Electron Microscopic Study
Chang, H. T., Wilson, C. J., & Kitai, S. T. (1981) · Science · doi:10.1126/science.7256286 · Cited by 271 · see citing works
A Golgi study of rat neostriatal neurons: Light microscopic analysis
Chang, H. T., Wilson, C. J., & Kitai, S. T. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902080202 · Cited by 266 · see citing works
Fallon, J. H., Seroogy, K. B., Loughlin, S. E., Morrison, R. S., Bradshaw, R. A., Knaver, D. J., & Cunningham, D. D. (1984) · Science · doi:10.1126/science.6144184 · Cited by 262 · see citing works
Gallyas, F., Wolff, J. R., Böttcher, H., & Záborszky, L. (1980) · Stain Technology · doi:10.3109/10520298009067258 · Cited by 236 · see citing works
Dual olfactory representation in the rat thalamus: An anatomical and electrophysiological study
Price, J. L., & Slotnick, B. M. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902150106 · Cited by 233 · see citing works
Active Sodium and Chloride Transport in the Single Celled Marine Alga Halicystis Ovalis
Blount, R. W., & Levedahl, B. H. (1960) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1960.tb01922.x · Cited by 210 · see citing works
The thalamostriatal projection in the cat
Beckstead, R. M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230302 · Cited by 206 · see citing works
The olfactory connections of the lateral hypothalamus in the rat, mouse and hamster
Scott, J. W., & Leonard, C. M. (1971) · The Journal of Comparative Neurology · doi:10.1002/cne.901410305 · Cited by 185 · see citing works
Hedreen, J. C., & Chalmers, J. P. (1972) · Brain Research · doi:10.1016/0006-8993(72)90248-x · Cited by 182 · see citing works
Young, W. S., Alheid, G., & Heimer, L. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-06-01626.1984 · Cited by 179 · see citing works
Self-citationThe primate globus pallidus: a Golgi and electron microscopic study.
Fox, C. A., Andrade, A. N., Qui, L., & Rafols, J. A. (1974) · PubMed · Cited by 173 · see citing works
Fallon, J. H., Loughlin, S. E., & Ribak, C. E. (1983) · The Journal of Comparative Neurology · doi:10.1002/cne.902180106 · Cited by 166 · see citing works
Newman, R. S., & Winans, S. S. (1980) · The Journal of Comparative Neurology · doi:10.1002/cne.901910204 · Cited by 142 · see citing works
Switzer, R. C., Hill, J., & Heimer, L. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90005-7 · Cited by 131 · see citing works
Self-citationCell configurations in the olfactory tubercle of the rat
Millhouse, O. E., & Heimer, L. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902280409 · Cited by 129 · see citing works
Self-citationThe termination of strio-pallidal and strio-nigral fibres
Kemp, J. M. (1970) · Brain Research · doi:10.1016/0006-8993(70)90312-4 · Cited by 113 · see citing works
The ventral striatopallidothalamic projection: II. The ventral pallidothalamic link
Zahm, D. S., Záborszky, L., Alheid, G. F., & Heimer, L. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902550410 · Cited by 108 · see citing works
Self-citationSiegel, A., Fukushima, T., Meibach, R. C., Burke, L., Edinger, H. M., & Weiner, S. (1977) · Brain Research · doi:10.1016/0006-8993(77)91048-4 · Cited by 94 · see citing works
de Olmos, J. S. (2008) · Brain Behavior and Evolution · doi:10.1159/000125825 · Cited by 87 · see citing works
Origin of olfactory projections to lateral hypothalamus and nuclei gemini of the rat
Scott, J. W., & Chafin, B. R. (1975) · Brain Research · doi:10.1016/0006-8993(75)90948-8 · Cited by 79 · see citing works
A Golgi study on the globus pallidus of the mouse
Iwahori, N., & Mizuno, N. (1981) · The Journal of Comparative Neurology · doi:10.1002/cne.901970104 · Cited by 59 · see citing works
Origins of olfactory bulb centrifugal fibres in the cat
Dennis, B. J., & Kerr, D. I. B. (1976) · Brain Research · doi:10.1016/0006-8993(76)90868-4 · Cited by 58 · see citing works
Heimer, L. (1970) · Springer eBooks · doi:10.1007/978-3-642-85986-1_8 · Cited by 58 · see citing works
Self-citationBenjamin, R. M., Jackson, J. C., Golden, G. T., & West, C. H. K. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902070407 · Cited by 38 · see citing works
Heimer, L., & Hoesen, G. W. V. (1979) · Elsevier eBooks · doi:10.1016/b978-0-08-023174-7.50013-8 · Cited by 31 · see citing works
Self-citationCortico-hypothalamic connexions in the rabbit: an experimental neuro-anatomical study.
Po, L. (1960) · PubMed · Cited by 28 · see citing works
Small injections of fluorescent tracers by iontophoresis or chronic implantation of micropipettes
Alheid, G. F., & Carlsen, J. (1982) · Brain Research · doi:10.1016/0006-8993(82)90209-8 · Cited by 18 · see citing works
Self-citationAnatomical Methods for Tracing Connections in the Central Nervous System
Heimer, L., & Lohman, A. H. M. (1975) · Elsevier eBooks · doi:10.1016/b978-0-12-278656-3.50007-7 · Cited by 6 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ikemoto, S. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.004 · Cited by 1,477 · see citing works
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217 · see citing works
Self-citationOn the significance of subterritories in the “accumbens” part of the rat ventral striatum
Zahm, D. S., & Brog, J. S. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90202-d · Cited by 1,040 · see citing works
Self-citationGroenewegen, H. J. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90339-9 · Cited by 732 · see citing works
Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708 · see citing works
Groenewegen, H. J., Berendse, H. W., Wolters, J. G., & Lohman, A. H. M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62677-1 · Cited by 506 · see citing works
Brain reward circuitry beyond the mesolimbic dopamine system: a neurobiological theory
Ikemoto, S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.02.001 · Cited by 454 · see citing works
Groenewegen, H. J., Berendse, H. W., & Haber, S. N. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90115-v · Cited by 456 · see citing works
Piecing together the Puzzle of Basal Forebrain Anatomy
Heimer, L., & Alheid, G. F. (1991) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4757-0145-6_1 · Cited by 310 · see citing works
Self-citationUsuda, I., Tanaka, K., & Chiba, T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00359-x · Cited by 248 · see citing works
Basal ganglia circuit loops, dopamine and motivation: a review and enquiry
Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226 · see citing works
Smelling sounds: Olfactory-auditory sensory convergence in the olfactory tubercle
Wesson, D. W., & Wilson, D. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6003-09.2010 · Cited by 150 · see citing works
Efferent connections of the rostral linear nucleus of the ventral tegmental area in the rat
Del-Fava, F., Hasue, R. H., Ferreira, J. G. P., & Shammah-Lagnado, S. J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.039 · Cited by 56 · see citing works
Martiros, N., Kapoor, V., Kim, S. E., & Murthy, V. N. (2022) · eLife · doi:10.7554/elife.75463 · Cited by 41 · see citing works
Heimer, L., Zahm, D. S., & Schmued, L. C. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90177-6 · Cited by 35 · see citing works
Self-citation
- Authors
- Heimer, L., Zaborszky, L., Zahm, D. S., & Alheid, G. F.
- Affiliations
- University of Virginia (US)
- Saint Louis University (US)
- ORCID
- Zahm, D. S.
- Venue
- Journal of Comparative Neurology
- Publisher
- Wiley
- Published
- 1987-01-22
- Volume
- 255
- Issue
- 4
- Pages
- 571-591
- ISSN
- 0021-9967 (ISSN-L)
- 1096-9861
- OpenAlex
- W2014989557
- Cited by
- 117
- References
- 59
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 5 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Comparative Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS 01799, NS-17743)
- National Center for Research Resources (2-507RR05431-24)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- olfactory tubercle, ventral pallidum, striatal projections, anterograde tracing, retrograde tracing, glutamic acid decarboxylase, rats
- MeSH terms
- Animals, Corpus Striatum, Globus Pallidus, Male, Nerve Degeneration, Neural Pathways, Synaptic Transmission, Olfactory Bulb, Phytohemagglutinins, Rats, Inbred Strains, Thalamus, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
