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Cited by 362

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Regulatory T cells – a brief history and perspective

Sakaguchi, Shimon, Wing, Kajsa, Miyara, Makoto·2007·European Journal of Immunology
DOI 10.1002/eji.200737593
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Abstract

It is now widely accepted that the normal immune system harbors a regulatory T-cell population specialized for immune suppression. It was found initially that some CD4(+) T cells in normal animals were capable of suppressing autoimmunity. Characterization of this autoimmune-suppressive CD4(+) T cell population revealed that they constitutively expressed the CD25 molecule, which made it possible to distinguish them from other T cells, delineate their developmental pathways, in particular their thymic development, and characterize their potent in vivo and in vitro immunosuppressive activity. The marker also helped to identify human regulatory T cells with similar functional and phenotypic characteristics. Recent studies have shown that CD25(+)CD4(+) regulatory T cells specifically express the transcription factor Foxp3. Genetic anomaly of Foxp3 causes autoimmune and inflammatory disease in rodents and humans through affecting the development and function of CD25(+)CD4(+) regulatory T cells. These findings at the cellular and molecular levels altogether provide firm evidence for Foxp3(+)CD25(+)CD4(+) regulatory T cells as an indispensable cellular constituent of the normal immune system and for their crucial roles in establishing and maintaining immunologic self-tolerance and immune homeostasis. They can be exploited for clinical use to treat immunological diseases and control physiological and pathological immune responses.

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Metadata

Authors
Sakaguchi, S., Wing, K., & Miyara, M.
Venue
European Journal of Immunology
Publisher
Wiley
Published
2007-11
Volume
37
Issue
S1
Pages
S116-S123
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
DOI
10.1002/eji.200737593
OpenAlex
W2066521804
Cited by
362
References
9
FWCI
9.43
Type
journal article
Language
en
Open access
closed
Licence
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 2861 d)

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Sakaguchi, S., Wing, K., & Miyara, M. (2007). Regulatory T cells – a brief history and perspective. European Journal of Immunology. https://doi.org/10.1002/eji.200737593

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