Cited by 53Gestational Diabetes Research and ManagementDiabetes, Cardiovascular Risks, and LipoproteinsBirth, Development, and Health

Maternal metabolic factors and the association with gestational diabetes: a systematic review and meta-analysis

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Habibi, Nahal, Mousa, Aya, Tay, Chau Thien, Khomami, Mahnaz Bahri, Patten, Rhiannon K., Andraweera, Prabha H., Wassie, Molla, Vandersluys, Jared +4 more·2022·Diabetes/Metabolism Research and Reviews

Abstract

Gestational diabetes (GDM) is associated with several adverse outcomes for the mother and child. Higher levels of individual lipids are associated with risk of GDM and metabolic syndrome (MetS), a clustering of risk factors also increases risk for GDM. Metabolic factors can be modified by diet and lifestyle. This review comprehensively evaluates the association between MetS and its components, measured in early pregnancy, and risk for GDM. Databases (Cumulative Index to Nursing and Allied Health Literature, PubMed, Embase, and Cochrane Library) were searched from inception to 5 May 2021. Eligible studies included ≥1 metabolic factor (waist circumference, blood pressure, fasting plasma glucose (FPG), triglycerides, and high‐density lipoprotein cholesterol), measured at <16 weeks' gestation. At least two authors independently screened potentially eligible studies. Heterogeneity was quantified using I 2 . Data were pooled by random‐effects models and expressed as odds ratio and 95% confidence intervals (CIs). Of 7213 articles identified, 40 unique articles were included in meta‐analysis. In analyses adjusting for maternal age and body mass index, GDM was increased with increasing FPG (odds ratios [OR] 1.92; 95% CI 1.39–2.64, k = 7 studies) or having MetS (OR 2.52; 1.65, 3.84, k = 3). Women with overweight (OR 2.17; 95% CI 1.89, 2.50, k = 12) or obesity (OR 4.34; 95% CI 2.79–6.74, k = 9) also were at increased risk for GDM. Early pregnancy assessment of glucose or the MetS, offers a potential opportunity to detect and treat individual risk factors as an approach towards GDM prevention; weight loss for pregnant women with overweight or obesity is not recommended. Systematic review registration: PROSPERO CRD42020199225.

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Authors
Habibi, N., Mousa, A., Tay, C. T., Khomami, M. B., Patten, R. K., Andraweera, P. H., Wassie, M., Vandersluys, J., Aflatounian, A., Bianco‐Miotto, T., Zhou, S. J., & Grieger, J. A.
Affiliations
  • The University of Adelaide (AU)
  • Monash University (AU)
  • Victoria University (AU)
  • Lyell McEwin Hospital (AU)
  • UNSW Sydney (AU)
Corresponding author
Grieger, Jessica A.
Venue
Diabetes/Metabolism Research and Reviews
Publisher
Wiley
Published
2022-04-25
Volume
38
Issue
5
Pages
e3532-e3532
ISSN
  • 1520-7552 (ISSN-L)
  • 1520-7560
OpenAlex
W4223942051
Cited by
53
References
136
Citations by year
2026: 11 · 2025: 18 · 2024: 11 · 2023: 9 · 2022: 4
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Diabetes/Metabolism Research and Reviews (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
  • Victoria University Research Repository (Victoria University) (submittedVersion, cc-by)
Funders
National Health and Medical Research Council (GNT 2009038, GNT 1161871)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
gestational diabetes mellitus, metabolic syndrome, fasting blood glucose, waist circumference, blood pressure, triglycerides, HDL cholesterol, maternal obesity, maternal overweight, early pregnancy screening, GDM prevention
MeSH terms
Female, Humans, Obesity, Pregnancy, Body Mass Index, Diabetes, Gestational, Metabolic Syndrome, Overweight

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