Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: Current status and working hypotheses
Open accessAbstract
Cognitive neuroscience studies of Attention Deficit Hyperactivity Disorder (ADHD) suggest multiple loci of pathology with respect to both cognitive domains and neural circuitry. Cognitive deficits extend beyond executive functioning to include spatial, temporal, and lower‐level “nonexecutive” functions. Atypical functional anatomy extends beyond frontostriatal circuits to include posterior cortices, limbic regions, and the cerebellum. Pathophysiology includes dopaminergic as well as noradrenergic neurotransmitter systems. We review the major insights gained from functional brain imaging studies in ADHD and discuss working hypotheses regarding their neurochemical underpinnings. © 2008 Wiley‐Liss, Inc. Dev Disabil Res Rev 2008;14:261–267.
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Existing studies also observed the involvement of the fronto-striatal circuit in working memory impairment and delay aversion in ADHD.
“Moreover, existing studies also observed the involvement of the fronto-striatal circuit in working memory impairment and delay aversion in ADHD (Castellanos et al., 2006; Vaidya and Stollstorff, 2008; Darki and Klingberg, 2015; Bollmann et al., 2017).”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Vaidya and Stollstorff, 2008
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- Authors
- Vaidya, C. J., & Stollstorff, M.
- Affiliations
- Children's National (US)
- Georgetown University (US)
- Corresponding author
- Vaidya, Chandan J.
- ORCID
- Vaidya, Chandan J.
- Venue
- Developmental Disabilities Research Reviews
- Publisher
- Wiley
- Published
- 2008-01
- Volume
- 14
- Issue
- 4
- Pages
- 261-267
- ISSN
- 1940-5510 (ISSN-L)
- 1940-5529
- PMC
- PMC4437560
- OpenAlex
- W2112435834
- Cited by
- 95
- References
- 23
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 4 · 2012: 13
- FWCI
- 1.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Developmental Disabilities Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH65395, R01MH065395)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, executive function, frontostriatal circuits, posterior cortex, limbic system, cerebellum, dopamine signaling, noradrenergic neurotransmission, functional neuroimaging, ADHD pathophysiology
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Cognition Disorders, Corpus Striatum, Frontal Lobe, Humans, Magnetic Resonance Imaging, Nerve Net, Neuropsychological Tests, Neurosciences, Parietal Lobe, Temporal Lobe
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