Defective Mer Receptor Tyrosine Kinase Signaling in Bone Marrow Cells Promotes Apoptotic Cell Accumulation and Accelerates Atherosclerosis

A blast from the past: clearance of apoptotic cells regulates immune responses

Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574 · see citing works

Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215 · see citing works

TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response

Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. A., & Lemke, G. (2007) · Cell · doi:10.1016/j.cell.2007.10.034 · Cited by 1,055 · see citing works

Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967 · see citing works

Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

Lu, Q., & Lemke, G. (2001) · Science · doi:10.1126/science.1061663 · Cited by 699 · see citing works

Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

Clarke, M. C. H., Figg, N. L., Maguire, J. J., Davenport, A. P., Goddard, M. J., Littlewood, T. D., & Bennett, M. R. (2006) · Nature Medicine · doi:10.1038/nm1459 · Cited by 645 · see citing works

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

Geng, Y., & Libby, P. (1995) · PubMed · Cited by 641 · see citing works

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

Tabas, I. A. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000184783.04864.9f · Cited by 641 · see citing works

Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

Cohen, P. L., Caricchio, R., Abraham, V., Camenisch, T. D., Jennette, J. C., Roubey, R. A. S., Earp, H. S., Matsushima, G. K., & Reap, E. A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012094 · Cited by 637 · see citing works

Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques

Mallat, Z., Hugel, B., Ohan, J., Lesèche, G., Freyssinet, J., & Tedgui, A. (1999) · Circulation · doi:10.1161/01.cir.99.3.348 · Cited by 636 · see citing works

Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis

Schrijvers, D. M., De Meyer, G. R. Y., Kockx, M. M., Herman, A. G., & Martinet, W. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000166517.18801.a7 · Cited by 509 · see citing works

Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: Evidence that oxidation-specific epitopes mediate macrophage recognition

Chang, M.-K., Bergmark, C., Laurila, A., Hörkkö, S., Han, K., Friedman, P., Dennis, E. A., & Witztum, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6353 · Cited by 456 · see citing works

Minimally Modified LDL Binds to CD14, Induces Macrophage Spreading via TLR4/MD-2, and Inhibits Phagocytosis of Apoptotic Cells

Miller, Y. I., Viriyakosol, S., Binder, C. J., Feramisco, J. R., Kirkland, T. N., & Witztum, J. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209634200 · Cited by 398 · see citing works

Localization of Apoptotic Macrophages at the Site of Plaque Rupture in Sudden Coronary Death

Kolodgie, F. D., Narula, J., BURKE, A. P., Haider, N., Farb, A. A., Hui-Liang, Y., Smialek, J. E., & Virmani, R. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64641-x · Cited by 363 · see citing works

Apoptotic Cells with Oxidation-specific Epitopes Are Immunogenic and Proinflammatory

Chang, M.-K., Binder, C. J., Miller, Y. I., Subbanagounder, G., Silverman, G. J., Berliner, J. A., & Witztum, J. L. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031763 · Cited by 334 · see citing works

The phosphatidylserine receptor: a crucial molecular switch?

Henson, P. M., Bratton, D. L., & Fadok, V. A. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085094 · Cited by 321 · see citing works

Apoptotic cells induce Mer tyrosine kinase–dependent blockade of NF-κB activation in dendritic cells

Sen, P., Wallet, M. A., Yi, Z., Huang, Y., Henderson, M., Mathews, C. E., Earp, H. S., Matsushima, G. K., Baldwin, A. S., & Tisch, R. (2006) · Blood · doi:10.1182/blood-2006-04-017368 · Cited by 237 · see citing works

Apolipoprotein E Modulates Clearance of Apoptotic Bodies In Vitro and In Vivo, Resulting in a Systemic Proinflammatory State in Apolipoprotein E-Deficient Mice

Grainger, D. J., Reckless, J., & McKilligin, E. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.10.6366 · Cited by 183 · see citing works

Complement C1q Reduces Early Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

Bhatia, V. K., Yun, S., Leung, V. W. Y., Grimsditch, D. C., Benson, G. M., Botto, M., Boyle, J. J., & Haskard, D. O. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060406 · Cited by 166 · see citing works

Autophosphorylation Docking Site Tyr-867 in Mer Receptor Tyrosine Kinase Allows for Dissociation of Multiple Signaling Pathways for Phagocytosis of Apoptotic Cells and Down-modulation of Lipopolysaccharide-inducible NF-κB Transcriptional Activation

Tibrewal, N., Wu, Y., D’Mello, V., Akakura, R., George, T. C., Varnum, B. C., & Birge, R. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706906200 · Cited by 156 · see citing works

Leukocyte Transglutaminase 2 Expression Limits Atherosclerotic Lesion Size

Boisvert, W. A., Rose, D. M., Boullier, A., Quehenberger, O., Sydlaske, A. D., Johnson, K. A., Curtiss, L. K., & Terkeltaub, R. A. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000203503.82693.c1 · Cited by 95 · see citing works

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601 · see citing works

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Bäck, M., Yurdagul, A., Tabas, I., Öörni, K., & Kovanen, P. T. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0169-2 · Cited by 1,341 · see citing works

Macrophage death and defective inflammation resolution in atherosclerosis

Tabas, I. (2010) · Nature Reviews Immunology · doi:10.1038/nri2675 · Cited by 1,120 · see citing works

Efferocytosis in health and disease

Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066 · see citing works

Monocyte-macrophages and T cells in atherosclerosis

Tabas, I., & Lichtman, A. H. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.008 · Cited by 646 · see citing works

Biology of the TAM Receptors

Lemke, G. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009076 · Cited by 598 · see citing works

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works

The role of efferocytosis in atherosclerosis

Kojima, Y., Weissman, I. L., & Leeper, N. J. (2017) · Circulation · doi:10.1161/circulationaha.116.025684 · Cited by 289 · see citing works

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

Cai, B., Thorp, E. B., Doran, A. C., Sansbury, B. E., Daemen, M. J. A. P., Dorweiler, B., Spite, M., Fredman, G., & Tabas, I. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90520 · Cited by 262 · see citing works

The role of non-resolving inflammation in atherosclerosis

Kasikara, C., Doran, A. C., Cai, B., & Tabas, I. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97950 · Cited by 266 · see citing works

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

Yvan-Charvet, L., Pagler, T. A., Seimon, T. A., Thorp, E., Welch, C. L., Witztum, J. L., Tabas, I., & Tall, A. R. (2010) · Circulation Research · doi:10.1161/circresaha.110.217281 · Cited by 217 · see citing works

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

Thorp, E., & Tabas, I. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209115 · Cited by 231 · see citing works

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation: Effects of Hyperlipidemia-Mediated Inhibition of Phagocytosis

Clarke, M. C. H., Talib, S., Figg, N. L., & Bennett, M. R. (2010) · Circulation Research · doi:10.1161/circresaha.109.208389 · Cited by 216 · see citing works

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

Cai, B., Kasikara, C., Doran, A. C., Ramakrishnan, R., Birge, R. B., & Tabas, I. (2018) · Science Signaling · doi:10.1126/scisignal.aar3721 · Cited by 175 · see citing works

Cyclin-dependent kinase inhibitor 2B regulates efferocytosis and atherosclerosis

Kojima, Y., Downing, K., Kundu, R., Miller, C., Dewey, F., Lancero, H., Raaz, U., Perisic, L., Hedin, U., Schadt, E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci70391 · Cited by 148 · see citing works

Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

Tajbakhsh, A., Rezaee, M., Kovanen, P. T., & Sahebkar, A. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.003 · Cited by 134 · see citing works

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability

Petri, M. H., Laguna-Fernández, A., Gonzalez-Diez, M., Paulsson-Berne, G., Hansson, G. K., & Bäck, M. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvu224 · Cited by 125 · see citing works

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

Thorp, E., Subramanian, M., & Tabas, I. (2011) · European Journal of Immunology · doi:10.1002/eji.201141719 · Cited by 107 · see citing works

The many ways tissue phagocytes respond to dying cells

Blander, J. M. (2017) · Immunological Reviews · doi:10.1111/imr.12537 · Cited by 84 · see citing works

In Vitro Modeling of Atherosclerosis Using iPSC‐Derived Blood Vessel Organoids

Kong, D., Ryu, J., Shin, N., Lee, S., Kim, N. G., Kim, H., Kim, M., Choi, J., Kim, D., & Kang, K. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202400919 · Cited by 36 · see citing works

Growth Arrest-Specific Factor 6 (GAS6) Is Increased in COVID-19 Patients and Predicts Clinical Outcome

Morales, A., Rojo‐Rello, S., Cristóbal, H., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9040335 · Cited by 33 · see citing works

Expression of Gas6 Receptors, Tyro3, Axl, and Mertk, in Oocytes and Embryos and Effects of Mertk RNAi on the Oocyte Maturation

Kim, K., Lee, S.-E., & Lee, K. (2012) · 발생과 생식 · Cited by 1 · see citing works

Sustained Release of Gas6 via mPEG-PLGA Nanoparticles Enhances the Therapeutic Effects of MERTK Gene Therapy in RCS Rats

Wu, S., Mao, Y., Liu, Q., Yan, X., Zhang, J., & Wang, N. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.794299 · Cited by 9 · see citing works

Axl-dependent signalling: a clinical update

Korshunov, V. A. (2011) · Clinical Science · doi:10.1042/cs20110411 · Cited by 156 · see citing works

The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer

Uribe, D. J., Mandell, E. K., Watson, A., Martinez, J. D., Leighton, J. A., Ghosh, S., & Rothlin, C. V. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179979 · Cited by 42 · see citing works